Trisenox and disease progression Patient Reports February 13, 2012

Trisenox Side Effects Report #5853398-1
Trisenox side effect was reported by a Physician from ITALY on Aug 09, 2006. Male patient, 71 years of age, weighting 183.0 lb, was diagnosed with myelodysplastic syndrome and was treated with Trisenox. After drug was administered, patient experienced the following side effects: cachexia, disease progression, dyspnoea, myelodysplastic syndrome. Trisenox dosage: 21 MG TWICE WEEKLY INTRAVENOUS DRIP. During the same period patient was treated with ASCORBIC ACID, PURINETHOL, VINCRISTINE. Patient died on 07/25/2006.

Trisenox Side Effects Report #5919002-9
Trisenox side effect was reported by a Physician from ITALY on Oct 01, 2008. Male patient, 71 years of age, weighting 183.0 lb, was diagnosed with myelodysplastic syndrome and was treated with Trisenox. After drug was administered, patient experienced the following side effects: cachexia, disease progression, dyspnoea. Trisenox dosage: 21 MG TWICE WEEKLY INTRAVENOUS DRIP. During the same period patient was treated with ASCORBIC ACID, PURINETHOL, VINCRISTINE, MORPHINE. Patient died on 07/25/2006.

Trisenox Side Effects Report #5926588-7
Trisenox side effect was reported by a Health Professional from ITALY on Oct 01, 2008. Male patient, 71 years of age, weighting 183.0 lb, was diagnosed with myelodysplastic syndrome and was treated with Trisenox. After drug was administered, patient experienced the following side effects: cachexia, disease progression, dyspnoea, myelodysplastic syndrome. Trisenox dosage: 21 MG TWICE WEEKLY INTRAVENOUS DRIP. During the same period patient was treated with ASCORBIC ACID, PURINETHOL, VINCRISTINE, MORPHINE. Patient died on 07/25/2006.

Trisenox Side Effects Report #4687390-X
Trisenox side effect was reported by a Physician from on May 20, 2005. Male patient, 65 years of age, was diagnosed with myelodysplastic syndrome, neutropenia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: anaemia, chills, disease progression, dyspnoea exertional, febrile neutropenia, myelodysplastic syndrome, oral candidiasis, pain in extremity, productive cough. Trisenox dosage: unknown. During the same period patient was treated with VITAMIN D, FILGRASTIM. Patient was hospitalized. Patient recovered.


Trisenox Side Effects Report #4638338-5
Trisenox side effect was reported by a Physician from on Mar 31, 2005. Female patient, 72 years of age, was diagnosed with multiple myeloma  and was treated with Trisenox. After drug was administered, patient experienced the following side effects: bronchopneumonia, disease progression, neuropathy. Trisenox dosage: unknown. During the same period patient was treated with SYNTHROID. Patient died on 08/19/2004.

Trisenox Side Effects Report #5371533-9
Trisenox side effect was reported by a Physician from UNITED STATES on June 15, 2007. Female patient, 55 years of age, weighting 213.8 lb, was diagnosed with multiple myeloma , neoplasm recurrence and was treated with Trisenox. After drug was administered, patient experienced the following side effects: atrial fibrillation , cardiotoxicity, disease progression, ejection fraction decreased, fall , fatigue, pain , pericardial effusion, pleural effusion. Trisenox dosage: 0.25 MG/KG DAYS 1-5 INTRAVENOUS DRIP. During the same period patient was treated with ASCORBIC ACID, BORTEZOMIB, ZYDONE. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #5515366-9
Trisenox side effect was reported by a Physician from UNITED STATES on Oct 26, 2007. Female patient, weighting 85.76 lb, was diagnosed with multiple myeloma  and was treated with Trisenox. After drug was administered, patient experienced the following side effects: angina pectoris, bacteraemia, bacteria stool identified, bence jones protein urine present, chest pain , culture urine positive, dialysis , disease progression. Trisenox dosage: 11.5 MG DAILY FOR 7 DAYS INTRAVENOUS DRIP. During the same period patient was treated with ASCORBIC ACID, MELPHALAN, PROPOXYPHENE HC, ESTRADIOL, VALGANCICLOVIR HC, CALCIUM CARBONATE W, ISOSORBIDE MONONITRATE, HYDRALAZINE. Patient was hospitalized. Patient died on 05/11/2007.

Trisenox Side Effects Report #5024916-0
Trisenox side effect was reported by a Physician from JAPAN on May 24, 2006. Male patient, 73 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, cerebral haemorrhage, disease progression, fibrin d dimer increased, white blood cell count decreased. Trisenox dosage: 8.625 MG QD INTRAVENOUS DRIP. During the same period patient was treated with ALLOPURINOL, GABEXATE MESILATE, CEFEPIME DIHYDROCHLORIDE, ACYCLOVIR, LIDOCAINE, MEXILETINE HYDROCHLORIDE, OSELTAMIVIR PHOSPHATE, MEROPENEM TRIHYDRATE. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #6065662-4
Trisenox side effect was reported by a Physician from JAPAN on Jan 19, 2009. Female patient, 67 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: cytomegalovirus test positive, dialysis , disease progression, electrocardiogram qt prolonged, hypokalaemia, hypomagnesaemia, intestinal obstruction, renal failure. Trisenox dosage: 5.85 MG QD INTRAVENOUS DRIP. During the same period patient was treated with POTASSIUM, MAGNESIUM. Patient was hospitalized and became disabled. Patient recovered.


Trisenox Side Effects Report #5087026-2
Trisenox side effect was reported by a Physician from JAPAN on Aug 09, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis, putamen haemorrhage. Trisenox dosage: 8.025 MG QD INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN SODIM, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.

Trisenox Side Effects Report #5116822-8
Trisenox side effect was reported by a Physician from JAPAN on Sept 08, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood fibrinogen decreased, blood lactate dehydrogenase increased, cerebral haemorrhage, depressed level of consciousness, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis. Trisenox dosage: 8.025 MG Q72HR INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.

Trisenox Side Effects Report #5142705-3
Trisenox side effect was reported by a Physician from JAPAN on Oct 17, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood fibrinogen decreased, blood lactate dehydrogenase increased, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis, prothrombin time prolonged. Trisenox dosage: 8.025 MG Q72HR INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.

Trisenox Side Effects Report #6081250-8
Trisenox side effect was reported by a Health Professional from UNITED STATES on Feb 05, 2009. Female patient was treated with Trisenox. After drug was administered, patient experienced the following side effects: disease progression. Trisenox dosage: unknown. Patient died on 01/01/2009.