Naglazyme and activated partial thromboplastin time prolonged Patient Reports February 11, 2012

Naglazyme Side Effects Report #5397131-9
Naglazyme side effect was reported by a Health Professional from UNITED STATES on July 06, 2007. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, carpal tunnel syndrome , disease recurrence, gastrointestinal haemorrhage, hypertension, infusion related reaction, mastoiditis, rash erythematous, trigger finger. Naglazyme dosage: 1 MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE, CLONIDINE, HYDROCORTISONE SUCCINATE. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5412401-3
Naglazyme side effect was reported by a Health Professional from UNITED STATES on July 25, 2007. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abdominal pain , activated partial thromboplastin time prolonged, aortic valve incompetence, carpal tunnel syndrome , condition aggravated, disease recurrence, gastrointestinal haemorrhage, haematochezia, headache . Naglazyme dosage: 1 MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5464001-7
Naglazyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 05, 2007. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi, attention deficit/hyperactivity disorder and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: abdominal pain , activated partial thromboplastin time prolonged, anal fissure, aortic valve incompetence, carpal tunnel syndrome , chest pain , disease recurrence, dizziness , dysuria. Naglazyme dosage: 1 MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE, CLONIDINE. Patient was hospitalized. Patient recovered.

Naglazyme Side Effects Report #5694143-2
Naglazyme side effect was reported by a Health Professional from UNITED STATES on Mar 18, 2008. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi, attention deficit/hyperactivity disorder and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, carpal tunnel syndrome , disease recurrence, gastrointestinal haemorrhage, malignant hypertension, urticaria. Naglazyme dosage: 1MG/KG; QW; IV. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE, HYDROCORTISONE SUCCINATE. Patient was hospitalized. Patient recovered.


Naglazyme Side Effects Report #5926209-3
Naglazyme side effect was reported by a Physician from UNITED STATES on Oct 02, 2008. Female patient, child 7 years of age, weighting 46.96 lb, was diagnosed with mucopolysaccharidosis vi, attention deficit/hyperactivity disorder and was treated with Naglazyme. After drug was administered, patient experienced the following side effects: activated partial thromboplastin time prolonged, bone marrow transplant , gastrointestinal haemorrhage, hypertension, infusion related reaction, international normalised ratio abnormal, mastoiditis, urticaria. Naglazyme dosage: 1 MG/KG; QW; IVDRP. During the same period patient was treated with METHYLPHENIDATE, PREDNISONE, LANSOPRAZOLE, CALCIUM CARBONATE, DIPHENHYDRAMINE, HYDROCORTISONE SUCCINATE. Patient was hospitalized. Patient recovered.