Myozyme and atelectasis Patient Reports February 13, 2012

Myozyme Side Effects Report #6065653-3
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Jan 22, 2009. Female patient, child 4 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, blood immunoglobulin g increased, cardiac arrest , escherichia urinary tract infection, hypokalaemia, hypoxia, impaired gastric emptying, leukopenia, lobar pneumonia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with PNEUMOCOCCAL CONJUGATE VACCINE. Patient recovered.

Myozyme Side Effects Report #6077634-4
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Feb 02, 2009. Female patient, child 4 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, escherichia urinary tract infection, hypercapnia, hypokalaemia, lethargy, leukopenia, lobar pneumonia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with PNEUMOCOCCAL CONJUGATE VACCINE. Patient recovered.

Myozyme Side Effects Report #5585848-2
Myozyme side effect was reported by a Physician from ARGENTINA on Dec 21, 2007. Female patient, child 3 years of age, weighting 35.27 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bronchospasm, device failure, pneumonia , respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUTICASONE PROPIONATE, FERROUS SULPHATE, SALBUTAMOL, CARNITENE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5625286-7
Myozyme side effect was reported by a Physician from ARGENTINA on Jan 30, 2008. Female patient, child 3 years of age, weighting 35.27 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bronchospasm, device failure, infusion related reaction, oxygen saturation decreased, pneumonia , pyrexia, respiratory distress. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with FLUTICASONE PROPIONATE, FEROUS SULPHATE, SALBUTAMOL, CARNITENE. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5328162-2
Myozyme side effect was reported by a Physician from ARGENTINA on Apr 30, 2007. Male patient, child 2 years of age, weighting 30.86 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, device migration, hypoxia, pyrexia, tracheal disorder. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, FLUTICASONE PROPIONATE, ALBUTEROL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5510570-8
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 23, 2007. Female patient, child 2 years of age, weighting 28.22 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, conjunctivitis, decubitus ulcer, disease recurrence, hypoxia, pneumonia , tracheitis. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, PREVACID, ENALAPRIL MALEATE, ALBUTEROL, ATROVENT. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5694194-8
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Mar 20, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, impaired gastric emptying, ischaemia, oesophageal obstruction, pyloric stenosis, staphylococcal infection . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5718873-9
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Apr 09, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, hypertrophic cardiomyopathy, hypotension, ill-defined disorder, impaired gastric emptying, myocardial ischaemia, nausea , oesophageal disorder. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5797830-0
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on June 23, 2008. Female patient, child 2 years of age, weighting 24.25 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: activities of daily living impaired, atelectasis, blood cholesterol increased, blood culture positive, blood triglycerides increased, bradycardia, electrocardiogram st segment depression, electrocardiogram t wave inversion, hypertrophic cardiomyopathy. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5783173-8
Myozyme side effect was reported by a Physician from COLOMBIA on June 06, 2008. Male patient, 13 years of age, weighting 99.21 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, pneumonia . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with THEOPHYLLINE, FLUOXETINE, SALBUTAMOL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5847461-9
Myozyme side effect was reported by a Physician from COLOMBIA on July 30, 2008. Male patient, 13 years of age, weighting 99.21 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, pleural effusion, pneumonia , tibia fracture. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with THEOPHYLLINE, FLUOXETINE, SALBUTAMOL. Patient recovered.

Myozyme Side Effects Report #5366201-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 05, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, dysphagia, hypertension, hypertonia, hypoxia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5375663-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 18, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, acute respiratory distress syndrome, aspiration, asthenia, atelectasis, condition aggravated, disease progression, disease recurrence, dysphagia. Myozyme dosage: 20 MG/KG Q2WKS; IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5375663-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 18, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, acute respiratory distress syndrome, aspiration, asthenia, atelectasis, condition aggravated, disease progression, disease recurrence, dysphagia. Myozyme dosage: 20 MG/KG Q2WKS; IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5460684-6
Myozyme side effect was reported by a Physician from BRAZIL on Sept 04, 2007. Male patient, child 1 years of age, weighting 21.58 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, body temperature increased, bronchospasm, cyanosis, hyperhidrosis, hypertrophic cardiomyopathy, pallor, palmar erythema, peripheral coldness. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, PROPRANOLOL, CAPTOPRIL. Patient recovered.

Myozyme Side Effects Report #5209130-8
Myozyme side effect was reported by a Physician from BRAZIL on Dec 28, 2006. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: areflexia, atelectasis, blood calcium increased, blood glucose increased, blood lactic acid increased, blood potassium decreased, cardiac failure, cardio-respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient recovered.

Myozyme Side Effects Report #5286975-X
Myozyme side effect was reported by a Physician from BRAZIL on Mar 14, 2007. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, cardiac arrest , hypertrophic cardiomyopathy, mitral valve incompetence, pneumonia , rhinorrhoea. Myozyme dosage: 20 MG/KG, Q2WKS; IV. During the same period patient was treated with ALPHA. Patient died on 03/14/2007.

Myozyme Side Effects Report #5293816-3
Myozyme side effect was reported by a Physician from BRAZIL on Mar 22, 2007. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abnormal faeces, areflexia, atelectasis, blood bicarbonate increased, blood calcium decreased, blood glucose increased, blood lactic acid increased, blood ph increased. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5350978-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 23, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, aspiration, asthenia, atelectasis, dysphagia, hypertension, hypertonia, respiratory syncytial virus infection . Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5369481-3
Myozyme side effect was reported by a Physician from UNITED STATES on June 06, 2007. Male patient, weighting 16.76 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: anaemia, atelectasis, blood culture positive, cardiac failure acute, condition aggravated, dilatation ventricular, heart rate decreased, lung infiltration. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with UNASYN, FENTANYL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5081197-X
Myozyme side effect was reported by a Physician from UNITED STATES on July 27, 2006. Female patient, weighting 22.07 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, atelectasis, bacterial culture positive, bronchiolitis, hypotension, hypoventilation, klebsiella infection, left ventricle outflow tract obstruction, listless. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5196520-5
Myozyme side effect was reported by a Consumer or non-health professional from GERMANY on Dec 08, 2006. Female patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, atelectasis, cardiac arrest , cardiac failure congestive, cardiac ventricular disorder, pleural effusion, respiratory disorder. Myozyme dosage: 20 MG/KG QOW IV. During the same period patient was treated with ALPHA. Patient was hospitalized. Patient died on 12/06/2006.

Myozyme Side Effects Report #5199501-0
Myozyme side effect was reported by a Physician from BRAZIL on Dec 15, 2006. Female patient, weighting 20.06 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: areflexia, atelectasis, blood calcium decreased, blood glucose increased, blood ph increased, blood potassium decreased, cardiac failure, cardio-respiratory arrest, clonic convulsion. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5382043-7
Myozyme side effect was reported by a Physician from UNITED STATES on June 21, 2007. Female patient, weighting 15.48 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bradycardia, respiratory arrest. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with PULMICORT, ALBUTEROL, CAPTOPRIL, PREVACID. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5390882-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on July 02, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, condition aggravated, disease progression, dysphagia, glycogen storage disease type ii. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient died on 06/30/2007.

Myozyme Side Effects Report #5681087-5
Myozyme side effect was reported by a Consumer or non-health professional from TAIWAN, PROVINCE OF CHINA on Mar 13, 2008. Female patient, weighting 20.50 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, atelectasis, bronchiolitis, catheter related infection, gastric haemorrhage, left ventricular hypertrophy, lymphocytosis, neutropenia. Myozyme dosage: 40 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with CAPTOPRIL, FUROSEMIDE, CARVEDILOL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5796381-7
Myozyme side effect was reported by a Physician from UNITED STATES on June 18, 2008. Male patient, weighting 11.90 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, band neutrophil percentage decreased, blood magnesium increased, faeces discoloured, grunting, hypertrophic cardiomyopathy, irritability, lymphocyte percentage increased, metapneumovirus infection. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with OXYGEN. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5973885-5
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 10, 2008. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, apnoea, aspartate aminotransferase increased, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, cardiomegaly, chest x-ray abnormal. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLOVENT. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6046012-6
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 05, 2009. Male patient, weighting 22.05 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: agitation, apnoea, atelectasis, bradycardia, bronchiolitis, cardio-respiratory arrest, congestive cardiomyopathy, conjunctivitis, erythema. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 01/05/2009.


Myozyme Side Effects Report #6088083-7
Myozyme side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Feb 11, 2009. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, bacteria sputum identified, blood immunoglobulin g increased, breath sounds abnormal, collapse of lung, dysphonia, escherichia infection, hypercapnia. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with SMECTA, ZYRTEC, SINGULAIR. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6111986-1
Myozyme side effect was reported by a Physician from CANADA on Mar 03, 2009. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: aspiration, atelectasis, choking . Myozyme dosage: unknown. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6130974-2
Myozyme side effect was reported by a Physician from CANADA on Mar 13, 2009. Female patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: atelectasis, choking . Myozyme dosage: unknown. Patient was hospitalized. Patient recovered.