Xigris and disseminated intravascular coagulation Patient Reports February 12, 2012

Xigris Side Effects Report #4549348-0
Xigris side effect was reported by a Physician from on Dec 20, 2004. Female patient, 76 years of age, weighting 154.3 lb, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, antithrombin iii decreased, blood fibrinogen increased, disseminated intravascular coagulation, epistaxis, fibrin d dimer increased, haemoglobin decreased, injection site haemorrhage, multi-organ failure. Xigris dosage: unknown. During the same period patient was treated with ANTITHROMBIN III, HEPARIN, MIDAZOLAM, CISATRACURIUM, FENTANYL, NORADRENALINE, DOPAMINE, DOBUTAMINE. Patient died on 12/16/2004.

Xigris Side Effects Report #5376919-4
Xigris side effect was reported by a Physician from FRANCE on June 28, 2007. Male patient, 57 years of age, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac arrest , disseminated intravascular coagulation, hypotension, metabolic acidosis, septic shock. Xigris dosage: unknown. During the same period patient was treated with NOREPINEPHRINE. Patient died on 06/15/2007.

Xigris Side Effects Report #6106423-7
Xigris side effect was reported by a Physician from UNITED STATES on Mar 04, 2009. Male patient, 55 years of age, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation. Xigris dosage: unknown. Patient died on 01/01/2009.

Xigris Side Effects Report #6111793-X
Xigris side effect was reported by a Physician from UNITED STATES on Mar 04, 2009. Male patient, 55 years of age, was diagnosed with septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation. Xigris dosage: unknown. Patient died on 01/01/2009.


Xigris Side Effects Report #5756984-2
Xigris side effect was reported by a Physician from CANADA on May 23, 2008. Female patient, weighting 224.9 lb, was diagnosed with septic shock, blood pressure decreased, endotracheal intubation and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac fibrillation, disseminated intravascular coagulation, haemoglobin decreased, international normalised ratio increased, neutropenia, pneumonia staphylococcal, renal failure, septic shock, thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with LEVOPHED, VASOPRESSIN, PROPOFOL, FENTANYL, HEPARIN. Patient died on 04/16/2008.

Xigris Side Effects Report #5071846-4
Xigris side effect was reported by a Consumer or non-health professional from UNITED STATES on July 13, 2006. Female patient, 79 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, renal disorder, respiratory failure, septic shock. Xigris dosage: unknown. During the same period patient was treated with LEVOPHED. Patient died on 07/03/2006.

Xigris Side Effects Report #5505422-3
Xigris side effect was reported by a Physician from UNITED STATES on Oct 26, 2007. Female patient, 79 years of age, weighting 198.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, disseminated intravascular coagulation. Xigris dosage: unknown. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #5140066-7
Xigris side effect was reported by a Physician from UNITED STATES on Oct 05, 2006. Female patient, 77 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: catheter site haemorrhage, disseminated intravascular coagulation, hydronephrosis, oedema, respiratory failure, thrombocytopenia, ureteric obstruction. Xigris dosage: unknown. During the same period patient was treated with HEPARIN, PROPOFOL, ZOSYN, ZITHROMAX, ARANESP. Patient died.

Xigris Side Effects Report #4546444-9
Xigris side effect was reported by a Pharmacist from on Dec 14, 2004. Female patient, 74 years of age, weighting 132.3 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemodialysis, thrombocytopenia. Xigris dosage: 120 MG. During the same period patient was treated with RANITIDINE, CEFUROXIME, METRONIDAZOLE, AMOXICILLIN, PENICILLIN, HEPARIN. Patient died on 10/03/2004.


Xigris Side Effects Report #4853082-7
Xigris side effect was reported by a Pharmacist from UNITED STATES on Nov 22, 2005. Male patient, 74 years of age, weighting 130.1 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: accidental overdose, blood potassium decreased, bradycardia, cardiac arrest , device failure, dialysis , disseminated intravascular coagulation, haematocrit decreased, haemoglobin decreased. Xigris dosage: 20 MG,. During the same period patient was treated with NOREPINEPHRINE BITARTRATE, PHENYLEPHRINE, DOBUTAMINE, CIPROFLOXACIN, ZOSYN, TOBRAMYCIN, ZITHROMAX, MIDAZOLAM. Patient died on 10/08/2005.

Xigris Side Effects Report #5690277-7
Xigris side effect was reported by a Physician from BRAZIL on Mar 19, 2008. Female patient, 69 years of age, weighting 198.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemoglobin decreased, haemorrhage, shock haemorrhagic. Xigris dosage: unknown. During the same period patient was treated with TEICOPLANIN, PIPERACILLIN W, PANTOPRAZOLE, DORMONID, NORADRENALINE. Patient was hospitalized. Patient recovered.

Xigris Side Effects Report #4562459-9
Xigris side effect was reported by a Pharmacist from on Dec 31, 2004. Male patient, 66 years of age, weighting 216.1 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac arrest , disseminated intravascular coagulation, myocardial infarction, septic shock. Xigris dosage: unknown. During the same period patient was treated with TAZOCIN, ZANTAC, VANCOMYCIN, NEUPOGEN, ALLOPURINOL, LEVOPHED, CIPROFLOXACIN. Patient died on 11/01/2004.

Xigris Side Effects Report #4995385-1
Xigris side effect was reported by a Physician from UNITED STATES on Apr 17, 2006. Male patient, 61 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemorrhage. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #5626283-8
Xigris side effect was reported by a Physician from UNITED STATES on Feb 05, 2008. Female patient, 57 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, disseminated intravascular coagulation. Xigris dosage: unknown. During the same period patient was treated with LEVOPHED, VASOPRESSIN, OXYGEN. Patient died on 12/01/2007.


Xigris Side Effects Report #5735869-1
Xigris side effect was reported by a Physician from UNITED STATES on May 05, 2008. Female patient, 57 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, disseminated intravascular coagulation, sepsis . Xigris dosage: unknown. During the same period patient was treated with LEVOPHED, VASOPRESSIN, OXYGEN, PREVACID. Patient died on 01/04/2008.

Xigris Side Effects Report #4752537-3
Xigris side effect was reported by a Pharmacist from CANADA on Aug 08, 2005. Female patient, 55 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: blood pressure decreased, disseminated intravascular coagulation, haemorrhage, international normalised ratio increased, renal failure chronic, thrombocytopenia. Xigris dosage: unknown. Patient died on 07/18/2005.

Xigris Side Effects Report #4758587-5
Xigris side effect was reported by a Pharmacist from CANADA on Aug 08, 2005. Female patient, 55 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: condition aggravated, disseminated intravascular coagulation, haemorrhage, international normalised ratio increased, renal failure chronic, thrombocytopenia. Xigris dosage: unknown. Patient died on 07/18/2005.

Xigris Side Effects Report #4824151-2
Xigris side effect was reported by a Physician from UNITED STATES on Oct 25, 2005. Female patient, 53 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: deep vein thrombosis , disseminated intravascular coagulation. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #4595979-1
Xigris side effect was reported by a Physician from on Feb 09, 2005. Female patient, 50 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemorrhage intracranial, thrombocytopenia. Xigris dosage: unknown. Patient was hospitalized. Patient recovered.


Xigris Side Effects Report #4638493-7
Xigris side effect was reported by a Physician from on Mar 24, 2005. Male patient, 48 years of age, weighting 176.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cardiac arrest , disseminated intravascular coagulation. Xigris dosage: unknown. During the same period patient was treated with ADRENALINE, NORADRENALINE, PROPOFOL, ALFENTANIL, TERLIPRESSIN, HYDROCORTISONE, MEROPENEM, TEICOPLANIN. Patient recovered.

Xigris Side Effects Report #4703749-6
Xigris side effect was reported by a Physician from on June 15, 2005. Male patient, 40 years of age, weighting 180.8 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: candidiasis, catheter site haemorrhage, condition aggravated, disseminated intravascular coagulation, fungaemia, gastritis erosive, gastrointestinal haemorrhage, sepsis . Xigris dosage: unknown. During the same period patient was treated with PRIMAXIN, STEROIDS, HEPARIN, INSULIN, CYCLOSPORINE, MYCOPHENOLATE MOFETIL, VASOPRESSINECTION, NEOSYNEPHRINE. Patient died on 03/01/2005.

Xigris Side Effects Report #4931488-5
Xigris side effect was reported by a Physician from UNITED STATES on Feb 08, 2006. Female patient, 39 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis , thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with HEPARIN. Patient recovered.

Xigris Side Effects Report #4994045-0
Xigris side effect was reported by a Physician from UNITED KINGDOM on Apr 19, 2006. Female patient, 39 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemodialysis, haemorrhagic fever, rectal haemorrhage, vaginal haemorrhage. Xigris dosage: unknown. Patient died.

Xigris Side Effects Report #5002864-X
Xigris side effect was reported by a Physician from UNITED KINGDOM on Apr 26, 2006. Female patient, 39 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: convulsion, disseminated intravascular coagulation, haemorrhagic fever, pupil fixed, rectal haemorrhage, subarachnoid haemorrhage, vaginal haemorrhage. Xigris dosage: unknown. Patient died.


Xigris Side Effects Report #5034299-8
Xigris side effect was reported by a Physician from UNITED KINGDOM on June 01, 2006. Female patient, 39 years of age, weighting 99.21 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: convulsion, disseminated intravascular coagulation, haemorrhagic fever, multi-organ failure, rectal haemorrhage, subarachnoid haemorrhage, vaginal haemorrhage. Xigris dosage: unknown. Patient died on 03/13/2006.

Xigris Side Effects Report #5864407-8
Xigris side effect was reported by a Physician from UNITED STATES on Aug 18, 2008. Male patient, 30 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, gastrointestinal haemorrhage. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #5475963-6
Xigris side effect was reported by a Physician from UNITED STATES on Sept 24, 2007. Male patient, 24 years of age, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemorrhage, thrombocytopenia. Xigris dosage: unknown. Patient recovered.

Xigris Side Effects Report #4752727-X
Xigris side effect was reported by a Pharmacist from UNITED STATES on Aug 09, 2005. Male patient, 23 years of age, weighting 176.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, disseminated intravascular coagulation, platelet count decreased. Xigris dosage: unknown. During the same period patient was treated with IMIPENEM, VANCOMYCIN, FLAGYL, PREVACID. Patient recovered.

Xigris Side Effects Report #4764308-2
Xigris side effect was reported by a Pharmacist from UNITED STATES on Aug 23, 2005. Male patient, 23 years of age, weighting 176.4 lb, was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, disseminated intravascular coagulation, international normalised ratio increased. Xigris dosage: unknown. During the same period patient was treated with IMIPENEM, VANCOMYCIN, FLAGYL, PREVACID. Patient recovered.


Xigris Side Effects Report #4802965-2
Xigris side effect was reported by a Physician from GERMANY on Sept 30, 2005. Female patient was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: cerebral haematoma, disseminated intravascular coagulation, haemorrhage intracranial, thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with PRAXIPARINE. Patient was hospitalized. Patient died on 08/03/2004.

Xigris Side Effects Report #4806863-X
Xigris side effect was reported by a Consumer or non-health professional from BELGIUM on Sept 30, 2005. Female patient was diagnosed with sepsis  and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haematoma, haemorrhage intracranial, thrombocytopenia. Xigris dosage: unknown. During the same period patient was treated with FRAXIPARINE. Patient was hospitalized. Patient died on 08/03/2004.

Xigris Side Effects Report #5706560-2
Xigris side effect was reported by a Physician from CZECH REPUBLIC on Apr 03, 2008. Female patient, 16 years of age, weighting 141.1 lb, was diagnosed with meningococcal sepsis, septic shock and was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, thrombocytopenia. Xigris dosage: 0.024 MG/KG, EVERY HOUR. During the same period patient was treated with CEFOTAXIME, HYDROCORTISONE, NORADRENALINE, HEPARIN, OMEPRAZOLE, METOCLOPRAMIDE, FUROSEMIDE, FRESH FROZEN PLASMA. Patient recovered.

Xigris Side Effects Report #5051889-7
Xigris side effect was reported by a Health Professional from UNITED STATES on June 19, 2006. Male patient, 65 years of age, was diagnosed with disseminated intravascular coagulation and was treated with Xigris. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, disseminated intravascular coagulation, gastrointestinal haemorrhage, platelet count decreased, sepsis . Xigris dosage: unknown. Patient died on 06/01/2006.

Xigris Side Effects Report #4759179-4
Xigris side effect was reported by a Physician from SAUDI ARABIA on Aug 11, 2005. Male patient, 52 years of age, was treated with Xigris. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, multi-organ failure, thrombocytopenia. Xigris dosage: 2.16 MG HOUR. During the same period patient was treated with CEFEPIME, CIPROFLOXACIN, NEUPOGEN, HYDROCORTISONE, FLUCONAZOLE, VANCOMYCIN. Patient died on 06/15/2005.


Xigris Side Effects Report #4781680-8
Xigris side effect was reported by a Consumer or non-health professional from ICELAND on Sept 08, 2005. Female patient, 50 years of age, was treated with Xigris. After drug was administered, patient experienced the following side effects: blood pressure increased, disseminated intravascular coagulation, multi-organ failure, mydriasis, nervous system disorder, pupillary reflex impaired. Xigris dosage: unknown. Patient recovered.