Orfadin and cardio-respiratory arrest Patient Reports February 12, 2012

Orfadin Side Effects Report #5989666-2
Orfadin side effect was reported by a Consumer or non-health professional from ISRAEL on May 30, 2006. Male patient, child 8 years of age, was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: blood calcium decreased, blood sodium decreased, cardio-respiratory arrest, cyanosis, depressed level of consciousness, dyspnoea, hypotonia, portal hypertension, protein total decreased. Orfadin dosage: 1 MG/KG. Patient was hospitalized. Patient died.

Orfadin Side Effects Report #5106195-9
Orfadin side effect was reported by a Health Professional from AUSTRIA on Aug 21, 2006. Male patient was diagnosed with tyrosinaemia and was treated with Orfadin. After drug was administered, patient experienced the following side effects: alpha 1 foetoprotein increased, aspiration, cardio-respiratory arrest, dry skin, hepatic failure, liver transplant , loss of consciousness, lymphoma , pruritus. Orfadin dosage: 0.5-1.5 MG/KG MG/KG/DAY, ORAL. Patient recovered.