Prograf and thrombotic microangiopathy Patient Reports February 10, 2012

Prograf Side Effects Report #6073210-8
Prograf side effect was reported by a Physician from JAPAN on Jan 29, 2009. Male patient, 54 years of age, was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: engraft failure, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with CYTARABINE. Patient died.

Prograf Side Effects Report #5336432-7
Prograf side effect was reported by a Physician from JAPAN on May 11, 2007. Male patient, 51 years of age, was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: aspergillosis, fungal infection

, renal impairment, retinitis, retinopathy, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with STEROIDECTION. Patient died.

Prograf Side Effects Report #5753055-6
Prograf side effect was reported by a Health Professional from SWITZERLAND on May 09, 2008. Male patient, 26 years of age, was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, haemoglobin decreased, kidney fibrosis, platelet count decreased, renal tubular atrophy, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with RAPAMUNE, CYCLOSPORINE, CELLCEPT, PREDNISOLONE ACETATE, DIFLUCAN, BACTRIM, FAMVIR. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #6109188-8
Prograf side effect was reported by a Physician from JAPAN on Feb 25, 2009. Male patient, 23 years of age, was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with PREDNISOLONE. Patient recovered.

Prograf Side Effects Report #5292091-3
Prograf side effect was reported by a Physician from JAPAN on Mar 19, 2007. Male patient, 20 years of age, weighting 154.3 lb, was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood creatinine increased, convulsion, neurotoxicity, reversible posterior leukoencephalopathy syndrome, thrombotic microangiopathy. Prograf dosage: 1.9 MG, IV NOS. During the same period patient was treated with PREDNISOLONE, NEUTROGIN, CARBENIN, HABEKACIN, DIFLUCAN. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5224666-1
Prograf side effect was reported by a Physician from JAPAN on Jan 15, 2007. Female patient was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.02 MG/KG, D, IV DRIP; IV DRIP. Patient died.

Prograf Side Effects Report #5261579-3
Prograf side effect was reported by a Physician from JAPAN on Feb 22, 2007. Female patient was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.02 MG/KG, CONTINUOUS, IV DRIP. During the same period patient was treated with METHOTREXATE. Patient died.

Prograf Side Effects Report #5261581-1
Prograf side effect was reported by a Physician from JAPAN on Feb 22, 2007. Female patient was diagnosed with stem cell transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.02 MG/KG, CONTINUOUS, IV DRIP. During the same period patient was treated with METHOTREXATE. Patient died.

Prograf Side Effects Report #5536717-5
Prograf side effect was reported by a Physician from JAPAN on Nov 21, 2007. Female patient, 66 years of age, was diagnosed with rheumatoid arthritis

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, cytomegalovirus infection

, pulmonary alveolar haemorrhage, pulmonary congestion, thrombotic microangiopathy, ventricular fibrillation. Prograf dosage: 3 MG, UID/QD, ORAL. During the same period patient was treated with PREDNISOLONE, LANSOPRAZOLE, BAKTAR, FUNGIZONE, LEVOTHYROXINE, BONALON, ETANERCEPT. Patient died on 11/07/2007.

Prograf Side Effects Report #5649029-6
Prograf side effect was reported by a Physician from JAPAN on Feb 13, 2008. Female patient, 56 years of age, was diagnosed with renal transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: ascites, blood bilirubin increased, blood lactate dehydrogenase increased, haematocrit decreased, haemodialysis, haemoglobin decreased, thrombotic microangiopathy, transplant rejection. Prograf dosage: 0.15 MG/KG, BID, ORAL. During the same period patient was treated with MYCOPHENOLATE MOFETIL, AZATHIOPRINE. Patient recovered.

Prograf Side Effects Report #5694205-X
Prograf side effect was reported by a Physician from JAPAN on Mar 17, 2008. Female patient, 56 years of age, was diagnosed with renal transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: ascites, complications of transplanted kidney, peritoneal dialysis, thrombotic microangiopathy, transplant rejection. Prograf dosage: 0.15 MG/KG, BID, ORAL; ORAL. During the same period patient was treated with CELLCEPT, AZATHIOPRINE. Patient recovered.

Prograf Side Effects Report #5810749-1
Prograf side effect was reported by a Health Professional from UNITED STATES on June 30, 2008. Female patient, 51 years of age, was diagnosed with renal transplant, polyomavirus-associated nephropathy and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood lactate dehydrogenase increased, dialysis

, ecchymosis, kidney transplant rejection, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with LEFLUNOMIDE, ANTITHYMOCYTE IMMUNOGLOBULIN, MYCOPHENOLATE MOFETIL. Patient recovered.

Prograf Side Effects Report #5918349-X
Prograf side effect was reported by a Health Professional from UNITED STATES on June 30, 2008. Female patient, 51 years of age, was diagnosed with renal transplant, polyomavirus-associated nephropathy and was treated with Prograf. After drug was administered, patient experienced the following side effects: kidney transplant rejection, polyomavirus-associated nephropathy, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with LEFLUNOMIDE, THYMOGLOBULIN, MYCOPHENOLATE MOFETIL. Patient recovered.

Prograf Side Effects Report #5650723-1
Prograf side effect was reported by a Physician from JAPAN on Feb 14, 2008. Female patient, 48 years of age, weighting 141.1 lb, was diagnosed with renal transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood pressure increased, duodenitis, thrombotic microangiopathy, urine output decreased. Prograf dosage: 4 MG, BID, ORAL; 2 MG, BID, ORAL. During the same period patient was treated with SIMULECT, CELLCEPT, SOL MEDROL, ADALATLET, MUCOSTA. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5650720-6
Prograf side effect was reported by a Physician from JAPAN on Feb 14, 2008. Male patient, 47 years of age, was diagnosed with renal transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: abdominal pain

, blood pressure systolic increased, complications of transplanted kidney, haemodialysis, renal artery stenosis, renal impairment, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with SIMULECT, MYCOPHENOLATE MOFETIL, PREDNISOLONE, CYCLOSPORINE. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5564530-1
Prograf side effect was reported by a Physician from BRAZIL on Nov 27, 2007. Female patient was diagnosed with renal and pancreas transplant and was treated with Prograf. After drug was administered, patient experienced the following side effects: complications of transplant surgery, complications of transplanted kidney, haematocrit decreased, haemodialysis, kidney transplant rejection, shock haemorrhagic, thrombotic microangiopathy. Prograf dosage: 0.15 MG/KG. During the same period patient was treated with PREDNISOLONE ACETATE. Patient recovered.

Prograf Side Effects Report #5069087-X
Prograf side effect was reported by a Physician from UNITED STATES on July 19, 2006. Female patient, 63 years of age, weighting 129.0 lb, was diagnosed with prophylaxis against transplant rejection and was treated with Prograf. After drug was administered, patient experienced the following side effects: cardiac failure, enterococcal infection, multi-organ failure, pseudomonas infection, renal failure acute, respiratory failure, staphylococcal infection

, thrombotic microangiopathy. Prograf dosage: 1 MG, BID, ORAL. Patient was hospitalized. Patient died on 06/27/2006.

Prograf Side Effects Report #5049209-7
Prograf side effect was reported by a Health Professional from FRANCE on Nov 16, 2004. Male patient, 47 years of age, was diagnosed with prophylaxis against transplant rejection and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, haemoglobin decreased, haptoglobin decreased, platelet count decreased, renal failure acute, thrombotic microangiopathy. Prograf dosage: 4 MG 1X PER 1 DAY. During the same period patient was treated with CELLCEPT, PREDNISONE, ASPEGIC, OMEPRAZOLE, PROPRANOLOL, EUCALCIC, PRAVASTATIN, VALACYCLOVIR. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5139298-3
Prograf side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 13, 2006. Female patient, 37 years of age, was diagnosed with prophylaxis against transplant rejection, graft versus host disease, lung neoplasm and was treated with Prograf. After drug was administered, patient experienced the following side effects: leukoencephalopathy, renal failure acute, subarachnoid haemorrhage, thrombotic microangiopathy. Prograf dosage: 0.5 MG, UID/QD. During the same period patient was treated with SIROLIMUS, AMIBISOME, VORICONAZOLE. Patient died.

Prograf Side Effects Report #4765491-5
Prograf side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 25, 2005. Male patient, 25 years of age, weighting 226.2 lb, was diagnosed with prophylaxis against transplant rejection and was treated with Prograf. After drug was administered, patient experienced the following side effects: anaemia, blood creatinine increased, blood urea increased, graft dysfunction, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with CORTICOSTEROID NOS, MYCOPHENOLATE MOFETIL, ZENAPAX. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5403454-7
Prograf side effect was reported by a Physician from JAPAN on July 12, 2007. Male patient, 69 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: catheter related infection, cholangitis, disease recurrence, hepatic function abnormal, hepatitis c

, multi-organ failure, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL. Patient died.

Prograf Side Effects Report #5504680-9
Prograf side effect was reported by a Physician from JAPAN on Oct 18, 2007. Female patient, 51 years of age, weighting 119.0 lb, was diagnosed with liver transplant

, hepatitis c

and was treated with Prograf. After drug was administered, patient experienced the following side effects: anorexia, haemorrhagic cerebral infarction, thrombotic microangiopathy, vasculitis

, viral infection

. Prograf dosage: 3.25 MG, BID, ORAL; 8 MG, ORAL. During the same period patient was treated with PEGYLATED INTERFERON, MEDROL, REBETOL, SOL MEDROL. Patient recovered.

Prograf Side Effects Report #5989277-9
Prograf side effect was reported by a Physician from JAPAN on Nov 28, 2008. Female patient, 51 years of age, weighting 119.0 lb, was diagnosed with liver transplant

, hepatitis c

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, cerebral infarction, therapeutic agent toxicity, thrombotic microangiopathy. Prograf dosage: 3.25 MG, BID, ORAL 8 MG,/D ORAL. During the same period patient was treated with PEGYLATED INTERFERON, MEDROL, REBETOL, SOL MEDROL, INTERFERON ALFA. Patient recovered.

Prograf Side Effects Report #5947867-3
Prograf side effect was reported by a Physician from JAPAN on Oct 31, 2008. Female patient, 50 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: haematoma infection, intra-abdominal haematoma, serratia infection, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, MYCOPHENOLATE MOFETIL, STEROID, ANTITHYMOCYTE IMMUNOGLOBULIN, PROSTAGLANDIN E. Patient recovered.

Prograf Side Effects Report #5626157-2
Prograf side effect was reported by a Physician from JAPAN on Jan 23, 2008. Male patient, 48 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #5300362-7
Prograf side effect was reported by a Physician from JAPAN on Mar 26, 2007. Male patient, 41 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: continuous haemodiafiltration, graft thrombosis, pleural haemorrhage, renal impairment, systemic mycosis, thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5085447-5
Prograf side effect was reported by a Physician from JAPAN on July 31, 2006. Male patient, 41 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: haemodialysis, pleural haemorrhage, renal impairment, systemic mycosis, thrombotic microangiopathy, transplant rejection. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5186570-7
Prograf side effect was reported by a Physician from JAPAN on Dec 05, 2006. Male patient, 41 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: continuous haemodiafiltration, pleural haemorrhage, renal impairment, systemic mycosis, thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5626067-0
Prograf side effect was reported by a Physician from JAPAN on Jan 23, 2008. Female patient, 39 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: accidental exposure, anaemia, epilepsy

, incorrect dose administered, thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #5300359-7
Prograf side effect was reported by a Physician from JAPAN on Mar 26, 2007. Male patient, 33 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acidosis, continuous haemodiafiltration, graft thrombosis, hepatic artery thrombosis, renal failure, thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5085445-1
Prograf side effect was reported by a Physician from JAPAN on July 31, 2006. Male patient, 33 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acidosis, complications of transplanted kidney, haemodialysis, hepatic artery thrombosis, infection

, renal failure, thrombotic microangiopathy, transplant rejection. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5626486-2
Prograf side effect was reported by a Physician from JAPAN on Jan 23, 2008. Female patient, 23 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: biliary anastomosis complication, cholangitis, multi-organ failure, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, PROSTAGLANDIN I. Patient died on 09/09/2002.

Prograf Side Effects Report #4565816-X
Prograf side effect was reported by a Physician from on Jan 19, 2005. Female patient, 23 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cholangitis, complications of transplanted liver, suture related complication, thrombotic microangiopathy. Prograf dosage: unknown. Patient died on 09/09/2002.

Prograf Side Effects Report #4726193-4
Prograf side effect was reported by a Physician from JAPAN on July 07, 2005. Female patient, 23 years of age, was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cholangitis, thrombotic microangiopathy. Prograf dosage: unknown. Patient died on 09/09/2002.

Prograf Side Effects Report #4699473-9
Prograf side effect was reported by a Physician from on June 06, 2005. Female patient was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: arteriopathic disease, diabetes mellitus, glomerulonephritis focal, thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #4699474-0
Prograf side effect was reported by a Physician from on June 06, 2005. Female patient was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: arteriopathic disease, glomerulonephritis focal, nephropathy toxic, thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #4699478-8
Prograf side effect was reported by a Physician from on June 06, 2005. Female patient was diagnosed with liver transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: angiopathy, arteriopathic disease, dialysis

, thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #5340085-1
Prograf side effect was reported by a Pharmacist from UNITED STATES on May 25, 2007. Female patient, 71 years of age, weighting 200.0 lb, was diagnosed with heart transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: infection

, renal failure acute, renal ischaemia, renal transplant, renal tubular necrosis, thrombocytopenia, thrombotic microangiopathy, tremor. Prograf dosage: 2.5 MG BID PO. During the same period patient was treated with ACTOS, LASIX, PRILOSEC, POTASSIUM ACETATE, IRBESARTAN, XANAX, INSULIN. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5504677-9
Prograf side effect was reported by a Physician from GERMANY on Oct 15, 2007. Female patient, child 8 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: anaemia, leukoencephalopathy, neurotoxicity, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #4961653-2
Prograf side effect was reported by a Physician from JAPAN on Mar 16, 2006. Male patient, 61 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: encephalitis

, graft versus host disease, human herpesvirus 6 infection, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE. Patient recovered.

Prograf Side Effects Report #5011367-8
Prograf side effect was reported by a Physician from JAPAN on May 10, 2006. Female patient, 61 years of age, weighting 98.33 lb, was diagnosed with bone marrow transplant

, graft versus host disease and was treated with Prograf. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, encephalitis herpes, graft versus host disease, liver disorder, renal failure acute, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with PREDNISOLONE, PREDONINE, METHOTREXATE, ALLOPURINOL. Patient died on 10/12/2004.

Prograf Side Effects Report #4961776-8
Prograf side effect was reported by a Physician from JAPAN on Mar 16, 2006. Female patient, 60 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: encephalitis herpes, graft versus host disease, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE. Patient died on 01/01/2004.

Prograf Side Effects Report #5721421-0
Prograf side effect was reported by a Physician from JAPAN on Apr 16, 2008. Female patient, child 6 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, blood lactate dehydrogenase increased, cytomegalovirus enterocolitis, disease progression, malnutrition, renal impairment, sepsis

, thrombotic microangiopathy, toxic encephalopathy. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE, METHYLPREDNISOLONE, GANCICLOVIR. Patient died on 01/27/2007.

Prograf Side Effects Report #5074163-1
Prograf side effect was reported by a Physician from JAPAN on July 24, 2006. Male patient, 59 years of age, weighting 93.70 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood creatine increased, cerebral haemorrhage, dehydration, diabetic coma, leukoencephalopathy, pancreatitis acute, pneumonia

, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with SOL MEDROL, PRIMPERAN, NEO MINOPHAGEN C, TIENAM, FUNGUARD, NEUPOGEN. Patient was hospitalized. Patient died on 06/23/2004.

Prograf Side Effects Report #4941567-4
Prograf side effect was reported by a Physician from JAPAN on Feb 27, 2006. Male patient, 59 years of age, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood beta-d-glucan increased, engraftment syndrome, graft versus host disease, haemoptysis, mucormycosis, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD, CYCLOSPORINE, METHYLPREDNISOLONE, ITRACONAZOLE. Patient died on 09/01/2005.

Prograf Side Effects Report #4961650-7
Prograf side effect was reported by a Physician from JAPAN on Mar 15, 2006. Male patient, 59 years of age, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood beta-d-glucan increased, candidiasis, graft versus host disease, haemoptysis, mucormycosis, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD, CYCLOSPORINE, METHYLPREDNISOLONE, ITRACONAZOLE. Patient died on 09/01/2005.

Prograf Side Effects Report #4962817-4
Prograf side effect was reported by a Physician from JAPAN on Mar 15, 2006. Male patient, 59 years of age, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood beta-d-glucan increased, candida sepsis, graft versus host disease, haemoptysis, mucormycosis, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD, CYCLOSPORINE, METHYLPREDNISOLONE. Patient died on 09/01/2005.

Prograf Side Effects Report #5766324-0
Prograf side effect was reported by a Physician from JAPAN on May 30, 2008. Male patient, 57 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5872356-4
Prograf side effect was reported by a Physician from JAPAN on July 30, 2008. Male patient, 57 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4707056-7
Prograf side effect was reported by a Physician from JAPAN on June 17, 2005. Male patient, 56 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: adenoviral haemorrhagic cystitis, cytomegalovirus infection

, erythema, graft versus host disease, renal impairment, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5015900-1
Prograf side effect was reported by a Physician from JAPAN on May 18, 2006. Female patient, 55 years of age, weighting 94.80 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cytomegalovirus infection

, encephalopathy, febrile neutropenia, graft versus host disease, hydrocephalus

, thrombotic microangiopathy. Prograf dosage: 0.7 MG, CONTINUOUS, IV DRIP. During the same period patient was treated with GASTER D, ZOVIRAX, SOL MEDROL, MEROPEN, VANCOMYCIN, NEUTROGIN, METHOTREXATE, DIFLUCAN. Patient died on 04/21/2005.

Prograf Side Effects Report #5927289-1
Prograf side effect was reported by a Physician from JAPAN on Oct 08, 2008. Female patient, 54 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHYLPREDNISOLONE. Patient recovered.

Prograf Side Effects Report #5974193-9
Prograf side effect was reported by a Physician from JAPAN on Nov 14, 2008. Male patient, 54 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: aspartate aminotransferase increased, blood bilirubin unconjugated increased, blood lactate dehydrogenase increased, microangiopathic haemolytic anaemia, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHYLPREDNISOLONE, PREDNISONE, DEXAMETHASONE. Patient recovered.

Prograf Side Effects Report #5674468-7
Prograf side effect was reported by a Physician from JAPAN on Feb 29, 2008. Female patient, 53 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, complications of transplant surgery, dysuria, pain

, pain in extremity, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with PREDNISOLONE, MYCOPHENOLATE MOFETIL. Patient died.

Prograf Side Effects Report #5047215-X
Prograf side effect was reported by a Physician from JAPAN on June 13, 2006. Female patient, 52 years of age, weighting 92.59 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: depressed level of consciousness, engraftment syndrome, haemorrhagic cerebral infarction, infection in an immunocompromised host, renal failure, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with ZOVIRAX, GASTER DLET, MUCOSTA, URSO, FUNGUARD, VANCOMYCIN, MEROPEN, NEUPOGEN. Patient died on 04/10/2004.

Prograf Side Effects Report #4595720-2
Prograf side effect was reported by a Physician from on Feb 10, 2005. Female patient, 52 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: engraftment syndrome, haemorrhagic cerebral infarction, loss of consciousness, renal failure, restlessness, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with MYCOPHENOLATE MOFETIL, FLUDARENE, MELPHALAN. Patient died on 04/10/2004.

Prograf Side Effects Report #4813388-4
Prograf side effect was reported by a Physician from JAPAN on Oct 17, 2005. Male patient, 52 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4818338-2
Prograf side effect was reported by a Physician from JAPAN on Oct 25, 2005. Male patient, 52 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5037376-0
Prograf side effect was reported by a Physician from JAPAN on June 13, 2006. Female patient, 52 years of age, weighting 92.59 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: haemorrhagic cerebral infarction, infection in an immunocompromised host, loss of consciousness, renal failure, restlessness, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with ZOVIRAX, GASTER DLET, MUCOSTA, URSO, FUNGUARD, VANCOMYCIN, MEROPEN, NEUPOGEN. Patient died on 04/10/2004.

Prograf Side Effects Report #5902813-3
Prograf side effect was reported by a Physician from JAPAN on Sept 18, 2008. Female patient, 48 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, red blood cell count increased, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE, METHYLPREDNISOLONE, CYCLOPHOSPHAMIDE. Patient recovered.

Prograf Side Effects Report #5909475-X
Prograf side effect was reported by a Physician from JAPAN on Sept 25, 2008. Female patient, 48 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, condition aggravated, renal impairment, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE, METHYLPREDNISOLONE, CYCLOPHOSPHAMIDE. Patient died.

Prograf Side Effects Report #5954519-2
Prograf side effect was reported by a Physician from JAPAN on Nov 04, 2008. Female patient, 48 years of age, was diagnosed with bone marrow transplant

, bone marrow conditioning regimen and was treated with Prograf. After drug was administered, patient experienced the following side effects: bone marrow transplant

, cerebral toxoplasmosis, cytomegalovirus enterocolitis, encephalopathy, neutrophil count increased, renal impairment, sepsis

, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: 1.2 MG, IV DRIP : 1.2 MG, CONTINOUS, IV DRIP. During the same period patient was treated with CYCLOPHOSPHAMIDE, METHOTREXATE, FUNGUARD, MEROPEN, FINIBAX, TARGOCID. Patient was hospitalized. Patient died on 09/19/2008.

Prograf Side Effects Report #4565814-6
Prograf side effect was reported by a Physician from on Jan 18, 2005. Male patient, 47 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cerebral disorder, cerebral haemorrhage, convulsion, encephalitis herpes, encephalopathy, thrombotic microangiopathy. Prograf dosage: unknown. Patient died on 08/22/2001.

Prograf Side Effects Report #4961638-6
Prograf side effect was reported by a Physician from JAPAN on Mar 16, 2006. Male patient, 47 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cerebral haemorrhage, convulsion, encephalitis herpes, encephalopathy, graft versus host disease, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE. Patient died on 08/22/2001.

Prograf Side Effects Report #5096753-2
Prograf side effect was reported by a Physician from JAPAN on Aug 18, 2006. Female patient, 42 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.03 MG/KG. Patient died.

Prograf Side Effects Report #5113373-1
Prograf side effect was reported by a Physician from JAPAN on Sept 05, 2006. Female patient, 42 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.03 MG/KG. Patient died.

Prograf Side Effects Report #4961774-4
Prograf side effect was reported by a Physician from JAPAN on Mar 16, 2006. Female patient, 42 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: complications of transplant surgery, encephalitis

, graft versus host disease, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with METHOTREXATE. Patient died on 01/01/2002.

Prograf Side Effects Report #5015898-6
Prograf side effect was reported by a Physician from JAPAN on May 10, 2006. Female patient, 42 years of age, weighting 112.4 lb, was diagnosed with bone marrow transplant

, graft versus host disease and was treated with Prograf. After drug was administered, patient experienced the following side effects: depressed level of consciousness, encephalitis herpes, graft versus host disease, hepatic failure, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. During the same period patient was treated with CYCLOSPORINE, METHOTREXATE. Patient died on 06/18/2002.

Prograf Side Effects Report #5030527-3
Prograf side effect was reported by a Physician from JAPAN on June 02, 2006. Female patient, 42 years of age, weighting 112.4 lb, was diagnosed with bone marrow transplant

, graft versus host disease and was treated with Prograf. After drug was administered, patient experienced the following side effects: condition aggravated, encephalitis herpes, graft versus host disease, haemodialysis, hepatic failure, metastases to liver, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: 0.5 MG, CONTINUOUS, IV NOS; SEE IMAGE. During the same period patient was treated with CYCLOSPORINE. Patient died on 06/18/2002.

Prograf Side Effects Report #5207353-5
Prograf side effect was reported by a Physician from JAPAN on Dec 27, 2006. Female patient, 41 years of age, weighting 170.9 lb, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: encephalitis herpes, engraftment syndrome, graft versus host disease, hepatic enzyme increased, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD. Patient recovered.

Prograf Side Effects Report #5266676-4
Prograf side effect was reported by a Physician from JAPAN on Feb 22, 2007. Female patient, 41 years of age, weighting 170.9 lb, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, encephalitis herpes, engraftment syndrome, hepatic enzyme increased, hyponatraemia, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD. Patient recovered.

Prograf Side Effects Report #5193194-4
Prograf side effect was reported by a Physician from JAPAN on Dec 08, 2006. Female patient, 41 years of age, weighting 170.9 lb, was diagnosed with bone marrow transplant

, fungal infection

and was treated with Prograf. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, encephalitis herpes, engraftment syndrome, graft versus host disease, hepatic enzyme increased, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: 0.5 MG, SEE IMAGE. During the same period patient was treated with FUNGUARD. Patient recovered.

Prograf Side Effects Report #5477633-7
Prograf side effect was reported by a Physician from JAPAN on Sept 20, 2007. Male patient, 41 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: graft versus host disease, non-hodgkin's lymphoma recurrent, thrombotic microangiopathy. Prograf dosage: 0.03 MG/LG, /D. During the same period patient was treated with METHOTREXATE, PREDNISONE, MYCOPHENOLATE MOFETIL. Patient recovered.

Prograf Side Effects Report #5535118-3
Prograf side effect was reported by a Physician from JAPAN on Nov 15, 2007. Male patient, child 4 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cystitis haemorrhagic, pseudomembranous colitis, thrombotic microangiopathy. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #5688151-5
Prograf side effect was reported by a Physician from JAPAN on Mar 11, 2008. Female patient, 39 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: abdominal pain

, anxiety

, graft versus host disease, idiopathic pneumonia syndrome, jaundice

, no therapeutic response, oral intake reduced, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with ETANERCEPT, MYCOPHENOLATE MOFETIL, METHYLPREDNISOLONE. Patient died.

Prograf Side Effects Report #5906745-6
Prograf side effect was reported by a Physician from JAPAN on Sept 25, 2008. Male patient, 39 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cholestasis, infection

, thrombotic microangiopathy, vanishing bile duct syndrome. Prograf dosage: unknown. During the same period patient was treated with PREDNISOLONE, CYCLOSPORINE. Patient died.

Prograf Side Effects Report #5936052-7
Prograf side effect was reported by a Physician from JAPAN on Oct 23, 2008. Male patient, 39 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cerebrovascular disorder, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with PREDNISONE, CYCLOSPORINE, STEROID. Patient recovered.

Prograf Side Effects Report #4813391-4
Prograf side effect was reported by a Physician from JAPAN on Oct 17, 2005. Female patient, 39 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4818337-0
Prograf side effect was reported by a Physician from JAPAN on Oct 25, 2005. Female patient, 39 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4813394-X
Prograf side effect was reported by a Physician from JAPAN on Oct 17, 2005. Male patient, 38 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: multi-organ failure, thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4852964-X
Prograf side effect was reported by a Physician from JAPAN on Nov 30, 2005. Male patient, 38 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: multi-organ failure, thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #4551225-6
Prograf side effect was reported by a Physician from on Dec 22, 2004. Female patient, 35 years of age, weighting 103.6 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: depressed level of consciousness, disorientation, encephalopathy, memory impairment, nervous system disorder, psychiatric symptom, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with PREDNISOLONE, MORPHINE. Patient recovered.

Prograf Side Effects Report #5266621-1
Prograf side effect was reported by a Physician from JAPAN on Feb 26, 2007. Female patient, 34 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5054102-X
Prograf side effect was reported by a Physician from JAPAN on June 28, 2006. Female patient, 34 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5132675-6
Prograf side effect was reported by a Physician from JAPAN on Oct 02, 2006. Female patient, 34 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5043320-2
Prograf side effect was reported by a Physician from JAPAN on June 22, 2006. Female patient, 34 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: unknown. Patient died.

Prograf Side Effects Report #5096716-7
Prograf side effect was reported by a Physician from JAPAN on Aug 18, 2006. Female patient, 32 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acute graft versus host disease in skin, blood lactate dehydrogenase increased, red blood cell abnormality, stem cell transplant, thrombocytopenia, thrombotic microangiopathy. Prograf dosage: 0.03 MG/KG. During the same period patient was treated with METHYLPREDNISOLONE, MYCOPHENOLATE MOFETIL. Patient died on 10/20/2002.

Prograf Side Effects Report #4941546-7
Prograf side effect was reported by a Physician from JAPAN on Feb 27, 2006. Male patient, child 2 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, diarrhoea, gastrointestinal disorder, graft versus host disease in skin, shock haemorrhagic, staphylococcal sepsis, thrombotic microangiopathy, upper gastrointestinal haemorrhage. Prograf dosage: unknown. Patient died on 01/01/2005.

Prograf Side Effects Report #5663679-2
Prograf side effect was reported by a Physician from JAPAN on Feb 22, 2008. Male patient, 13 years of age, weighting 170.9 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cytomegalovirus infection

, hyperglycaemia, nephrotic syndrome, staphylococcal infection

, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #5679816-X
Prograf side effect was reported by a Physician from JAPAN on Mar 05, 2008. Male patient, 13 years of age, weighting 170.9 lb, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: cytomegalovirus infection

, hyperglycaemia, nephrotic syndrome, staphylococcal infection

, thrombotic microangiopathy, venoocclusive liver disease. Prograf dosage: unknown. Patient recovered.

Prograf Side Effects Report #4868764-0
Prograf side effect was reported by a Physician from JAPAN on Dec 08, 2005. Male patient, 13 years of age, was diagnosed with bone marrow transplant

, bronchopulmonary aspergillosis and was treated with Prograf. After drug was administered, patient experienced the following side effects: brain abscess, brain oedema, bronchopulmonary aspergillosis, depressed level of consciousness, nervous system disorder, speech disorder, staphylococcal infection

, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD, STEROID. Patient died on 01/01/2005.

Prograf Side Effects Report #4546150-0
Prograf side effect was reported by a Physician from on Dec 22, 2004. Male patient, child 10 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: headache

, intestinal ischaemia, photophobia, thrombotic microangiopathy, tremor. Prograf dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, MELPHALAN, ATGAM, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #4559460-8
Prograf side effect was reported by a Physician from on Dec 22, 2004. Male patient, child 10 years of age, was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: headache

, intestinal ischaemia, photophobia, thrombotic microangiopathy, tremor. Prograf dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, MELPHALAN, ATGAM, METHYLPREDNISOLONE. Patient was hospitalized. Patient recovered.

Prograf Side Effects Report #5124462-X
Prograf side effect was reported by a Physician from JAPAN on Sept 22, 2006. Female patient was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: bone marrow transplant

, convulsion, depressed level of consciousness, hyperglycaemia, respiratory disorder, thrombotic microangiopathy. Prograf dosage: unknown. During the same period patient was treated with FUNGUARD. Patient died on 09/11/2006.

Prograf Side Effects Report #6093290-3
Prograf side effect was reported by a Physician from JAPAN on Feb 13, 2009. Female patient was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.03MG/KG, CONTINUOUS, IV DRIP. During the same period patient was treated with METHOTREXATE. Patient recovered.

Prograf Side Effects Report #6093301-5
Prograf side effect was reported by a Physician from JAPAN on Feb 13, 2009. Female patient was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.03MG/KG, CONTINUOUS, IV DRIP. During the same period patient was treated with METHOTREXATE. Patient recovered.

Prograf Side Effects Report #6093305-2
Prograf side effect was reported by a Physician from JAPAN on Feb 13, 2009. Female patient was diagnosed with bone marrow transplant

and was treated with Prograf. After drug was administered, patient experienced the following side effects: thrombotic microangiopathy. Prograf dosage: 0.03 MG/KG, CONTINUOUS, IV DRIP. During the same period patient was treated with METHOTREXATE. Patient recovered.

Prograf Side Effects Report #6093441-0
Prograf side effect was reported by a Physician from JAPAN on Feb 13, 2009. Female patient was diagnosed with bone marrow transplant

Prograf and thrombotic microangiopathy

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Prograf and thrombotic microangiopathy Patient Reports February 10, 2012

side effects of Prograf