Tacrolimus and convulsion Patient Reports February 12, 2012

Tacrolimus Side Effects Report #5201138-1
Tacrolimus side effect was reported by a Physician from JAPAN on Dec 18, 2006. Male patient, 29 years of age, weighting 140.7 lb, was diagnosed with stem cell transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: abdominal pain upper, alanine aminotransferase increased, aspartate aminotransferase increased, bk virus infection, bronchopulmonary aspergillosis, cerebral aspergillosis, chronic graft versus host disease, convulsion, cytomegalovirus antigen positive. Tacrolimus dosage: unknown. During the same period patient was treated with GASTER D ORODISPERSABLE CRLET, ZOVIRAX, MEDICON, URSO, BIOFERMIN R, BACTAR, ULCERLMIN. Patient was hospitalized. Patient died on 10/02/2005.

Tacrolimus Side Effects Report #4950834-X
Tacrolimus side effect was reported by a Pharmacist from JAPAN on Nov 24, 2005. Male patient, 27 years of age, was diagnosed with stem cell transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, encephalitis viral, encephalopathy, graft versus host disease, herpes simplex , renal impairment. Tacrolimus dosage: unknown. During the same period patient was treated with SANDIMMUNE. Patient died on 01/31/2006.

Tacrolimus Side Effects Report #4955361-1
Tacrolimus side effect was reported by a Pharmacist from JAPAN on Nov 24, 2005. Male patient, 27 years of age, was diagnosed with stem cell transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, encephalitis viral, graft versus host disease, herpes simplex , renal impairment. Tacrolimus dosage: unknown. During the same period patient was treated with SANDIMMUNE. Patient died on 01/31/2006.

Tacrolimus Side Effects Report #5234401-9
Tacrolimus side effect was reported by a Pharmacist from UNITED STATES on Feb 07, 2007. Male patient, 59 years of age, weighting 173.3 lb, was diagnosed with renal transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: aspiration, convulsion, incorrect dose administered, treatment noncompliance. Tacrolimus dosage: 0.5 MG BID PTA. Patient died on 01/19/2007.


Tacrolimus Side Effects Report #5641803-5
Tacrolimus side effect was reported by a Health Professional from JAPAN on Feb 18, 2008. Female patient, 24 years of age, was diagnosed with renal transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: altered state of consciousness, convulsion, leukoencephalopathy, nuclear magnetic resonance imaging abnormal. Tacrolimus dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL, PREDONINE, SIMULECT. Patient was hospitalized. Patient recovered.

Tacrolimus Side Effects Report #5503567-5
Tacrolimus side effect was reported by a Physician from JAPAN on Oct 15, 2007. Female patient, child 12 years of age, weighting 103.6 lb, was diagnosed with renal transplant and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: brain oedema, complex partial seizures, convulsion, disorientation, epilepsy , grand mal convulsion, leukoencephalopathy, loss of consciousness, memory impairment. Tacrolimus dosage: 13 MG, /D, ORAL; 6.5 MG, /D, ORAL. During the same period patient was treated with PROGRAF, PREDNISONE, AZATHIOPRINE, NICARDIPINE HYDROCHLORIDE, PIPERACILLIN. Patient was hospitalized. Patient died.

Tacrolimus Side Effects Report #5466911-3
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Sept 06, 2007. Male patient, child 10 years of age, weighting 66.14 lb, was diagnosed with renal transplant, kidney transplant rejection and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, malignant hypertension, reversible posterior leukoencephalopathy syndrome. Tacrolimus dosage: 7 MG, ORAL. During the same period patient was treated with SIROLIMUS, ALFACALCIDOL, BENDROFLUAZIDE, COTRIMOXAZOLE RATIOPHARM, MAGNESIUM GLYCEROPHOSPHATE, NEORECORMON, NIFEDIPINE, NYSTATIN. Patient recovered.

Tacrolimus Side Effects Report #5477628-3
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Sept 18, 2007. Male patient, child 10 years of age, weighting 66.14 lb, was diagnosed with renal transplant, kidney transplant rejection and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: acidosis, blood magnesium decreased, bone disorder, convulsion, kidney transplant rejection, malignant hypertension, nephrogenic anaemia, reversible posterior leukoencephalopathy syndrome. Tacrolimus dosage: 7 MG, ORAL. During the same period patient was treated with SIROLIMUS, ALFACALCIDOL, BENDROFLUAZIDE, COTRIMOXAZOLE RATIOPHARM, MAGNESIUM GLYCEROPHOSPHATE, NEORECORMON, NIFEDIPINE, NYSTATIN. Patient recovered.

Tacrolimus Side Effects Report #5757749-8
Tacrolimus side effect was reported by a Physician from JAPAN on May 20, 2008. Female patient, 36 years of age, weighting 134.5 lb, was diagnosed with lupus nephritis and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: cellulitis , convulsion, enterococcal bacteraemia, hepatic encephalopathy, histiocytosis haematophagic, loss of consciousness, staphylococcal bacteraemia. Tacrolimus dosage: 1 MG, /D, ORAL; 1.5 MG, /D, ORAL. During the same period patient was treated with PREDNISOLONE, BUFFERINLET, ALFAROL, PARIET, LOXONIN, OPALMON, CINAL. Patient was hospitalized and became disabled. Patient recovered.


Tacrolimus Side Effects Report #5768592-8
Tacrolimus side effect was reported by a Physician from JAPAN on June 02, 2008. Female patient, 36 years of age, weighting 134.5 lb, was diagnosed with lupus nephritis and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: cellulitis , convulsion, discomfort, enterococcal bacteraemia, hepatic encephalopathy, histiocytosis haematophagic, liver disorder, loss of consciousness, platelet count decreased. Tacrolimus dosage: 1 MG, /D, ORAL; 1.5 MG, /D, ORAL. During the same period patient was treated with PREDNISOLONE, BUFFERINLET, ALFAROL, PARIET, LOXONIN, OPALMON, CINAL. Patient was hospitalized and became disabled. Patient recovered.

Tacrolimus Side Effects Report #5776146-2
Tacrolimus side effect was reported by a Physician from JAPAN on June 06, 2008. Female patient, 36 years of age, weighting 134.5 lb, was diagnosed with lupus nephritis and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: blood culture positive, cellulitis , convulsion, enterococcal bacteraemia, hepatic encephalopathy, histiocytosis haematophagic, loss of consciousness, staphylococcal bacteraemia. Tacrolimus dosage: 1 MG, ORAL. During the same period patient was treated with PREDNISOLONE, BUFFERIN, ALFAROL, RABEPRAZOLE, LOXONIN, OPALMON, CINAL, LOSARTAN POTASSIUM. Patient was hospitalized and became disabled. Patient recovered.

Tacrolimus Side Effects Report #5297631-6
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Mar 28, 2007. Male patient, 59 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: angiodysplasia, anxiety , bacterial infection , blood culture positive, cerebral atrophy, convulsion, diarrhoea, eosinophilia, human herpesvirus 8 infection. Tacrolimus dosage: 3.00 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISONE, INSULIN, MORPHINE, PANTOPRAZOLE, RAPAMYCIN, PIPERACILLIN, TAZOBACTAM, CORTICOSTEROIDS. Patient was hospitalized. Patient died on 09/15/2005.

Tacrolimus Side Effects Report #5306505-3
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Apr 03, 2007. Male patient, 59 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: anxiety , ascites, blood culture positive, cerebral atrophy, convulsion, diarrhoea, encephalopathy, eosinophilia, human herpesvirus 8 infection. Tacrolimus dosage: 3.00 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISONE, INSULIN, MORPHINE, PANTOPRAZOLE, RAPAMYCIN, PIPERACILLIN, TAZOBACTAM, CORTICOSTEROIDS. Patient was hospitalized. Patient died on 09/15/2005.

Tacrolimus Side Effects Report #5319731-4
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Apr 17, 2007. Male patient, 59 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: angiodysplasia, anxiety , cerebral atrophy, convulsion, diarrhoea, eosinophilia, febrile neutropenia, human herpesvirus 8 infection, liver transplant rejection. Tacrolimus dosage: 3.00 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISONE, METHYLPREDNISOLONE, INSULIN, MORPHINE, PANTOPRAZOLE, RAPAMYCIN, PIPERACILLIN, TAZOBACTAM. Patient was hospitalized. Patient died on 09/15/2005.


Tacrolimus Side Effects Report #5343399-4
Tacrolimus side effect was reported by a Health Professional from GERMANY on May 18, 2007. Male patient, 58 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: abdominal infection, abdominal sepsis, aspiration tracheal abnormal, bone marrow failure, candidiasis, cholestasis, continuous haemodiafiltration, convulsion, enterococcal infection. Tacrolimus dosage: 3 MG, BID, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, PREDNISONE, ANTITHROMBIN II, TRIMETHOPRIM, CALCIUM CHLORIDE, CILASTATIN W. Patient was hospitalized. Patient died on 09/07/2005.

Tacrolimus Side Effects Report #5371934-9
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on June 15, 2007. Male patient, 58 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: abdominal infection, aspiration tracheal abnormal, asthenia, bone marrow failure, candidiasis, cerebral haemorrhage, continuous haemodiafiltration, convulsion, enterococcal infection. Tacrolimus dosage: 3 MG, BID, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, PREDNISONE, ANTITHROMBIN II, TRIMETHOPRIM, CALCIUM, CILASTIN W, METAMIZOLE. Patient was hospitalized. Patient died on 09/07/2005.

Tacrolimus Side Effects Report #5371932-5
Tacrolimus side effect was reported by a Physician from UNITED KINGDOM on June 11, 2007. Female patient, 52 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest , cardiac failure, cerebral atrophy, convulsion, pathogen resistance, septic shock, staphylococcal sepsis. Tacrolimus dosage: 3 MG, UID/QD, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE, INSULIN, FUROSEMIDE, BLOOD AND RELATED PRODUCTS, ALBUMIN. Patient died on 08/10/2005.

Tacrolimus Side Effects Report #4753513-7
Tacrolimus side effect was reported by a Health Professional from UNITED KINGDOM on Aug 09, 2005. Male patient, 50 years of age, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: atrioventricular block, biliary ischaemia, cholestasis, convulsion, hepatitis c , lumbar vertebral fracture, syncope, transplant rejection, vertebral injury. Tacrolimus dosage: unknown. During the same period patient was treated with TACROLIMUS CAP, TACROLIMUS CAP, TACROLIMUS CAP, TACROLIMUS CAP, TACROLIMUS CAP, MYCOPHENOLATE MOFETIL, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Tacrolimus Side Effects Report #5019493-4
Tacrolimus side effect was reported by a Pharmacist from UNITED STATES on June 05, 2006. Female patient, weighting 134.7 lb, was diagnosed with liver transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: ammonia increased, convulsion, hyperglycaemia, hyponatraemia, loss of consciousness. Tacrolimus dosage: 1 MG BID PO. During the same period patient was treated with FERROUS SULPHATE, PROPRANOLOL, OMEPRAZOLE, TYLENOL, NORVASC. Patient recovered.


Tacrolimus Side Effects Report #4789501-4
Tacrolimus side effect was reported by a Pharmacist from UNITED STATES on Oct 05, 2005. Male patient, 55 years of age, weighting 202.8 lb, was diagnosed with immunosuppression and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: agitation, blood creatinine increased, blood pressure increased, convulsion. Tacrolimus dosage: 2 MG PO Q12 HOURS. During the same period patient was treated with LASIX, GANCICLOVIR, MEDROL, CELLCEPT, PERCOCET, ZANTAC, COLACE. Patient recovered.

Tacrolimus Side Effects Report #5247333-7
Tacrolimus side effect was reported by a Pharmacist from UNITED STATES on Feb 23, 2007. Female patient, 42 years of age, weighting 103.4 lb, was diagnosed with immunosuppression, prophylaxis against transplant rejection and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: blood phosphorus increased, convulsion, renal failure acute. Tacrolimus dosage: 4MG TWICE DAILY PO. During the same period patient was treated with HYDROCORTISONE, GANCICLOVIR, DIPHENHYDRAMINE, OPIUM TINCTURE, SERTRALINE, ESOMEPRAZOLE MAGNESIUM. Patient was hospitalized. Patient recovered.

Tacrolimus Side Effects Report #5401906-7
Tacrolimus side effect was reported by a Consumer or non-health professional from BELGIUM on July 02, 2007. Female patient, 15 years of age, was diagnosed with immunosuppression, helicobacter gastritis and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, dehydration, diarrhoea, haemoconcentration, oliguria, renal disorder, vomiting. Tacrolimus dosage: unknown. During the same period patient was treated with CLARITHROMYCIN, AMOXICILLIN, OMEPRAZOLE. Patient recovered.

Tacrolimus Side Effects Report #5664394-1
Tacrolimus side effect was reported by a Pharmacist from UNITED STATES on Mar 11, 2008. Male patient, 28 years of age, weighting 145.5 lb, was diagnosed with heart transplant  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, renal impairment. Tacrolimus dosage: 2 MG BID PO. During the same period patient was treated with VALGANCYCLOVIR. Patient was hospitalized. Patient recovered.

Tacrolimus Side Effects Report #4630924-1
Tacrolimus side effect was reported by a Pharmacist from on Apr 07, 2005. Female patient, 62 years of age, weighting 112.4 lb, was diagnosed with graft versus host disease, prophylaxis and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, encephalopathy, mental status changes, nuclear magnetic resonance imaging brain abnormal. Tacrolimus dosage: 1.5MG IV OVER 24 HRS. Patient died on 03/18/2004.


Tacrolimus Side Effects Report #4961761-6
Tacrolimus side effect was reported by a Health Professional from GERMANY on Mar 16, 2006. Male patient, 61 years of age, weighting 174.2 lb, was diagnosed with fungal infection  and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: bronchopulmonary aspergillosis, condition aggravated, convulsion, creatinine renal clearance decreased, cystitis, cytomegalovirus infection , disease recurrence, dry skin, epstein-barr virus infection. Tacrolimus dosage: unknown. During the same period patient was treated with POSACONAZOLE, ACYCLOVIR, SANDIMMUNE, DECORTIN, CELLCEPT, GANCICLOVIR. Patient was hospitalized. Patient recovered.

Tacrolimus Side Effects Report #5255093-9
Tacrolimus side effect was reported by a Consumer or non-health professional from JAPAN on Feb 21, 2007. Female patient, 15 years of age, was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, cytomegalovirus chorioretinitis, depressed level of consciousness, diarrhoea haemorrhagic, haemorrhage, histiocytosis haematophagic, pyrexia, shock haemorrhagic, skin erosion. Tacrolimus dosage: unknown. During the same period patient was treated with OCTREOTIDE ACETATE, CYCLOSPORINE. Patient recovered.

Tacrolimus Side Effects Report #5267095-7
Tacrolimus side effect was reported by a Consumer or non-health professional from JAPAN on Mar 06, 2007. Female patient, 15 years of age, was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, cytomegalovirus antigen positive, cytomegalovirus chorioretinitis, depressed level of consciousness, diarrhoea, diarrhoea haemorrhagic, dyskinesia, dysphagia, graft versus host disease. Tacrolimus dosage: unknown. During the same period patient was treated with OCTREOTIDE ACETATE, CYCLOSPORINE, STEROIDS NOS, FLUDARABINE, BUSULFAN, DEXAMETHASONE, IMMUNE GLOBULIN INTRAVENOUS. Patient recovered.

Tacrolimus Side Effects Report #5276077-0
Tacrolimus side effect was reported by a Consumer or non-health professional from JAPAN on Mar 13, 2007. Female patient, 15 years of age, was diagnosed with diarrhoea and was treated with Tacrolimus. After drug was administered, patient experienced the following side effects: convulsion, cytomegalovirus antigen positive, cytomegalovirus chorioretinitis, depressed level of consciousness, diarrhoea, diarrhoea haemorrhagic, dyskinesia, dysphagia, graft versus host disease. Tacrolimus dosage: unknown. During the same period patient was treated with SANDOSTATIN, SANDIMMUNE, STEROIDS NOS, FLUDARABINE, BUSULFAN, DEXAMETHASONE, IMMUNE GLOBULIN INTRAVENOUS. Patient recovered.