Naglazyme and hypotonia Patient Reports February 11, 2012

Naglazyme Side Effects Report #5586061-5
Naglazyme side effect was reported by a Physician from BRAZIL on Dec 20, 2007. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: clonus, condition aggravated, disease progression, gait disturbance, hyperreflexia, hypotonia, muscle spasticity, muscular weakness, off label use. Naglazyme dosage: 1.5 ML; QM;INTH; 15 MG; X1; IV. Patient recovered.

Naglazyme Side Effects Report #5613391-0
Naglazyme side effect was reported by a Physician from BRAZIL on Jan 11, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abasia, central nervous system lesion, clonus, condition aggravated, csf protein increased, hyperreflexia, hypotonia, meningeal disorder, muscle spasticity. Naglazyme dosage: 1.5 ML;QM;INTH, 15 MG;X1;IV. Patient recovered.

Naglazyme Side Effects Report #5629946-3
Naglazyme side effect was reported by a Physician from BRAZIL on Jan 30, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abasia, cervical cord compression, disease progression, hypotonia, meningeal disorder, pyramidal tract syndrome. Naglazyme dosage: 1.5 ML; QM; INTH, 15 MG; X1; IV, 15 MG; X1; IV, 1.5 ML; X1; INTH, 15 MG; X1; IV. Patient recovered.

Naglazyme Side Effects Report #5663681-0
Naglazyme side effect was reported by a Physician from BRAZIL on Feb 22, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: condition aggravated, diffuse axonal injury, gait disturbance, hypotonia, intervertebral disc disorder, muscle spasticity, oxygen saturation decreased, pyramidal tract syndrome. Naglazyme dosage: 1.5 ML;QM;INTH;15 MG;X1;IV. Patient recovered.


Naglazyme Side Effects Report #5704286-2
Naglazyme side effect was reported by a Physician from BRAZIL on Mar 25, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abasia, clonus, disease progression, hyperreflexia, hypotonia, ill-defined disorder, immune system disorder, muscle spasticity, muscular weakness. Naglazyme dosage: 1.5 ML; QM; INTH, 15 MG; X1; IV, 15 MG; X1; IV, 1.5 ML; X1; INTH, 15 MG; X1; IV, 1 ML/KG; QW; IV. Patient recovered.

Naglazyme Side Effects Report #5796870-5
Naglazyme side effect was reported by a Physician from BRAZIL on Mar 26, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: condition aggravated, disease progression, gait disturbance, hypotonia, muscle spasticity, muscular weakness, nuclear magnetic resonance imaging brain abnormal, oxygen saturation decreased. Naglazyme dosage: 1.5 ML QM INTH; 15 MG X1 IV; 15 MG X1 IV; 1.5 ML X1 INTH; 15 MG X1 IV; 1 ML/KG QW IV. Patient recovered.

Naglazyme Side Effects Report #6139866-6
Naglazyme side effect was reported by a Physician from BRAZIL on Mar 13, 2009. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: arthropathy, clonus, gait disturbance, hepatosplenomegaly, hyperreflexia, hypotonia, incontinence, meningitis , movement disorder . Naglazyme dosage: 1.5 ML; QM; INTH, 15 MG; X1; IV, 1.5 ML; X1; INTH, 1 ML/KG; QW; IV, ; INTH. Patient recovered.