Naglazyme and aortic valve incompetence Patient Reports February 11, 2012

Naglazyme Side Effects Report #5412401-3
Naglazyme side effect was reported by a Health Professional from UNITED STATES on July 25, 2007. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abdominal pain , activated partial thromboplastin time prolonged, aortic valve incompetence, carpal tunnel syndrome , condition aggravated, disease recurrence, gastrointestinal haemorrhage, haematochezia, headache . Naglazyme dosage: 1 MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5464001-7
Naglazyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 05, 2007. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi, attention deficit/hyperactivity disorder and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abdominal pain , activated partial thromboplastin time prolonged, anal fissure, aortic valve incompetence, carpal tunnel syndrome , chest pain , disease recurrence, dizziness , dysuria. Naglazyme dosage: 1 MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE, CLONIDINE. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5646419-2
Naglazyme side effect was reported by a Physician from IRELAND on Feb 13, 2008. Female patient, child 11 years of age, weighting 44.09 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: aortic valve incompetence, cardiac arrest , mitral valve incompetence, pneumonia , pulmonary haemorrhage, pulmonary hypertension , respiratory tract infection, tricuspid valve incompetence. Naglazyme dosage: 20 MG QW IV. During the same period patient was treated with MEROPENEM, VANCOMYCIN, ERYTHROMYCIN, CIPROFLOXACIN, VORICONAZOLE, MILRINONE LACTATE, FUROSEMIDE, MORPHINE. Patient was hospitalized. Patient died on 01/25/2008.

Naglazyme Side Effects Report #5673975-0
Naglazyme side effect was reported by a Consumer or non-health professional from IRELAND on Feb 29, 2008. Female patient, child 11 years of age, weighting 44.09 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, aortic valve incompetence, back pain , blood pressure decreased, cardiac arrest , diarrhoea, headache , hepatomegaly. Naglazyme dosage: 20 MG; QW; IV. During the same period patient was treated with MEROPENEM, VANCOMYCIN, ERYTHROMYCIN, CIPROFLOXACIN, VORICONAZOLE, MILRINONE LACTATE, FUROSEMIDE, MORPHINE. Patient was hospitalized. Patient died on 01/25/2008.