Methotrexate and neurotoxicity Patient Reports February 11, 2012

Methotrexate Side Effects Report #5201696-7
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 09, 2006. Male patient, 20 years of age, was diagnosed with t-cell type acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE, VINCRISTINE, DOXORUBICIN, CYTARABINE, ELSPAR, CYCLOPHOSPHAMIDE. Patient recovered.

Methotrexate Side Effects Report #4622959-X
Methotrexate side effect was reported by a Consumer or non-health professional from on Oct 23, 2003. Female patient, 18 years of age, was diagnosed with t-cell type acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cerebral ischaemia, cortical laminar necrosis, hypercalcaemia of malignancy, neurotoxicity, paraneoplastic syndrome, tumour lysis syndrome. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, DAUNORUBICIN, PREDNISONE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #6092834-5
Methotrexate side effect was reported by a Consumer or non-health professional from on Feb 16, 2009. Male patient, 16 years of age, was diagnosed with t-cell type acute leukaemia, prophylaxis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: central nervous system lesion, laboratory test abnormal, leukoencephalopathy, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE, CYCLOPHOSPHAMIDE, LEUCOVORIN CALCIUM, LEUCOVORIN CALCIUM, HYDROCORTISONE, CYTARABINE. Patient recovered.

Methotrexate Side Effects Report #5201695-5
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 09, 2006. Male patient, 13 years of age, was diagnosed with t-cell type acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE, VINCRISTINE, DOXORUBICIN, MERCAPTOPURINE, CYTARABINE. Patient recovered.

Methotrexate Side Effects Report #5975046-2
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Nov 17, 2008. Female patient, 82 years of age, was diagnosed with rheumatoid arthritis

and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alveolitis allergic, cd4 lymphocytes decreased, hypocapnia, hypoxia, lymphopenia, neurotoxicity, normochromic normocytic anaemia, vitamin b12 decreased. Methotrexate dosage: 15 MG WEEKLY. During the same period patient was treated with PREDNISONE. Patient recovered.

Methotrexate Side Effects Report #5995345-8
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Dec 02, 2008. Female patient, 82 years of age, was diagnosed with rheumatoid arthritis

and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: asthenia, cd4 lymphocytes decreased, cerebellar syndrome, dysarthria, gait disturbance, hyporeflexia, lymphopenia, neurotoxicity, normochromic normocytic anaemia. Methotrexate dosage: 15 MG WEEKLY. During the same period patient was treated with PREDNISONE, FOLIC ACID. Patient recovered.

Methotrexate Side Effects Report #4957669-2
Methotrexate side effect was reported by a Health Professional from UNITED STATES on Mar 15, 2006. Male patient, 61 years of age, was diagnosed with non-hodgkin's lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: mucosal inflammation, neurotoxicity, renal failure. Methotrexate dosage: 1990 MG ONCE IV. During the same period patient was treated with CIPRO, FLUCONAZOLE, ATIVAN, ALLOPURINOL, ACYCLOVIR, BACTRIM, VALSARTAN, HYDROCHLOROTHIAZIDE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4909141-3
Methotrexate side effect was reported by a Health Professional from UNITED STATES on Jan 25, 2006. Male patient, 61 years of age, was diagnosed with mantle cell lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: mucosal inflammation, neurotoxicity, renal failure. Methotrexate dosage: 1990 MG ONCE IV. During the same period patient was treated with CYTARABINE, CIPRO, FLUCONAZOLE, ATIVAN, ALLOPURINOL, ACYCLOVIR, BACTRIM, VALSARTAN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5354905-8
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Male patient, 67 years of age, was diagnosed with lymphoma

and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #5354904-6
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Female patient, 54 years of age, was diagnosed with lymphoma

and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: leukoencephalopathy, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #6084858-9
Methotrexate side effect was reported by a Physician from UNITED STATES on Feb 03, 2009. Male patient, 16 years of age, was diagnosed with lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: affect lability, dysarthria, facial paresis, hemiplegia, leukoencephalopathy, neurotoxicity, nuclear magnetic resonance imaging brain abnormal. Methotrexate dosage: 12 MG; TWICEA WEEK; INTRATHECAL. During the same period patient was treated with HYDROCORTISONE, CYTARABINE, PREDNISONE, VINCRISTINE, DAUNORUBICIN, PEGASPARGASE, DACTINOMYCIN. Patient recovered.

Methotrexate Side Effects Report #5989273-1
Methotrexate side effect was reported by a Consumer or non-health professional from ITALY on Nov 25, 2008. Male patient, 27 years of age, was diagnosed with lymphocytic infiltration and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: ataxia

, disease progression, encephalopathy, hallucination, visual, meningoradiculitis, neurotoxicity, quadriparesis, sleep disorder

, visual impairment. Methotrexate dosage: 3500 MG/M2, INTRAVENOUS (NOT OTHERWISE SPECIFIED); TWO CYCLES. Patient died.

Methotrexate Side Effects Report #5310203-X
Methotrexate side effect was reported by a Physician from MALAYSIA on Apr 12, 2007. Male patient, 17 years of age, was diagnosed with leukaemic lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: hypertension, hypoaesthesia, myelopathy, neurotoxicity, paraesthesia, paraplegia, sensory loss, tachycardia. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE, DEXAMETHASONE. Patient recovered.

Methotrexate Side Effects Report #6106899-5
Methotrexate side effect was reported by a Physician from SWITZERLAND on Feb 25, 2009. Male patient, 14 years of age, was diagnosed with leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cerebellar atrophy, coma, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5688113-8
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on Mar 18, 2008. Female patient, 35 years of age, was diagnosed with glioblastoma multiforme and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: brain herniation, intracranial pressure increased, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with PHENOBARBITAL, DEXAMETHASONE, BICARBONATE, DEXTROSE. Patient died.

Methotrexate Side Effects Report #5778060-5
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on June 06, 2008. Female patient, 35 years of age, was diagnosed with glioblastoma multiforme and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: brain herniation, intracranial pressure increased, neurotoxicity, unresponsive to stimuli. Methotrexate dosage: unknown. During the same period patient was treated with PHENOBARBITAL, DEXAMETHASONE, DEXTROSE INFUSION FLUID, BICARBONATE IN PLASTIC CONTAINER. Patient died.

Methotrexate Side Effects Report #5425851-6
Methotrexate side effect was reported by a Health Professional from UNITED STATES on Aug 13, 2007. Male patient, 28 years of age, was diagnosed with central nervous system neoplasm, lymphoma

and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, brain oedema, facial palsy, gait disturbance, gliosis, hemiparesis, neurotoxicity, paraesthesia, upper motor neurone lesion. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #5355147-2
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Male patient, 68 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #5387442-5
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Female patient, 68 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: disease recurrence, neurotoxicity. Methotrexate dosage: 6MG/M2-IV; DAYS 1 AND 10. Patient died.

Methotrexate Side Effects Report #5387433-4
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Male patient, 66 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. Patient died.

Methotrexate Side Effects Report #5354901-0
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Female patient, 65 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #5354902-2
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Male patient, 63 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #5387410-3
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Female patient, 63 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. Patient died.

Methotrexate Side Effects Report #5387435-8
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Male patient, 63 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: disease progression, neurotoxicity. Methotrexate dosage: 6MG/M2-IV; DAYS 1 AND 10. Patient died.

Methotrexate Side Effects Report #5354903-4
Methotrexate side effect was reported by a Physician from UNITED STATES on May 29, 2007. Male patient, 61 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, CYTARABINE, PROCARBAZINE. Patient died.

Methotrexate Side Effects Report #5387445-0
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Male patient, 58 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: 8MG/M2-IV; DAYS 1 AND 10. Patient died.

Methotrexate Side Effects Report #5387444-9
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Female patient, 48 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cerebral disorder, disease recurrence, neurotoxicity. Methotrexate dosage: 8MG/M2-IV; DAYS 1 AND 10. Patient died.

Methotrexate Side Effects Report #5493753-5
Methotrexate side effect was reported by a Consumer or non-health professional from on Oct 16, 2007. Male patient, 28 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with PHENYTOIN. Patient recovered.

Methotrexate Side Effects Report #5387415-2
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 26, 2007. Female patient, 18 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: central nervous system lymphoma, neurotoxicity, pneumonia

, recurrent cancer. Methotrexate dosage: unknown. Patient died.

Methotrexate Side Effects Report #4724400-5
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on July 08, 2005. Female patient, 16 years of age, was diagnosed with bone sarcoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, asthenia, dysarthria, dysphagia, neurotoxicity, somnolence. Methotrexate dosage: unknown. During the same period patient was treated with HYDROMORPHONE HYDROCHLORIDE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4844572-1
Methotrexate side effect was reported by a Health Professional from GERMANY on Nov 16, 2005. Female patient, 16 years of age, was diagnosed with bone sarcoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, asthenia, dysarthria, dysphagia, neurotoxicity, somnolence, therapeutic agent toxicity. Methotrexate dosage: 1200 MG/M2 PER_CYCLE IV. During the same period patient was treated with DILAUDID. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5201703-1
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 09, 2006. Female patient, 15 years of age, was diagnosed with b-cell type acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, DOXORUBICIN, CYTARABINE, DEXAMETHASONE, PEGYLATED L, CYCLOPHOSPHAMIDE, THIOGUANINE. Patient recovered.

Methotrexate Side Effects Report #5201693-1
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 09, 2006. Female patient, 17 years of age, was diagnosed with b precursor type acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: 12 MG FREQ UNK IT. During the same period patient was treated with VINCRISTINE, ELSPAR, PREDNISONE, DAUNORUBICIN, MERCAPTOPURINE, CYCLOPHOSPHAMIDE. Patient recovered.

Methotrexate Side Effects Report #4911113-X
Methotrexate side effect was reported by a Consumer or non-health professional from on Jan 31, 2006. Male patient, child 9 years of age, was diagnosed with acute lymphocytic leukaemia, convulsion and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, coma, convulsion, hepatotoxicity, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with DIAZEPAM. Patient recovered.

Methotrexate Side Effects Report #5989282-2
Methotrexate side effect was reported by a Health Professional from TURKEY on Nov 25, 2008. Female patient, 58 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal discomfort, blood pressure increased, nausea

, neurotoxicity, pelvic pain

, perineal pain, urinary incontinence

. Methotrexate dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, VINCRISTINE, DOXORUBICIN, DEXAMETHASONE. Patient recovered.

Methotrexate Side Effects Report #6138826-9
Methotrexate side effect was reported by a Consumer or non-health professional from on Mar 25, 2009. Female patient, 35 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: central nervous system infection, hyperbilirubinaemia, leukoencephalopathy, metabolic disorder

, neurotoxicity. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #5634184-4
Methotrexate side effect was reported by a Consumer or non-health professional from CANADA on Feb 08, 2008. Male patient, child 3 years of age, weighting 29.32 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: altered state of consciousness, aphasia

, corneal reflex decreased, neurotoxicity, staring, tremor, unresponsive to stimuli, urinary incontinence

. Methotrexate dosage: unknown. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5642513-0
Methotrexate side effect was reported by a Health Professional from CANADA on Feb 18, 2008. Male patient, child 3 years of age, weighting 29.32 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, depressed level of consciousness, excessive eye blinking, neurotoxicity, staring, unresponsive to stimuli, urinary incontinence

. Methotrexate dosage: unknown. During the same period patient was treated with ACETAMINOPHEN, ACYCLOVIR, ALLOPURINOL. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4628219-5
Methotrexate side effect was reported by a Consumer or non-health professional from on Jan 25, 2002. Female patient, child 3 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: autoimmune disorder, csf protein increased, gait disturbance, neurotoxicity, peripheral motor neuropathy, radiculopathy. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE, HYDROCORTISONE, VINCRISTINE, ELSPAR, MERCAPTOPURINE. Patient recovered.

Methotrexate Side Effects Report #4707436-X
Methotrexate side effect was reported by a Health Professional from UNITED KINGDOM on June 27, 2005. Female patient, 22 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, dysphasia, dyspraxia, encephalopathy, neurotoxicity, toxic induced encephalopathy. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4954399-8
Methotrexate side effect was reported by a Consumer or non-health professional from on Mar 07, 2006. Male patient, 18 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, aplasia, faecal incontinence, hyporeflexia, neurotoxicity, nuclear magnetic resonance imaging abnormal, paraparesis, sensory disturbance, sensory loss. Methotrexate dosage: unknown. During the same period patient was treated with CYTARABINE, CYCLOPHOSPHAMIDE, DEXAMETHASONE, VINCRISTINE, DAUNORUBICIN, PREDNISOLONE, MERCAPTOPURINE. Patient recovered.

Methotrexate Side Effects Report #4726866-3
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 14, 2005. Male patient, 17 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cranial neuropathy, dysarthria, facial paresis, hemiparesis, neurotoxicity, nuclear magnetic resonance imaging abnormal. Methotrexate dosage: unknown. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #6067654-8
Methotrexate side effect was reported by a Consumer or non-health professional from on Feb 02, 2009. Male patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: ischaemic cerebral infarction, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with CALCIUM FOLINATE. Patient recovered.

Methotrexate Side Effects Report #6074513-3
Methotrexate side effect was reported by a Health Professional from GERMANY on Jan 20, 2009. Male patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cerebral infarction, cerebral ischaemia, cranial neuropathy, mood altered, neurotoxicity, peripheral motor neuropathy, pyramidal tract syndrome. Methotrexate dosage: unknown. During the same period patient was treated with CALCIUM FOLINATE. Patient recovered.

Methotrexate Side Effects Report #4544937-1
Methotrexate side effect was reported by a Physician from on Dec 20, 2004. Female patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, asthenia, neurotoxicity. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4551542-X
Methotrexate side effect was reported by a Physician from on Dec 30, 2004. Female patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, blood pressure increased, hemiparesis, neurotoxicity, post procedural complication, simple partial seizures. Methotrexate dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE, ASPARGINASE. Patient recovered.

Methotrexate Side Effects Report #4551983-0
Methotrexate side effect was reported by a Consumer or non-health professional from on Dec 29, 2004. Female patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arthropathy, asthenia, cerebral infarction, coordination abnormal, facial nerve disorder, facial paresis, neurotoxicity. Methotrexate dosage: 10500 MG, IV. During the same period patient was treated with MERCAPTOPURINE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4729867-4
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Dec 29, 2004. Male patient, 15 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arthropathy, cerebral infarction, coordination abnormal, dysarthria, facial paresis, hemiparesis, hypoaesthesia, neurotoxicity. Methotrexate dosage: 10500 MG. During the same period patient was treated with MERCAPTOPURINE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4551538-8
Methotrexate side effect was reported by a Health Professional from on Dec 30, 2004. Male patient, 14 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, facial palsy, neurotoxicity, post procedural complication, quadriparesis. Methotrexate dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE, ASPARGINASE. Patient recovered.

Methotrexate Side Effects Report #6067655-X
Methotrexate side effect was reported by a Consumer or non-health professional from on Feb 02, 2009. Male patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: demyelination, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with CALCIUM FOLINATE. Patient recovered.

Methotrexate Side Effects Report #6071724-8
Methotrexate side effect was reported by a Health Professional from GERMANY on Jan 20, 2009. Male patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: demyelination, intention tremor, monoparesis, neurotoxicity, peripheral motor neuropathy, reflexes abnormal, speech disorder. Methotrexate dosage: unknown. During the same period patient was treated with CALCIUM FOLINATE. Patient recovered.

Methotrexate Side Effects Report #6074514-5
Methotrexate side effect was reported by a Health Professional from GERMANY on Jan 20, 2009. Male patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: demyelination, intention tremor, neurotoxicity, paresis, peripheral motor neuropathy, reflexes abnormal, speech disorder. Methotrexate dosage: unknown. During the same period patient was treated with CALCIUM FOLINATE. Patient recovered.

Methotrexate Side Effects Report #4596527-2
Methotrexate side effect was reported by a Consumer or non-health professional from on Nov 14, 2003. Female patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arachnoiditis, neurotoxicity. Methotrexate dosage: unknown. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4763234-2
Methotrexate side effect was reported by a Consumer or non-health professional from ALBANIA on Aug 19, 2005. Male patient, 13 years of age, was diagnosed with acute lymphocytic leukaemia, convulsion and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: convulsion, dialysis

, encephalopathy, neurotoxicity, renal failure acute, respiratory arrest. Methotrexate dosage: 500 MG/M2 IV. During the same period patient was treated with LORAZEPAM, LAXIS, OMEPRAZOLE, HYDROCORTISONE, CYTARABINE, LEUCOVORIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4796573-X
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Dec 19, 2004. Male patient, 13 years of age, weighting 110.2 lb, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: dysarthria, hypoaesthesia, neurotoxicity, paraesthesia. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4551546-7
Methotrexate side effect was reported by a Physician from on Dec 30, 2004. Female patient, child 12 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: aphasia

, facial palsy, hemiparesis, neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with DEXAMETHASONE, VINCRISTINE, ASPARGINASE. Patient recovered.

Methotrexate Side Effects Report #4657030-4
Methotrexate side effect was reported by a Consumer or non-health professional from on Apr 20, 2005. Female patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with LEUCOVORIN CALCIUM, PREDNISONE, VINCRISTINE, ELSPAR, DAUNORUBICIN, MERCAPTOPURINE. Patient recovered.

Methotrexate Side Effects Report #4701529-9
Methotrexate side effect was reported by a Consumer or non-health professional from on June 14, 2005. Female patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: creatinine renal clearance decreased, neurotoxicity, renal failure. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4705201-0
Methotrexate side effect was reported by a Consumer or non-health professional from on June 14, 2005. Male patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity, renal failure. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4720208-5
Methotrexate side effect was reported by a Consumer or non-health professional from FRANCE on June 15, 2005. Female patient was diagnosed with acute lymphocytic leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity, renal failure. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4726869-9
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on June 14, 2005. Male patient, 13 years of age, was diagnosed with acute leukaemia and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: dysarthria, hypoaesthesia, neurotoxicity, paraesthesia. Methotrexate dosage: 5 G/M2 PER_CYCLE/12 MG PER_CYCLE/5000 MG PER_CYCLE IV/IT/IV/IT. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5839663-2
Methotrexate side effect was reported by a Consumer or non-health professional from GERMANY on Aug 04, 2008. Female patient, 82 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity, pneumonitis. Methotrexate dosage: unknown. During the same period patient was treated with PREDNISONE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #6003021-0
Methotrexate side effect was reported by a Consumer or non-health professional from ITALY on Dec 04, 2008. Male patient, 27 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: ataxia

, disease progression, hallucination, visual, meningoradiculitis, neurotoxicity, quadriparesis, reversible posterior leukoencephalopathy syndrome, sleep disorder

, visual impairment. Methotrexate dosage: 3500 MG/M2. Patient died.

Methotrexate Side Effects Report #5955729-0
Methotrexate side effect was reported by a Consumer or non-health professional from on Nov 11, 2008. Male patient, 24 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: neurotoxicity. Methotrexate dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, DEXAMETHASONE, VINCRISTINE, ADRIAMYCIN PFS, ELSPAR, PREDNISOLONE, CYTARABINE. Patient recovered.

Methotrexate Side Effects Report #4652851-6
Methotrexate side effect was reported by a Consumer or non-health professional from on Apr 15, 2005. Female patient, 22 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bacterial infection

, blood magnesium decreased, body temperature increased, central line infection, conversion disorder, dissociation, mutism, neurotoxicity. Methotrexate dosage: 62.5 MG OTH, IT. Patient recovered.

Methotrexate and neurotoxicity

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Methotrexate and neurotoxicity Patient Reports February 11, 2012

side effects of Methotrexate