Trisenox and blood lactate dehydrogenase increased Patient Reports February 13, 2012

Trisenox Side Effects Report #6073095-X
Trisenox side effect was reported by a Physician from JAPAN on Jan 28, 2009. Male patient, 85 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, blood lactate dehydrogenase increased, diarrhoea, electrocardiogram qt prolonged, gamma-glutamyltransferase increased, hyperglycaemia, leukocytosis, leukopenia. Trisenox dosage: 8.4 MG DAILY INTRAVENOUS. During the same period patient was treated with GABEXATE MESILATE. Patient recovered.

Trisenox Side Effects Report #5309186-8
Trisenox side effect was reported by a Physician from JAPAN on Apr 09, 2007. Female patient, 77 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood albumin decreased, blood lactate dehydrogenase increased, electrocardiogram qt prolonged, fibrin d dimer increased, gamma-glutamyltransferase increased, protein total decreased, white blood cell count decreased. Trisenox dosage: 9.315 MG QD INTRAVENOUS DRIP. During the same period patient was treated with FAMOTIDINE, SIMVASTATIN. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #5081599-1
Trisenox side effect was reported by a Physician from JAPAN on July 27, 2006. Female patient, 77 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood albumin decreased, blood lactate dehydrogenase increased, c-reactive protein increased, electrocardiogram qt prolonged, fibrin d dimer increased, gamma-glutamyltransferase increased, protein total decreased. Trisenox dosage: 9.315 MG QD INTRAVENOUS DRIP. Patient recovered.

Trisenox Side Effects Report #4781090-3
Trisenox side effect was reported by a Physician from JAPAN on Sept 07, 2005. Male patient, 72 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, condition aggravated, gamma-glutamyltransferase increased, hepatic function abnormal, hypokalaemia. Trisenox dosage: 6 MG (6 MG, IVI). During the same period patient was treated with BIAPENEM, VANCOMYCIN, CLINDAMYCIN, CEFTAZIDIME, ALLOPURINOL, TOSUFOXACIN, FLUCONAZOLE, FAMOTIDINE. Patient recovered.


Trisenox Side Effects Report #4950882-X
Trisenox side effect was reported by a Physician from JAPAN on Mar 01, 2006. Male patient, 72 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, gamma-glutamyltransferase increased, hepatic function abnormal, hypokalaemia. Trisenox dosage: 6.6 MG QD INTRAVENOUS DRIP. During the same period patient was treated with BIAPENEM, TOSUFLOXACIN TOSILATE, FLUCONAZOLE, FAMOTIDINE. Patient recovered.

Trisenox Side Effects Report #5589390-4
Trisenox side effect was reported by a Physician from JAPAN on Dec 26, 2007. Male patient, 70 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, depressed level of consciousness, gamma-glutamyltransferase increased, herpes simplex , pancytopenia, respiratory failure, shock. Trisenox dosage: 8.4 MG QD INTRAVENOUS DRIP. During the same period patient was treated with CYTARABINE, METHOTREXATE. Patient was hospitalized. Patient died on 12/02/2007.

Trisenox Side Effects Report #5233587-X
Trisenox side effect was reported by a Physician from JAPAN on Jan 23, 2007. Female patient, 67 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, blood lactate dehydrogenase increased, febrile neutropenia, gamma-glutamyltransferase increased, hepatic function abnormal, platelet count decreased, white blood cell count decreased. Trisenox dosage: 7.95 MG QD INTRAVENOUS DRIP. Patient recovered.

Trisenox Side Effects Report #5248064-X
Trisenox side effect was reported by a Physician from JAPAN on Feb 07, 2007. Female patient, 67 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, blood lactate dehydrogenase increased, febrile neutropenia, gamma-glutamyltransferase increased, hepatic function abnormal, platelet count decreased, white blood cell count decreased. Trisenox dosage: 7.95 MG QD INTRAVENOUS DRIP. Patient recovered.

Trisenox Side Effects Report #5257757-X
Trisenox side effect was reported by a Physician from JAPAN on Feb 15, 2007. Female patient, 67 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anaemia, aspartate aminotransferase increased, blood lactate dehydrogenase increased, febrile neutropenia, gamma-glutamyltransferase increased, hepatic function abnormal, platelet count decreased, protein total decreased. Trisenox dosage: 7.95 MG QD INTRAVENOUS DRIP. Patient recovered.


Trisenox Side Effects Report #5393083-6
Trisenox side effect was reported by a Physician from JAPAN on June 27, 2007. Male patient, 67 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood alkaline phosphatase increased, blood lactate dehydrogenase increased, cardio-respiratory arrest, electrocardiogram qt prolonged, febrile neutropenia, gamma-glutamyltransferase increased, hyperglycaemia, staphylococcal sepsis. Trisenox dosage: 9.69 MG QD INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, QUETIAPINE FUMARATE, VANCOMYCIN HYDROCHLORIDE, CEFEPIME DIHYDROCHLORIDE, METHYLPHENIDATE, PAROXETINE HYDROCHLORIDE HYDRATE. Patient died on 01/19/2006.

Trisenox Side Effects Report #6016196-4
Trisenox side effect was reported by a Health Professional from JAPAN on Nov 13, 2008. Female patient, 66 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, gamma-glutamyltransferase increased, hepatic function abnormal, pericardial effusion, pseudomembranous colitis. Trisenox dosage: 4.75 MG QD INTRAVENOUS DRIP. During the same period patient was treated with ANTITHROMBIN, INSULIN. Patient recovered.

Trisenox Side Effects Report #5397293-3
Trisenox side effect was reported by a Physician from JAPAN on July 09, 2007. Female patient, 65 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, cerebral haemorrhage, disseminated intravascular coagulation, hypokalaemia, leukocytosis. Trisenox dosage: 8.75 MG QD INTRAVENOUS DRIP. During the same period patient was treated with IDARUBICIN, DANAPAROID. Patient died on 04/28/2007.

Trisenox Side Effects Report #5087026-2
Trisenox side effect was reported by a Physician from JAPAN on Aug 09, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis, putamen haemorrhage. Trisenox dosage: 8.025 MG QD INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN SODIM, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.

Trisenox Side Effects Report #5116822-8
Trisenox side effect was reported by a Physician from JAPAN on Sept 08, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, blood fibrinogen decreased, blood lactate dehydrogenase increased, cerebral haemorrhage, depressed level of consciousness, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis. Trisenox dosage: 8.025 MG Q72HR INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.


Trisenox Side Effects Report #5142705-3
Trisenox side effect was reported by a Physician from JAPAN on Oct 17, 2006. Male patient, 63 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood fibrinogen decreased, blood lactate dehydrogenase increased, disease progression, disseminated intravascular coagulation, fibrin degradation products increased, leukocytosis, prothrombin time prolonged. Trisenox dosage: 8.025 MG Q72HR INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, FAMOTIDINE, BROTIZOLAM, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, BICARBONATE. Patient died on 12/26/2005.

Trisenox Side Effects Report #5408384-2
Trisenox side effect was reported by a Physician from JAPAN on July 25, 2007. Female patient, 58 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, back disorder, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, bone pain, disseminated intravascular coagulation, electrocardiogram qt prolonged, gamma-glutamyltransferase increased. Trisenox dosage: 7.245 MG QD INTRAVENOUS DRIP. During the same period patient was treated with IDARUBICIN, NAFAMOSTAT MESILATE, GLUCOSE W, ELECTROLYTE, PARENTERAL FLUID OF HIGH, INSULIN. Patient recovered.

Trisenox Side Effects Report #5632251-2
Trisenox side effect was reported by a Physician from JAPAN on Jan 28, 2008. Female patient, 58 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, aspartate aminotransferase increased, blood creatine phosphokinase increased, blood creatinine increased, blood lactate dehydrogenase increased, blood potassium decreased, dyspnoea, electrocardiogram qt prolonged. Trisenox dosage: 8.85 MG QD INTRAVENOUS DRIP. During the same period patient was treated with IDARUBICIN, POTASSIUM SUPPLEMENT, GABEXATE MESILATE, CARPERITIDE, MICAFUNGIN. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #5718737-0
Trisenox side effect was reported by a Physician from JAPAN on Apr 10, 2008. Female patient, 58 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, aspartate aminotransferase increased, blood bilirubin increased, blood lactate dehydrogenase increased, blood potassium decreased, blood urea increased, electrocardiogram qt prolonged, gamma-glutamyltransferase increased. Trisenox dosage: 8.85 MG QD INTRAVENOUS DRIP. During the same period patient was treated with IDARUBICIN, POTASSIUM SUPPLEMENT, GABEXATE MESILATE, CARPERITIDE, MICAFUNGIN. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #5266132-3
Trisenox side effect was reported by a Physician from JAPAN on Feb 27, 2007. Female patient, 57 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, aspartate aminotransferase increased, blood alkaline phosphatase increased, blood bilirubin increased, blood lactate dehydrogenase increased, c-reactive protein increased, condition aggravated, disseminated intravascular coagulation. Trisenox dosage: unknown. During the same period patient was treated with CYTARABINE, IDARUBICIN, DANAPAROID, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, MONOAMMONIUM GLYCYRRHIZINATE. Patient died on 12/31/2006.


Trisenox Side Effects Report #4678283-2
Trisenox side effect was reported by a Physician from on Dec 27, 2004. Male patient, 55 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, body temperature increased, c-reactive protein increased, constipation , dyspnoea, hypoxia, pleural effusion. Trisenox dosage: 12.3 MG (12.3 MG, DAILY), INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #4697856-4
Trisenox side effect was reported by a Physician from on June 02, 2005. Male patient, 55 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, body temperature increased, constipation , pleural effusion. Trisenox dosage: 12.3 MG (12.3 MG DAILY) INTRAVENOUS. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Trisenox Side Effects Report #5933636-7
Trisenox side effect was reported by a Physician from JAPAN on Oct 16, 2008. Male patient, 42 years of age, weighting 133.8 lb, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, cardiomegaly, gamma-glutamyltransferase increased, hyperglycaemia, hyperuricaemia, hypoalbuminaemia. Trisenox dosage: 8.7 MG QD INTRAVENOUS DRIP. During the same period patient was treated with DEXAMETHASONE PHOSPHATE, DEXAMETHASONE PHOSPHATE, DEXAMETHASONE PHOSPHATE, IDARUBICIN HYDROCHLORIDE, LANSOPRAZOLE, ITRACONAZOLE. Patient recovered.

Trisenox Side Effects Report #5175210-9
Trisenox side effect was reported by a Physician from JAPAN on Nov 22, 2006. Female patient, 37 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: accelerated idioventricular rhythm, acute promyelocytic leukaemia differentiation syndrome, alanine aminotransferase increased, alopecia, aspartate aminotransferase increased, blood lactate dehydrogenase increased, c-reactive protein increased, electrocardiogram qt corrected interval prolonged, gamma-glutamyltransferase increased. Trisenox dosage: 8.978 MG QD INTRAVENOUS DRIP. During the same period patient was treated with MEXILETINE HYDROCHLORIDE, GRANISETRON. Patient recovered.

Trisenox Side Effects Report #5574034-8
Trisenox side effect was reported by a Physician from JAPAN on Dec 14, 2007. Male patient, 28 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, electrocardiogram qt prolonged, gamma-glutamyltransferase increased, haemoglobin decreased, tonsillitis. Trisenox dosage: 12 MG QD; INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, SULFAMETHOXAZOLE AND TRIMETHOPRIM, FLUCONAZOLE, OMEPRAZOLE, ROXATIDINE ACETATE, FAMOTIDINE. Patient recovered.


Trisenox Side Effects Report #5580740-1
Trisenox side effect was reported by a Physician from JAPAN on Dec 06, 2007. Male patient, 28 years of age, was diagnosed with acute promyelocytic leukaemia and was treated with Trisenox. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood lactate dehydrogenase increased, c-reactive protein increased, electrocardiogram qt prolonged, gamma-glutamyltransferase increased, haemoglobin decreased, hepatic function abnormal, tonsillitis. Trisenox dosage: 12 MG QD INTRAVENOUS DRIP. During the same period patient was treated with DALTEPARIN, SULFAMETHOXAZOLE AND TRIMETHOPRIM, FLUCONAZOLE, OMEPRAZOLE, ROXATIDINE ACETATE, FAMOTIDINE. Patient was hospitalized. Patient recovered.