Myozyme and chest discomfort Patient Reports February 13, 2012

Myozyme Side Effects Report #5677967-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on Mar 05, 2008. Female patient, child 9 years of age, weighting 66.14 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anxiety , chest discomfort, cyanosis, dyspnoea, eye swelling, flushing, hypersensitivity, nausea , pallor. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLONASE, CONCERTA, ALBUTEROL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5799564-5
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 20, 2008. Female patient, child 9 years of age, weighting 66.14 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anxiety , aphasia , blood pressure increased, chest discomfort, cyanosis, dyspnoea, eye swelling, flushing, hypersensitivity. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLONASE, CONCERTA, ALBUTEROL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5832451-2
Myozyme side effect was reported by a Physician from UNITED STATES on July 21, 2008. Female patient, child 9 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, chest discomfort, cough, cyanosis, dysgeusia, dyspnoea, face oedema, flushing, headache . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with PREDNISONE, BENADRYL. Patient recovered.

Myozyme Side Effects Report #6055334-4
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 02, 2009. Female patient, child 9 years of age, weighting 66.14 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anxiety , blood pressure increased, chest discomfort, circumoral oedema, cyanosis, dyspnoea, eye swelling, flushing, hypersensitivity. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with FLONASE, CONCERTA, ALBUTEROL. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #6109493-5
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 20, 2009. Female patient, child 9 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: angioedema, antibody test positive, arthralgia, bronchospasm, catheter site erythema, catheter site pruritus, chest discomfort, cough, cyanosis. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with PREDNISONE, BENADRYL. Patient recovered.

Myozyme Side Effects Report #6067771-2
Myozyme side effect was reported by a Health Professional from UNITED STATES on Jan 20, 2009. Male patient, 60 years of age, weighting 264.6 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, blood immunoglobulin g increased, blood pressure increased, cardiac disorder, chest discomfort, chills, dyspepsia, fall , flushing. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with LORATADINE, METHYLSULFONYLMETHANE, DARVOCET, SYNTHROID, FELDENE, SULAR, CLONIDINE, HYDROCHLOROTHIAZIDE. Patient recovered.

Myozyme Side Effects Report #6081262-4
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 03, 2009. Male patient, 60 years of age, weighting 264.6 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: angioedema, arthralgia, blood pressure increased, chest discomfort, chills, dyspepsia, flushing, headache , infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with LORATADINE, METHYLSULFONYLMETHANE, DARVOCET, SYNTHROID, FELDENE, SULAR, CLONIDINE, HYDROCHLOROTHIAZIDE. Patient recovered.

Myozyme Side Effects Report #5424565-6
Myozyme side effect was reported by a Physician from UNITED KINGDOM on June 19, 2007. Female patient, 56 years of age, weighting 183.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, chills, feeling hot, flushing, peripheral circulatory failure. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FLECAINIDE ACETATE, AMITRIPTYLINE, PARACETAMOL, FEMOSTON, FERROUS GLOCUNATE. Patient recovered.

Myozyme Side Effects Report #5248067-5
Myozyme side effect was reported by a Physician from GERMANY on Feb 08, 2007. Female patient, 55 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, chest discomfort, dyspnoea, infusion related reaction, oxygen saturation decreased, respiratory distress. Myozyme dosage: 1200 MG Q2WKS IV. Patient recovered.


Myozyme Side Effects Report #5170229-6
Myozyme side effect was reported by a Physician from GERMANY on Nov 21, 2006. Female patient, 55 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, infusion related reaction, oxygen saturation decreased, respiratory distress. Myozyme dosage: 1200 MG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5582791-X
Myozyme side effect was reported by a Physician from ITALY on Dec 17, 2007. Female patient, 49 years of age, weighting 128.1 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, chest pain , circumoral oedema, flushing, paraesthesia, paraesthesia oral, pruritus, refusal of treatment by patient. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5761739-9
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 16, 2008. Female patient, 48 years of age, weighting 165.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac disorder, chest discomfort, contusion, dyspnoea, hypersensitivity, infusion related reaction, septal panniculitis. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, SYNTHROID, VESICARE, ZOLOFT. Patient recovered.

Myozyme Side Effects Report #5775965-6
Myozyme side effect was reported by a Physician from UNITED STATES on May 30, 2008. Female patient, 48 years of age, weighting 165.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, chest discomfort, dyspnoea, flushing, hypersensitivity, throat tightness. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, SYNTHROID, VESICARE, ZOLOFT. Patient recovered.

Myozyme Side Effects Report #5933430-7
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 16, 2008. Female patient, 48 years of age, weighting 165.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, chest discomfort, dyspnoea, flushing, hypersensitivity, throat tightness. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with DIPHENHYDRAMINE, SYNTHROID, VESICARE, ZOLOFT. Patient recovered.


Myozyme Side Effects Report #5216727-8
Myozyme side effect was reported by a Consumer or non-health professional from FRANCE on Jan 04, 2007. Female patient, 45 years of age, weighting 123.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, back pain , blood pressure decreased, chest discomfort, chest pain , erythema, flushing, infusion related reaction, nausea . Myozyme dosage: unknown. During the same period patient was treated with FERROUS SULPHATE, POLARAMINE, TELFAST. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5285770-5
Myozyme side effect was reported by a Health Professional from UNITED STATES on Oct 10, 2006. Female patient, 45 years of age, weighting 126.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, heart rate increased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with NEXIUM, LISINOPRIL. Patient recovered.

Myozyme Side Effects Report #5192529-6
Myozyme side effect was reported by a Physician from FRANCE on Dec 06, 2006. Female patient, 45 years of age, weighting 123.5 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic shock, back pain , chest discomfort, chest pain , flushing, nausea , oedema, respiratory disorder, skin discolouration. Myozyme dosage: unknown. During the same period patient was treated with FERROUS SULPHATE, POLARAMINE, TELFAST. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5285760-2
Myozyme side effect was reported by a Health Professional from UNITED STATES on Dec 07, 2006. Female patient, 37 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, infusion site reaction. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5236949-X
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Female patient, 37 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin e increased, chest discomfort, chest pain , dyspnoea, feeling abnormal, infusion related reaction, rash , throat tightness, urticaria. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with TYLENOL, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.


Myozyme Side Effects Report #5272563-8
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 08, 2007. Female patient, 37 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , chest discomfort, chest pain , disease recurrence, infusion related reaction, oedema peripheral, rash , skin reaction, throat tightness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with TYLENOL, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5614459-5
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 21, 2008. Female patient, 37 years of age, weighting 112.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , blood immunoglobulin e increased, blood immunoglobulin g increased, chest discomfort, chest pain , dyspnoea, infusion related reaction, oedema peripheral, rash . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ACETAMINOPHEN, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5336329-2
Myozyme side effect was reported by a Physician from UNITED STATES on May 09, 2007. Female patient, 33 years of age, weighting 160.9 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, dizziness , dyspnoea, flushing, headache , hypersensitivity, nausea , oxygen saturation decreased, peak expiratory flow rate decreased. Myozyme dosage: 10 MG/KG QWK IV. During the same period patient was treated with PREDNISONE, SYNTHROID, NAPROXEN, HYDROCODONE BITARTRATE, HYDROCORTISONE. Patient recovered.

Myozyme Side Effects Report #5945821-9
Myozyme side effect was reported by a Health Professional from UNITED KINGDOM on Oct 27, 2008. Female patient, 33 years of age, weighting 112.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, chest discomfort, cold sweat, flushing, malaise, pallor. Myozyme dosage: 1000 MG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5285777-8
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 07, 2006. Male patient, 28 years of age, weighting 95.68 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: chest discomfort, dyspnoea, nausea . Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.


Myozyme Side Effects Report #5081199-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 27, 2006. Male patient, 14 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, bronchospasm, chest discomfort, chills, cyanosis, flushing, infusion related reaction, tachycardia, tachypnoea. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, BENADRYL, TYLENOL, STEROID. Patient recovered.

Myozyme Side Effects Report #5330164-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 01, 2007. Male patient, 13 years of age, weighting 123.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure decreased, chest discomfort, flushing, hyperhidrosis, respiratory tract irritation, spinal disorder, supraventricular tachycardia, weight increased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5302484-3
Myozyme side effect was reported by a Physician from GERMANY on Mar 29, 2007. Female patient, weighting 159.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, chest discomfort, erythema, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.