Temodal and depressed level of consciousness Patient Reports February 12, 2012

Temodal Side Effects Report #5557069-0
Temodal side effect was reported by a Physician from JAPAN on Dec 06, 2007. Male patient, 71 years of age, weighting 114.6 lb, was diagnosed with oligodendroglioma and was treated with Temodal. After drug was administered, patient experienced the following side effects: activities of daily living impaired, depressed level of consciousness, disease progression, lymphocyte count decreased, pneumonia , tumour haemorrhage. Temodal dosage: 75 MG/M2; QD; PO. During the same period patient was treated with BAKTAR, TAKEPRON OD, AMLODIN, DIOVAN, ASPIRIN, URSO, PREDNISOLONE, AZULFIDINE EN. Patient died on 05/25/2007.

Temodal Side Effects Report #4639165-5
Temodal side effect was reported by a Physician from on Apr 07, 2005. Female patient, 24 years of age, was diagnosed with oligodendroglioma and was treated with Temodal. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, contusion, convulsion, depressed level of consciousness, haematoma, hemiparesis, hypoaesthesia, malignant neoplasm progression, malignant oligodendroglioma. Temodal dosage: 200MG QD X5D ORAL. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #4567994-5
Temodal side effect was reported by a Physician from on Jan 20, 2005. Female patient, 24 years of age, was diagnosed with malignant oligodendroglioma and was treated with Temodal. After drug was administered, patient experienced the following side effects: asthenia, cerebral haemorrhage, depressed level of consciousness, grand mal convulsion, haematoma, hemiparesis, hypoaesthesia, intracranial tumour haemorrhage, malignant oligodendroglioma. Temodal dosage: 200 MG QD X5D ORAL. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5888713-6
Temodal side effect was reported by a Physician from FRANCE on Sept 12, 2008. Male patient, 78 years of age, weighting 143.3 lb, was diagnosed with lymphoma  and was treated with Temodal. After drug was administered, patient experienced the following side effects: bone marrow failure, dehydration, depressed level of consciousness, hypoxia, lung infiltration, neutropenia, oxygen saturation decreased, pulmonary oedema, septic shock. Temodal dosage: 255 MG QD PO. During the same period patient was treated with METHOTREXATE, LOVENOX, NEUPOGEN, ARANESP, INIPOMP, MONOTILDIEM, COVERSYL. Patient was hospitalized. Patient died on 08/13/2008.


Temodal Side Effects Report #5724458-0
Temodal side effect was reported by a Physician from JAPAN on Apr 24, 2008. Male patient, 76 years of age, weighting 134.5 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: aspiration, depressed level of consciousness, pneumonia . Temodal dosage: 145 MG/M2;QD;PO. During the same period patient was treated with MAGNESIUM OXIDE, KYTRIL, ISOBIDE, GLYCEOL. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5878587-1
Temodal side effect was reported by a Physician from JAPAN on Sept 03, 2008. Male patient, 70 years of age, weighting 127.9 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: condition aggravated, depressed level of consciousness, hypophagia, neoplasm progression, oedema. Temodal dosage: 72 MG/M2; QD; PO, 150 MG/M2; QD; PO. During the same period patient was treated with COTRIM, PHENOBARBITAL, FAMOTIDINE, CHLORIDE, MAGNESIUM OXIDE. Patient recovered.

Temodal Side Effects Report #5313619-0
Temodal side effect was reported by a Physician from JAPAN on Apr 16, 2007. Female patient, 69 years of age, weighting 130.1 lb, was diagnosed with glioblastoma multiforme, recurrent cancer and was treated with Temodal. After drug was administered, patient experienced the following side effects: bone marrow failure, depressed level of consciousness, gastrointestinal haemorrhage, hepatic function abnormal, pneumonia , pulmonary fibrosis , scleroderma . Temodal dosage: unknown. During the same period patient was treated with BAKTAR, DEPAKENE, RINDERON, TAGAMET. Patient died on 01/19/2007.

Temodal Side Effects Report #5776194-2
Temodal side effect was reported by a Physician from JAPAN on June 09, 2008. Female patient, 69 years of age, weighting 130.1 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: bone marrow failure, c-reactive protein increased, condition aggravated, depressed level of consciousness, gastric ulcer, hepatic function abnormal, melaena, neoplasm progression, pneumonia . Temodal dosage: 150 MG/M2;QD; PO. During the same period patient was treated with BAKTAR, DEPAKENE, BETAMETHASONE, TAGAMET, ZYPREXA. Patient died on 01/19/2007.

Temodal Side Effects Report #5909523-7
Temodal side effect was reported by a Physician from JAPAN on Sept 29, 2008. Female patient, 69 years of age, weighting 130.1 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: bone marrow failure, depressed level of consciousness, gastric ulcer, gastrointestinal haemorrhage, hepatic function abnormal, pneumonia aspiration, pulmonary fibrosis , scleroderma . Temodal dosage: 150 MG/M2/QD;PO : 150 MG/M2;QD;PO. During the same period patient was treated with COTRIM, DEPAKENE, RINDERON, TAGAMET, ZYPREXA. Patient died on 01/19/2007.


Temodal Side Effects Report #5808036-0
Temodal side effect was reported by a Physician from JAPAN on June 30, 2008. Male patient, 64 years of age, weighting 112.4 lb, was diagnosed with glioblastoma multiforme, disease recurrence and was treated with Temodal. After drug was administered, patient experienced the following side effects: bronchitis bacterial, decubitus ulcer, depressed level of consciousness, lymphocyte count decreased, pneumocystis jiroveci pneumonia, pneumonia cytomegaloviral, respiratory failure, sputum retention. Temodal dosage: 150 MG/M2; QD; PO; 200 MG/M2; QD; PO. During the same period patient was treated with BETAMETHASONE, EXCEGRAN, PHENOBARBITAL. Patient died on 01/12/2007.

Temodal Side Effects Report #5297402-0
Temodal side effect was reported by a Physician from JAPAN on Mar 29, 2007. Female patient, 60 years of age, was diagnosed with glioblastoma multiforme, recurrent cancer and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, platelet count decreased, tumour haemorrhage. Temodal dosage: 150 MG/M2; QD; PO. During the same period patient was treated with NIMUSTINE HYDROCHLORIDE, PROCARBAZINE, SELENICA, TAKEPRON OD, PURSENNID. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5324236-0
Temodal side effect was reported by a Physician from ISRAEL on Apr 27, 2007. Male patient, 57 years of age, weighting 189.6 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hypotension, pyrexia, septic shock, streptococcal sepsis. Temodal dosage: 75 MG/M2;QD;PO. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5328189-0
Temodal side effect was reported by a Physician from ISRAEL on May 04, 2007. Male patient, 57 years of age, weighting 189.6 lb, was diagnosed with glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hypotension, septic shock, streptococcal sepsis. Temodal dosage: 75 MG/M2; QD; PO. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5352141-2
Temodal side effect was reported by a Physician from ISRAEL on May 30, 2007. Male patient, 57 years of age, weighting 189.6 lb, was diagnosed with glioblastoma multiforme, brain oedema and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hypotension, platelet count decreased, pyrexia, streptococcal sepsis. Temodal dosage: 160 MG;QD;PO. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient recovered.


Temodal Side Effects Report #5371676-X
Temodal side effect was reported by a Physician from ISRAEL on June 18, 2007. Male patient, 57 years of age, weighting 189.6 lb, was diagnosed with glioblastoma multiforme, brain oedema and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, septic shock, streptococcal sepsis. Temodal dosage: 160 MG; QD; PO. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5215556-9
Temodal side effect was reported by a Physician from JAPAN on Jan 09, 2007. Female patient, 65 years of age, weighting 114.6 lb, was diagnosed with glioblastoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, depressed level of consciousness, leukopenia, no therapeutic response, pneumocystis jiroveci pneumonia, respiratory failure. Temodal dosage: unknown. During the same period patient was treated with DEPAKENE, DOGMATYL, ZYLORIC, TRANSAMIN, BLOPRESS, COMELIAN. Patient was hospitalized. Patient died on 11/08/2006.

Temodal Side Effects Report #5225202-6
Temodal side effect was reported by a Physician from JAPAN on Jan 24, 2007. Female patient, 65 years of age, weighting 114.6 lb, was diagnosed with glioblastoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood beta-d-glucan increased, depressed level of consciousness, no therapeutic response, platelet count decreased, pneumocystis jiroveci pneumonia, respiratory failure, white blood cell count decreased. Temodal dosage: unknown. During the same period patient was treated with DEPAKENE, DOGMATYL, ZYLORIC, TRANSAMIN, BLOPRESS, COMELIAN. Patient was hospitalized. Patient died on 11/08/2006.

Temodal Side Effects Report #5199805-1
Temodal side effect was reported by a Physician from JAPAN on Dec 26, 2006. Female patient, 65 years of age, weighting 114.6 lb, was diagnosed with glioblastoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, blood beta-d-glucan increased, depressed level of consciousness, leukopenia, no therapeutic response, platelet count decreased, pneumocystis jiroveci pneumonia, respiratory failure. Temodal dosage: 150 + 200 MG/M2;QD; PO -SEE IMAGE. During the same period patient was treated with DEPAKENE, DOGMATYL, ZYLORIC, TRANSAMIN, BLOPRESS, COMELIAN. Patient was hospitalized. Patient died on 11/08/2006.

Temodal Side Effects Report #5378518-7
Temodal side effect was reported by a Physician from JAPAN on June 29, 2007. Female patient, 65 years of age, weighting 114.6 lb, was diagnosed with glioblastoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, depressed level of consciousness, leukopenia, platelet count decreased, pneumocystis jiroveci pneumonia, respiratory failure. Temodal dosage: unknown. During the same period patient was treated with DEPAKENE, DOGMATYL, ALLOPURINOL, TRANSAMIN, BLOPRESS, COMELIAN. Patient was hospitalized. Patient died on 11/08/2006.


Temodal Side Effects Report #5445958-7
Temodal side effect was reported by a Physician from JAPAN on Aug 29, 2007. Male patient, 65 years of age, weighting 138.9 lb, was diagnosed with glioblastoma, recurrent cancer and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, disease progression, interstitial lung disease, multi-organ failure, pneumocystis jiroveci pneumonia. Temodal dosage: 150 MG/M2; QD; PO, 150 MG/M2; QD; PO, 150 MG/M2; QD; PO. During the same period patient was treated with EXCEGRAN, DEPAKENE, IRINOTECAN. Patient died on 03/07/2007.

Temodal Side Effects Report #5582865-3
Temodal side effect was reported by a Physician from JAPAN on Dec 25, 2007. Male patient, 64 years of age, weighting 90.39 lb, was diagnosed with ependymoma malignant and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, lung neoplasm malignant, malignant pleural effusion, nausea , pneumonia aspiration, pneumonia staphylococcal. Temodal dosage: 150 MG/M2;QD;PO, 200 MG/M2;QD;PO, 200 MG/M2;QD;PO, 200 MG/M2;QD;PO. During the same period patient was treated with PHENYTOIN CAP, CYANOCOBALAMIN, RINDERON. Patient died on 03/05/2007.

Temodal Side Effects Report #5525189-2
Temodal side effect was reported by a Physician from JAPAN on Nov 13, 2007. Female patient, 69 years of age, weighting 130.1 lb, was diagnosed with disease recurrence, glioblastoma multiforme and was treated with Temodal. After drug was administered, patient experienced the following side effects: bone marrow failure, depressed level of consciousness, gastric ulcer, gastrointestinal haemorrhage, hepatic function abnormal, pneumonia aspiration, pulmonary fibrosis , scleroderma . Temodal dosage: 150 MG/M2; QD; PO. During the same period patient was treated with BACTRIM, DEPAKENE, RINDERON, TAGAMET. Patient died on 01/19/2007.

Temodal Side Effects Report #4786005-X
Temodal side effect was reported by a Physician from ITALY on Aug 08, 2005. Female patient, 60 years of age, weighting 220.5 lb, was diagnosed with cerebral disorder, neoplasm and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hepatic failure, hepatotoxicity, oedema peripheral, oliguria, urine output decreased. Temodal dosage: unknown. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient died on 08/05/2005.

Temodal Side Effects Report #5694326-1
Temodal side effect was reported by a Physician from FRANCE on Mar 27, 2008. Female patient, 74 years of age, weighting 152.1 lb, was diagnosed with central nervous system lymphoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: anaemia, depressed level of consciousness, haematotoxicity, hypotension, klebsiella sepsis, lymphopenia, myocardial infarction, neutropenia, pneumonia . Temodal dosage: 270 MG;QD;PO. During the same period patient was treated with METHOTREXATE, ATORVASTATIN CALCIUM, SECTRAL, LEUCOVORIN CALCIUM, LASILIX, LOVENOX. Patient was hospitalized. Patient recovered.


Temodal Side Effects Report #4811265-6
Temodal side effect was reported by a Physician from ITALY on Oct 17, 2005. Female patient, 60 years of age, weighting 220.5 lb, was diagnosed with brain neoplasm and was treated with Temodal. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase mb increased, blood creatinine increased, blood urea increased, dehydration, depressed level of consciousness, hepatic failure, hepatotoxicity, oedema peripheral. Temodal dosage: 290 MG* ORAL. During the same period patient was treated with DEXAMETHASONE. Patient was hospitalized. Patient died on 08/05/2005.

Temodal Side Effects Report #5448209-2
Temodal side effect was reported by a Physician from JAPAN on Aug 31, 2007. Male patient, 63 years of age, weighting 134.5 lb, was diagnosed with astrocytoma, neoplasm recurrence and was treated with Temodal. After drug was administered, patient experienced the following side effects: accident, activities of daily living impaired, depressed level of consciousness, fall , spinal compression fracture, thoracic vertebral fracture. Temodal dosage: 150 MG/M2; QD; PO; 200 MG/M2; QD; PO. Patient died on 03/16/2007.

Temodal Side Effects Report #5681105-4
Temodal side effect was reported by a Physician from JAPAN on Mar 21, 2008. Male patient, 63 years of age, weighting 134.5 lb, was diagnosed with astrocytoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: accident, depressed level of consciousness, fall , respiratory disorder, spinal compression fracture. Temodal dosage: unknown. During the same period patient was treated with NAVOBAN, RINDERON, GASTER D, GLYSENNID. Patient died on 03/16/2007.

Temodal Side Effects Report #4952215-1
Temodal side effect was reported by a Physician from CANADA on Mar 09, 2006. Female patient, 46 years of age, weighting 130.1 lb, was diagnosed with astrocytoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: brain oedema, coma, depressed level of consciousness, malignant neoplasm progression, rash papular, swelling face. Temodal dosage: 120 MG ORAL. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #4758189-0
Temodal side effect was reported by a Physician from GERMANY on Aug 19, 2005. Female patient, 24 years of age, weighting 154.3 lb, was diagnosed with astrocytoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: brain oedema, convulsion, depressed level of consciousness, extensor plantar response, gaze palsy, mydriasis, neoplasm progression, petechiae, sepsis . Temodal dosage: 340 MG QS ORAL. During the same period patient was treated with PANTOZOL. Patient was hospitalized. Patient died on 08/12/2005.


Temodal Side Effects Report #5901029-4
Temodal side effect was reported by a Physician from JAPAN on Sept 19, 2008. Female patient, 58 years of age, weighting 92.59 lb, was diagnosed with anaplastic astrocytoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: acute respiratory failure, depressed level of consciousness, pneumocystis jiroveci pneumonia, pneumonia pneumococcal. Temodal dosage: 200 MG;QD;PO. During the same period patient was treated with DECADRON, MUCOSTA, DEPAS. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #6071680-2
Temodal side effect was reported by a Physician from JAPAN on Feb 02, 2009. Female patient, 58 years of age, weighting 92.59 lb, was diagnosed with anaplastic astrocytoma, recurrent cancer and was treated with Temodal. After drug was administered, patient experienced the following side effects: acute respiratory failure, depressed level of consciousness, immunodeficiency, lymphocyte count decreased, pneumocystis jiroveci pneumonia, pneumonia pneumococcal. Temodal dosage: unknown. Patient was hospitalized. Patient recovered.

Temodal Side Effects Report #5228758-2
Temodal side effect was reported by a Physician from JAPAN on Jan 24, 2007. Female patient, 42 years of age, weighting 145.5 lb, was diagnosed with anaplastic astrocytoma and was treated with Temodal. After drug was administered, patient experienced the following side effects: brain scan abnormal, depressed level of consciousness, tumour haemorrhage. Temodal dosage: 150 MG/M2; QD; PO. During the same period patient was treated with NIDRAN, ALEVIATIN, BISOLVON, ULCERLMIN, THYRADIN S, ZANTAC, PREDONINE. Patient recovered.

Temodal Side Effects Report #5492796-5
Temodal side effect was reported by a Physician from JAPAN on Jan 24, 2007. Female patient, 42 years of age, weighting 145.5 lb, was diagnosed with anaplastic astrocytoma, neoplasm recurrence and was treated with Temodal. After drug was administered, patient experienced the following side effects: depressed level of consciousness, hepatic function abnormal, intracranial tumour haemorrhage. Temodal dosage: 150 MG/M2;QD;PO. During the same period patient was treated with NIDRAN, PHENYTOIN CAP, BISOLVON, SUCRALFATE, THYRADIN S, ZANTAC. Patient recovered.