Myozyme and infusion related reaction Patient Reports February 13, 2012

Myozyme Side Effects Report #5226776-1
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 15, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, bradycardia, bronchospasm, cardiac arrest

, gastroenteritis

, infusion related reaction, oedema. Myozyme dosage: unknown. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5237944-7
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 29, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, bronchospasm, cardiac arrest

, erythema, gastroenteritis

, vasoconstriction. Myozyme dosage: 40 MG/KG QWK IV. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6096715-2
Myozyme side effect was reported by a Physician from ITALY on Feb 17, 2009. Male patient, 73 years of age, weighting 174.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthmatic crisis, influenza like illness, infusion related reaction, no therapeutic response. Myozyme dosage: 20 MG/KG, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5156536-1
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 30, 2006. Male patient, 71 years of age, weighting 201.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, bladder perforation, catheter related complication, iatrogenic injury, infusion related reaction, pneumonia

, urinary tract infection

, viral infection

. Myozyme dosage: 20 MG/KG Q2WKS; IV. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5897060-8
Myozyme side effect was reported by a Physician from UNITED STATES on Sept 10, 2008. Male patient, 66 years of age, weighting 189.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood potassium decreased, dysphagia, electrolyte imbalance, hypothyroidism, infusion related reaction, mastication disorder, movement disorder

, somnolence. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with COZAAR, NORVASC, INDAPAMIDE, ZOLOFT, THYROID SUPPLEMENT, FISH OIL SUPPLEMENT, VITAMIN, POTASSIUM. Patient recovered.

Myozyme Side Effects Report #5379543-2
Myozyme side effect was reported by a Physician from UNITED STATES on June 19, 2007. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, prophylaxis and was treated with Myozyme. After drug was administered, patient experienced the following side effects: infusion related reaction, myocardial infarction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL LIQUI. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5401311-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 11, 2007. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction, prophylaxis and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain

, blood immunoglobulin g increased, bradycardia, chills, hypotension, hypothermia

, infusion related reaction, myocardial infarction, pallor. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5752263-8
Myozyme side effect was reported by a Physician from UNITED STATES on May 14, 2008. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain

, bradycardia, chills, hypersensitivity, hypotension, hypothermia

, infusion related reaction, myocardial infarction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5887099-0
Myozyme side effect was reported by a Health Professional from GERMANY on Aug 12, 2008. Male patient, 60 years of age, weighting 262.4 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: fatigue, feeling hot, infusion related reaction, myalgia, nausea

. Myozyme dosage: unknown. During the same period patient was treated with ACETYLSALICYLIC ACID SRT, BISOPRLOL, RAMIPRIL. Patient recovered.

Myozyme Side Effects Report #5853417-2
Myozyme side effect was reported by a Physician from ISRAEL on Aug 06, 2008. Female patient, child 6 years of age, weighting 44.09 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: activities of daily living impaired, chills, face oedema, fatigue, flushing, heart rate increased, hypersensitivity, infusion related reaction, nonspecific reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5319721-1
Myozyme side effect was reported by a Physician from GERMANY on Apr 18, 2007. Male patient, 59 years of age, weighting 158.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cyanosis, hypersensitivity, infusion related reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ATACAND, CARMEN. Patient recovered.

Myozyme Side Effects Report #5248067-5
Myozyme side effect was reported by a Physician from GERMANY on Feb 08, 2007. Female patient, 55 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, chest discomfort, dyspnoea, infusion related reaction, oxygen saturation decreased, respiratory distress. Myozyme dosage: 1200 MG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5170229-6
Myozyme side effect was reported by a Physician from GERMANY on Nov 21, 2006. Female patient, 55 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, infusion related reaction, oxygen saturation decreased, respiratory distress. Myozyme dosage: 1200 MG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5319722-3
Myozyme side effect was reported by a Physician from GERMANY on Apr 18, 2007. Female patient, 51 years of age, weighting 158.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypersensitivity, hypotension, infusion related reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ENTHYROX. Patient recovered.

Myozyme Side Effects Report #5761739-9
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 16, 2008. Female patient, 48 years of age, weighting 165.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac disorder, chest discomfort, contusion, dyspnoea, hypersensitivity, infusion related reaction, septal panniculitis. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, SYNTHROID, VESICARE, ZOLOFT. Patient recovered.

Myozyme Side Effects Report #5625287-9
Myozyme side effect was reported by a Physician from AUSTRALIA on Jan 25, 2008. Female patient, 47 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acquired diaphragmatic eventration, bronchiectasis, infusion related reaction, lung disorder, lung injury, pleural fibrosis, pneumothorax, procedural complication, respiratory failure. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ESOMEPRAZOLE, CITALOPRAM HYDROBROMIDE, OXYBUTYNIN CHLORIDE, ACETAMINOPHEN. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5216727-8
Myozyme side effect was reported by a Consumer or non-health professional from FRANCE on Jan 04, 2007. Female patient, 45 years of age, weighting 123.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, back pain

, blood pressure decreased, chest discomfort, chest pain

, erythema, flushing, infusion related reaction, nausea

. Myozyme dosage: unknown. During the same period patient was treated with FERROUS SULPHATE, POLARAMINE, TELFAST. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5186262-4
Myozyme side effect was reported by a Consumer or non-health professional from FRANCE on Nov 28, 2006. Female patient, 44 years of age, weighting 123.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic shock, infusion related reaction. Myozyme dosage: unknown. During the same period patient was treated with FERROUS SULPHATE, POLARAMINE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5255825-X
Myozyme side effect was reported by a Physician from ITALY on Feb 15, 2007. Male patient, 40 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hypercoagulation, infusion related reaction, pain in extremity, protein s decreased, venous occlusion. Myozyme dosage: 1300 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5332845-8
Myozyme side effect was reported by a Physician from GREECE on May 11, 2007. Female patient, 40 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: erythema, flushing, infusion related reaction, lower respiratory tract infection, no therapeutic response, oedema peripheral, pharyngitis, pseudomonas infection, sputum culture positive. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5236949-X
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Female patient, 37 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin e increased, chest discomfort, chest pain

, dyspnoea, feeling abnormal, infusion related reaction, rash

, throat tightness, urticaria. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with TYLENOL, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5272563-8
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 08, 2007. Female patient, 37 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain

, chest discomfort, chest pain

, disease recurrence, infusion related reaction, oedema peripheral, rash

, skin reaction, throat tightness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with TYLENOL, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5614459-5
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 21, 2008. Female patient, 37 years of age, weighting 112.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain

, blood immunoglobulin e increased, blood immunoglobulin g increased, chest discomfort, chest pain

, dyspnoea, infusion related reaction, oedema peripheral, rash

. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ACETAMINOPHEN, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5681125-X
Myozyme side effect was reported by a Physician from GERMANY on Mar 11, 2008. Female patient, 36 years of age, weighting 147.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cough, dyspnoea, hypersensitivity, infusion related reaction, obstructive airways disorder, stridor. Myozyme dosage: unknown. During the same period patient was treated with RANITIDINE, FENISTIL, PREDNISOLONE, EFEROX, ORGAMETRIL, LYRICA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5755486-7
Myozyme side effect was reported by a Physician from GERMANY on May 19, 2008. Female patient, 36 years of age, weighting 147.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: dyspnoea, hypersensitivity, infusion related reaction, stridor. Myozyme dosage: unknown. During the same period patient was treated with RANITIDINE, FENISTIL, PREDNSOLON, EFEROX, ORGAMETRIL, LYRICA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5935025-8
Myozyme side effect was reported by a Health Professional from UNITED KINGDOM on Oct 20, 2008. Female patient, 33 years of age, weighting 112.9 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: dizziness

, fall

, heart rate decreased, hypotension, infusion related reaction, pallor, syncope. Myozyme dosage: 1000 MG/DAY, Q2W, INTRAVENOUS. During the same period patient was treated with CHLORPHENIRAMINE MALEATE, ACETAMINOPHEN. Patient recovered.

Myozyme Side Effects Report #5506909-X
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 18, 2007. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hyperparathyroidism, infusion related reaction, muscular weakness, oxygen saturation decreased, urinary tract infection

. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5625286-7
Myozyme side effect was reported by a Physician from ARGENTINA on Jan 30, 2008. Female patient, child 3 years of age, weighting 35.27 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bronchospasm, device failure, infusion related reaction, oxygen saturation decreased, pneumonia

, pyrexia, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUTICASONE PROPIONATE, FEROUS SULPHATE, SALBUTAMOL, CARNITENE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5995082-X
Myozyme side effect was reported by a Physician from BRAZIL on Dec 03, 2008. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, choking

, cough, hypotension, influenza, infusion related reaction, pyrexia, viral infection

. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5102881-5
Myozyme side effect was reported by a Physician from KOREA, REPUBLIC OF on Aug 24, 2006. Female patient, 29 years of age, weighting 74.96 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: face oedema, flushing, gastric ulcer, infusion related reaction, pneumonia bacterial, pruritus, rash maculo-papular, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with RANITIDINE, TAZOBACTAM, ISEPAMICIN. Patient recovered.

Myozyme Side Effects Report #5166543-0
Myozyme side effect was reported by a Physician from TURKEY on Nov 15, 2006. Female patient, 28 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: dyspnoea, hypersensitivity, infusion related reaction, rash

. Myozyme dosage: unknown. Patient recovered.

Myozyme Side Effects Report #5483158-5
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Sept 25, 2007. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest

, oxygen saturation decreased, regurgitation, respiratory failure. Myozyme dosage: unknown. Patient recovered.

Myozyme Side Effects Report #5713823-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on Apr 09, 2008. Male patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: ear infection

, erythema, infusion related reaction, lung disorder, oxygen saturation decreased, rash

, erythema, glycogen storage disease type ii, infusion related reaction, lung disorder, oxygen saturation decreased, rash

, erythema, infusion related reaction, pneumonia aspiration, rash

, tachycardia. Myozyme dosage: 300 MG, Q2W, INTRAVENOUS. During the same period patient was treated with ACETAMINOPHEN. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5081199-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 27, 2006. Male patient, 14 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, bronchospasm, chest discomfort, chills, cyanosis, flushing, infusion related reaction, tachycardia, tachypnoea. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, BENADRYL, TYLENOL, STEROID. Patient recovered.

Myozyme Side Effects Report #5533877-7
Myozyme side effect was reported by a Physician from ITALY on Nov 14, 2007. Male patient, child 10 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: dysphagia, erythema, infusion related reaction, throat tightness. Myozyme dosage: unknown. Patient recovered.

Myozyme Side Effects Report #5849650-6
Myozyme side effect was reported by a Physician from JAPAN on Aug 13, 2008. Female patient, child 10 years of age, weighting 48.50 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthma

, cough, hypersensitivity, infusion related reaction, stridor, urticaria. Myozyme dosage: 450 MG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5945823-2
Myozyme side effect was reported by a Physician from JAPAN on Oct 22, 2008. Female patient, child 10 years of age, weighting 48.50 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthma

, hypersensitivity, infusion related reaction, urticaria. Myozyme dosage: 450 MG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5450622-4
Myozyme side effect was reported by a Health Professional from UNITED STATES on Aug 27, 2007. Female patient, child 1 years of age, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, catheter related infection, culture positive, device failure, device related infection, fungal infection

, infusion related reaction, respiratory distress. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5504743-8
Myozyme side effect was reported by a Physician from SPAIN on Oct 17, 2007. Male patient, child 1 years of age, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, hyperhidrosis, infusion related reaction, lip oedema, pharyngeal oedema, respiratory arrest, stridor, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5518847-7
Myozyme side effect was reported by a Physician from SPAIN on Oct 29, 2007. Male patient, child 1 years of age, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, cyanosis, disease recurrence, dyspnoea, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory tract infection, transaminases increased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5245892-1
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 01, 2007. Male patient, weighting 15.21 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood magnesium increased, blood pressure decreased, cardio-respiratory arrest, heart rate decreased, hypersensitivity, infection

, infusion related reaction, respiratory distress, respiratory rate increased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with DIPHENHYDRAMINE, ACETAMINOPHEN, POTASSIUM CHLORIDE, FAMOTIDINE, DIGOXIN, PROPRANOLOL, FUROSEMIDE, HYDROCHLOROTHIAZIDE. Patient recovered.

Myozyme Side Effects Report #5293817-5
Myozyme side effect was reported by a Physician from ITALY on Mar 22, 2007. Female patient, weighting 14.33 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: central line infection, cyanosis, hypotension, infusion related reaction, oxygen saturation decreased. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5339706-9
Myozyme side effect was reported by a Physician from UNITED STATES on May 11, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood urine, bronchial hyperreactivity, candidiasis, central line infection, eosinophilia, haematuria, influenza, infusion related reaction, protein urine present. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with METHOTREXATE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5093635-7
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 15, 2006. Male patient, weighting 16.53 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin e increased, blood immunoglobulin g increased, blood pressure decreased, infusion related reaction, tachycardia, urticaria. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CLARINEX, DIPHENHYDRAMINE, RANITIDINE, XOPENEX, PULMICORT, REGLAN. Patient recovered.

Myozyme Side Effects Report #5097560-7
Myozyme side effect was reported by a Physician from BRAZIL on Aug 18, 2006. Male patient, weighting 19.82 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, cyanosis, infusion related reaction, pallor, rash

, vomiting. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, CAPTOPRIL, LASIX. Patient recovered.

Myozyme Side Effects Report #5100817-4
Myozyme side effect was reported by a Health Professional from BRAZIL on Aug 23, 2006. Female patient, weighting 16.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: infusion related reaction, pallor, pulse absent, pyrexia, tremor. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5106859-7
Myozyme side effect was reported by a Physician from BRAZIL on Aug 31, 2006. Male patient, weighting 19.82 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, complement factor increased, cyanosis, erythema, infusion related reaction, lethargy, oxygen saturation decreased, pallor, rash

. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, CAPTOPRIL, LASIX. Patient recovered.

Myozyme Side Effects Report #5117729-2
Myozyme side effect was reported by a Physician from BRAZIL on Sept 12, 2006. Female patient, weighting 15.43 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: body temperature decreased, hypotension, infusion related reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE, DIGOXIN, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5160220-8
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 06, 2006. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: condition aggravated, conjunctival hyperaemia, disease progression, erythema, flushing, hypertrophic cardiomyopathy, infusion related reaction, muscular weakness, nausea

. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5449823-0
Myozyme side effect was reported by a Physician from SPAIN on Aug 27, 2007. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, cyanosis, dyspnoea, hyperhidrosis, infusion related reaction, lip oedema, nasopharyngitis, pharyngeal oedema. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5477556-3
Myozyme side effect was reported by a Physician from SPAIN on Sept 18, 2007. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, hyperhidrosis, infusion related reaction, lip oedema, pharyngeal oedema, respiratory arrest, stridor, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.

Myozyme Side Effects Report #5550504-3
Myozyme side effect was reported by a Physician from BELGIUM on Nov 21, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: infusion related reaction, pyrexia, respiratory disorder. Myozyme dosage: unknown. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5586084-6
Myozyme side effect was reported by a Health Professional from UNITED STATES on Dec 27, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest

. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 12/21/2007.

Myozyme Side Effects Report #5626421-7
Myozyme side effect was reported by a Physician from SLOVENIA on Jan 28, 2008. Female patient, weighting 21.83 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: antibody test abnormal, electrocardiogram qt prolonged, electroencephalogram abnormal, epilepsy

, hyperhidrosis, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EVITOL, VITAMIN B, COENZYME Q, VITAMIN E. Patient recovered.

Myozyme Side Effects Report #5635628-4
Myozyme side effect was reported by a Physician from FRANCE on Feb 05, 2008. Female patient, weighting 13.67 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, crying, cyanosis, dyspnoea, erythema, infusion related reaction, moaning, nervousness, pyrexia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5678162-8
Myozyme side effect was reported by a Physician from FRANCE on Mar 05, 2008. Female patient, weighting 13.67 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, cyanosis, dyspnoea, erythema, hyperthermia, infusion related reaction, lacrimation increased, moaning, nervousness. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with LASIX, LEVOCARNIL, DEXTRIN. Patient recovered.

Myozyme Side Effects Report #5689669-1
Myozyme side effect was reported by a Physician from SPAIN on Mar 13, 2008. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, cardiac failure, cyanosis, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory failure, transaminases increased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG, Q2W, INTRAVENOUS; 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 02/01/2008.

Myozyme Side Effects Report #5759052-9
Myozyme side effect was reported by a Physician from SPAIN on Mar 13, 2008. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, cardiac failure, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory failure, respiratory tract infection. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient died on 02/01/2008.

Myozyme Side Effects Report #5826876-9
Myozyme side effect was reported by a Physician from FRANCE on July 17, 2008. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, incorrect dose administered, infusion related reaction. Myozyme dosage: 150 MG, 4W, INTRAVENOUS; 100 MG, Q4W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5849977-8
Myozyme side effect was reported by a Physician from UNITED STATES on Aug 04, 2008. Male patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: hyperhidrosis, infusion related reaction, oxygen saturation decreased, pallor, petechiae, rash

, respiratory distress, retching, tachycardia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with RANITIDINE, PREDNISONE, CETIRIZINE, XOPENEX, PULMICORT, IPRATROPIUM BR, METOCLORPAMIDE, FLUCONAZOLE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5850383-0
Myozyme side effect was reported by a Physician from UNITED STATES on Aug 01, 2008. Male patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: grunting, hyperhidrosis, infusion related reaction, oxygen saturation decreased, pallor, petechiae, rash

, respiratory distress, retching. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with RANITIDINE, PREDNISONE, CETIRIZINE, XOPENEX, PULMICORT, IPRATROPIUM BR, METOCLOPRAMIDE, FLUCONAZOLE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5875731-7
Myozyme side effect was reported by a Physician from UNITED STATES on Aug 27, 2008. Male patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood immunoglobulin g increased, blood pressure decreased, crying, hyperhidrosis, infusion related reaction, nasal congestion, oxygen saturation decreased, pallor. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with RANITIDINE, PREDNISONE, CETIRIZINE, XOPENEX, PULMICORT, IPRATROPIUM BR, METOCLOPRAMIDE, FLUCONAZOLE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5875740-8
Myozyme side effect was reported by a Health Professional from UNITED STATES on Aug 26, 2008. Male patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, bronchiolitis, choking

, conjunctivitis, erythema, influenza, infusion related reaction, pneumonia aspiration, respiratory arrest. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5887199-5
Myozyme side effect was reported by a Physician from JAPAN on Sept 02, 2008. Male patient, weighting 30.86 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, erythema, infusion related reaction, oxygen saturation decreased, rash

. Myozyme dosage: 300 MG, Q2W, INTRAVENOUS. During the same period patient was treated with ATARAX, ENALAPRIL MALEATE, ANTIBIOTICS, FUROSEMIDE, ASPIRIN, PICOSULPHATE. Patient recovered.

Myozyme Side Effects Report #5912760-9
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Sept 29, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: congestive cardiomyopathy, infusion related reaction, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient recovered.

Myozyme Side Effects Report #5955955-0
Myozyme side effect was reported by a Health Professional from UNITED STATES on Oct 29, 2008. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, cardio-respiratory arrest, influenza, infusion related reaction, left ventricular hypertrophy, loss of consciousness, pneumonia aspiration, pyrexia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLOVENT. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5977628-0
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 11, 2008. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory failure, clostridium difficile toxin test positive, collapse of lung, diaphragm muscle weakness, increased bronchial secretion, infusion related reaction, laryngeal oedema, lung infection pseudomonal, pleural effusion. Myozyme dosage: 250 MG, Q2W, INTRAVENOUS. During the same period patient was treated with BUDESONIDE, CETIRIZINE, DNASE, IPRATROPIUM BROMIDE, LEVALBUTEROL, LORAZEPAM, RANITIDINE, CROMOLYN. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5988374-1
Myozyme side effect was reported by a Physician from CROATIA (local name: Hrvatska) on Nov 24, 2008. Female patient, weighting 18.52 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood pressure increased, bronchial obstruction, bronchospasm, dyspnoea, hypersensitivity, infusion related reaction, irritability. Myozyme dosage: 200 MG, QW, INTRAVENOUS : 200 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6030969-3
Myozyme side effect was reported by a Physician from CROATIA (local name: Hrvatska) on Dec 15, 2008. Female patient, weighting 18.52 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood pressure increased, bronchial obstruction, bronchospasm, hypersensitivity, infusion related reaction, irritability, no therapeutic response, nosocomial infection. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6055095-9
Myozyme side effect was reported by a Physician from GREECE on Jan 15, 2009. Male patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cyanosis, hypersensitivity, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #6077626-5
Myozyme side effect was reported by a Physician from GREECE on Jan 29, 2009. Male patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cyanosis, infusion related reaction, tryptase increased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6088082-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Feb 09, 2009. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cardiac hypertrophy, cardiomegaly, cardiopulmonary failure, congestive cardiomyopathy, infusion related reaction, muscular weakness, respiratory failure. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient died on 11/05/2008.

Myozyme Side Effects Report #6088084-9
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Feb 09, 2009. Female patient, weighting 18.96 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: infusion related reaction, sepsis

, viral infection

. Myozyme dosage: unknown. During the same period patient was treated with RITUXIMAB, METHOTREXATE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6088518-X
Myozyme side effect was reported by a Physician from GREECE on Feb 12, 2009. Male patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cyanosis, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6094701-X
Myozyme side effect was reported by a Physician from GREECE on Feb 13, 2009. Male patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, cyanosis, disease recurrence, hypersensitivity, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6111294-9
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Mar 02, 2009. Female patient, weighting 18.96 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: infusion related reaction, sepsis

. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6111696-0
Myozyme side effect was reported by a Pharmacist from UNITED STATES on Mar 10, 2009. Male patient, weighting 38.80 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anxiety

, flushing, hypotension, hypoxia, infusion related reaction, tachycardia. Myozyme dosage: 350 MG EVERY 2 WEEKS IV DRIP. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6131096-7
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Mar 10, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood immunoglobulin g increased, diarrhoea, dysphagia, erythema, hypotonia, infusion related reaction, lung infection. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with STEROIDS, ACETAMINOPHEN, PREDNISOLONE, METHYLPREDNISOLONE, ANTIHISTAMINES, HYDROCORTISONE, ZANTAC. Patient was hospitalized. Patient recovered.

Myozyme and infusion related reaction

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Myozyme and infusion related reaction Patient Reports February 13, 2012

side effects of Myozyme