Nilotinib and blood creatinine increased Patient Reports February 11, 2012

Nilotinib Side Effects Report #5682312-7
Nilotinib side effect was reported by a Physician from UNITED STATES on Mar 21, 2008. Female patient, 36 years of age, weighting 170.4 lb, was diagnosed with gastrointestinal stromal tumour and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: abdominal distension, abdominal pain , ascites, blood creatinine increased, constipation , dehydration, gastrointestinal tube insertion, hypotension. Nilotinib dosage: 400 MG, BID. Patient was hospitalized. Patient died on 03/12/2008.

Nilotinib Side Effects Report #6039277-8
Nilotinib side effect was reported by a Physician from UNITED KINGDOM on Jan 13, 2009. Male patient was diagnosed with chronic myeloid leukaemia and was treated with Nilotinib. After drug was administered, patient experienced the following side effects: blast cell count increased, blood creatinine increased, blood urea increased, c-reactive protein increased, chest x-ray abnormal, diarrhoea, disease progression, dyspnoea, nausea . Nilotinib dosage: 800 MG, QD. Patient died.