Topotecan and platelet count decreased Patient Reports February 11, 2012

Topotecan Side Effects Report #4725529-8
Topotecan side effect was reported by a Pharmacist from UNITED STATES on July 22, 2005. Female patient, 76 years of age, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: dyspnoea, haematocrit decreased, haemoglobin decreased, international normalised ratio increased, petechiae, platelet count decreased. Topotecan dosage: unknown. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5011259-4
Topotecan side effect was reported by a Health Professional from UNITED STATES on May 23, 2006. Female patient, 76 years of age, weighting 207.2 lb, was diagnosed with ovarian cancer, recurrent cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: ascites, dyspnoea, fluid retention, platelet count decreased, stent placement. Topotecan dosage: 4.95 MG, Q 1WK, IV. During the same period patient was treated with LOVENOX, TYLENOL. Patient was hospitalized. Patient died on 03/20/2006.

Topotecan Side Effects Report #5017934-X
Topotecan side effect was reported by a Physician from UNITED STATES on May 23, 2006. Female patient, 76 years of age, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: ascites, dyspnoea exacerbated, fluid retention, platelet count decreased. Topotecan dosage: 2.5MGM2 CYCLIC. During the same period patient was treated with LOVENOX, TYLENOL. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5112711-3
Topotecan side effect was reported by a Physician from GERMANY on Sept 18, 2006. Female patient, weighting 222.7 lb, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, haemoglobin decreased, leukopenia, platelet count decreased, thrombocytopenia, white blood cell count decreased. Topotecan dosage: 2.48MG PER DAY. During the same period patient was treated with BELOC ZOK, DELIX, TORSEMIDE. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #5157506-X
Topotecan side effect was reported by a Physician from GERMANY on Sept 18, 2006. Female patient, weighting 222.7 lb, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, haemoglobin decreased, leukopenia, platelet count decreased, thrombocytopenia, white blood cell count decreased. Topotecan dosage: 2.48MG PER DAY. During the same period patient was treated with BELOC ZOK, DELIX, TORSEMIDE. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5494950-5
Topotecan side effect was reported by a Physician from UNITED STATES on Oct 22, 2007. Male patient, 60 years of age, was diagnosed with neoplasm and was treated with Topotecan. After drug was administered, patient experienced the following side effects: epistaxis, haematuria, haemoglobin decreased, headache , neutrophil toxic granulation present, platelet count decreased, rhinitis, sinus congestion, sinus headache. Topotecan dosage: 1.2MGM2 CYCLIC. During the same period patient was treated with DIMETICONE, OMEPRAZOLE, GEMFIBROZIL, TELMISARTAN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5527800-9
Topotecan side effect was reported by a Physician from UNITED STATES on Nov 21, 2007. Male patient, 60 years of age, was diagnosed with neoplasm and was treated with Topotecan. After drug was administered, patient experienced the following side effects: epistaxis, haematuria, haemoglobin decreased, headache , neutrophil toxic granulation present, platelet count decreased, rhinitis, sinus congestion, sinus headache. Topotecan dosage: 1.2MGM2 CYCLIC. During the same period patient was treated with DIMETICONE, OMEPRAZOLE, GEMFIBROZIL, TELMISARTAN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5527837-X
Topotecan side effect was reported by a Physician from UNITED STATES on Nov 21, 2007. Male patient, 60 years of age, was diagnosed with neoplasm and was treated with Topotecan. After drug was administered, patient experienced the following side effects: epistaxis, flank pain, haematuria, haemoglobin decreased, headache , neutrophil toxic granulation present, platelet count decreased, rhinitis, sinus congestion. Topotecan dosage: 1.2MGM2 CYCLIC. During the same period patient was treated with DIMETICONE, OMEPRAZOLE, GEMFIBROZIL, TELMISARTAN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4758768-0
Topotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 31, 2005. Female patient, weighting 193.8 lb, was diagnosed with cervix carcinoma, squamous cell carcinoma and was treated with Topotecan. After drug was administered, patient experienced the following side effects: cervix carcinoma recurrent, dizziness , fatigue, haematocrit decreased, haemoglobin decreased, neutrophil count decreased, platelet count decreased, squamous cell carcinoma, white blood cell count decreased. Topotecan dosage: unknown. During the same period patient was treated with CISPLATIN, TOPROL, LISINOPRIL, LANTUS. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #5712828-6
Topotecan side effect was reported by a Physician from UNITED STATES on Apr 21, 2008. Male patient, 79 years of age, weighting 119.3 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, anorexia, asthenia, dehydration, neutropenia, orthostatic hypotension, platelet count decreased, pyrexia, white blood cell count decreased. Topotecan dosage: 6.5MGM2 CYCLIC. During the same period patient was treated with CARBOPLATIN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5421056-3
Topotecan side effect was reported by a Physician from UNITED STATES on Aug 16, 2007. Female patient, 78 years of age, weighting 140.2 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, arthralgia, dyspnoea, fall , gastrointestinal haemorrhage, haematuria, muscular weakness, platelet count decreased. Topotecan dosage: 4MGM2 CYCLIC. During the same period patient was treated with CARBOPLATIN, NEULASTA. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4768744-X
Topotecan side effect was reported by a Physician from JAPAN on Sept 05, 2005. Male patient, 77 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, haemoglobin decreased, platelet count decreased, red blood cell count decreased, respiratory failure, white blood cell count decreased. Topotecan dosage: 1MG PER DAY. During the same period patient was treated with CEFTRIAXZONE, RINGERS ACETATE, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, ONDANSETRON, LANSOPRAZOLE, ASPIRIN, LACTOMIN. Patient died on 12/05/2002.

Topotecan Side Effects Report #5477201-7
Topotecan side effect was reported by a Health Professional from JAPAN on Oct 02, 2007. Male patient, 76 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: haemoglobin decreased, neutrophil count decreased, neutrophil count increased, platelet count decreased, red blood cell count decreased, white blood cell count increased. Topotecan dosage: 2MG PER DAY. During the same period patient was treated with NEUPOGEN, ZOFRAN. Patient recovered.

Topotecan Side Effects Report #5520854-5
Topotecan side effect was reported by a Health Professional from JAPAN on Nov 16, 2007. Male patient, 76 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: haemoglobin decreased, neutrophil count decreased, platelet count decreased, red blood cell count decreased, white blood cell count decreased. Topotecan dosage: 2MG PER DAY. During the same period patient was treated with NEUPOGEN, ZOFRAN. Patient recovered.


Topotecan Side Effects Report #4781267-7
Topotecan side effect was reported by a Physician from JAPAN on Sept 14, 2005. Male patient, 76 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, haemoglobin decreased, neutrophil count decreased, platelet count decreased, red blood cell count decreased, white blood cell count decreased. Topotecan dosage: unknown. During the same period patient was treated with AMRUBICIN HYDROCHLORIDE, GRANISETRON, ZOLPIDEM TARTRATE, MAGNESIUM OXIDE, NORFLOXACIN, CEFDINIR, FILGRASTIM, CEFAZOLIN. Patient recovered.

Topotecan Side Effects Report #4791700-2
Topotecan side effect was reported by a Physician from JAPAN on Sept 14, 2005. Male patient, 76 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, blood alkaline phosphatase increased, blood lactate dehydrogenase increased, haemoglobin decreased, neutrophil count decreased, platelet count decreased, red blood cell count decreased, white blood cell count decreased. Topotecan dosage: unknown. During the same period patient was treated with AMRUBICIN HYDROCHLORIDE, GRANISETRON, ZOLPIDEM TARTRATE, MAGNESIUM OXIDE, NORFLOXACIN, CEFDINIR, FILGRASTIM, CEFAZOLIN. Patient recovered.

Topotecan Side Effects Report #5571725-X
Topotecan side effect was reported by a Physician from POLAND on Dec 18, 2007. Male patient, 75 years of age, weighting 143.3 lb, was diagnosed with infection prophylaxis, oral candidiasis and was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, leukopenia, oral candidiasis, platelet count decreased. Topotecan dosage: unknown. During the same period patient was treated with RADIATION, DEXAVEN, CYCLONAMINE, AUGMENTIN, MICONAZOLE. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5588685-8
Topotecan side effect was reported by a Physician from POLAND on Jan 06, 2008. Male patient, 75 years of age, weighting 143.3 lb, was diagnosed with infection prophylaxis, oral candidiasis and was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, disease progression, leukopenia, oral candidiasis, platelet count decreased. Topotecan dosage: 1.1MGM2 PER DAY. During the same period patient was treated with RADIATION, DEXAVEN, CYCLONAMINE, AUGMENTIN, MICONAZOLE. Patient was hospitalized. Patient died on 01/02/2007.

Topotecan Side Effects Report #5208979-5
Topotecan side effect was reported by a Physician from GERMANY on Jan 12, 2007. Male patient, 74 years of age, weighting 187.4 lb, was diagnosed with hypertension and was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, c-reactive protein increased, cough, haemoglobin decreased, hypokalaemia, nausea , platelet count decreased, productive cough. Topotecan dosage: 1MGM2 PER DAY. During the same period patient was treated with CISPLATIN, FENTANYL TRANSDERMAL SYSTEM, CAPTOPRIL, PRAVASTATIN, THEOPHYLLINE, ALLOPURINOL. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #4766055-X
Topotecan side effect was reported by a Physician from JAPAN on Sept 05, 2005. Male patient, 74 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, hypoalbuminaemia, hypochloraemia, hyponatraemia, hypoproteinaemia, leukopenia, lung neoplasm malignant, platelet count decreased. Topotecan dosage: 1.1MG PER DAY. During the same period patient was treated with AMRUBICIN HYDROCHLORIDE, TRIFLUID, METOCLOPRAMIDE, LENOGRASTIM, NEO MINOPHAGEN C, FAMOTIDINE, BETAMIPRON, GLUCOSE. Patient died on 04/08/2005.

Topotecan Side Effects Report #4770847-0
Topotecan side effect was reported by a Physician from JAPAN on Sept 05, 2005. Male patient, 71 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: blood alkaline phosphatase increased, blood lactate dehydrogenase increased, haemoglobin decreased, liver disorder, neutrophil count decreased, platelet count decreased, pre-existing disease, red blood cell count decreased, white blood cell count decreased. Topotecan dosage: 1.43MG PER DAY. During the same period patient was treated with AMRUBICIN HYDROCHLORIDE, GRANISETRON, SOLITA, AMINOPHYLLINE, METHYLPREDNISOLONE SUCCINATE, LENOGRASTIM, REBAMIPIDE, GLIMEPIRIDE. Patient was hospitalized. Patient died on 10/19/2004.

Topotecan Side Effects Report #4775958-1
Topotecan side effect was reported by a Health Professional from JAPAN on Sept 14, 2005. Male patient, 69 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anorexia, hypokalaemia, platelet count decreased, white blood cell count decreased. Topotecan dosage: 1.1MG PER DAY. During the same period patient was treated with GRANISETRON, OXYCODONE. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4690304-X
Topotecan side effect was reported by a Physician from on June 09, 2005. Male patient, 68 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: blood alkaline phosphatase decreased, cough, neutrophil count decreased, platelet count decreased, white blood cell count decreased. Topotecan dosage: 1.1MG PER DAY. During the same period patient was treated with CARBOPLATIN, METOCLOPRAMIDE, CHLORIDE, ETIZOLAM, LEVOFLOXACIN, PENTAZOCINE LACTATE, SENNOSIDE, KETOPROFEN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4771922-7
Topotecan side effect was reported by a Physician from JAPAN on June 09, 2005. Male patient, 68 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: blood alkaline phosphatase decreased, cough, neutrophil count decreased, platelet count decreased, white blood cell count decreased. Topotecan dosage: 1.1MG PER DAY. During the same period patient was treated with CARBOPLATIN, METOCLOPRAMIDE, CHLORIDE, ETIZOLAM, LEVOFLOXACIN, PENTAZOCINE LACTATE, SENNOSIDE, KETOPROFEN. Patient recovered.


Topotecan Side Effects Report #4766051-2
Topotecan side effect was reported by a Health Professional from JAPAN on Sept 07, 2005. Male patient, 63 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: haemoglobin decreased, lung neoplasm, neutropenia, platelet count decreased. Topotecan dosage: 1.3MG PER DAY. During the same period patient was treated with AMRUBICIN HYDROCHLORIDE, LENOGRASTIM, GRANISETRON, MAGNESIUM OXIDE, CLARITHROMYCIN, CARBAZOCHROME SULFONATE, TRANEXAMIC ACID, LEVOFLOXACIN. Patient was hospitalized. Patient died on 04/19/2005.

Topotecan Side Effects Report #5283006-2
Topotecan side effect was reported by a Health Professional from UNITED STATES on Mar 29, 2007. Female patient, weighting 102.0 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, balance disorder, disease progression, platelet count decreased. Topotecan dosage: 3MG/M2 D 1,8,15 Q28 IV. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5153307-7
Topotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 16, 2006. Female patient, weighting 233.7 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: neutrophil count decreased, platelet count decreased. Topotecan dosage: 12.5 MG. Patient recovered.