Myozyme and bronchospasm 
Myozyme and bronchospasm Patient Reports February 13, 2012
Myozyme Side Effects Report #6109493-5
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 20, 2009. Female patient, child 9 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: angioedema, antibody test positive, arthralgia, bronchospasm, catheter site erythema, catheter site pruritus, chest discomfort, cough, cyanosis. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with PREDNISONE, BENADRYL. Patient recovered.
Myozyme Side Effects Report #5226776-1
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 15, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, bradycardia, bronchospasm, cardiac arrest
, gastroenteritis , infusion related reaction, oedema. Myozyme dosage: unknown. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5237944-7
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 29, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, bronchospasm, cardiac arrest
, erythema, gastroenteritis , infusion related reaction, oedema peripheral, rash , vasoconstriction. Myozyme dosage: 40 MG/KG QWK IV. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5255123-4
Myozyme side effect was reported by a Physician from NETHERLANDS on Feb 14, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, autonomic nervous system imbalance, blood immunoglobulin e increased, bradycardia, bronchospasm, cardiac arrest
, eosinophilia, erythema, gastroenteritis . Myozyme dosage: 40 MG/KG QWK IV. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5325824-8
Myozyme side effect was reported by a Physician from GERMANY on Apr 26, 2007. Female patient, 58 years of age, weighting 159.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, dyspnoea, erythema, oxygen saturation decreased, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5248067-5
Myozyme side effect was reported by a Physician from GERMANY on Feb 08, 2007. Female patient, 55 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, chest discomfort, dyspnoea, infusion related reaction, oxygen saturation decreased, respiratory distress. Myozyme dosage: 1200 MG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5585848-2
Myozyme side effect was reported by a Physician from ARGENTINA on Dec 21, 2007. Female patient, child 3 years of age, weighting 35.27 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bronchospasm, device failure, pneumonia
, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUTICASONE PROPIONATE, FERROUS SULPHATE, SALBUTAMOL, CARNITENE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5625286-7
Myozyme side effect was reported by a Physician from ARGENTINA on Jan 30, 2008. Female patient, child 3 years of age, weighting 35.27 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bronchospasm, device failure, infusion related reaction, oxygen saturation decreased, pneumonia
, pyrexia, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUTICASONE PROPIONATE, FEROUS SULPHATE, SALBUTAMOL, CARNITENE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #6081258-2
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 02, 2009. Male patient, child 3 years of age, weighting 37.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, anxiety
, blood pressure decreased, bronchospasm, cyanosis, fatigue, feeding tube complication, flushing, heart rate increased. Myozyme dosage: 350 MG, Q2W, INTRAVENOUS. During the same period patient was treated with BENADRYL, ACETAMINOPHEN, DECADRON. Patient recovered.Myozyme Side Effects Report #6101010-9
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 17, 2009. Male patient, child 3 years of age, weighting 37.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, anxiety
, blood pressure decreased, bronchospasm, cyanosis, fatigue, flushing, heart rate increased, hypoxia. Myozyme dosage: 350 MG, Q2W, INTRAVENOUS. During the same period patient was treated with BENADRYL, ACETAMINOPHEN, DECADRON. Patient recovered.Myozyme Side Effects Report #6125057-1
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 05, 2009. Male patient, child 3 years of age, weighting 37.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, antibody test positive, anxiety
, blood pressure decreased, bronchospasm, cyanosis, fatigue, flushing, hypoxia. Myozyme dosage: 350 MG, Q2W, INTRAVENOUS. During the same period patient was treated with BENADRYL, ACETAMINOPHEN, DECADRON. Patient recovered.Myozyme Side Effects Report #6137899-7
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 17, 2009. Male patient, child 3 years of age, weighting 37.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, anxiety
, blood pressure decreased, bronchospasm, cyanosis, fatigue, flushing, heart rate increased, hypoxia. Myozyme dosage: 350 MG, Q2W, INTRAVENOUS. During the same period patient was treated with BENADRYL, ACETAMINOPHEN, DECADRON. Patient recovered.Myozyme Side Effects Report #5081199-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 27, 2006. Male patient, 14 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood pressure increased, bronchospasm, chest discomfort, chills, cyanosis, flushing, infusion related reaction, tachycardia, tachypnoea. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, BENADRYL, TYLENOL, STEROID. Patient recovered.
Myozyme Side Effects Report #5339799-9
Myozyme side effect was reported by a Physician from UNITED STATES on May 11, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, bronchospasm, disease recurrence, hypotension, oxygen saturation decreased, wheezing. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5460684-6
Myozyme side effect was reported by a Physician from BRAZIL on Sept 04, 2007. Male patient, child 1 years of age, weighting 21.58 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, body temperature increased, bronchospasm, cyanosis, hyperhidrosis, hypertrophic cardiomyopathy, pallor, palmar erythema, peripheral coldness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, PROPRANOLOL, CAPTOPRIL. Patient recovered.
Myozyme Side Effects Report #5504743-8
Myozyme side effect was reported by a Physician from SPAIN on Oct 17, 2007. Male patient, child 1 years of age, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, hyperhidrosis, infusion related reaction, lip oedema, pharyngeal oedema, respiratory arrest, stridor, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.
Myozyme Side Effects Report #5302484-3
Myozyme side effect was reported by a Physician from GERMANY on Mar 29, 2007. Female patient, weighting 159.8 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, chest discomfort, erythema, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5372572-4
Myozyme side effect was reported by a Physician from MALAYSIA on June 12, 2007. Female patient, weighting 13.23 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arrhythmia
, asthma , bronchial hyperreactivity, bronchospasm, pneumonia aspiration, ventricular fibrillation. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 06/12/2007.Myozyme Side Effects Report #5097560-7
Myozyme side effect was reported by a Physician from BRAZIL on Aug 18, 2006. Male patient, weighting 19.82 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, cyanosis, infusion related reaction, pallor, rash
, vomiting. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, CAPTOPRIL, LASIX. Patient recovered.Myozyme Side Effects Report #5106859-7
Myozyme side effect was reported by a Physician from BRAZIL on Aug 31, 2006. Male patient, weighting 19.82 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, complement factor increased, cyanosis, erythema, infusion related reaction, lethargy, oxygen saturation decreased, pallor, rash
. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, CAPTOPRIL, LASIX. Patient recovered.Myozyme Side Effects Report #5408309-X
Myozyme side effect was reported by a Physician from MALAYSIA on July 26, 2007. Female patient, weighting 13.23 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, ventricular fibrillation, ventricular tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with SALBUTAMOL, HYDROCORTISONE, ANTIBIOTICS, FUROSEMIDE. Patient died on 06/12/2007.
Myozyme Side Effects Report #5449823-0
Myozyme side effect was reported by a Physician from SPAIN on Aug 27, 2007. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, cyanosis, dyspnoea, hyperhidrosis, infusion related reaction, lip oedema, nasopharyngitis, pharyngeal oedema. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.
Myozyme Side Effects Report #5477556-3
Myozyme side effect was reported by a Physician from SPAIN on Sept 18, 2007. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, hyperhidrosis, infusion related reaction, lip oedema, pharyngeal oedema, respiratory arrest, stridor, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ACTOCORTINA, SPIRONOLACTONE, CARVEDILOL. Patient recovered.
Myozyme Side Effects Report #5689669-1
Myozyme side effect was reported by a Physician from SPAIN on Mar 13, 2008. Male patient, weighting 27.56 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaphylactic reaction, bronchospasm, cardiac failure, cyanosis, infusion related reaction, nasopharyngitis, respiratory arrest, respiratory failure, transaminases increased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS; 40 MG/KG, Q2W, INTRAVENOUS; 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 02/01/2008.
Myozyme Side Effects Report #5714330-4
Myozyme side effect was reported by a Physician from ISRAEL on Apr 10, 2008. Male patient, weighting 21.83 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, cyanosis, dyspnoea, hypersensitivity, oxygen saturation decreased. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL. Patient recovered.
Myozyme Side Effects Report #5724720-1
Myozyme side effect was reported by a Health Professional from ISRAEL on Apr 18, 2008. Male patient, weighting 21.83 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, cyanosis, dyspnoea, hypersensitivity, oxygen saturation decreased. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL. Patient recovered.
Myozyme Side Effects Report #5747234-1
Myozyme side effect was reported by a Physician from ISRAEL on Apr 27, 2008. Male patient, weighting 21.83 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bronchospasm, cyanosis, dyspnoea, hypersensitivity, oxygen saturation decreased. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL. Patient recovered.
Myozyme Side Effects Report #5988374-1
Myozyme side effect was reported by a Physician from CROATIA (local name: Hrvatska) on Nov 24, 2008. Female patient, weighting 18.52 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood pressure increased, bronchial obstruction, bronchospasm, dyspnoea, hypersensitivity, infusion related reaction, irritability. Myozyme dosage: 200 MG, QW, INTRAVENOUS : 200 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5995076-4
Myozyme side effect was reported by a Physician from CROATIA (local name: Hrvatska) on Dec 05, 2008. Female patient, weighting 18.52 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood pressure increased, bronchial obstruction, bronchospasm, dyspnoea, hypersensitivity, irritability, nosocomial infection, oxygen saturation decreased. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #6030969-3
Myozyme side effect was reported by a Physician from CROATIA (local name: Hrvatska) on Dec 15, 2008. Female patient, weighting 18.52 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood pressure increased, bronchial obstruction, bronchospasm, hypersensitivity, infusion related reaction, irritability, no therapeutic response, nosocomial infection. Myozyme dosage: 200 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.