Mitoxantrone and acute myeloid leukaemia Patient Reports February 12, 2012

Mitoxantrone Side Effects Report #5578559-0
Mitoxantrone side effect was reported by a Consumer or non-health professional from BELGIUM on Dec 17, 2007. Female patient, 53 years of age, was diagnosed with secondary progressive multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 20 MG, 8 IN , INTRAVENOUS. Patient recovered.

Mitoxantrone Side Effects Report #4816251-8
Mitoxantrone side effect was reported by a Consumer or non-health professional from FRANCE on Oct 13, 2005. Female patient, 51 years of age, was diagnosed with secondary progressive multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, lung disorder, septic shock. Mitoxantrone dosage: 20 MG,. During the same period patient was treated with AZATHIOPRINE, INTERFERON BETA. Patient died on 12/13/2001.

Mitoxantrone Side Effects Report #5022371-8
Mitoxantrone side effect was reported by a Consumer or non-health professional from FRANCE on May 19, 2006. Female patient, 51 years of age, was diagnosed with secondary progressive multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, anaemia, chromosome abnormality, haemorrhagic disorder, lung disorder, neutropenia, septic shock, thrombocytopenia. Mitoxantrone dosage: 20 MG. During the same period patient was treated with AZATHIOPRINE, INTERFERON BETA. Patient died on 12/13/2001.

Mitoxantrone Side Effects Report #4950530-9
Mitoxantrone side effect was reported by a Physician from UNITED STATES on Mar 06, 2006. Female patient, 47 years of age, was diagnosed with secondary progressive multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, acute respiratory failure, amenorrhoea, asthenia, dizziness , haematoma, haemorrhoids, hypotension. Mitoxantrone dosage: 12 MG/M2, ONCE. During the same period patient was treated with AVONEX. Patient was hospitalized. Patient died.


Mitoxantrone Side Effects Report #5578560-7
Mitoxantrone side effect was reported by a Consumer or non-health professional from BELGIUM on Dec 17, 2007. Male patient, 42 years of age, was diagnosed with secondary progressive multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 20 MG, 7 IN, INTRAVENOUS. Patient died.

Mitoxantrone Side Effects Report #6023110-4
Mitoxantrone side effect was reported by a Physician from on Dec 09, 2008. Female patient, 48 years of age, was diagnosed with relapsing-remitting multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute graft versus host disease in intestine, acute myeloid leukaemia, pancytopenia. Mitoxantrone dosage: 120MG. During the same period patient was treated with AZATHIOPRINE. Patient was hospitalized. Patient died.

Mitoxantrone Side Effects Report #5160875-8
Mitoxantrone side effect was reported by a Physician from ITALY on Nov 08, 2006. Female patient, 35 years of age, was diagnosed with relapsing-remitting multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, nuclear magnetic resonance imaging abnormal, spinal disorder, stem cell transplant, treatment related secondary malignancy. Mitoxantrone dosage: unknown. Patient was hospitalized. Patient recovered.

Mitoxantrone Side Effects Report #5963896-8
Mitoxantrone side effect was reported by a Consumer or non-health professional from ITALY on Nov 10, 2008. Female patient, 35 years of age, was diagnosed with relapsing-remitting multiple sclerosis and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, bone marrow transplant . Mitoxantrone dosage: 95 MG/M2, 1 IN 1 MONTHS, INTRAVENOUS (NOT OTHERWISE SPECIFIED). Patient was hospitalized. Patient recovered.

Mitoxantrone Side Effects Report #5158983-0
Mitoxantrone side effect was reported by a Pharmacist from UNITED STATES on Nov 06, 2006. Male patient, 64 years of age, was diagnosed with prostate cancer  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: abdominal pain , acute myeloid leukaemia, blood bilirubin increased, chromosome analysis abnormal, febrile neutropenia, hypotension, hypoxia, lung infiltration, multi-organ failure. Mitoxantrone dosage: 12 MG/M2 Q3W. During the same period patient was treated with PREDNISONE, GOSERELIN, BICALUTAMIDE. Patient died.


Mitoxantrone Side Effects Report #4673759-6
Mitoxantrone side effect was reported by a Consumer or non-health professional from on Apr 21, 2005. Female patient was diagnosed with non-hodgkin's lymphoma and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, myelodysplastic syndrome, pneumonia . Mitoxantrone dosage: 8 MG/M2 OTH. During the same period patient was treated with DOXORUBICIN, VINCRISTINE, ETOPOSIDE, LEUKERAN, PREDNISONE, PREDNISOLONE, CYCLOPHOSPHAMIDE, IFOSFAMIDE. Patient died.

Mitoxantrone Side Effects Report #5031040-X
Mitoxantrone side effect was reported by a Consumer or non-health professional from AUSTRIA on Apr 21, 2005. Female patient was diagnosed with non-hodgkin's lymphoma and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, myelodysplastic syndrome, pneumonia . Mitoxantrone dosage: 8 MG/M2 OTH IV. During the same period patient was treated with DOXORUBICIN, VINCRISTINE, ETOPOSIDE, CHLORAMBUCIL, PREDNISONE, PREDNISOLONE, CYCLOPHOSPHAMIDE. Patient died.

Mitoxantrone Side Effects Report #4710985-1
Mitoxantrone side effect was reported by a Pharmacist from UNITED STATES on July 08, 2005. Male patient, 46 years of age, weighting 194.7 lb, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 12 MG/M2 IV Q 3 MONTH X 5 DOSES. Patient recovered.

Mitoxantrone Side Effects Report #4568379-8
Mitoxantrone side effect was reported by a Consumer or non-health professional from on Jan 13, 2005. Female patient, 45 years of age, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute leukaemia, acute myeloid leukaemia, chromosome abnormality, csf test abnormal, fatigue, infection , night sweats, pyrexia, stem cell transplant. Mitoxantrone dosage: 12 MG/M2, ONCE, INTRAVENOUS, NOT OTHERWISE SPECIFIED). During the same period patient was treated with TROSPIUM CHLORIDE, METHIONINE, IODINE. Patient recovered.

Mitoxantrone Side Effects Report #5725930-X
Mitoxantrone side effect was reported by a Physician from UNITED STATES on Apr 14, 2008. Male patient, 42 years of age, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, refusal of treatment by patient. Mitoxantrone dosage: unknown. Patient died.


Mitoxantrone Side Effects Report #5094503-7
Mitoxantrone side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 17, 2006. Male patient, 41 years of age, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, dysplasia, monocytosis. Mitoxantrone dosage: 12 MG/M2 OTH. Patient recovered.

Mitoxantrone Side Effects Report #5115566-6
Mitoxantrone side effect was reported by a Physician from UNITED STATES on Sept 12, 2006. Male patient, 41 years of age, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 12 MG/M2 OTH. Patient died.

Mitoxantrone Side Effects Report #4710982-6
Mitoxantrone side effect was reported by a Pharmacist from UNITED STATES on July 08, 2005. Female patient, 39 years of age, weighting 136.7 lb, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 12 MG/M2 IV Q MONTH X 3 THEN 12 MG/M2 IV Q 3 MONTHS X 10 DOSES. Patient recovered.

Mitoxantrone Side Effects Report #4692286-3
Mitoxantrone side effect was reported by a Consumer or non-health professional from on June 01, 2005. Female patient, 28 years of age, was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 120 MG TOTAL. During the same period patient was treated with METHOTREXATE. Patient recovered.

Mitoxantrone Side Effects Report #5756836-8
Mitoxantrone side effect was reported by a Consumer or non-health professional from UNITED STATES on May 13, 2008. Female patient was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, blast cell crisis, blood alkaline phosphatase increased, chronic myeloid leukaemia, marrow hyperplasia, thrombocythaemia, urinary tract infection . Mitoxantrone dosage: 18 MG, 1 IN 2 MONTHS. During the same period patient was treated with AVONEX. Patient recovered.


Mitoxantrone Side Effects Report #5009799-7
Mitoxantrone side effect was reported by a Consumer or non-health professional from FRANCE on May 11, 2006. Female patient was diagnosed with multiple sclerosis  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, ejection fraction decreased, haemorrhage, neutropenia, respiratory distress, sepsis . Mitoxantrone dosage: 20 MG MONTHLY UNK. Patient recovered.

Mitoxantrone Side Effects Report #5239532-5
Mitoxantrone side effect was reported by a Consumer or non-health professional from FRANCE on Jan 29, 2007. Male patient, 64 years of age, was diagnosed with metastases to bone, prostate cancer metastatic and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, malignant neoplasm progression, prostate cancer . Mitoxantrone dosage: 12 MG/M2 Q21DAYS IV. During the same period patient was treated with DOCETAXEL, IROFULVEN, CAPECITABINE. Patient died.

Mitoxantrone Side Effects Report #4641735-5
Mitoxantrone side effect was reported by a Consumer or non-health professional from on Apr 04, 2005. Female patient, 75 years of age, was diagnosed with lymphoma  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia. Mitoxantrone dosage: 10 MG/M2, 1 IN 1 CYCLE, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, DEXAMETHASONE, RITUXIMAB, CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE, PREDNISONE. Patient died.

Mitoxantrone Side Effects Report #4641764-1
Mitoxantrone side effect was reported by a Consumer or non-health professional from on Apr 04, 2005. Female patient, 42 years of age, was diagnosed with lymphoma  and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, myelodysplastic syndrome, refractory anaemia with ringed sideroblasts. Mitoxantrone dosage: unknown. During the same period patient was treated with FLUDARABINE PHOSPHATE, DEXAMETHASONE, RITUXIMAB, INTERFERON ALFA. Patient died.

Mitoxantrone Side Effects Report #5935214-2
Mitoxantrone side effect was reported by a Health Professional from ITALY on Oct 17, 2008. Male patient, 75 years of age, was diagnosed with follicle centre lymphoma, follicular grade i, ii, iii stage iv and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, bone marrow failure, pancytopenia, pyrexia. Mitoxantrone dosage: unknown. During the same period patient was treated with DEXAMETHASONE. Patient died.


Mitoxantrone Side Effects Report #5935211-7
Mitoxantrone side effect was reported by a Health Professional from ITALY on Oct 17, 2008. Female patient, 56 years of age, was diagnosed with follicle centre lymphoma, follicular grade i, ii, iii stage iv and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute graft versus host disease, acute myeloid leukaemia, pancytopenia. Mitoxantrone dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE, DOXORUBICIN, PREDNISONE, CYCLOPHOSPHAMIDE. Patient died on 03/01/2007.

Mitoxantrone Side Effects Report #5905868-5
Mitoxantrone side effect was reported by a Health Professional from UNITED STATES on Oct 01, 2008. Male patient, 41 years of age, weighting 195.0 lb, was diagnosed with demyelination and was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, borrelia infection, central nervous system lesion, condition aggravated, demyelination. Mitoxantrone dosage: unknown. During the same period patient was treated with ZOFRAN, IV SOLUMEDROL. Patient recovered.

Mitoxantrone Side Effects Report #4641921-4
Mitoxantrone side effect was reported by a Consumer or non-health professional from on Apr 04, 2005. Female patient, 58 years of age, was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, myelodysplastic syndrome. Mitoxantrone dosage: 10 MG/M2, 1 IN 1 CYCLE, INTRAVENOUS. During the same period patient was treated with FLUDARABINE PHOSPHATE, DEXAMETHASONE, RITUXIMAB, INTERFERON ALFA. Patient died.

Mitoxantrone Side Effects Report #5883949-2
Mitoxantrone side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 12, 2008. Male patient, weighting 248.5 lb, was treated with Mitoxantrone. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, limb injury, oedema peripheral, white blood cell count decreased. Mitoxantrone dosage: 72 MG. Patient recovered.