Oncaspar and pancytopenia Patient Reports February 11, 2012

Oncaspar Side Effects Report #6136431-1
Oncaspar side effect was reported by a Physician from UNITED STATES on Mar 11, 2009. Male patient, 23 years of age, weighting 116.4 lb, was diagnosed with precursor b-lymphoblastic lymphoma and was treated with Oncaspar. After drug was administered, patient experienced the following side effects: anaphylactic reaction, aspartate aminotransferase increased, cardio-respiratory arrest, epistaxis, headache , hyperglycaemia, liver function test abnormal, pancytopenia, peripheral motor neuropathy. Oncaspar dosage: unknown. During the same period patient was treated with VINCRISTINE, METHOTREXATE, MERCAPTOPURINE, ACYCLOVIR, BACTRIM DS, LEVAQUIN, PENICILLIN V POTASSIUM, COUMADIN. Patient was hospitalized. Patient recovered.

Oncaspar Side Effects Report #4628299-7
Oncaspar side effect was reported by a Health Professional from on Mar 18, 2005. Female patient, child 9 years of age, weighting 81.57 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Oncaspar. After drug was administered, patient experienced the following side effects: abdominal pain , acidosis, acute respiratory distress syndrome, hypotension, oliguria, pancytopenia, petechiae, septic shock. Oncaspar dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, DEXAMETHASONE, METHOTREXATE. Patient died on 08/27/2002.

Oncaspar Side Effects Report #4628313-9
Oncaspar side effect was reported by a Physician from on Mar 18, 2005. Female patient, child 8 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Oncaspar. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, ecchymosis, fluid overload, liver disorder, necrosis, oedema, pancytopenia, post procedural cellulitis, post procedural complication. Oncaspar dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNOMYCIN, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Oncaspar Side Effects Report #4672935-6
Oncaspar side effect was reported by a Health Professional from on May 09, 2005. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Oncaspar. After drug was administered, patient experienced the following side effects: blood culture positive, candidiasis, haemophilus infection, immunosuppression, multi-organ failure, pancytopenia, peritoneal haemorrhage, respiratory distress, respiratory syncytial virus infection . Oncaspar dosage: unknown. During the same period patient was treated with VINCRISTINE, DEXAMETHASONE, CYTARABINE, METHOTREXATE, DOXORUBICIN. Patient was hospitalized. Patient died on 02/19/2002.