Zactima and disease progression Patient Reports February 12, 2012

Zactima Side Effects Report #5901539-X
Zactima side effect was reported by a Health Professional from UNITED STATES on Sept 26, 2008. Male patient, 34 years of age, weighting 229.3 lb, was diagnosed with malignant glioma and was treated with Zactima. After drug was administered, patient experienced the following side effects: disease progression, dyspnoea, fatigue, hypoxia, myalgia, oedema, oral candidiasis, pneumocystis jiroveci pneumonia, pulmonary embolism . Zactima dosage: 100MG QOD X 28 DAYS. During the same period patient was treated with ETOPOSIDE, PROTONIX, MINOCYCLINE, DEXAMETHASONE, TYLENOL, LASIX, CLINDAMYCIN, FUROSEMIDE. Patient was hospitalized. Patient recovered.

Zactima Side Effects Report #5862765-1
Zactima side effect was reported by a Health Professional from UNITED STATES on Aug 27, 2008. Male patient, 40 years of age, weighting 172.0 lb, was diagnosed with glioblastoma multiforme and was treated with Zactima. After drug was administered, patient experienced the following side effects: confusional state, diarrhoea, disease progression, dizziness , nausea , postoperative fever, urinary incontinence . Zactima dosage: ZACTIMA300MG QD. During the same period patient was treated with HYDROXYUREA, GLEEVEC, LEXAPRO, DILANTIN. Patient was hospitalized. Patient recovered.

Zactima Side Effects Report #6000210-6
Zactima side effect was reported by a Health Professional from UNITED STATES on Dec 11, 2008. Male patient, weighting 141.3 lb, was diagnosed with glioblastoma multiforme and was treated with Zactima. After drug was administered, patient experienced the following side effects: asthenia, disease progression, peripheral motor neuropathy. Zactima dosage: 300MG QD DAILY X 28 DAYS PO. During the same period patient was treated with GLEEVEC, HYDREA, LAMICTAL, KEPPRA, VALTREX, COLACE, METAMUCIL, DECADRON. Patient was hospitalized. Patient recovered.

Zactima Side Effects Report #6003586-9
Zactima side effect was reported by a Health Professional from UNITED STATES on Dec 12, 2008. Male patient, weighting 141.3 lb, was diagnosed with glioblastoma multiforme and was treated with Zactima. After drug was administered, patient experienced the following side effects: asthenia, disease progression, peripheral motor neuropathy. Zactima dosage: 300MG QD DAILY X 28 DAYS PO. During the same period patient was treated with GLEEVEC, HYDREA, LAMICTAL, KEPPRA, VALTREX, COLACE, METAMUCIL, DECADRON. Patient was hospitalized. Patient recovered.


Zactima Side Effects Report #6023453-4
Zactima side effect was reported by a Health Professional from UNITED STATES on Dec 26, 2008. Male patient, weighting 141.3 lb, was diagnosed with glioblastoma multiforme and was treated with Zactima. After drug was administered, patient experienced the following side effects: asthenia, disease progression, neurological decompensation, peripheral motor neuropathy. Zactima dosage: 300MG QD DAILY X 28 DAYS PO. During the same period patient was treated with HYDREA, GLEEVEC, LAMICTAL, KEPPRA, VALTREX, COLACE, METAMUCIL, DECADRON. Patient died on 12/20/2008.