Propofol and lactic acidosis Patient Reports February 11, 2012

Propofol Side Effects Report #4689137-X
Propofol side effect was reported by a Physician from on May 31, 2005. Male patient, child 7 years of age, was diagnosed with sedation, anaesthesia and was treated with Propofol. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, injury, lactic acidosis, procedural complication, rhabdomyolysis. Propofol dosage: TOTAL DOSE 6.1 MG/KG BW). During the same period patient was treated with THIOPENTAL, MIVACURIUM, FENTANYL, SEVOFLURANE. Patient recovered.

Propofol Side Effects Report #4816621-8
Propofol side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 31, 2005. Male patient, 49 years of age, was diagnosed with sedation and was treated with Propofol. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, cardiac arrest , circulatory collapse, haemodialysis, hepatic failure, lactic acidosis, mitochondrial toxicity, propofol infusion syndrome, renal failure. Propofol dosage: 2.4 MG/KG/HR. During the same period patient was treated with VASOPRESSIN, NOREPINEPHRINE, ZOSYN, VANCOMYCIN, CEFEPIME, DROTRECOGIN ALFA. Patient died on 05/12/2005.

Propofol Side Effects Report #5004139-1
Propofol side effect was reported by a Health Professional from UNITED STATES on May 11, 2006. Male patient, 21 years of age, was diagnosed with sedation, reduction of increased intracranial pressure and was treated with Propofol. After drug was administered, patient experienced the following side effects: cardiomyopathy , lactic acidosis, metabolic acidosis, propofol infusion syndrome, ventricular dysfunction. Propofol dosage: unknown. During the same period patient was treated with DOPAMINE, NOREPINEPHRINE. Patient recovered.

Propofol Side Effects Report #5360750-X
Propofol side effect was reported by a Health Professional from UNITED STATES on June 11, 2007. Female patient, 36 years of age, was diagnosed with intubation, sedation, status epilepticus and was treated with Propofol. After drug was administered, patient experienced the following side effects: cardiomyopathy , lactic acidosis, propofol infusion syndrome, renal failure acute, rhabdomyolysis. Propofol dosage: unknown. During the same period patient was treated with TOPIRAMATE, BENZODIAZEPINES, PHENOBARBITAL. Patient died.


Propofol Side Effects Report #4928602-4
Propofol side effect was reported by a Health Professional from LEBANON on Feb 22, 2006. Female patient, 36 years of age, was diagnosed with intubation, sedation, status epilepticus and was treated with Propofol. After drug was administered, patient experienced the following side effects: cardiomyopathy , lactic acidosis, propofol infusion syndrome, renal failure, rhabdomyolysis. Propofol dosage: INTIAL DOSE INCREASED THEN DECREASED BUT ALWAYS { 5MG/KG/HR. During the same period patient was treated with TOPIRAMATE, BENZODIAZEPINES, PHENOBARBITAL, VALPROIC ACID. Patient died.

Propofol Side Effects Report #4673626-8
Propofol side effect was reported by a Health Professional from on Mar 08, 2005. Male patient, 63 years of age, was diagnosed with cor pulmonale, asthma , respiratory disorder, prophylaxis and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis. Propofol dosage: unknown. During the same period patient was treated with ADRENALINE, SALBUTAMOL, ATROVENT, RANITIDINE. Patient recovered.

Propofol Side Effects Report #5799983-7
Propofol side effect was reported by a Health Professional from UNITED STATES on June 20, 2008. Male patient, 64 years of age, was diagnosed with convulsion, status epilepticus and was treated with Propofol. After drug was administered, patient experienced the following side effects: dyslipidaemia, hyperkalaemia, hypotension, lactic acidosis, propofol infusion syndrome, renal failure acute, rhabdomyolysis, shock. Propofol dosage: unknown. During the same period patient was treated with FOSPHENYTOIN. Patient died.

Propofol Side Effects Report #5973267-6
Propofol side effect was reported by a Physician from UNITED STATES on Nov 11, 2008. Male patient, 64 years of age, was diagnosed with convulsion and was treated with Propofol. After drug was administered, patient experienced the following side effects: anoxic encephalopathy, blood creatine phosphokinase increased, blood triglycerides increased, hypotension, lactic acidosis, myoglobin blood increased, propofol infusion syndrome, renal failure acute. Propofol dosage: 1 MG/JG BOLUS, INFUSION OF 120-140 ?G/KG/MI. Patient was hospitalized. Patient died.

Propofol Side Effects Report #6038223-0
Propofol side effect was reported by a Physician from UNITED KINGDOM on Jan 05, 2009. Male patient, 67 years of age, weighting 167.6 lb, was diagnosed with anaesthesia, mechanical ventilation, atrial fibrillation  and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis, propofol infusion syndrome. Propofol dosage: INITIAL DOSE 0.8MG/KG/HR (60MG/HR). During the same period patient was treated with DIGOXIN. Patient recovered.


Propofol Side Effects Report #5990390-0
Propofol side effect was reported by a Health Professional from CHILE on Dec 03, 2008. Female patient, 43 years of age, was diagnosed with anaesthesia and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis. Propofol dosage: 7 MG / KG / HOUR. Patient recovered.

Propofol Side Effects Report #6028434-2
Propofol side effect was reported by a Health Professional from CHILE on Dec 29, 2008. Female patient, 43 years of age, was diagnosed with anaesthesia, sedation, convulsion, grand mal convulsion and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis. Propofol dosage: 7 MG / KG / HOUR. During the same period patient was treated with VALPROIC ACID, REMIFENTANIL, LORAZEPAM, MIDAZOLAM. Patient recovered.

Propofol Side Effects Report #4694817-6
Propofol side effect was reported by a Physician from on June 06, 2005. Male patient, 42 years of age, weighting 169.8 lb, was diagnosed with anaesthesia and was treated with Propofol. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, hypertension, lactic acidosis, myoglobinuria, procedural hypertension, propofol infusion syndrome, renal impairment, rhabdomyolysis. Propofol dosage: 5.2 MG KG^-1 H^-1. During the same period patient was treated with METHYLPREDNISOLONE, SEVOFLURANE, HETASTARCH IN CHLORIDE. Patient recovered.

Propofol Side Effects Report #5109181-8
Propofol side effect was reported by a Health Professional from UNITED STATES on Sept 18, 2006. Female patient, 71 years of age, was diagnosed with cerebral ischaemia and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis, multi-organ failure. Propofol dosage: unknown. During the same period patient was treated with OXYGENATED FLUOROCARBON NUTRIENT EMULSION. Patient died.

Propofol Side Effects Report #5127142-X
Propofol side effect was reported by a Health Professional from UNITED STATES on Sept 18, 2006. Female patient, 71 years of age, was diagnosed with cerebral ischaemia and was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis, multi-organ failure. Propofol dosage: unknown. During the same period patient was treated with OXYGENATED FLUOROCARBON NUTIRENT EMULSION, ARTIFICIAL CEREBROSPINAL FLUID, ARTIFICIAL CEREBROSPINAL FLUID. Patient died.


Propofol Side Effects Report #4615350-3
Propofol side effect was reported by a Consumer or non-health professional from on Mar 08, 2005. Female patient was treated with Propofol. After drug was administered, patient experienced the following side effects: lactic acidosis. Propofol dosage: 30 MG / HR. Patient recovered.