Topotecan and pancytopenia Patient Reports February 11, 2012

Topotecan Side Effects Report #4753832-4
Topotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 23, 2005. Female patient, 64 years of age, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, ear discomfort, febrile neutropenia, pancytopenia, pharyngolaryngeal pain. Topotecan dosage: unknown. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4773801-8
Topotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 23, 2005. Female patient, 64 years of age, weighting 174.4 lb, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, dysphonia, ear discomfort, febrile neutropenia, flatulence, hypomagnesaemia, nasopharyngitis, pancytopenia, pharyngolaryngeal pain. Topotecan dosage: 2.2MG SEE TEXT. During the same period patient was treated with THALIDOMIDE, TENORMIN, ASPIRIN, MAGNESIUM, AMILORIDE. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5392427-9
Topotecan side effect was reported by a Physician from GERMANY on July 17, 2007. Female patient, weighting 178.6 lb, was diagnosed with ovarian cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: febrile neutropenia, pancytopenia, pyrexia, urinary tract infection . Topotecan dosage: 2.43MG PER DAY. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4768706-2
Topotecan side effect was reported by a Physician from UNITED STATES on Sept 02, 2005. Female patient, 65 years of age, weighting 170.4 lb, was diagnosed with non-small cell lung cancer, urinary tract infection  and was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, chest pain , chronic obstructive pulmonary disease, dyspnoea, electrocardiogram t wave inversion, gastrointestinal haemorrhage, pancytopenia, urinary tract infection . Topotecan dosage: 1.5MG CYCLIC. During the same period patient was treated with LEVAQUIN. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #5578640-6
Topotecan side effect was reported by a Health Professional from UNITED STATES on Dec 28, 2007. Male patient, 79 years of age, weighting 141.0 lb, was diagnosed with metastatic gastric cancer and was treated with Topotecan. After drug was administered, patient experienced the following side effects: febrile neutropenia, pancytopenia. Topotecan dosage: 7 MG IV. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4761487-8
Topotecan side effect was reported by a Physician from UNITED STATES on Aug 30, 2005. Female patient, 46 years of age, weighting 116.2 lb, was diagnosed with cervix carcinoma recurrent and was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, cervix carcinoma recurrent, dehydration, depressed level of consciousness, mental status changes, moaning, pancytopenia, tachycardia, vomiting. Topotecan dosage: .75MGM2 CYCLIC. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient died on 08/22/2001.

Topotecan Side Effects Report #5115266-2
Topotecan side effect was reported by a Physician from UNITED STATES on Aug 28, 2006. Female patient, 54 years of age, weighting 97.00 lb, was diagnosed with cervix carcinoma and was treated with Topotecan. After drug was administered, patient experienced the following side effects: diarrhoea, eating disorder , hyperkalaemia, hyponatraemia, nausea , neutropenia, pancytopenia, sepsis . Topotecan dosage: 2MGM2 WEEKLY. During the same period patient was treated with CISPLATIN, FENTANYL, DARVOCET, LOMOTIL, BACTRIM DS. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5946535-1
Topotecan side effect was reported by a Physician from PORTUGAL on Nov 04, 2008. Male patient, 74 years of age, weighting 164.7 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: cerebrovascular accident, depressed level of consciousness, epistaxis, pancytopenia. Topotecan dosage: 2.8MGDL PER DAY. During the same period patient was treated with WARFARIN. Patient was hospitalized. Patient died.

Topotecan Side Effects Report #6064539-8
Topotecan side effect was reported by a Physician from UNITED STATES on Jan 28, 2009. Female patient, 74 years of age, was diagnosed with nausea , pain  and was treated with Topotecan. After drug was administered, patient experienced the following side effects: blood potassium decreased, constipation , encephalitis , fall , febrile neutropenia, loss of consciousness, malaise, pancytopenia, pyrexia. Topotecan dosage: 2MG CYCLIC. During the same period patient was treated with METOCLOPRAMIDE, MACROGOL, SENNA, DOCUSATE, REGLAN, COUMADIN, PERCOCET. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #5242710-2
Topotecan side effect was reported by a Physician from UNITED STATES on Feb 21, 2007. Female patient, 67 years of age, weighting 114.2 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: contusion, fall , pancytopenia, subdural haematoma. Topotecan dosage: 4.5MGM2 CYCLIC. During the same period patient was treated with CARBOPLATIN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5258831-4
Topotecan side effect was reported by a Physician from UNITED STATES on Mar 08, 2007. Female patient, 67 years of age, weighting 114.2 lb, was diagnosed with hyponatraemia, hypertension, anxiety  and was treated with Topotecan. After drug was administered, patient experienced the following side effects: contusion, fall , pancytopenia, subdural haematoma. Topotecan dosage: 6MGM2 CYCLIC. During the same period patient was treated with CARBOPLATIN, LOPRESSOR, ZOLOFT. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5259928-5
Topotecan side effect was reported by a Physician from UNITED STATES on Mar 08, 2007. Female patient, 67 years of age, weighting 114.2 lb, was diagnosed with hypertension, anxiety  and was treated with Topotecan. After drug was administered, patient experienced the following side effects: contusion, fall , pancytopenia, subdural haematoma. Topotecan dosage: 6MGM2 CYCLIC. During the same period patient was treated with CARBOPLATIN, LOPRESSOR, ZOLOFT. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5465782-9
Topotecan side effect was reported by a Physician from GERMANY on Sept 17, 2007. Female patient, 67 years of age, weighting 167.6 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: haematuria, pancytopenia, pyrexia. Topotecan dosage: .75MGM2 SEE TEXT. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5376096-X
Topotecan side effect was reported by a Physician from HUNGARY on June 22, 2007. Female patient, 64 years of age, weighting 174.2 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, fatigue, leukopenia, neutropenia, pancytopenia, pyrexia, syncope, thrombocytopenia. Topotecan dosage: 1.1MGM2 PER DAY. During the same period patient was treated with RADIATION. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #5384177-X
Topotecan side effect was reported by a Physician from HUNGARY on July 06, 2007. Female patient, 64 years of age, weighting 174.2 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: anaemia, bedridden, fatigue, impaired self-care, leukopenia, neutropenia, pancytopenia, pyrexia. Topotecan dosage: 4MG PER DAY. During the same period patient was treated with RADIATION. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4697159-8
Topotecan side effect was reported by a Health Professional from on June 21, 2005. Female patient, 64 years of age, weighting 171.0 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: asthenia, ear discomfort, febrile neutropenia, increased upper airway secretion, pancytopenia, pharyngolaryngeal pain. Topotecan dosage: 1.25 MG/M2 D1-5 IV. During the same period patient was treated with TENORMIN, ASPIRIN, THALIDOMIDE, MAGNESIUM, AMILORIDE. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #5397758-4
Topotecan side effect was reported by a Physician from GERMANY on July 19, 2007. Male patient, 62 years of age, weighting 185.4 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: dehydration, gastric haemorrhage, headache , metastases to central nervous system, pancytopenia, renal failure, somnolence, vertigo, vomiting. Topotecan dosage: 1MGM2 PER DAY. During the same period patient was treated with CISPLATIN, DEXAMETHASONE. Patient was hospitalized. Patient died on 08/05/2005.

Topotecan Side Effects Report #4745939-2
Topotecan side effect was reported by a Physician from GERMANY on July 27, 2005. Male patient, 62 years of age, weighting 185.4 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: dehydration, gastric haemorrhage, headache , metastases to central nervous system, pancytopenia, renal failure, somnolence, vertigo, vomiting. Topotecan dosage: 1MGM2 PER DAY. During the same period patient was treated with CISPLATIN, DEXAMETHASONE. Patient was hospitalized. Patient died on 08/05/2005.

Topotecan Side Effects Report #5299328-5
Topotecan side effect was reported by a Pharmacist from UNITED STATES on Apr 11, 2007. Female patient, 61 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: neutropenia, pancytopenia, thrombocytopenia. Topotecan dosage: unknown. Patient was hospitalized. Patient recovered.


Topotecan Side Effects Report #4662339-4
Topotecan side effect was reported by a Pharmacist from on May 13, 2005. Male patient, 57 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: hypotension, pancytopenia. Topotecan dosage: 2.9MG IV QD X 4 D. During the same period patient was treated with TRAZODONE, GABAPENTIN, SCOPOLAMINE, PHENERGAN, OMEPRAZOLE, METOPROLOL, REGLAN, METFORMIN. Patient was hospitalized. Patient recovered.

Topotecan Side Effects Report #4770843-3
Topotecan side effect was reported by a Physician from JAPAN on Sept 05, 2005. Female patient, 53 years of age, was treated with Topotecan. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, haemoglobin decreased, leukopenia, pancytopenia, vomiting. Topotecan dosage: unknown. During the same period patient was treated with ZOPICLONE, SENNOSIDE, GRANISETRON, PICOSULPHATE, BROTIZOLAM, MORPHINE HYDROCHLORIDE, LOXOPROFEN, REBAMIPIDE. Patient died on 12/15/2003.

Topotecan Side Effects Report #5417768-8
Topotecan side effect was reported by a Pharmacist from UNITED STATES on Aug 15, 2007. Female patient, weighting 147.0 lb, was treated with Topotecan. After drug was administered, patient experienced the following side effects: pancytopenia, pyrexia. Topotecan dosage: unknown. During the same period patient was treated with NEUPOGEN, COUMADIN, LACTULOSE, TOPROL, NYSTATIN, LASIX, PROTONIX. Patient was hospitalized. Patient recovered.