Nilotinib and dyspnoea Patient Reports February 11, 2012

Nilotinib Side Effects Report #5721657-9
Nilotinib side effect was reported by a Physician from FRANCE on Apr 15, 2008. Female patient, 79 years of age, weighting 88.18 lb, was diagnosed with gastrointestinal stromal tumour, weight decreased and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: cardiac pacemaker insertion, dyspnoea, oedema peripheral, sinoatrial block, sinus arrest, sinus bradycardia, supraventricular extrasystoles. Nilotinib dosage: 400 MG, BID. During the same period patient was treated with ASPIRIN, CORDARONE. Patient was hospitalized. Patient recovered.

Nilotinib Side Effects Report #5723326-8
Nilotinib side effect was reported by a Physician from FRANCE on Apr 21, 2008. Female patient, 79 years of age, weighting 88.18 lb, was diagnosed with gastrointestinal stromal tumour, weight decreased and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: cardiac pacemaker insertion, dyspnoea, oedema peripheral, sinoatrial block, sinus arrest, sinus bradycardia, supraventricular extrasystoles. Nilotinib dosage: 400 MG, BID. During the same period patient was treated with ASPIRIN, CORDARONE. Patient was hospitalized. Patient recovered.

Nilotinib Side Effects Report #5518989-6
Nilotinib side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Nov 08, 2007. Male patient, 60 years of age, was diagnosed with gastrointestinal stromal tumour, insomnia, pain  and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: abdominal distension, abdominal pain , acinetobacter bacteraemia, constipation , decreased appetite, diarrhoea, dyspnoea, faecal volume decreased. Nilotinib dosage: 800MG DAILY. During the same period patient was treated with ZOPICLONE, FENTANYL, MORPHINE, LORAZEPAM, RIVOTRIL, GABAPENTIN. Patient was hospitalized. Patient recovered.

Nilotinib Side Effects Report #5541515-2
Nilotinib side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Nov 29, 2007. Male patient, 60 years of age, was diagnosed with gastrointestinal stromal tumour, insomnia, pain  and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: abdominal distension, abdominal pain , acinetobacter bacteraemia, decreased appetite, diarrhoea, dyspnoea, faecal volume decreased, ileus. Nilotinib dosage: 800MG DAILY. During the same period patient was treated with ZOPICLONE, FENTANYL, MORPHINE, LORAZEPAM, RIVOTRIL, GABAPENTIN. Patient was hospitalized. Patient recovered.


Nilotinib Side Effects Report #5567835-3
Nilotinib side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Dec 10, 2007. Male patient, 60 years of age, was diagnosed with gastrointestinal stromal tumour, insomnia, pain , urinary incontinence  and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: abdominal distension, abdominal pain , acinetobacter bacteraemia, blood pressure decreased, decreased appetite, diarrhoea, dyspnoea, faecal volume decreased. Nilotinib dosage: 800MG DAILY. During the same period patient was treated with NILOTINIB VS IMATINIB, NILOTINIB VS IMATINIB, ZOPICLONE, FENTANYL, MORPHINE, LORAZEPAM, RIVOTRIL, GABAPENTIN. Patient was hospitalized. Patient died on 12/09/2007.

Nilotinib Side Effects Report #5662650-4
Nilotinib side effect was reported by a Physician from FRANCE on Mar 04, 2008. Male patient, weighting 180.8 lb, was diagnosed with gastrointestinal stromal tumour and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: breath sounds abnormal, dyspnoea, oxygen consumption decreased, pulmonary oedema. Nilotinib dosage: 400MG. Patient was hospitalized. Patient died on 03/02/2008.

Nilotinib Side Effects Report #5634982-7
Nilotinib side effect was reported by a Physician from KOREA, REPUBLIC OF on Feb 12, 2008. Male patient, 60 years of age, weighting 194.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase mb abnormal, dyspnoea, electrocardiogram qt prolonged, hyperbilirubinaemia, left ventricular hypertrophy, leukocytosis. Nilotinib dosage: 800MG DAILY. Patient was hospitalized. Patient recovered.

Nilotinib Side Effects Report #5709718-1
Nilotinib side effect was reported by a Physician from KOREA, REPUBLIC OF on Apr 09, 2008. Male patient, 60 years of age, weighting 194.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase mb abnormal, dyspnoea, electrocardiogram qt prolonged, hyperbilirubinaemia, left ventricular hypertrophy, leukocytosis. Nilotinib dosage: 800MG DAILY. Patient was hospitalized. Patient recovered.

Nilotinib Side Effects Report #5718424-9
Nilotinib side effect was reported by a Physician from KOREA, REPUBLIC OF on Apr 15, 2008. Male patient, 60 years of age, weighting 194.0 lb, was diagnosed with chronic myeloid leukaemia and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase mb abnormal, dyspnoea, electrocardiogram qt prolonged, hyperbilirubinaemia, left ventricular hypertrophy, leukocytosis. Nilotinib dosage: 800MG DAILY. Patient was hospitalized. Patient recovered.


Nilotinib Side Effects Report #6039277-8
Nilotinib side effect was reported by a Physician from UNITED KINGDOM on Jan 13, 2009. Male patient was diagnosed with chronic myeloid leukaemia and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: blast cell count increased, blood creatinine increased, blood urea increased, c-reactive protein increased, chest x-ray abnormal, diarrhoea, disease progression, dyspnoea, nausea . Nilotinib dosage: 800 MG, QD. Patient died.