Vorinostat and asthenia Patient Reports February 12, 2012

Vorinostat Side Effects Report #5621663-9
Vorinostat side effect was reported by a Health Professional from UNITED STATES on Jan 22, 2008. Male patient, 56 years of age, weighting 150.0 lb, was diagnosed with non-small cell lung cancer, anxiety  and was treated with Vorinostat. After drug was administered, patient experienced the following side effects: asthenia, diabetes mellitus inadequate control, disorientation, dysuria, fall , loss of consciousness, malignant neoplasm progression, muscle spasms, muscular weakness. Vorinostat dosage: 200 MG/BID/PO. During the same period patient was treated with ERLOTINIB HYDROCHLORIDE, ATIVAN, ALTACE, CENTRUM SILVER, EXCEDRIN, LOMOTIL, ZYRTEC. Patient was hospitalized and became disabled. Patient recovered.

Vorinostat Side Effects Report #5744666-2
Vorinostat side effect was reported by a Physician from UNITED STATES on Apr 30, 2008. Female patient, 71 years of age, weighting 152.0 lb, was diagnosed with acute myeloid leukaemia, rosacea , hyperlipidaemia, acute leukaemia, myelodysplastic syndrome, hypertension, antibiotic prophylaxis and was treated with Vorinostat. After drug was administered, patient experienced the following side effects: asthenia, bundle branch block right, electrocardiogram qt prolonged, nausea , oral disorder, syncope, treatment noncompliance. Vorinostat dosage: 400 MG/DAILY/PO. During the same period patient was treated with DOXYCYCLINE, GEMFIBROZIL, DECITABINE, BISOPROLOL FUMARATE AND HYDROCHLOROTHIAZIDE, AVELOX. Patient was hospitalized. Patient recovered.

Vorinostat Side Effects Report #5869283-5
Vorinostat side effect was reported by a Physician from UNITED STATES on Aug 15, 2008. Female patient, 71 years of age, weighting 152.0 lb, was diagnosed with acute myeloid leukaemia, myelodysplastic syndrome, rosacea , hyperlipidaemia and was treated with Vorinostat. After drug was administered, patient experienced the following side effects: asthenia, bundle branch block right, hypophagia, nausea , syncope, syncope vasovagal, urinary tract obstruction. Vorinostat dosage: 400 MG/DAILY/PO. During the same period patient was treated with DOXYCYCLINE, GEMFIBROZIL, DECITABINE. Patient was hospitalized. Patient recovered.