Raltegravir and hepatic necrosis Patient Reports February 12, 2012

Raltegravir Side Effects Report #5636880-1
Raltegravir side effect was reported by a Physician from AUSTRALIA on Feb 13, 2008. Male patient, 45 years of age, was diagnosed with hiv infection , castleman's disease and was treated with Raltegravir. After drug was administered, patient experienced the following side effects: abdominal distension, cholestasis, hepatic necrosis, hepatosplenomegaly, hyperglycaemia, immune reconstitution syndrome. Raltegravir dosage: 400 MG/BID; PO. During the same period patient was treated with ETRAVIRINE, DEXAMETHASONE, DARUNAVIR, LAMIVUDINE, RITONAVIR, TENOFOVIR. Patient was hospitalized. Patient died.

Raltegravir Side Effects Report #6106741-2
Raltegravir side effect was reported by a Physician from AUSTRALIA on Feb 17, 2009. Male patient, 45 years of age, was diagnosed with hiv infection , castleman's disease and was treated with Raltegravir. After drug was administered, patient experienced the following side effects: abdominal distension, aids related complex, anal abscess, cholestatic liver injury, disease progression, hepatic necrosis, hepatitis c . Raltegravir dosage: 400 MG/BID PO. During the same period patient was treated with DEXAMETHASONE, BACTRIM DS, CALTRATE, OSTELIN, ALPRAZOLAM, AMPHOTERICIN B. Patient was hospitalized. Patient died.