Naglazyme and disease progression Patient Reports February 11, 2012

Naglazyme Side Effects Report #5586061-5
Naglazyme side effect was reported by a Physician from BRAZIL on Dec 20, 2007. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: clonus, condition aggravated, disease progression, gait disturbance, hyperreflexia, hypotonia, muscle spasticity, muscular weakness, off label use. Naglazyme dosage: 1.5 ML; QM;INTH; 15 MG; X1; IV. Patient recovered.

Naglazyme Side Effects Report #5591022-6
Naglazyme side effect was reported by a Physician from BRAZIL on Dec 26, 2007. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: arthropathy, csf protein increased, disease progression, meningeal disorder, myelopathy, nuclear magnetic resonance imaging brain abnormal, spinal cord compression. Naglazyme dosage: 1.5 ML; QM; INTH; 15 MG; X1; IV. Patient recovered.

Naglazyme Side Effects Report #5629946-3
Naglazyme side effect was reported by a Physician from BRAZIL on Jan 30, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abasia, cervical cord compression, disease progression, hypotonia, meningeal disorder, pyramidal tract syndrome. Naglazyme dosage: 1.5 ML; QM; INTH, 15 MG; X1; IV, 15 MG; X1; IV, 1.5 ML; X1; INTH, 15 MG; X1; IV. Patient recovered.

Naglazyme Side Effects Report #5704286-2
Naglazyme side effect was reported by a Physician from BRAZIL on Mar 25, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abasia, clonus, disease progression, hyperreflexia, hypotonia, ill-defined disorder, immune system disorder, muscle spasticity, muscular weakness. Naglazyme dosage: 1.5 ML; QM; INTH, 15 MG; X1; IV, 15 MG; X1; IV, 1.5 ML; X1; INTH, 15 MG; X1; IV, 1 ML/KG; QW; IV. Patient recovered.


Naglazyme Side Effects Report #5796870-5
Naglazyme side effect was reported by a Physician from BRAZIL on Mar 26, 2008. Male patient, child 7 years of age, weighting 32.19 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: condition aggravated, disease progression, gait disturbance, hypotonia, muscle spasticity, muscular weakness, nuclear magnetic resonance imaging brain abnormal, oxygen saturation decreased. Naglazyme dosage: 1.5 ML QM INTH; 15 MG X1 IV; 15 MG X1 IV; 1.5 ML X1 INTH; 15 MG X1 IV; 1 ML/KG QW IV. Patient recovered.

Naglazyme Side Effects Report #5911799-7
Naglazyme side effect was reported by a Physician from COLOMBIA on Sept 18, 2008. Male patient, child 5 years of age, weighting 24.25 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: disease progression, sleep apnoea syndrome. Naglazyme dosage: 10 MG; QW; IVDRIP. During the same period patient was treated with CETIRIZIN, CEFALEXIN, OXYGEN. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5776618-0
Naglazyme side effect was reported by a Physician from COLOMBIA on June 02, 2008. Male patient, child 12 years of age, weighting 39.68 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: bronchial obstruction, cardiac failure, cardio-respiratory arrest, cardiomyopathy , disease progression, mucopolysaccharidosis vi, multi-organ failure, pulmonary hypertension , renal failure. Naglazyme dosage: 20 MG; QW; IV. During the same period patient was treated with ALDACTONE, FUROSEMIDE, SILDENAFIL, CARVEDILOL. Patient was hospitalized. Patient died on 04/22/2008.

Naglazyme Side Effects Report #6077128-6
Naglazyme side effect was reported by a Physician from SWITZERLAND on Jan 26, 2009. Female patient was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: disease progression, mucopolysaccharidosis. Naglazyme dosage: unknown. Patient died.

Naglazyme Side Effects Report #6096859-5
Naglazyme side effect was reported by a Physician from SWITZERLAND on Feb 10, 2009. Female patient was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: cardiopulmonary failure, disease progression, mucopolysaccharidosis vi. Naglazyme dosage: 1 MG/KG; QW; IVDRP. Patient died on 12/16/2008.


Naglazyme Side Effects Report #5955493-5
Naglazyme side effect was reported by a Physician from CHILE on Oct 28, 2008. Male patient, child 10 years of age, weighting 33.07 lb, was diagnosed with mucopolysaccharidosis and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, apnoea, bradycardia, bronchial disorder, convulsion, disease progression, hypotension, mucosal membrane hyperplasia, pneumonia . Naglazyme dosage: 15 MG; QW; IVDRP. Patient was hospitalized. Patient died on 10/28/2008.