Myozyme and blood immunoglobulin g increased Patient Reports February 13, 2012

Myozyme Side Effects Report #5796386-6
Myozyme side effect was reported by a Physician from UNITED STATES on June 19, 2008. Female patient, child 9 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, blood immunoglobulin g increased, catheter site erythema, catheter site pruritus, cough, dyspnoea, flushing, headache . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with PREDNISONE, BENADRYL. Patient recovered.

Myozyme Side Effects Report #5401311-3
Myozyme side effect was reported by a Physician from UNITED STATES on July 11, 2007. Female patient, 61 years of age, weighting 121.3 lb, was diagnosed with glycogen storage disease type ii, infusion related reaction, prophylaxis and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , blood immunoglobulin g increased, bradycardia, chills, hypotension, hypothermia , infusion related reaction, myocardial infarction, pallor. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with EPINEPHRINE, EVISTA, CALTRATE, ALPHAGAN, CENTRUM, ADVIL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6067771-2
Myozyme side effect was reported by a Health Professional from UNITED STATES on Jan 20, 2009. Male patient, 60 years of age, weighting 264.6 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, blood immunoglobulin g increased, blood pressure increased, cardiac disorder, chest discomfort, chills, dyspepsia, fall , flushing. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with LORATADINE, METHYLSULFONYLMETHANE, DARVOCET, SYNTHROID, FELDENE, SULAR, CLONIDINE, HYDROCHLOROTHIAZIDE. Patient recovered.

Myozyme Side Effects Report #6065653-3
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Jan 22, 2009. Female patient, child 4 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, blood immunoglobulin g increased, cardiac arrest , escherichia urinary tract infection, hypokalaemia, hypoxia, impaired gastric emptying, leukopenia, lobar pneumonia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with PNEUMOCOCCAL CONJUGATE VACCINE. Patient recovered.


Myozyme Side Effects Report #5614459-5
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 21, 2008. Female patient, 37 years of age, weighting 112.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , blood immunoglobulin e increased, blood immunoglobulin g increased, chest discomfort, chest pain , dyspnoea, infusion related reaction, oedema peripheral, rash . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ACETAMINOPHEN, BENADRYL, TOPROL, CELEBREX, PAXIL. Patient recovered.

Myozyme Side Effects Report #5249165-2
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Feb 09, 2007. Male patient, child 3 years of age, weighting 32.85 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, arthropod bite, aspartate aminotransferase increased, band neutrophil percentage increased, behcet's syndrome , blister, blood immunoglobulin g increased, blood lactate dehydrogenase increased, bone density decreased. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, AMBROXOL, CARDIOLOL, ISOMIL, BIOCAL, ANTIBIOPHILUS. Patient was hospitalized and became disabled. Patient recovered.

Myozyme Side Effects Report #5988186-9
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 21, 2008. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alopecia, blood immunoglobulin g increased, bronchial disorder, cardiac hypertrophy, cardiomyopathy , dehydration, disease progression, foreign body trauma, pneumonia . Myozyme dosage: unknown. Patient recovered.

Myozyme Side Effects Report #5692632-8
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 19, 2008. Male patient, 22 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthropathy, blood immunoglobulin g increased, hypochromic anaemia, joint effusion, oedema peripheral, pain in extremity, pain in jaw, pleuritic pain, red blood cell sedimentation rate increased. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5512664-X
Myozyme side effect was reported by a Physician from CHINA on Oct 22, 2007. Female patient, child 2 years of age, weighting 13.87 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, alpha haemolytic streptococcal infection, blood immunoglobulin g increased, blood sodium decreased, cardiac failure, condition aggravated, electrolyte imbalance, fluid retention, gene mutation identification test positive. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with MILRINONE. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #6139096-8
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 18, 2009. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cardiopulmonary failure, influenza. Myozyme dosage: 20 MG/KG, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5366201-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 05, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, dysphagia, hypertension, hypertonia, hypoxia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5564570-2
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 30, 2007. Male patient, child 1 years of age, weighting 21.83 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alpha haemolytic streptococcal infection, areflexia, aspiration, blood immunoglobulin g increased, blood pressure diastolic decreased, bronchoalveolar lavage abnormal, catheter related infection, condition aggravated, dilatation ventricular. Myozyme dosage: unknown. During the same period patient was treated with RITUXIMAB, METHOTREXATE, IMMUNE GLOBULIN INTRAVENOUS, BENADRYL, TYLENOL, BUDESONIDE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5229673-0
Myozyme side effect was reported by a Physician from GREECE on Jan 18, 2007. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, alanine aminotransferase increased, aspartate aminotransferase increased, blood immunoglobulin g increased, cardio-respiratory arrest, cardiopulmonary failure, cyanosis, diarrhoea, dilatation ventricular. Myozyme dosage: 20 MG/KG QWK IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.

Myozyme Side Effects Report #5233304-3
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood creatine phosphokinase increased, blood immunoglobulin g increased, c-reactive protein increased, candidiasis, central line infection, echocardiogram abnormal, enterococcal infection, eyelid function disorder. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE, BENADRYL. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5294077-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on Mar 23, 2007. Male patient, weighting 11.68 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bacteraemia, blepharospasm, blood culture positive, blood immunoglobulin g increased, body temperature decreased, bronchial hyperreactivity, central line infection, condition aggravated, device related infection. Myozyme dosage: unknown. During the same period patient was treated with BACTRIM. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5314296-5
Myozyme side effect was reported by a Physician from UNITED STATES on Apr 11, 2007. Male patient, weighting 11.90 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, anti-platelet antibody positive, aspartate aminotransferase increased, bacteraemia, blood alkaline phosphatase increased, blood culture positive, blood immunoglobulin g increased, catheter related infection, enterococcal infection. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with PULMICORT, XOPENEX, TYLENOL, CHLORAL HYDRATE, LASIX, NYSTATIN, VITAMIN D. Patient recovered.

Myozyme Side Effects Report #5093635-7
Myozyme side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 15, 2006. Male patient, weighting 16.53 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin e increased, blood immunoglobulin g increased, blood pressure decreased, infusion related reaction, tachycardia, urticaria. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CLARINEX, DIPHENHYDRAMINE, RANITIDINE, XOPENEX, PULMICORT, REGLAN. Patient recovered.

Myozyme Side Effects Report #5390882-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on July 02, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, condition aggravated, disease progression, dysphagia, glycogen storage disease type ii. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient died on 06/30/2007.

Myozyme Side Effects Report #5829500-4
Myozyme side effect was reported by a Physician from UNITED STATES on July 16, 2008. Female patient, weighting 7.94 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, catheter placement, diarrhoea, oxygen saturation decreased, vomiting. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5875731-7
Myozyme side effect was reported by a Physician from UNITED STATES on Aug 27, 2008. Male patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood immunoglobulin g increased, blood pressure decreased, crying, hyperhidrosis, infusion related reaction, nasal congestion, oxygen saturation decreased, pallor. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with RANITIDINE, PREDNISONE, CETIRIZINE, XOPENEX, PULMICORT, IPRATROPIUM BR, METOCLOPRAMIDE, FLUCONAZOLE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5885628-4
Myozyme side effect was reported by a Physician from CHINA on Sept 08, 2008. Female patient, weighting 13.89 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acinetobacter infection, alpha haemolytic streptococcal infection, aspiration tracheal abnormal, blood immunoglobulin g increased, blood sodium decreased, cardiac arrest , cardiac failure, condition aggravated, disease recurrence. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with MILRINONE. Patient was hospitalized. Patient died on 09/06/2008.

Myozyme Side Effects Report #5887199-5
Myozyme side effect was reported by a Physician from JAPAN on Sept 02, 2008. Male patient, weighting 30.86 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, erythema, infusion related reaction, oxygen saturation decreased, rash . Myozyme dosage: 300 MG, Q2W, INTRAVENOUS. During the same period patient was treated with ATARAX, ENALAPRIL MALEATE, ANTIBIOTICS, FUROSEMIDE, ASPIRIN, PICOSULPHATE. Patient recovered.

Myozyme Side Effects Report #5945735-4
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Oct 31, 2008. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, congestive cardiomyopathy, malaise, muscular weakness, respiratory failure, respiratory tract infection. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient recovered.

Myozyme Side Effects Report #5989754-0
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Dec 02, 2008. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cytomegalovirus infection , hypokinesia, muscular weakness, pyrexia, social avoidant behaviour. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.


Myozyme Side Effects Report #6052485-5
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 14, 2009. Female patient, weighting 17.42 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: bacteraemia, blood immunoglobulin g increased, blood pressure decreased, cardiac murmur, catheter related infection, enterococcal infection, escherichia infection, febrile convulsion, heart rate increased. Myozyme dosage: 20 MG/KG, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6088082-5
Myozyme side effect was reported by a Physician from UNITED KINGDOM on Feb 09, 2009. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, cardiac hypertrophy, cardiomegaly, cardiopulmonary failure, congestive cardiomyopathy, infusion related reaction, muscular weakness, respiratory failure. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS; 20 MG/KG, QW, INTRAVENOUS. During the same period patient was treated with DESLORATADINE, ASPIRIN, CAPTOPRIL, CARVEDILOL, FUROSEMIDE. Patient died on 11/05/2008.

Myozyme Side Effects Report #6088083-7
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Feb 11, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bacteria sputum identified, blood immunoglobulin g increased, breath sounds abnormal, collapse of lung, dysphonia, escherichia infection, hypercapnia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with SMECTA, ZYRTEC, SINGULAIR. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6131096-7
Myozyme side effect was reported by a Physician from UNITED ARAB EMIRATES on Mar 10, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, blood immunoglobulin g increased, diarrhoea, dysphagia, erythema, hypotonia, infusion related reaction, lung infection. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with STEROIDS, ACETAMINOPHEN, PREDNISOLONE, METHYLPREDNISOLONE, ANTIHISTAMINES, HYDROCORTISONE, ZANTAC. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6133166-6
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 11, 2009. Female patient, weighting 7.94 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: blood immunoglobulin g increased, central venous catheterisation, oxygen saturation decreased, post procedural complication, post procedural diarrhoea, procedural vomiting. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.