Sirolimus and blood creatinine increased Patient Reports February 11, 2012

Sirolimus Side Effects Report #5477901-9
Sirolimus side effect was reported by a Health Professional from AUSTRALIA on Oct 02, 2007. Female patient, 67 years of age, was diagnosed with renal transplant and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: axillary mass, blood creatinine increased, hepatic lesion, liver function test abnormal, metastases to bone marrow, neuroendocrine carcinoma of the skin, oedema peripheral. Sirolimus dosage: unknown. During the same period patient was treated with PREDNISOLONE, CICLOSPORIN. Patient died.

Sirolimus Side Effects Report #5634998-0
Sirolimus side effect was reported by a Consumer or non-health professional from JAPAN on Feb 18, 2008. Male patient, 37 years of age, was diagnosed with renal transplant and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood culture positive, diarrhoea, epstein-barr virus infection, glomerulonephritis membranoproliferative, kidney enlargement, lymphoproliferative disorder, nephrectomy, pyrexia. Sirolimus dosage: unknown. During the same period patient was treated with SIMULECT, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5683934-X
Sirolimus side effect was reported by a Consumer or non-health professional from JAPAN on Mar 19, 2008. Male patient, 37 years of age, was diagnosed with renal transplant and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood culture positive, diarrhoea, epstein-barr virus infection, glomerulonephritis membranoproliferative, kidney enlargement, lymphoproliferative disorder, nephrectomy, pyrexia. Sirolimus dosage: unknown. During the same period patient was treated with SIMULECT, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #4560763-1
Sirolimus side effect was reported by a Consumer or non-health professional from on Jan 20, 2005. Male patient, 51 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, kidney transplant rejection. Sirolimus dosage: 4 MG 1X PER 1 DAY ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient was hospitalized. Patient recovered.


Sirolimus Side Effects Report #5020472-1
Sirolimus side effect was reported by a Consumer or non-health professional from ITALY on May 29, 2006. Female patient, 48 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, glomerular filtration rate decreased, renal infarct, renal ischaemia, renal necrosis. Sirolimus dosage: unknown. During the same period patient was treated with CYCLOSPORINE, METHYLPREDNISOLONE, PREDNISONE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #4754224-4
Sirolimus side effect was reported by a Consumer or non-health professional from GERMANY on Aug 17, 2005. Female patient, 47 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, kidney transplant rejection. Sirolimus dosage: 2 MG ORAL. During the same period patient was treated with METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL, TACROLIMUS. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #4962844-7
Sirolimus side effect was reported by a Health Professional from GERMANY on Mar 21, 2006. Female patient, 47 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, sialoadenitis. Sirolimus dosage: 6+ 3 + 2 MG ORAL SEE IMAGE. During the same period patient was treated with CELLCEPT, BISOPROLOL FUMARATE, MODIP, RAMIPRIL, ACTRAPHANE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5009242-8
Sirolimus side effect was reported by a Consumer or non-health professional from ITALY on May 10, 2006. Male patient, 44 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, diabetes mellitus, kidney transplant rejection, nephropathy toxic. Sirolimus dosage: unknown. During the same period patient was treated with CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5096644-7
Sirolimus side effect was reported by a Consumer or non-health professional from ITALY on Aug 24, 2006. Female patient, 40 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood triglycerides increased, blood urea increased, complications of transplanted kidney, platelet count decreased. Sirolimus dosage: 4 MG 1X PER 1 DAY ORAL. During the same period patient was treated with CYCLOSPORINE. Patient was hospitalized. Patient recovered.


Sirolimus Side Effects Report #5043071-4
Sirolimus side effect was reported by a Consumer or non-health professional from ITALY on June 19, 2006. Female patient, 40 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood triglycerides increased, platelet count decreased. Sirolimus dosage: 4 MG 1X PER 1 DAY ORAL. During the same period patient was treated with CYCLOSPORINE. Patient recovered.

Sirolimus Side Effects Report #5165131-X
Sirolimus side effect was reported by a Consumer or non-health professional from ITALY on Nov 20, 2006. Male patient, 38 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, dialysis , kidney transplant rejection. Sirolimus dosage: 4 MG 1X PER 1 DAY ORAL. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5053134-5
Sirolimus side effect was reported by a Health Professional from BELGIUM on July 03, 2006. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, disease recurrence, focal glomerulosclerosis, proteinuria. Sirolimus dosage: 15 + 4 + 5MG 1X PER 1 DAY ORAL - SEE IMAGE. During the same period patient was treated with TACROLIMUS, ZENAPAX, CORTICOSTEROIDS. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5427809-X
Sirolimus side effect was reported by a Physician from KOREA, REPUBLIC OF on Aug 17, 2007. Female patient, weighting 159.4 lb, was diagnosed with prophylaxis against transplant rejection, infection prophylaxis, antifungal prophylaxis, anaemia prophylaxis, antibiotic prophylaxis and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, kidney transplant rejection, urinary tract infection enterococcal. Sirolimus dosage: unknown. During the same period patient was treated with SEPTRIN, NYSTATIN, PYRIDOXINE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5591636-3
Sirolimus side effect was reported by a Physician from ITALY on Jan 14, 2008. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, complications of transplanted kidney, renal tubular necrosis. Sirolimus dosage: unknown. Patient was hospitalized. Patient recovered.


Sirolimus Side Effects Report #5597107-2
Sirolimus side effect was reported by a Physician from UNITED STATES on Jan 14, 2008. Male patient, weighting 167.6 lb, was diagnosed with prophylaxis against transplant rejection, hypertension and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, fluid overload. Sirolimus dosage: unknown. During the same period patient was treated with METOPROLOL TARTRATE, ZENAPAX, PROGRAF. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5033248-6
Sirolimus side effect was reported by a Consumer or non-health professional from BELGIUM on June 08, 2006. Male patient was diagnosed with prophylaxis against transplant rejection and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: blood creatinine increased, disease recurrence, focal glomerulosclerosis, proteinuria. Sirolimus dosage: 15 MG 1X PER 1 DAY ORAL; SEE IMAGE. During the same period patient was treated with TACROLIMUS, ZENAPAX, CORTICOSTEROIDS. Patient was hospitalized. Patient recovered.

Sirolimus Side Effects Report #5072854-X
Sirolimus side effect was reported by a Health Professional from FRANCE on July 28, 2006. Male patient, 75 years of age, was diagnosed with neoplasm prophylaxis and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: anaemia, atrial flutter, blood creatinine increased, diarrhoea, pleural effusion, pneumonia , proteinuria. Sirolimus dosage: 3 MG 1X PER 1 DAY ORAL. Patient was hospitalized and became disabled. Patient recovered.

Sirolimus Side Effects Report #5633562-7
Sirolimus side effect was reported by a Health Professional from TURKEY on Feb 07, 2008. Female patient, child 12 years of age, was diagnosed with renal transplant and was treated with Sirolimus. After drug was administered, patient experienced the following side effects: bk virus infection, blood creatinine increased, complications of transplanted kidney, dyspnoea, kidney transplant rejection, pericardial effusion, polyomavirus-associated nephropathy, pyrexia, renal impairment. Sirolimus dosage: unknown. During the same period patient was treated with LEFLUNAMIDE, MYCOPHENOLATE MOFETIL, PREDNISOLONE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.