Valproic and hyperammonaemia Patient Reports February 12, 2012

Valproic Side Effects Report #6020556-5
Valproic side effect was reported by a Consumer or non-health professional from ITALY on Dec 18, 2008. Female patient, 33 years of age, was diagnosed with psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: central pontine myelinolysis, coma, hyperammonaemia. Valproic dosage: unknown. During the same period patient was treated with PAROXETINE, FLURAZEPAM, LORAZEPAM, BENZODIAZEPINE. Patient recovered.

Valproic Side Effects Report #6034620-8
Valproic side effect was reported by a Consumer or non-health professional from ITALY on Jan 07, 2009. Female patient, 33 years of age, was diagnosed with psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: central pontine myelinolysis, coma, hyperammonaemia, metabolic encephalopathy, quadriparesis. Valproic dosage: unknown. During the same period patient was treated with PAROXETINE, FLURAZEPAM, LORAZEPAM, BENZODIAZEPINE. Patient recovered.

Valproic Side Effects Report #5978437-9
Valproic side effect was reported by a Consumer or non-health professional from ITALY on Nov 28, 2008. Female patient was diagnosed with psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: central pontine myelinolysis, coma, hyperammonaemia. Valproic dosage: unknown. Patient recovered.

Valproic Side Effects Report #5270368-5
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Mar 12, 2007. Male patient, child 11 years of age, was diagnosed with mania, aggression, agitation, psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia, mania. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, VALPROIC ACID, RISPERIDONE, LITHIUM CARBONATE, LITHIUM CARBONATE. Patient recovered.


Valproic Side Effects Report #5292241-9
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Apr 02, 2007. Male patient, child 11 years of age, was diagnosed with mania, aggression, agitation, psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia, mania. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, VALPROIC ACID, RISPERDAL, LITHIUM CARBONATE, LITHIUM CARBONATE. Patient recovered.

Valproic Side Effects Report #4978505-4
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on June 21, 2000. Female patient, 62 years of age, was diagnosed with grand mal convulsion and was treated with Valproic. After drug was administered, patient experienced the following side effects: abnormal behaviour, dementia , electroencephalogram abnormal, hyperammonaemia, laboratory test abnormal, memory impairment, parkinsonism, renal failure. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, VALPROIC ACID, SIMVASTATIN, NIFEDIPINE, ACETYLSALICYLATE LYSINE, ALDACTAZINE, RAUBASINE. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5635462-5
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Feb 14, 2008. Female patient, 62 years of age, was diagnosed with epilepsy , chronic obstructive pulmonary disease and was treated with Valproic. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, blood lactate dehydrogenase increased, depressed level of consciousness, hyperammonaemia, metabolic encephalopathy, supraventricular tachycardia. Valproic dosage: unknown. During the same period patient was treated with SOTALOL, BACLOFEN, PAROXETINE, LACTULOSE, ASPIRIN, OMEPRAZOLE, PREDNISONE. Patient was hospitalized and became disabled. Patient recovered.

Valproic Side Effects Report #5635524-2
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Feb 14, 2008. Female patient, 62 years of age, was diagnosed with epilepsy , chronic obstructive pulmonary disease and was treated with Valproic. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, blood lactate dehydrogenase increased, depressed level of consciousness, hyperammonaemia, metabolic encephalopathy, supraventricular tachycardia. Valproic dosage: unknown. During the same period patient was treated with SOTALOL, BACLOFEN, PAROXETINE, LACTULOSE, ASPIRIN, OMEPRAZOLE, PREDNISONE. Patient was hospitalized and became disabled. Patient recovered.

Valproic Side Effects Report #5767672-0
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on June 04, 2008. Female patient, 62 years of age, was diagnosed with epilepsy , chronic obstructive pulmonary disease and was treated with Valproic. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, blood lactate dehydrogenase increased, depressed level of consciousness, hyperammonaemia, metabolic encephalopathy, supraventricular tachycardia. Valproic dosage: unknown. During the same period patient was treated with SOTALOL, BACLOFEN, PAROXETINE, LACTULOSE, ASPIRIN, OMEPRAZOLE, PREDNISONE. Patient was hospitalized and became disabled. Patient recovered.


Valproic Side Effects Report #5620659-0
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Jan 30, 2008. Male patient, 41 years of age, was diagnosed with epilepsy  and was treated with Valproic. After drug was administered, patient experienced the following side effects: coma, convulsion, hyperammonaemia, hypotension, hypothermia , intentional overdose, lipase increased, metabolic acidosis, respiratory depression. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #4604930-7
Valproic side effect was reported by a Health Professional from on Sept 05, 2001. Male patient, 33 years of age, was diagnosed with epilepsy , schizophrenia and was treated with Valproic. After drug was administered, patient experienced the following side effects: diabetic ketoacidosis, disseminated intravascular coagulation, hyperammonaemia, hyperglycaemia, hypotension, loss of consciousness, pyrexia, respiratory distress. Valproic dosage: 500 MG, BID. During the same period patient was treated with CLOZAPINE. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5270362-4
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Mar 12, 2007. Male patient, child 11 years of age, was diagnosed with epilepsy , psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia, mania. Valproic dosage: unknown. During the same period patient was treated with RISPERIDONE, ETHOSUXIMIDE. Patient recovered.

Valproic Side Effects Report #5292242-0
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Apr 05, 2007. Male patient, child 11 years of age, was diagnosed with epilepsy , psychotic disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia, mania. Valproic dosage: unknown. During the same period patient was treated with RISPERDAL, ETHOSUXIMIDE. Patient recovered.

Valproic Side Effects Report #6124293-8
Valproic side effect was reported by a Physician from UNITED STATES on Mar 06, 2009. Male patient, child 11 years of age, was diagnosed with epilepsy , psychotic behaviour and was treated with Valproic. After drug was administered, patient experienced the following side effects: aggression, agitation, delusion, educational problem, hallucinations, mixed, hyperammonaemia, inappropriate affect, mania. Valproic dosage: unknown. During the same period patient was treated with RISPERIDONE, METHYLPHENIDATE, ETHOSUXIMIDE. Patient was hospitalized. Patient recovered.


Valproic Side Effects Report #6127338-4
Valproic side effect was reported by a Physician from UNITED STATES on Mar 06, 2009. Male patient, child 11 years of age, was diagnosed with epilepsy , psychotic behaviour and was treated with Valproic. After drug was administered, patient experienced the following side effects: aggression, agitation, disinhibition, hyperammonaemia, inappropriate affect, mania, pressure of speech. Valproic dosage: unknown. During the same period patient was treated with RISPERIDONE, METHYLPHENIDATE, ETHOSUXIMIDE. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5286960-8
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Mar 27, 2007. Female patient, 23 years of age, was diagnosed with convulsion prophylaxis and was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia, overdose, suicide attempt. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #4649329-2
Valproic side effect was reported by a Consumer or non-health professional from on Apr 21, 2005. Male patient, 30 years of age, was diagnosed with convulsion, mild mental retardation and was treated with Valproic. After drug was administered, patient experienced the following side effects: encephalopathy, hyperammonaemia. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, TOPIRAMATE, LORAZEPAM. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #4677933-4
Valproic side effect was reported by a Pharmacist from on May 27, 2005. Male patient, 25 years of age, weighting 139.1 lb, was diagnosed with convulsion and was treated with Valproic. After drug was administered, patient experienced the following side effects: delirium, hyperammonaemia. Valproic dosage: 1250 MG AM, 1000 PM PO. During the same period patient was treated with OMEPRAZOLE, TRAZODONE. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5489507-6
Valproic side effect was reported by a Pharmacist from UNITED STATES on Oct 16, 2007. Male patient, 48 years of age, was diagnosed with bipolar i disorder and was treated with Valproic. After drug was administered, patient experienced the following side effects: dental discomfort, hyperammonaemia, overdose. Valproic dosage: 875MG EVERY DAY PO. Patient was hospitalized. Patient recovered.


Valproic Side Effects Report #5392114-7
Valproic side effect was reported by a Pharmacist from UNITED STATES on July 18, 2007. Male patient, 49 years of age, weighting 130.0 lb, was diagnosed with bipolar disorder  and was treated with Valproic. After drug was administered, patient experienced the following side effects: amino acid metabolism disorder, delirium, encephalopathy, hyperammonaemia. Valproic dosage: 500 MG AT 9 AM PO; 1000 MG AT 9 PM PO. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5058386-3
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on July 12, 2006. Male patient, 15 years of age, was diagnosed with attention deficit/hyperactivity disorder, learning disorder , abnormal behaviour, affective disorder and was treated with Valproic. After drug was administered, patient experienced the following side effects: brain herniation, brain oedema, hyperammonaemia. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, VALPROIC ACID, VALPROIC ACID, DEXEDRINE, RISPERIDONE, CYPROHEPTADINE. Patient was hospitalized. Patient died.

Valproic Side Effects Report #5072984-2
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on July 12, 2006. Male patient, 15 years of age, was diagnosed with attention deficit/hyperactivity disorder, learning disorder , abnormal behaviour, affective disorder and was treated with Valproic. After drug was administered, patient experienced the following side effects: brain herniation, brain oedema, diabetes insipidus , hyperammonaemia, hypertension, status epilepticus. Valproic dosage: unknown. During the same period patient was treated with VALPROIC ACID, VALPROIC ACID, VALPROIC ACID, DEXEDRINE, RISPERIDONE. Patient was hospitalized. Patient died.

Valproic Side Effects Report #5006860-8
Valproic side effect was reported by a Health Professional from UNITED STATES on Aug 29, 2005. Male patient, 79 years of age, was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia. Valproic dosage: unknown. During the same period patient was treated with OLANZAPINE, PHENYTOIN, AMLODIPINE, FINASTERIDE, RISEDRONATE, ASPIRIN. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5417938-9
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Aug 08, 2007. Male patient, 43 years of age, weighting 165.3 lb, was treated with Valproic. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hyperammonaemia, hyperlactacidaemia, intentional overdose, pneumonia aspiration, respiratory failure. Valproic dosage: unknown. Patient was hospitalized. Patient recovered.


Valproic Side Effects Report #5418605-8
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Aug 08, 2007. Female patient, 43 years of age, weighting 110.2 lb, was treated with Valproic. After drug was administered, patient experienced the following side effects: areflexia, coma, electroencephalogram abnormal, hyperammonaemia, hyperlactacidaemia, intentional overdose. Valproic dosage: unknown. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5422652-X
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Aug 14, 2007. Male patient, 43 years of age, weighting 165.3 lb, was treated with Valproic. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hyperammonaemia, hyperlactacidaemia, intentional overdose, pneumonia aspiration, respiratory failure. Valproic dosage: unknown. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5425023-5
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Aug 14, 2007. Female patient, 43 years of age, weighting 110.2 lb, was treated with Valproic. After drug was administered, patient experienced the following side effects: areflexia, coma, electroencephalogram abnormal, hyperammonaemia, hyperlactacidaemia, intentional overdose. Valproic dosage: unknown. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5176631-0
Valproic side effect was reported by a Consumer or non-health professional from FRANCE on Dec 07, 2006. Female patient, 23 years of age, was treated with Valproic. After drug was administered, patient experienced the following side effects: coma, dialysis , hyperammonaemia, metabolic acidosis, overdose, suicide attempt. Valproic dosage: unknown. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #4632488-5
Valproic side effect was reported by a Consumer or non-health professional from on Apr 01, 2005. Male patient, 19 years of age, was treated with Valproic. After drug was administered, patient experienced the following side effects: blood pressure systolic increased, brain herniation, brain oedema, encephalopathy, hyperammonaemia, intentional misuse, lethargy. Valproic dosage: unknown. During the same period patient was treated with RISPERIDONE, VENLAFAXINE. Patient died.


Valproic Side Effects Report #6124306-3
Valproic side effect was reported by a Physician from UNITED STATES on Mar 06, 2009. Male patient, child 11 years of age, was treated with Valproic. After drug was administered, patient experienced the following side effects: affect lability, aggression, disinhibition, hyperammonaemia, impulsive behaviour, inappropriate affect, insomnia. Valproic dosage: 250 MG; BID; 750 MG; 625 MG; QD. During the same period patient was treated with RISPERIDONE, HALOPERIDOL, TOMOXETINE, METHYLPHENIDATE, LITHIUM CARBONATE, ARIPIPRAZOLE, DEXAMFETAMINE. Patient was hospitalized. Patient recovered.

Valproic Side Effects Report #5677591-6
Valproic side effect was reported by a Consumer or non-health professional from UNITED STATES on May 29, 2007. Female patient was treated with Valproic. After drug was administered, patient experienced the following side effects: hyperammonaemia. Valproic dosage: unknown. Patient recovered.

Valproic Side Effects Report #5928790-7
Valproic side effect was reported by a Health Professional from ALBANIA on Oct 20, 2008. Male patient was diagnosed with epilepsy  and was treated with Valproic. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, coma, confusional state, convulsion, hyperammonaemia, hypoglycaemia, reye's syndrome, vomiting. Valproic dosage: 30 MG/KG, UNK. During the same period patient was treated with PHENOBARBITAL. Patient was hospitalized. Patient recovered.