Xigris and respiratory failure Patient Reports February 12, 2012

Xigris Side Effects Report #4801897-3
Xigris side effect was reported by a Pharmacist from UNITED STATES on Oct 14, 2005. Male patient, 51 years of age, weighting 171.1 lb, was diagnosed with systemic inflammatory response syndrome and was treated with Xigris. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, culture stool positive, enterococcal infection, renal failure, respiratory failure, shock. Xigris dosage: unknown. During the same period patient was treated with DOBUTAMINE, VASOPRESSIN, NOREPINEPHRINE, PANTOPRAZOLE, PRIMAXIN, METRONIDAZOLE, FLUCONAZOLE, BICARBONATE. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #5966098-4
Xigris side effect was reported by a Physician from ITALY on Nov 12, 2008. Male patient, 66 years of age, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: catheter site haemorrhage, gastrointestinal haemorrhage, post procedural haemorrhage, renal failure, respiratory failure. Xigris dosage: unknown. During the same period patient was treated with NOREPINEPHRINE, ANTIBIOTICS, IMMUNOSUPPRESSIVE AGENTS, CORTICOSTEROID NOS. Patient recovered.

Xigris Side Effects Report #5333273-1
Xigris side effect was reported by a Physician from UNITED STATES on May 17, 2007. Male patient, 90 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: respiratory failure, sepsis . Xigris dosage: unknown. Patient died.

Xigris Side Effects Report #5071846-4
Xigris side effect was reported by a Consumer or non-health professional from UNITED STATES on July 13, 2006. Female patient, 79 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, renal disorder, respiratory failure, septic shock. Xigris dosage: unknown. During the same period patient was treated with LEVOPHED. Patient died on 07/03/2006.


Xigris Side Effects Report #5152523-8
Xigris side effect was reported by a Physician from UNITED STATES on Nov 07, 2006. Male patient, 78 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac failure, respiratory failure. Xigris dosage: unknown. Patient was hospitalized. Patient died on 11/04/2006.

Xigris Side Effects Report #5164690-0
Xigris side effect was reported by a Physician from UNITED STATES on Nov 07, 2006. Male patient, 78 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac failure, respiratory failure. Xigris dosage: unknown. Patient was hospitalized. Patient died on 11/04/2006.

Xigris Side Effects Report #5140066-7
Xigris side effect was reported by a Physician from UNITED STATES on Oct 05, 2006. Female patient, 77 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: catheter site haemorrhage, disseminated intravascular coagulation, hydronephrosis, oedema, respiratory failure, thrombocytopenia, ureteric obstruction. Xigris dosage: unknown. During the same period patient was treated with HEPARIN, PROPOFOL, ZOSYN, ZITHROMAX, ARANESP. Patient died.

Xigris Side Effects Report #5197081-7
Xigris side effect was reported by a Physician from UNITED KINGDOM on Dec 20, 2006. Male patient, 76 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: respiratory failure. Xigris dosage: 2.1 MG, EVERY HOUR. During the same period patient was treated with HEPARIN. Patient died on 12/20/2006.

Xigris Side Effects Report #4957338-9
Xigris side effect was reported by a Pharmacist from UNITED STATES on Mar 15, 2006. Female patient, 76 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cardiac arrest , cardio-respiratory arrest, hypotension, international normalised ratio increased, laboratory test interference, pneumothorax, respiratory failure. Xigris dosage: unknown. Patient died on 03/08/2006.


Xigris Side Effects Report #5977821-7
Xigris side effect was reported by a Physician from UNITED STATES on Nov 26, 2008. Female patient, 75 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: anaemia, respiratory failure. Xigris dosage: unknown. Patient died.

Xigris Side Effects Report #4693496-1
Xigris side effect was reported by a Consumer or non-health professional from on June 01, 2005. Female patient, 71 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: blood bicarbonate decreased, blood creatinine increased, blood ph decreased, haemorrhage, pco2 decreased, platelet count decreased, respiratory failure, white blood cell count increased. Xigris dosage: unknown. During the same period patient was treated with CIPRO, ZYVOX, LEVOPHED. Patient died on 05/29/2005.

Xigris Side Effects Report #4703751-4
Xigris side effect was reported by a Consumer or non-health professional from on June 13, 2005. Female patient, 71 years of age, weighting 138.9 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: blood bicarbonate decreased, blood creatinine increased, blood ph decreased, haematocrit decreased, haemorrhage, platelet count decreased, respiratory failure, septic shock. Xigris dosage: unknown. During the same period patient was treated with CIPRO, ZYVOX, LOVENOX, INSULIN, PREVACID, NORMAL SALINE, ALBUMIN NOS, MORPHINE SULPHATE. Patient died on 05/30/2005.

Xigris Side Effects Report #4753378-3
Xigris side effect was reported by a Pharmacist from UNITED STATES on Aug 08, 2005. Female patient, 71 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: respiratory failure. Xigris dosage: unknown. Patient died on 05/24/2005.

Xigris Side Effects Report #5322139-9
Xigris side effect was reported by a Physician from GERMANY on May 08, 2007. Male patient, 70 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: hepatic failure, renal failure, respiratory failure, sepsis . Xigris dosage: unknown. Patient died.


Xigris Side Effects Report #4898662-8
Xigris side effect was reported by a Pharmacist from UNITED STATES on Jan 11, 2006. Male patient, 70 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: hypotension, renal failure, respiratory failure. Xigris dosage: unknown. During the same period patient was treated with ANTIBIOTICS. Patient died on 01/05/2006.

Xigris Side Effects Report #5557932-0
Xigris side effect was reported by a Physician from GERMANY on Dec 07, 2007. Male patient, 69 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: renal failure acute, respiratory failure, shock. Xigris dosage: unknown. During the same period patient was treated with PRIMAXIN, VANCOMYCIN. Patient died.

Xigris Side Effects Report #5531387-4
Xigris side effect was reported by a Physician from GERMANY on Sept 28, 2007. Male patient, 55 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, condition aggravated, multi-organ failure, pneumonia , renal failure, respiratory failure, sepsis , shock. Xigris dosage: unknown. During the same period patient was treated with TAVANIC, TAZOBACTAM, NORADRENALIN. Patient died on 07/14/2007.

Xigris Side Effects Report #4777995-X
Xigris side effect was reported by a Physician from BELGIUM on Sept 06, 2005. Female patient, 51 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, intestinal perforation, lactic acidosis, necrotising fasciitis, renal failure acute, respiratory failure, septic shock, thrombocytopenia. Xigris dosage: 35.136 MG DAY. During the same period patient was treated with MIDAZOLAM, NOREPINEPHERINE. Patient was hospitalized. Patient died on 07/02/2005.

Xigris Side Effects Report #5767279-5
Xigris side effect was reported by a Physician from MEXICO on June 03, 2008. Male patient, 37 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac failure, respiratory failure. Xigris dosage: 40 MG, OTHER. Patient died on 06/03/2008.


Xigris Side Effects Report #5901330-4
Xigris side effect was reported by a Physician from MEXICO on Sept 18, 2008. Male patient, 37 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac failure, respiratory failure. Xigris dosage: 40 MG, OTHER. Patient died on 06/03/2008.

Xigris Side Effects Report #5646937-7
Xigris side effect was reported by a Physician from UNITED STATES on Feb 21, 2008. Male patient, weighting 180.0 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: chronic obstructive pulmonary disease, coronary artery disease , pneumonia , respiratory failure, sepsis . Xigris dosage: unknown. Patient was hospitalized. Patient died on 01/11/2008.

Xigris Side Effects Report #5828741-X
Xigris side effect was reported by a Physician from AUSTRALIA on July 24, 2008. Male patient was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: respiratory failure. Xigris dosage: unknown. Patient was hospitalized. Patient died on 09/05/2007.

Xigris Side Effects Report #4928192-6
Xigris side effect was reported by a Physician from GERMANY on Feb 03, 2006. Male patient, 15 years of age, weighting 154.3 lb, was diagnosed with meningococcal sepsis and was treated with Xigris. After drug was administered, patient experienced the following side effects: circulatory collapse, condition aggravated, meningococcal sepsis, multi-organ failure, renal failure, respiratory failure. Xigris dosage: unknown. During the same period patient was treated with CLAFORAN, ARIVEN, NORADRENALINE, DORMICUM ROCHE, SUFENTA, HYDROCORTISONE, OMEPRAZOLE. Patient was hospitalized. Patient died on 01/29/2006.

Xigris Side Effects Report #5211960-3
Xigris side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 16, 2007. Male patient, 89 years of age, was diagnosed with lung injury and was treated with Xigris. After drug was administered, patient experienced the following side effects: dialysis , disease progression, haemodynamic instability, organ failure, renal failure, respiratory failure, sepsis . Xigris dosage: unknown. During the same period patient was treated with NIMBEX, FENTANYL TRANSDERMAL SYSTEM, MIDAZOLAM HYDROCHLORIDE, NOREPINEPHRINE BITARTRATE, VASOPRESSIN, DIFLUCIN, MEROPENEM. Patient died on 12/06/2006.


Xigris Side Effects Report #5211958-5
Xigris side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 16, 2007. Female patient, 39 years of age, was diagnosed with lung injury and was treated with Xigris. After drug was administered, patient experienced the following side effects: increased upper airway secretion, respiratory failure, stridor, swelling. Xigris dosage: unknown. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #4709623-3
Xigris side effect was reported by a Health Professional from UNITED STATES on June 29, 2005. Male patient, 85 years of age, was diagnosed with clostridial infection and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac disorder, dialysis , hypotension, organ failure, renal failure, respiratory failure. Xigris dosage: unknown. Patient died on 05/01/2005.

Xigris Side Effects Report #4713620-1
Xigris side effect was reported by a Health Professional from UNITED STATES on June 28, 2005. Male patient, 85 years of age, was diagnosed with clostridial infection and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac disorder, dialysis , hypotension, renal failure, respiratory failure. Xigris dosage: unknown. Patient died on 05/01/2005.