Temozolomide and bone marrow failure Patient Reports February 11, 2012

Temozolomide Side Effects Report #5025435-8
Temozolomide side effect was reported by a Physician from UNITED STATES on May 30, 2006. Female patient, 66 years of age, was diagnosed with oligodendroglioma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, bone marrow failure, chromosomal deletion, mean cell volume increased, myelodysplastic syndrome, pancytopenia, refractory anaemia. Temozolomide dosage: unknown. During the same period patient was treated with CARMUSTINE IMPLANT OLIGODENDROGLIOMA. Patient died on 09/01/2005.

Temozolomide Side Effects Report #6019934-X
Temozolomide side effect was reported by a Health Professional from UNITED STATES on Dec 11, 2008. Male patient, 69 years of age, weighting 211.0 lb, was diagnosed with oesophageal carcinoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, constipation , dehydration, fatigue, fungus sputum test positive, hypoxia, pain , platelet count decreased. Temozolomide dosage: 335 MG;QD;PO; 335 MG;QD;PO. During the same period patient was treated with ALBUTEROL, MOMETASONE FUROATE, SERTRALINE, TRAZODONE, ALLOPURINOL. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #6052690-8
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 14, 2009. Male patient, 69 years of age, weighting 211.0 lb, was diagnosed with oesophageal carcinoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, constipation , dehydration, fungus sputum test positive, muscular weakness, pain , pneumonia , tachycardia, therapeutic response decreased. Temozolomide dosage: 335 MG; QD; PO. During the same period patient was treated with ALBUTEROL, MOMETASONE FUROATE, SERTRALINE, TRAZODONE, ALLOPURINOL. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #6072953-X
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 30, 2009. Male patient, 69 years of age, weighting 211.0 lb, was diagnosed with oesophageal carcinoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anxiety , asthenia, blood iron decreased, blood sodium decreased, bone marrow failure, constipation , depression , fungal infection , fungus sputum test positive. Temozolomide dosage: 335 MG; QD; PO. During the same period patient was treated with ALBUTEROL, MOMETASONE FUROATE, SERTRALINE, TRAZODONE, ALLOPURINOL. Patient was hospitalized. Patient recovered.


Temozolomide Side Effects Report #5469777-0
Temozolomide side effect was reported by a Physician from UNITED STATES on Sept 26, 2007. Female patient, 59 years of age, was diagnosed with metastatic malignant melanoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: antinuclear antibody positive, aplastic anaemia, bone marrow failure, ecchymosis, malignant neoplasm progression, metastases to liver, metastases to soft tissue, metastases to spleen, skin haemorrhage. Temozolomide dosage: 140 MG DAILY PO. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5118514-8
Temozolomide side effect was reported by a Physician from UNITED STATES on Sept 20, 2006. Male patient, 30 years of age, weighting 258.0 lb, was diagnosed with metastatic malignant melanoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anaemia haemolytic autoimmune, bone marrow failure, disease progression, ecchymosis, erythema, haematoma, pancytopenia, pyrexia, skin lesion. Temozolomide dosage: 360 MG;. During the same period patient was treated with ZOFRAN. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5123116-3
Temozolomide side effect was reported by a Physician from UNITED STATES on Sept 25, 2006. Male patient, 30 years of age, weighting 258.0 lb, was diagnosed with metastatic malignant melanoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anaemia haemolytic autoimmune, bone marrow failure, coombs test positive, haematoma, jaundice , pancytopenia, pyrexia, skin lesion. Temozolomide dosage: 360 MG. During the same period patient was treated with ZOFRAN. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5306485-0
Temozolomide side effect was reported by a Physician from UNITED KINGDOM on Apr 10, 2007. Male patient, 52 years of age, was diagnosed with metastases to nervous system and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, bronchopneumonia. Temozolomide dosage: 150 MG/M2;PO. During the same period patient was treated with LOMUSTINE, LANSOPRAZOLE. Patient died on 08/22/2002.

Temozolomide Side Effects Report #5292582-5
Temozolomide side effect was reported by a Physician from UNITED KINGDOM on Mar 26, 2007. Female patient, 50 years of age, was diagnosed with metastases to central nervous system and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anaemia, bone marrow failure, haemorrhage, leukopenia, neutropenia, pulmonary fibrosis , pyrexia, thrombocytopenia. Temozolomide dosage: 150 MG/M2;QD;PO. During the same period patient was treated with LOMUSTINE. Patient was hospitalized. Patient recovered.


Temozolomide Side Effects Report #5306529-6
Temozolomide side effect was reported by a Physician from UNITED KINGDOM on Apr 10, 2007. Female patient, 50 years of age, was diagnosed with metastases to central nervous system and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, haemorrhage, pulmonary fibrosis , pulmonary toxicity. Temozolomide dosage: 150 MG/M2;QD;PO. During the same period patient was treated with LOMUSTINE, NYSTATIN. Patient was hospitalized. Patient died on 02/26/2001.

Temozolomide Side Effects Report #5378542-4
Temozolomide side effect was reported by a Physician from UNITED KINGDOM on June 25, 2007. Female patient was diagnosed with metastases to central nervous system and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, cerebral haemorrhage. Temozolomide dosage: 150 MG/M2. During the same period patient was treated with LOMUSTINE. Patient died.

Temozolomide Side Effects Report #5401984-5
Temozolomide side effect was reported by a Physician from UNITED KINGDOM on July 20, 2007. Female patient was diagnosed with metastases to central nervous system and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, cerebral haemorrhage, leukopenia, neutropenia, thrombocytopenia. Temozolomide dosage: 150 MG/M2;. During the same period patient was treated with LOMUSTINE. Patient died on 04/17/2003.

Temozolomide Side Effects Report #5850674-3
Temozolomide side effect was reported by a Health Professional from UNITED KINGDOM on Aug 11, 2008. Female patient, child 3 years of age, was diagnosed with medulloblastoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood bilirubin increased, bone marrow failure, hepatomegaly, mucosal inflammation, prothrombin time prolonged. Temozolomide dosage: unknown. During the same period patient was treated with CISPLATIN, CYCLOPHOSPHAMIDE, ETOPOSIDE, METHOTREXATE, VINCRISTINE SULPHATE, GLUCARPIDASE. Patient recovered.

Temozolomide Side Effects Report #5871390-8
Temozolomide side effect was reported by a Health Professional from UNITED KINGDOM on Aug 22, 2008. Female patient, child 3 years of age, was diagnosed with medulloblastoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, ascites, blood bilirubin increased, bone marrow failure, hepatomegaly, mucosal inflammation. Temozolomide dosage: unknown. During the same period patient was treated with METHOTREXATE, CISPLATIN, CYCLOPHOSPHAMIDE, ETOPOSIDE, VINCRISTINE. Patient recovered.


Temozolomide Side Effects Report #5422609-9
Temozolomide side effect was reported by a Physician from UNITED STATES on Aug 10, 2007. Female patient, 79 years of age, weighting 157.6 lb, was diagnosed with glioblastoma multiforme and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: atrial fibrillation , bone marrow failure, disease progression, pancytopenia, sick sinus syndrome. Temozolomide dosage: 75 MG/M2; QD; PO, 150 MG/M2; QD; PO; 200 MG/M2; QD; PO. Patient died on 07/15/2007.

Temozolomide Side Effects Report #4965771-4
Temozolomide side effect was reported by a Physician from SOUTH AFRICA on Mar 24, 2006. Female patient, 67 years of age, weighting 121.3 lb, was diagnosed with glioblastoma multiforme and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: 300 MG QDX5D ORAL. During the same period patient was treated with ONDANSETRON. Patient was hospitalized. Patient died on 03/05/2006.

Temozolomide Side Effects Report #5878604-9
Temozolomide side effect was reported by a Health Professional from UNITED KINGDOM on Sept 02, 2008. Female patient, 64 years of age, weighting 187.2 lb, was diagnosed with glioblastoma multiforme and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, sepsis . Temozolomide dosage: 145 MG; PO. During the same period patient was treated with CO TRIMOXAZOLE, METOCLOPRAMIDE, ONDANSETRON, PHENYTOIN. Patient recovered.

Temozolomide Side Effects Report #5218962-1
Temozolomide side effect was reported by a Physician from UNITED STATES on Jan 09, 2007. Male patient, 63 years of age, was diagnosed with glioblastoma multiforme and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: aplastic anaemia, bone marrow failure, thrombocytopenia. Temozolomide dosage: 75 MG/M2;QD;PO. Patient died.

Temozolomide Side Effects Report #5873334-1
Temozolomide side effect was reported by a Physician from INDIA on Aug 25, 2008. Female patient, 30 years of age, was diagnosed with glioblastoma multiforme, antifungal prophylaxis and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: aplastic anaemia, bone marrow failure, gingival bleeding, pancytopenia, sepsis . Temozolomide dosage: 75 MG/M2; PO. During the same period patient was treated with TRIMETHOPRIM, PHENYTOIN. Patient was hospitalized. Patient died.


Temozolomide Side Effects Report #5475514-6
Temozolomide side effect was reported by a Physician from UNITED STATES on Sept 25, 2007. Male patient, 52 years of age, was diagnosed with astrocytoma and was treated with Temozolomide. After drug was administered, patient experienced the following side effects: aplastic anaemia, bone marrow failure, nephrolithiasis. Temozolomide dosage: unknown. During the same period patient was treated with ALLOPURINOL, KEPPRA, PROTONIX, DILANTIN, TOPROL. Patient died on 09/01/2006.

Temozolomide Side Effects Report #5470209-7
Temozolomide side effect was reported by a Physician from UNITED STATES on Sept 17, 2007. Male patient, 58 years of age, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: unknown. Patient died.

Temozolomide Side Effects Report #5224677-6
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 29, 2007. Female patient, weighting 151.5 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anorectal cellulitis, aplastic anaemia, bone marrow failure, febrile neutropenia, glioblastoma multiforme, haemorrhoids, malignant neoplasm progression, thrombocytopenia. Temozolomide dosage: 3640 MG. During the same period patient was treated with BACTRIM, DEXAMETHASONE, KEPPRA, QVC HERBS AND SUPPLEMENTS. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5363036-2
Temozolomide side effect was reported by a Pharmacist from UNITED STATES on June 12, 2007. Female patient was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: unknown. Patient died.

Temozolomide Side Effects Report #5363042-8
Temozolomide side effect was reported by a Pharmacist from UNITED STATES on June 12, 2007. Female patient was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: unknown. Patient died.


Temozolomide Side Effects Report #5146229-9
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 06, 2006. Female patient, weighting 151.5 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anorectal cellulitis, aplastic anaemia, bone marrow failure, febrile neutropenia, glioblastoma multiforme, haemorrhoids, malignant neoplasm progression, thrombocytopenia. Temozolomide dosage: 3640 MG. During the same period patient was treated with BACTRIM, DEXAMETHASONE, KEPPRA. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5162374-6
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 27, 2006. Female patient, weighting 151.5 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anorectal cellulitis, aplastic anaemia, bone marrow failure, febrile neutropenia, glioblastoma multiforme, haemorrhoids, malignant neoplasm progression, thrombocytopenia. Temozolomide dosage: 3640 MG. During the same period patient was treated with BACTRIM, DEXAMETHASONE, KEPPRA. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5393001-0
Temozolomide side effect was reported by a Pharmacist from UNITED STATES on July 11, 2007. Female patient was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: unknown. Patient died.

Temozolomide Side Effects Report #5394819-0
Temozolomide side effect was reported by a Pharmacist from UNITED STATES on July 11, 2007. Female patient was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: unknown. Patient died.

Temozolomide Side Effects Report #5407150-1
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 03, 2007. Female patient, weighting 157.6 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, pancytopenia, transfusion reaction. Temozolomide dosage: 1900 MG. Patient died on 07/15/2007.


Temozolomide Side Effects Report #5409693-3
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 08, 2007. Female patient, weighting 157.6 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, pancytopenia, transfusion reaction. Temozolomide dosage: unknown. Patient died on 07/15/2007.

Temozolomide Side Effects Report #5416467-6
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 13, 2007. Female patient, weighting 157.6 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, disease progression, transfusion reaction. Temozolomide dosage: 1900 MG. Patient died on 07/15/2007.

Temozolomide Side Effects Report #5456679-9
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 17, 2007. Female patient, weighting 138.0 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure. Temozolomide dosage: 1890 MG. Patient recovered.

Temozolomide Side Effects Report #5480530-4
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 04, 2007. Female patient, weighting 151.5 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: anorectal cellulitis, aplastic anaemia, blood product transfusion dependent, bone marrow failure, haemorrhoids, pyrexia. Temozolomide dosage: 3640 MG. During the same period patient was treated with BACTRIM, DEXAMETHASONE, KEPPRA, OVC HERBS AND SUPPLEMENTS. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5523033-0
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 16, 2007. Female patient, weighting 151.5 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: aplastic anaemia, bone marrow failure, cellulitis , haemorrhoids, lymphopenia, malignant neoplasm progression, proctalgia. Temozolomide dosage: 3640 MG. During the same period patient was treated with BACTRIM, DEXAMETHASONE, KEPPRA, OVC HERBS AND SUPPLEMENTS. Patient was hospitalized. Patient recovered.


Temozolomide Side Effects Report #5631761-1
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 19, 2008. Female patient, weighting 162.3 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, lymphopenia, neutropenia, thrombocytopenia, white blood cell count decreased. Temozolomide dosage: 1350 MG. During the same period patient was treated with DIAMOX SEQUELS, KEPPRA, LAMICTAL, LYBREL, ZOFRAN. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5636211-7
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 20, 2008. Female patient, weighting 162.3 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, lymphopenia, neutropenia, thrombocytopenia. Temozolomide dosage: 1350 MG. During the same period patient was treated with DIAMOX SEQUELS, KEPPRA, LAMICTAL, LYBREL, ZOFRAN. Patient was hospitalized. Patient recovered.

Temozolomide Side Effects Report #5638407-7
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 22, 2008. Female patient, weighting 153.0 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, neutrophil count abnormal, platelet count decreased, white blood cell count abnormal. Temozolomide dosage: 3675 MG. Patient recovered.

Temozolomide Side Effects Report #5648018-5
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 29, 2008. Female patient, weighting 157.6 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, disease progression, transfusion reaction. Temozolomide dosage: 1900 MG. Patient died on 07/15/2007.

Temozolomide Side Effects Report #5835055-0
Temozolomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 05, 2008. Male patient, weighting 187.8 lb, was treated with Temozolomide. After drug was administered, patient experienced the following side effects: bone marrow failure, chills, confusional state, constipation , groin pain, hypophagia, mental status changes, nausea , rash . Temozolomide dosage: 6665 MG. Patient was hospitalized. Patient recovered.