Myozyme and asthenia Patient Reports February 12, 2012

Myozyme Side Effects Report #6137500-2
Myozyme side effect was reported by a Physician from ITALY on Mar 23, 2009. Male patient, 73 years of age, weighting 174.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, asthmatic crisis, influenza like illness. Myozyme dosage: 20 MG/KG, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5680877-2
Myozyme side effect was reported by a Health Professional from UNITED STATES on Mar 15, 2008. Female patient, 72 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, bedridden, decreased appetite, respiratory failure. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient died on 12/13/2007.

Myozyme Side Effects Report #5122378-6
Myozyme side effect was reported by a Physician from UNITED STATES on Sept 20, 2006. Male patient, 71 years of age, weighting 201.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, bladder injury, post procedural complication, urinary tract infection , viral infection . Myozyme dosage: 20 MG/KG Q2WKS IV. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5156536-1
Myozyme side effect was reported by a Physician from UNITED STATES on Oct 30, 2006. Male patient, 71 years of age, weighting 201.3 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, bladder perforation, catheter related complication, iatrogenic injury, infusion related reaction, pneumonia , urinary tract infection , viral infection . Myozyme dosage: 20 MG/KG Q2WKS; IV. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5860760-X
Myozyme side effect was reported by a Health Professional from UNITED STATES on Aug 13, 2008. Male patient, 66 years of age, weighting 189.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, dysphagia, hypothyroidism, mastication disorder, movement disorder , somnolence. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with COZAAR, NORVASC, INDAPAMIDE, ZOLOFT, THYROID SUPPLEMENT, POTASSIUM CHLORIDE, FISH OIL SUPPLEMENT, VITAMIN. Patient recovered.

Myozyme Side Effects Report #5909597-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on Sept 26, 2008. Male patient, 66 years of age, weighting 189.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood potassium decreased, condition aggravated, dysphagia, feeling abnormal, hypothyroidism, mastication disorder, mobility decreased, paralysis . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with COZAAR, NORVASC, INDAPAMIDE, ZOLOFT, THYROID SUPPLEMENT, POTASSIUM, FISH OIL SUPPLEMENT, VITAMIN. Patient recovered.

Myozyme Side Effects Report #5942624-6
Myozyme side effect was reported by a Physician from ISRAEL on Oct 22, 2008. Female patient, child 6 years of age, weighting 39.68 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , asthenia, chills, developmental delay, diarrhoea, face oedema, fatigue, flushing, immunology test abnormal. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5975239-4
Myozyme side effect was reported by a Physician from ISRAEL on Nov 17, 2008. Female patient, child 6 years of age, weighting 41.45 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , asthenia, developmental delay, diarrhoea, face oedema, irritability, no therapeutic response, refusal of treatment by relative, urticaria. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5975623-9
Myozyme side effect was reported by a Physician from ISRAEL on Nov 17, 2008. Female patient, child 6 years of age, weighting 41.45 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , asthenia, developmental delay, diarrhoea, face oedema, irritability, muscular weakness, myopathy, no therapeutic response. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.


Myozyme Side Effects Report #6051071-0
Myozyme side effect was reported by a Physician from ISRAEL on Jan 12, 2009. Female patient, child 6 years of age, weighting 41.45 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal pain , asthenia, developmental delay, diarrhoea, face oedema, irritability, no therapeutic response, urticaria, vomiting. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5778476-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 03, 2008. Female patient, 53 years of age, weighting 131.2 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arthralgia, asthenia, balance disorder, gait disturbance, headache , muscular weakness, nausea , neuralgia, tinnitus . Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. During the same period patient was treated with EPHEDRINE SULPHATE, VITAMIN, CALCIUM, VITAMIN D. Patient recovered.

Myozyme Side Effects Report #5544126-8
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 23, 2007. Female patient, child 4 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, disease progression, eyelid ptosis, ill-defined disorder. Myozyme dosage: 20 MG/KG Q2WKS, IV. Patient recovered.

Myozyme Side Effects Report #5387617-5
Myozyme side effect was reported by a Physician from FRANCE on June 28, 2007. Female patient, child 3 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, disease progression, glycogen storage disease type ii, respiratory tract infection, urinary retention. Myozyme dosage: 20 MG/KG Q2WS IV. Patient died on 06/01/2007.

Myozyme Side Effects Report #5466850-8
Myozyme side effect was reported by a Physician from GERMANY on Sept 06, 2007. Female patient, 23 years of age, weighting 119.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, asthenia, dizziness , hypertension, no therapeutic response. Myozyme dosage: 1100 MG 2X/W IV. Patient recovered.


Myozyme Side Effects Report #5710669-7
Myozyme side effect was reported by a Physician from GERMANY on Apr 02, 2008. Female patient, 23 years of age, weighting 119.0 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, dizziness , gait disturbance, hypertension. Myozyme dosage: 20 MG/KG, Q2W, 10 MG/KG, Q2W, 1100 MG, 2X/W, INTRAVENOUS. Patient recovered.

Myozyme Side Effects Report #5566518-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on Dec 05, 2007. Male patient, 22 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: arrhythmia , asthenia, atrial fibrillation , blood potassium decreased, bundle branch block left, electrocardiogram st segment elevation, electrocardiogram t wave amplitude increased, flushing, palpitations. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient recovered.

Myozyme Side Effects Report #5368866-9
Myozyme side effect was reported by a Physician from FRANCE on June 06, 2007. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, respiratory tract infection, urinary retention. Myozyme dosage: 20 MG/KG Q2WKS IV. Patient died on 06/01/2007.

Myozyme Side Effects Report #5735807-1
Myozyme side effect was reported by a Physician from UNITED STATES on May 06, 2008. Female patient, child 2 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, pneumonia , respiratory failure. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient died on 04/25/2008.

Myozyme Side Effects Report #5829501-6
Myozyme side effect was reported by a Physician from UNITED STATES on July 17, 2008. Male patient, child 12 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, anxiety , arthralgia, asthenia, asthma , chest pain , dehydration, erythema, eye rolling. Myozyme dosage: 20 MG/KG, Q2W, INTRAVENOUS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5366201-3
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 05, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, dysphagia, hypertension, hypertonia, hypoxia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5375663-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 18, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, acute respiratory distress syndrome, aspiration, asthenia, atelectasis, condition aggravated, disease progression, disease recurrence, dysphagia. Myozyme dosage: 20 MG/KG Q2WKS; IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5375663-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on June 18, 2007. Male patient, child 1 years of age, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, acute respiratory distress syndrome, aspiration, asthenia, atelectasis, condition aggravated, disease progression, disease recurrence, dysphagia. Myozyme dosage: 20 MG/KG Q2WKS; IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5209170-9
Myozyme side effect was reported by a Physician from UNITED STATES on Dec 28, 2006. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood creatine phosphokinase increased, blood culture positive, candidiasis, central line infection, condition aggravated, enterococcal infection, feeding disorder, hyporeflexia. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5216726-6
Myozyme side effect was reported by a Physician from GREECE on Jan 04, 2007. Female patient, weighting 17.64 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abdominal infection, acute respiratory failure, alanine aminotransferase increased, antibody test positive, asthenia, cardiac failure, cardiac failure acute, cardiac index increased, cardiopulmonary failure. Myozyme dosage: 20 MG/KG QWK IV. During the same period patient was treated with ALPHA, HCL THIAZIDE, SPIRONOLACTONE, DIGITALIS, ENALAPRIL MALEATE. Patient was hospitalized. Patient died on 12/29/2006.


Myozyme Side Effects Report #5218784-1
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 09, 2007. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blepharospasm, blood creatine phosphokinase increased, blood culture positive, candidiasis, cardiac disorder, central line infection, endotracheal intubation complication, enterococcal infection. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5233304-3
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 26, 2007. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood creatine phosphokinase increased, blood immunoglobulin g increased, c-reactive protein increased, candidiasis, central line infection, echocardiogram abnormal, enterococcal infection, eyelid function disorder. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE, BENADRYL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5254709-0
Myozyme side effect was reported by a Physician from UNITED STATES on Feb 12, 2007. Female patient, weighting 21.16 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, cardiac failure, condition aggravated, respiratory failure, urinary tract infection . Myozyme dosage: 200 MG Q2WKS IV. During the same period patient was treated with LASIX, CAPTOPRIL, COREG. Patient was hospitalized. Patient died on 02/15/2007.

Myozyme Side Effects Report #5294076-X
Myozyme side effect was reported by a Physician from UNITED STATES on Mar 23, 2007. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood creatine phosphokinase increased, blood culture positive, blood immunoglobulin g decreased, candidiasis, central line infection, developmental delay, enterococcal infection, eyelid disorder. Myozyme dosage: 20 MG/KG, Q2WKS; IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE, BENADRYL. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #5350978-7
Myozyme side effect was reported by a Health Professional from UNITED STATES on May 23, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, aspiration, asthenia, atelectasis, dysphagia, hypertension, hypertonia, respiratory syncytial virus infection . Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient recovered.


Myozyme Side Effects Report #5390882-1
Myozyme side effect was reported by a Health Professional from UNITED STATES on July 02, 2007. Male patient was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: abasia, aspiration, asthenia, atelectasis, blood immunoglobulin g increased, condition aggravated, disease progression, dysphagia, glycogen storage disease type ii. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with ALPHA, CAPTOPRIL, STEROIDS. Patient was hospitalized. Patient died on 06/30/2007.

Myozyme Side Effects Report #5566508-0
Myozyme side effect was reported by a Physician from UNITED STATES on Nov 30, 2007. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blood creatine phosphokinase increased, blood culture positive, candidiasis, cardiac disorder, catheter related infection, central line infection, clostridial infection, enterococcal infection. Myozyme dosage: 20 MG/KG Q2WKS IV. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE. Patient was hospitalized. Patient recovered.

Myozyme Side Effects Report #6057977-0
Myozyme side effect was reported by a Health Professional from UNITED STATES on Jan 22, 2009. Female patient, weighting 11.46 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: apnoea, asthenia, cardiac arrest , respiratory failure. Myozyme dosage: 100 MG, Q2W, INTRAVENOUS. During the same period patient was treated with NYSTATIN, LASIX. Patient died on 01/06/2009.

Myozyme Side Effects Report #6059377-6
Myozyme side effect was reported by a Physician from UNITED STATES on Jan 20, 2009. Male patient, weighting 12.13 lb, was diagnosed with glycogen storage disease type ii and was treated with Myozyme. After drug was administered, patient experienced the following side effects: asthenia, blepharospasm, blood creatine phosphokinase increased, candidiasis, cardiomyopathy , catheter related infection, clostridial infection, enterobacter infection, enterococcal infection. Myozyme dosage: 20 MG/KG, Q2W; INTRAVENOUS. During the same period patient was treated with BUDESONIDE, XOPENEX, LANSOPRAZOLE, DIGOXIN, PROPRANOLOL, AMIODARONE, BENADRYL. Patient was hospitalized. Patient recovered.