Rasburicase and blood lactate dehydrogenase increased Patient Reports February 13, 2012

Rasburicase Side Effects Report #4582433-6
Rasburicase side effect was reported by a Physician from on Jan 21, 2005. Male patient, 44 years of age, weighting 207.2 lb, was diagnosed with hyperuricaemia, tumour lysis syndrome and was treated with Rasburicase. After drug was administered, patient experienced the following side effects: alanine aminotransferase decreased, aspartate aminotransferase increased, blood fibrinogen increased, blood lactate dehydrogenase increased, confusional state, dyspnoea, gamma-glutamyltransferase increased, liver function test abnormal. Rasburicase dosage: 0.2 MG/KG QD - INTRAVENOUS NOS. During the same period patient was treated with ALLOPURINOL, CYTARABINE, MITOXANTRONE, PIPERACILLIN, GENTAMICIN, CEFTAZIDIME, VANCOMYCIN. Patient recovered.

Rasburicase Side Effects Report #4903714-X
Rasburicase side effect was reported by a Health Professional from UNITED STATES on Jan 21, 2005. Male patient, weighting 207.2 lb, was diagnosed with hyperuricaemia and was treated with Rasburicase. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anti-hbs antibody positive, aspartate aminotransferase increased, blood lactate dehydrogenase increased, confusional state, cough, dyspnoea, liver function test abnormal, muscle twitching. Rasburicase dosage: unknown. During the same period patient was treated with ALLOPURINOL, CYTARABINE, MITOXANTRONE, ZOSYN, GENTAMICIN, FORTAZ, VANCOMYCIN, ACYCLOVIR. Patient recovered.