Xigris and prothrombin time prolonged Patient Reports February 12, 2012

Xigris Side Effects Report #5383276-6
Xigris side effect was reported by a Physician from UNITED STATES on July 05, 2007. Male patient, 75 years of age, was diagnosed with systemic inflammatory response syndrome, thrombosis prophylaxis and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, prothrombin time prolonged, subarachnoid haemorrhage. Xigris dosage: unknown. During the same period patient was treated with HEPARIN, ASPIRIN. Patient died on 04/08/2007.

Xigris Side Effects Report #4579397-8
Xigris side effect was reported by a Health Professional from on Jan 21, 2005. Female patient, 81 years of age, weighting 183.0 lb, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, haematocrit decreased, haemoglobin decreased, haemoptysis, platelet count decreased, prothrombin time prolonged. Xigris dosage: unknown. During the same period patient was treated with HEPARIN, LOVENOX, NOREPINEPHRINE BITARTRATE. Patient died on 01/04/2005.

Xigris Side Effects Report #4872684-5
Xigris side effect was reported by a Physician from ITALY on Dec 21, 2005. Male patient, 78 years of age, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cerebral haematoma, condition aggravated, convulsion, haemorrhage intracranial, infusion related reaction, international normalised ratio increased, prothrombin time prolonged, thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with ENOXAPARIN, NOREPINEPHRINE BITARTRATE, DOBUTAMINE. Patient was hospitalized. Patient died on 09/05/2005.

Xigris Side Effects Report #4562954-2
Xigris side effect was reported by a Physician from on Jan 10, 2005. Male patient, 80 years of age, weighting 165.3 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, convulsion, haemorrhage intracranial, incision site haemorrhage, international normalised ratio decreased, platelet count decreased, prothrombin time prolonged, upper gastrointestinal haemorrhage, wound haemorrhage. Xigris dosage: unknown. During the same period patient was treated with PIPERACILLIN W, MEROPENEM, METROGYL, PANTOPRAZOLE, LASIX, MANNITOL, TAXIM. Patient died on 12/30/2004.


Xigris Side Effects Report #4600095-6
Xigris side effect was reported by a Physician from on Feb 11, 2005. Male patient, 80 years of age, weighting 165.3 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, catheter site haemorrhage, convulsion, haemorrhage intracranial, incision site haemorrhage, international normalised ratio increased, platelet count decreased, prothrombin time prolonged, upper gastrointestinal haemorrhage. Xigris dosage: unknown. During the same period patient was treated with PIPERACILLIN W, MEROPENEM, METROGYL, PANTOPRAZOLE, LASIX, MANNITOL, TAXIM. Patient died on 12/30/2004.

Xigris Side Effects Report #4806759-3
Xigris side effect was reported by a Consumer or non-health professional from ITALY on Oct 03, 2005. Female patient, 68 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, haemoglobin decreased, haemothorax, platelet count decreased, prothrombin time prolonged, red blood cell count decreased. Xigris dosage: 37.4 MG. During the same period patient was treated with GABEXATE, SOLDESAM, DIFLUCAN, TRENTAL, FLUIMUCIL, OMEPRAZOLE, ASCORBIC ACID, ISOPTION. Patient was hospitalized. Patient died on 09/20/2005.

Xigris Side Effects Report #5113939-9
Xigris side effect was reported by a Physician from UNITED KINGDOM on Sept 03, 2006. Male patient, 61 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, prothrombin time prolonged, thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with NORADRENALINE. Patient recovered.

Xigris Side Effects Report #5200045-8
Xigris side effect was reported by a Physician from UNITED STATES on Dec 28, 2006. Male patient, 56 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: international normalised ratio increased, platelet count decreased, prothrombin time prolonged. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #5735865-4
Xigris side effect was reported by a Physician from UNITED STATES on May 06, 2008. Female patient, 54 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: haematuria, haemorrhage, incision site haemorrhage, international normalised ratio increased, prothrombin time prolonged. Xigris dosage: unknown. During the same period patient was treated with LOVENOX. Patient died on 03/18/2008.


Xigris Side Effects Report #4665001-7
Xigris side effect was reported by a Physician from on May 02, 2005. Male patient, 53 years of age, weighting 143.3 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood sodium increased, brain oedema, cerebral haemorrhage, haemoglobin decreased, intraventricular haemorrhage, platelet count increased, prothrombin time prolonged, white blood cell count increased. Xigris dosage: unknown. During the same period patient was treated with OMEPRAZOL, CEFTRIAXONE, METRONIDAZOLE, CHLORAMPHENICOL, TRAMADOL, ALBUMIN NOS, HYDROCORTISONE, VITAMIN K. Patient was hospitalized and became disabled. Patient died on 01/20/2005.

Xigris Side Effects Report #5618768-5
Xigris side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 29, 2008. Male patient, 51 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: deep vein thrombosis , haemorrhage, prothrombin time prolonged, pulmonary sepsis. Xigris dosage: unknown. During the same period patient was treated with ASPIRIN. Patient died on 01/23/2008.

Xigris Side Effects Report #4741622-8
Xigris side effect was reported by a Physician from MEXICO on July 22, 2005. Female patient, 43 years of age, weighting 176.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cardiopulmonary failure, neurological symptom, prothrombin time prolonged, pulmonary haemorrhage. Xigris dosage: unknown. Patient was hospitalized. Patient died.

Xigris Side Effects Report #4800832-1
Xigris side effect was reported by a Physician from MEXICO on Sept 09, 2005. Female patient, 43 years of age, weighting 176.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cardiopulmonary failure, nervous system disorder, prothrombin time prolonged, pulmonary haemorrhage. Xigris dosage: unknown. Patient was hospitalized. Patient died.

Xigris Side Effects Report #5237516-4
Xigris side effect was reported by a Physician from UNITED KINGDOM on Feb 03, 2007. Female patient, 38 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, prothrombin time prolonged. Xigris dosage: 0.024 MG/KG, EVERY HOUR. Patient recovered.


Xigris Side Effects Report #4561534-2
Xigris side effect was reported by a Pharmacist from on Jan 05, 2005. Female patient, 38 years of age, weighting 121.3 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: haemorrhage intracranial, international normalised ratio increased, mental status changes, platelet count decreased, prothrombin time prolonged, subdural haematoma. Xigris dosage: unknown. During the same period patient was treated with IMMUNOSUPPRESSANTS. Patient died on 11/17/2004.

Xigris Side Effects Report #4949360-3
Xigris side effect was reported by a Physician from UNITED STATES on Feb 24, 2006. Female patient, 33 years of age, weighting 123.5 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, condition aggravated, fibrin d dimer increased, fibrin degradation products increased, haemoglobin decreased, international normalised ratio increased, prothrombin time prolonged. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #4824063-4
Xigris side effect was reported by a Physician from UNITED STATES on Oct 26, 2005. Female patient, 24 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, life support, premature separation of placenta, prothrombin time prolonged, stillbirth. Xigris dosage: unknown. During the same period patient was treated with PHENYLEPHRINE, ATIVAN, VANCOMYCIN, GENTAMICIN, METHADONE, FENTANYL, ATROVENT, HEPARIN. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #5800209-6
Xigris side effect was reported by a Physician from UNITED STATES on June 20, 2008. Female patient, weighting 308.6 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: haematuria, haemorrhage, international normalised ratio increased, prothrombin time prolonged, sepsis . Xigris dosage: unknown. During the same period patient was treated with LOVENOX. Patient died on 03/18/2008.

Xigris Side Effects Report #4630747-3
Xigris side effect was reported by a Pharmacist from on Mar 17, 2005. Female patient, 57 years of age, weighting 392.4 lb, was diagnosed with abdominal sepsis and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, haemoglobin decreased, haemorrhage urinary tract, international normalised ratio increased, mouth haemorrhage, platelet count decreased, prothrombin time prolonged, septic shock. Xigris dosage: unknown. During the same period patient was treated with GENTAMICIN, ZOSYN, HEPARIN, AVELOX, TYLENOL, PHENYLEPHRINE, DOPAMINE, NOREPINEPHRINE. Patient died on 10/25/2004.


Xigris Side Effects Report #4614077-1
Xigris side effect was reported by a Physician from on Feb 28, 2005. Male patient, 48 years of age, was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, prothrombin time prolonged. Xigris dosage: unknown. During the same period patient was treated with ADRENALINE, NORADRENALINE. Patient died on 02/28/2005.

Xigris Side Effects Report #4746747-9
Xigris side effect was reported by a Physician from UNITED KINGDOM on July 30, 2005. Female patient, 38 years of age, was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood fibrinogen decreased, haemodialysis, haemoglobin decreased, prothrombin time prolonged. Xigris dosage: unknown. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #4824064-6
Xigris side effect was reported by a Physician from UNITED STATES on Oct 26, 2005. Male patient, weighting 1625 lb, was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood pressure abnormal, life support, premature separation of placenta, prothrombin time prolonged, stillbirth. Xigris dosage: unknown. During the same period patient was treated with PHENYLEPHRINE, ATIVAN, NICOTINE, VANCOMYCIN, GENTAMICIN, METHADONE, FENTANYL, ATROVENT. Patient died on 07/19/2005.