Myozyme and cardio-respiratory arrest Patient Reports February 13, 2012

Myozyme Side Effects Report #5504701-3
Myozyme side effect was reported by a Consumer or non-health professional from MEXICO on Oct 26, 2007. Female patient, 16 years of age, was diagnosed with mucopolysaccharidosis i and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, upper respiratory tract infection. Myozyme dosage: 0.58 MG/KG QWK IV. Patient died on 09/18/2007.

Myozyme Side Effects Report #5900843-9
Myozyme side effect was reported by a Physician from FRANCE on Sept 11, 2008. Female patient, 74 years of age, weighting 177.7 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, bundle branch block left, cardio-respiratory arrest, dysarthria, electrocardiogram st segment elevation, loss of control of legs, lung disorder, meningioma, meningorrhagia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS : 20 MG/KG, Q2W; INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5491420-5
Myozyme side effect was reported by a Physician from FRANCE on Oct 04, 2007. Male patient, 69 years of age, weighting 141.1 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, herpes zoster, oedema peripheral. Myozyme dosage: 1380 MG Q2WKS IV. Patient died on 10/02/2007.

Myozyme Side Effects Report #5585850-0
Myozyme side effect was reported by a Physician from FRANCE on Dec 14, 2007. Male patient, 69 years of age, weighting 141.1 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, respiratory failure. Myozyme dosage: 1380 MG, Q2W, INTRAVENOUS. During the same period patient was treated with AMOIR, TRANDOLAPRIL, DEBRIDAT, LACTULOSE. Patient died on 10/02/2007.


Myozyme Side Effects Report #5196519-9
Myozyme side effect was reported by a Physician from PORTUGAL on Dec 07, 2006. Female patient, child 5 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, cardio-respiratory arrest, cyanosis, dyspnoea, nasopharyngitis. Myozyme dosage: unknown. Patient died on 12/07/2006.

Myozyme Side Effects Report #5538424-1
Myozyme side effect was reported by a Physician from PORTUGAL on Nov 21, 2007. Female patient, child 5 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, cyanosis, dyspnoea, mydriasis, nasopharyngitis. Myozyme dosage: 20 MG Q2WKS IV. During the same period patient was treated with AMOXICILLIN. Patient died on 12/07/2006.

Myozyme Side Effects Report #5262288-7
Myozyme side effect was reported by a Physician from BRAZIL on Feb 23, 2007. Male patient, 46 years of age, weighting 165.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, respiratory failure. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 01/19/2007.

Myozyme Side Effects Report #5914019-2
Myozyme side effect was reported by a Physician from FRANCE on Sept 23, 2008. Female patient, 40 years of age, weighting 363.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration tracheal, cardio-respiratory arrest, loss of consciousness. Myozyme dosage: 1350 MG, Q2W, INTRAVENOUS. Patient died.

Myozyme Side Effects Report #6003460-8
Myozyme side effect was reported by a Physician from FRANCE on Dec 02, 2008. Male patient, 38 years of age, weighting 194.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, coma, psychotic disorder , refusal of treatment by patient. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with RISPERIDONE. Patient was hospitalized. Patient died on 10/25/2008.


Myozyme Side Effects Report #5383594-1
Myozyme side effect was reported by a Physician from TURKEY on June 27, 2007. Female patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardiac failure, cardio-respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 06/23/2007.

Myozyme Side Effects Report #5564699-9
Myozyme side effect was reported by a Physician from FRANCE on Nov 30, 2007. Male patient, child 1 years of age, weighting 26.46 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anoxia, cardio-respiratory arrest, catheter related infection, convulsion, hypotonia, respiratory failure, salivary hypersecretion, secretion discharge, staphylococcal infection . Myozyme dosage: 30 MG/KG 12WKS IV. During the same period patient was treated with RENITEC, FORTUM, PHOSPHONEUROS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5203378-4
Myozyme side effect was reported by a Physician from GREECE on Dec 22, 2006. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, alanine aminotransferase increased, aspartate aminotransferase increased, cardiac disorder, cardiac index increased, cardio-respiratory arrest, diarrhoea, lower respiratory tract infection. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.

Myozyme Side Effects Report #5229673-0
Myozyme side effect was reported by a Physician from GREECE on Jan 18, 2007. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, alanine aminotransferase increased, aspartate aminotransferase increased, blood immunoglobulin g increased, cardio-respiratory arrest, cardiopulmonary failure, cyanosis, diarrhoea, dilatation ventricular. Myozyme dosage: 20 MG/KG QWK IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.

Myozyme Side Effects Report #5245892-1
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 01, 2007. Male patient, weighting 15.21 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood magnesium increased, blood pressure decreased, cardio-respiratory arrest, heart rate decreased, hypersensitivity, infection , infusion related reaction, respiratory distress, respiratory rate increased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with DIPHENHYDRAMINE, ACETAMINOPHEN, POTASSIUM CHLORIDE, FAMOTIDINE, DIGOXIN, PROPRANOLOL, FUROSEMIDE, HYDROCHLOROTHIAZIDE. Patient recovered.


Myozyme Side Effects Report #5245994-X
Myozyme side effect was reported by a Physician from BRAZIL on Feb 06, 2007. Female patient, weighting 14.00 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaemia, anisocytosis, aspiration, bradycardia, brain oedema, cardio-respiratory arrest, cardiogenic shock, choking , hypotension. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, FERROUS SULPHATE, HYDROCORTISONE, HYDROXYZINE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5254712-0
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 12, 2007. Male patient, weighting 15.21 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood magnesium increased, blood pressure decreased, cardio-respiratory arrest, cough, crying, hypersensitivity, infection , pyrexia, respiratory distress. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with DIPHENHYDRAMINE, ACETAMINOPHEN, POTASSIUM CHLORIDE, FAMOTIDINE, DIGOXIN, PROPRANOLOL, FUROSEMIDE. Patient recovered.

Myozyme Side Effects Report #5290127-7
Myozyme side effect was reported by a Physician from GREECE on Mar 16, 2007. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, alanine aminotransferase increased, antibody test positive, aspartate aminotransferase increased, cardio-respiratory arrest, cardiopulmonary failure, cyanosis, diarrhoea, disease progression. Myozyme dosage: 20 MG/KG QWK IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.

Myozyme Side Effects Report #5298945-6
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 28, 2007. Female patient, weighting 21.16 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac failure, cardio-respiratory arrest, pneumonia , respiratory failure, urinary tract infection . Myozyme dosage: 200 MG Q2WKS IV. During the same period patient was treated with LASIX, CAPTOPRIL, COREG. Patient was hospitalized. Patient died on 02/15/2007.

Myozyme Side Effects Report #5102882-7
Myozyme side effect was reported by a Physician from AUSTRALIA on Aug 08, 2006. Male patient, weighting 11.29 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardio-respiratory arrest, ventricular fibrillation. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FUROSEMIDE, DIAZEPAM, PROPRANOLOL, SPIROOLACTONE. Patient died on 07/26/2006.


Myozyme Side Effects Report #5141827-0
Myozyme side effect was reported by a Physician from PORTUGAL on Oct 13, 2006. Female patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, cardio-respiratory arrest, choking , poor peripheral circulation, vomiting. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL, ACETYLSALICYLIC ACID SRT. Patient died on 10/13/2006.

Myozyme Side Effects Report #5160219-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on Nov 06, 2006. Male patient, weighting 13.23 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest. Myozyme dosage: 20 MG/KG ONCE IV. Patient died on 11/03/2006.

Myozyme Side Effects Report #5199501-0
Myozyme side effect was reported by a Physician from BRAZIL on Dec 15, 2006. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: areflexia, atelectasis, blood calcium decreased, blood glucose increased, blood ph increased, blood potassium decreased, cardiac failure, cardio-respiratory arrest, clonic convulsion. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5404196-4
Myozyme side effect was reported by a Physician from UNITED STATES on July 17, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood gases abnormal, cardio-respiratory arrest, oxygen saturation decreased, pneumonia aspiration, respiratory distress, respiratory failure. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient died on 07/19/2007.

Myozyme Side Effects Report #5416400-7
Myozyme side effect was reported by a Physician from UNITED STATES on July 31, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood chloride decreased, blood glucose increased, blood magnesium increased, blood ph decreased, blood potassium increased, blood sodium decreased, cardio-respiratory arrest, pneumonia aspiration, respiratory failure. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with UNASYN, ARGININ, HYDROCORTISONE, EPINEPHRINE. Patient was hospitalized. Patient died on 07/19/2007.


Myozyme Side Effects Report #5484870-4
Myozyme side effect was reported by a Physician from FRANCE on Sept 26, 2007. Male patient, weighting 26.46 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anoxia, aspiration, bronchial secretion retention, cardiac failure, cardio-respiratory arrest, catheter related infection, convulsion, hypotonia, lung infection. Myozyme dosage: 30 MG/KG Q2WKS IV. During the same period patient was treated with RENITEC, FORTUM, PHOSPHONEUROS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5746819-6
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on May 04, 2008. Male patient, weighting 10.80 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood creatine phosphokinase increased, cardiac failure, cardio-respiratory arrest, disease progression, hypertrophic cardiomyopathy, hypotonia. Myozyme dosage: 20 MG/KG, Q2W. During the same period patient was treated with PROPRANOLOL. Patient died on 04/14/2008.

Myozyme Side Effects Report #5842959-1
Myozyme side effect was reported by a Physician from KUWAIT on July 23, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: body temperature increased, cardio-respiratory arrest, coma, movement disorder , pneumonia , respiratory distress, tachypnoea, wheezing. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS. During the same period patient was treated with VENTOLIN, LASIX, ALDACTONE, CAPTOPRIL, DOPAMINE. Patient was hospitalized. Patient died on 07/18/2008.

Myozyme Side Effects Report #5861825-9
Myozyme side effect was reported by a Physician from BRAZIL on Aug 18, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest. Myozyme dosage: unknown. Patient died on 08/18/2008.

Myozyme Side Effects Report #5874850-9
Myozyme side effect was reported by a Physician from BRAZIL on Aug 28, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, cardiogenic shock. Myozyme dosage: unknown. Patient died on 08/18/2008.


Myozyme Side Effects Report #5930832-X
Myozyme side effect was reported by a Physician from KUWAIT on Oct 16, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, coma, hypotension, pneumonia , pyrexia, respiratory distress, tachycardia, wheezing. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS. During the same period patient was treated with VENTOLIN, LASIX, ALDACTONE, CAPTOPRIL, DOPAMINE. Patient was hospitalized and became disabled. Patient died on 07/18/2008.

Myozyme Side Effects Report #5955955-0
Myozyme side effect was reported by a Health Professional from UNITED STATES on Oct 29, 2008. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, cardio-respiratory arrest, influenza, infusion related reaction, left ventricular hypertrophy, loss of consciousness, pneumonia aspiration, pyrexia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLOVENT. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5973885-5
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 10, 2008. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, apnoea, aspartate aminotransferase increased, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, cardiomegaly, chest x-ray abnormal. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLOVENT. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6021278-7
Myozyme side effect was reported by a Physician from BRAZIL on Dec 15, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, cardiogenic shock, septic shock. Myozyme dosage: 20 MG/KG, ONCE, INTRAVENOUS. Patient died on 08/18/2008.

Myozyme Side Effects Report #6046012-6
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 05, 2009. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, apnoea, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, congestive cardiomyopathy, conjunctivitis, erythema. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 01/05/2009.


Myozyme Side Effects Report #6067772-4
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 27, 2009. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, apnoea, bronchiolitis, cardio-respiratory arrest, chest x-ray abnormal, conjunctivitis, erythema, influenza, infusion related reaction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 01/05/2009.