Myozyme and bradycardia 
Myozyme and bradycardia Patient Reports February 13, 2012
Myozyme Side Effects Report #5226776-1
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 15, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, bradycardia, bronchospasm, cardiac arrest
, gastroenteritis , infusion related reaction, oedema. Myozyme dosage: unknown. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5237944-7
Myozyme side effect was reported by a Physician from NETHERLANDS on Jan 29, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, bronchospasm, cardiac arrest
, erythema, gastroenteritis , infusion related reaction, oedema peripheral, rash , vasoconstriction. Myozyme dosage: 40 MG/KG QWK IV. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5255123-4
Myozyme side effect was reported by a Physician from NETHERLANDS on Feb 14, 2007. Female patient, child 8 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain upper, autonomic nervous system imbalance, blood immunoglobulin e increased, bradycardia, bronchospasm, cardiac arrest
, eosinophilia, erythema, gastroenteritis . Myozyme dosage: 40 MG/KG QWK IV. During the same period patient was treated with ZYRTEC, HYDROCORTISONE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5940267-1
Myozyme side effect was reported by a Physician from FRANCE on Oct 21, 2008. Female patient, 73 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, bradycardia, bronchitis
, cough, cyanosis, dysphagia, electrocardiogram abnormal, hypotension, tachypnoea. Myozyme dosage: unknown. During the same period patient was treated with TAMSULOSIN. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #6060121-7
Myozyme side effect was reported by a Physician from FRANCE on Jan 15, 2009. Female patient, 73 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, acute respiratory failure, bradycardia, bronchitis
, disease complication, dysphagia, heart sounds abnormal, hypotension. Myozyme dosage: unknown. During the same period patient was treated with TAMSULOSIN, AUGMENTIN, ANTIBIOTICS. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5401311-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 11, 2007. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction, prophylaxis and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain
, blood immunoglobulin g increased, bradycardia, chills, hypotension, hypothermia , infusion related reaction, myocardial infarction, pallor. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5752263-8
Myozyme side effect was reported by a Physician from UNITED STATES on May 14, 2008. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain
, bradycardia, chills, hypersensitivity, hypotension, hypothermia , infusion related reaction, myocardial infarction. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5766642-6
Myozyme side effect was reported by a Physician from UNITED STATES on May 27, 2008. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain
, bradycardia, chills, hypersensitivity, hypotension, hypothermia , myocardial infarction, pallor. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5887098-9
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Sept 03, 2008. Female patient, child 3 years of age, weighting 24.03 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, hypoxia, impaired gastric emptying, nausea , occult blood positive, respiratory failure, upper gastrointestinal haemorrhage. Myozyme dosage: 138 MG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #6024105-7
Myozyme side effect was reported by a Physician from UNITED STATES on Dec 18, 2008. Male patient, 23 years of age, weighting 56.44 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atrial fibrillation
, blood glucose increased, blood potassium decreased, blood pressure decreased, bradycardia, bundle branch block left, coma, respiratory arrest, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS, 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 12/19/2008.Myozyme Side Effects Report #5483158-5
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Sept 25, 2007. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, infusion related reaction, mechanical ventilation, myocardial ischaemia, nausea , oxygen saturation decreased, regurgitation, respiratory failure. Myozyme dosage: unknown. Patient recovered.Myozyme Side Effects Report #5502146-3
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Oct 16, 2007. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, impaired gastric emptying, myocardial ischaemia, nausea
, ventricular extrasystoles. Myozyme dosage: unknown. Patient recovered.Myozyme Side Effects Report #5510570-8
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 23, 2007. Female patient, child 2 years of age, weighting 28.22 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, conjunctivitis, decubitus ulcer, disease recurrence, hypoxia, pneumonia
, tracheitis. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, PREVACID, ENALAPRIL MALEATE, ALBUTEROL, ATROVENT. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5694194-8
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Mar 20, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, impaired gastric emptying, ischaemia, oesophageal obstruction, pyloric stenosis, staphylococcal infection
. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5718873-9
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Apr 09, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, ill-defined disorder, impaired gastric emptying, myocardial ischaemia, nausea
, oesophageal disorder. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5797830-0
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on June 23, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: activities of daily living impaired, atelectasis, blood cholesterol increased, blood culture positive, blood triglycerides increased, bradycardia, electrocardiogram st segment depression, electrocardiogram t wave inversion, hypertrophic cardiomyopathy. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #6081259-4
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 02, 2009. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac disorder, cyanosis, oxygen saturation decreased, respiratory arrest. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 02/02/2009.
Myozyme Side Effects Report #5450622-4
Myozyme side effect was reported by a Health Professional from UNITED STATES on Aug 27, 2007. Female patient, child 1 years of age, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, catheter related infection, culture positive, device failure, device related infection, fungal infection
, infusion related reaction, respiratory distress. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5226048-5
Myozyme side effect was reported by a Physician from BRAZIL on Jan 15, 2007. Female patient, weighting 14.00 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, choking
, cough, dysphagia, fatigue, haematocrit decreased, heart rate decreased, hypotension. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, FERROUS SULPHATE, HYDROCORTISONE, HYDROXYZINE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5285771-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on Oct 30, 2006. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with TYLENOL, BENADRYL. Patient recovered.
Myozyme Side Effects Report #5245994-X
Myozyme side effect was reported by a Physician from BRAZIL on Feb 06, 2007. Female patient, weighting 14.00 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaemia, anisocytosis, aspiration, bradycardia, brain oedema, cardio-respiratory arrest, cardiogenic shock, choking
, hypotension. Myozyme dosage: 20 MG/KG IV. During the same period patient was treated with PROPRANOLOL, FERROUS SULPHATE, HYDROCORTISONE, HYDROXYZINE. Patient was hospitalized. Patient recovered.Myozyme Side Effects Report #5268621-4
Myozyme side effect was reported by a Physician from BRAZIL on Feb 28, 2007. Female patient, weighting 16.31 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, brain oedema, cardiogenic shock, cardiomyopathy
, cyanosis, disease progression, pyrexia, tachycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with CARVEDILOL, CAPTOPRIL. Patient died on 02/13/2007.Myozyme Side Effects Report #5291323-5
Myozyme side effect was reported by a Physician from BRAZIL on Mar 20, 2007. Female patient, weighting 16.31 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, brain herniation, brain oedema, cardiogenic shock, cyanosis, disease progression, gastrointestinal haemorrhage, haematocrit decreased, haemoglobin decreased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with CARVEDILOL, CAPTOPRIL, RANITIDINE, PROTOVIT, FERROUS SULPHATE, ASCORBIC ACID, ZINC SULPHATE. Patient died on 02/13/2007.
Myozyme Side Effects Report #5298945-6
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 28, 2007. Female patient, weighting 21.16 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac failure, cardio-respiratory arrest, pneumonia
, respiratory failure, urinary tract infection . Myozyme dosage: 200 MG Q2WKS IV. During the same period patient was treated with LASIX, CAPTOPRIL, COREG. Patient was hospitalized. Patient died on 02/15/2007.Myozyme Side Effects Report #5089452-4
Myozyme side effect was reported by a Physician from AUSTRALIA on July 26, 2006. Male patient, weighting 11.29 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arrhythmia
, bradycardia, ventricular fibrillation. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 07/26/2006.Myozyme Side Effects Report #5102882-7
Myozyme side effect was reported by a Physician from AUSTRALIA on Aug 08, 2006. Male patient, weighting 11.29 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardio-respiratory arrest, ventricular fibrillation. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FUROSEMIDE, DIAZEPAM, PROPRANOLOL, SPIROOLACTONE. Patient died on 07/26/2006.
Myozyme Side Effects Report #5141827-0
Myozyme side effect was reported by a Physician from PORTUGAL on Oct 13, 2006. Female patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, cardio-respiratory arrest, choking
, poor peripheral circulation, vomiting. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with FUROSEMIDE, CAPTOPRIL, ACETYLSALICYLIC ACID SRT. Patient died on 10/13/2006.Myozyme Side Effects Report #5148156-X
Myozyme side effect was reported by a Physician from BRAZIL on Oct 23, 2006. Male patient, weighting 16.53 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, cardiac failure, condition aggravated, heart rate increased, pneumonia , respiratory rate increased, shock, ventricular fibrillation. Myozyme dosage: 20 MG/KG ONCE IV. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE. Patient died on 10/23/2006.Myozyme Side Effects Report #5382043-7
Myozyme side effect was reported by a Physician from UNITED STATES on June 21, 2007. Female patient, weighting 15.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with PULMICORT, ALBUTEROL, CAPTOPRIL, PREVACID. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #5424562-0
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 03, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.
Myozyme Side Effects Report #5586084-6
Myozyme side effect was reported by a Health Professional from UNITED STATES on Dec 27, 2007. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, catheter related infection, hypoxic encephalopathy, influenza, infusion related reaction, respiratory distress, respiratory failure, sepsis . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 12/21/2007.Myozyme Side Effects Report #5587783-2
Myozyme side effect was reported by a Physician from UNITED STATES on Dec 27, 2007. Female patient, weighting 7.72 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest
, hypoperfusion, pyrexia. Myozyme dosage: 20 MG/KG, ONCE, INTRAVENOUS. During the same period patient was treated with MILRINONE, FENTANYL, DOPAMINE, ESMOLOL, EPINEPHRINE, PANCURONIUM, FUROSEMIDE, VANCOMYCIN. Patient was hospitalized. Patient died on 12/16/2007.Myozyme Side Effects Report #5614282-1
Myozyme side effect was reported by a Physician from GERMANY on Jan 29, 2008. Male patient, weighting 12.79 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, failure to thrive, no therapeutic response, oxygen saturation decreased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CARVEDILOL, SPIRONOLACTONE, ALANINE. Patient recovered.
Myozyme Side Effects Report #5724272-6
Myozyme side effect was reported by a Physician from GERMANY on Apr 19, 2008. Male patient, weighting 12.79 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, bradycardia, developmental delay, failure to thrive, muscle disorder
, no therapeutic response, oxygen saturation decreased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CARVEDILOL, SPIRONOLACTONE, ALANINE. Patient recovered.Myozyme Side Effects Report #5894672-2
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Sept 10, 2008. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, blood creatine phosphokinase increased, bradycardia, collapse of lung, dysphagia, dyspnoea, hepatomegaly, hypertrophic cardiomyopathy, hypotonia. Myozyme dosage: 40 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CARVEDILOL, LASIX. Patient recovered.
Myozyme Side Effects Report #5973885-5
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 10, 2008. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, apnoea, aspartate aminotransferase increased, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, cardiomegaly, chest x-ray abnormal. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLOVENT. Patient was hospitalized. Patient recovered.
Myozyme Side Effects Report #6046012-6
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 05, 2009. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, apnoea, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, congestive cardiomyopathy, conjunctivitis, erythema. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 01/05/2009.