Protamine and multi-organ failure Patient Reports February 12, 2012

Protamine Side Effects Report #4701727-4
Protamine side effect was reported by a Physician from on Apr 26, 2005. Female patient, 66 years of age, weighting 207.2 lb, was diagnosed with haemorrhage, off label use and was treated with Protamine. After drug was administered, patient experienced the following side effects: bacteraemia, enterobacter infection, fungal infection , multi-organ failure, pneumonia , portal vein thrombosis, post procedural complication, stenotrophomonas infection, systemic candida. Protamine dosage: unknown. During the same period patient was treated with NIASTASE. Patient was hospitalized. Patient recovered.

Protamine Side Effects Report #4748666-0
Protamine side effect was reported by a Physician from CANADA on Apr 26, 2005. Female patient, 66 years of age, weighting 207.2 lb, was diagnosed with haemorrhage, off label use and was treated with Protamine. After drug was administered, patient experienced the following side effects: bacteraemia, candidiasis, fungal infection , hepatic enzyme increased, multi-organ failure, pneumonia , portal vein thrombosis, post procedural haemorrhage. Protamine dosage: unknown. During the same period patient was treated with NIASTASE. Patient was hospitalized. Patient recovered.

Protamine Side Effects Report #5199894-4
Protamine side effect was reported by a Pharmacist from UNITED STATES on Jan 02, 2007. Male patient, 54 years of age, weighting 275.6 lb, was treated with Protamine. After drug was administered, patient experienced the following side effects: anaphylactic reaction, multi-organ failure. Protamine dosage: 20MG ONCE IV. During the same period patient was treated with ATORVASTATIN CALCIUM, CALCITRIOL, CALCIUM ACETATE, FELODIPINE, FUROSEMIDE, INSULIN NPH, LISINOPRIL, METHADONE. Patient was hospitalized. Patient died on 11/18/2006.