Methotrexate and interstitial lung disease Patient Reports February 11, 2012

Methotrexate Side Effects Report #5477776-8
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on Oct 02, 2007. Female patient, weighting 117.7 lb, was diagnosed with t-cell lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, pleural effusion. Methotrexate dosage: 6840 MG IV DRIP. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4560232-9
Methotrexate side effect was reported by a Pharmacist from on Jan 20, 2005. Female patient, 63 years of age, weighting 130.1 lb, was diagnosed with spondylitis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, cardiac failure congestive, cardio-respiratory arrest, convulsion, interstitial lung disease, pneumonia , pneumonitis, renal failure acute. Methotrexate dosage: 15MG WEEKLY ORAL. During the same period patient was treated with AYGESTIN, ASPIRIN, PREMARIN, FOLIC ACID, NEURONTIN, PROTONIX, SKELAXIN, PERCOCET. Patient was hospitalized. Patient died on 10/22/2004.

Methotrexate Side Effects Report #5739766-7
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on May 12, 2008. Male patient, 87 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: angiogram pulmonary abnormal, interstitial lung disease, respiratory distress. Methotrexate dosage: unknown. During the same period patient was treated with HYDROXYCHLOROQUINE SULPHATE. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #4598897-8
Methotrexate side effect was reported by a Consumer or non-health professional from on Jan 16, 2004. Male patient, 78 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bronchiectasis, chronic obstructive airways disease exacerbated, computerised tomogram abnormal, emphysema, interstitial lung disease, lung consolidation, pulmonary hypertension , right ventricular failure. Methotrexate dosage: 15 MG WEEKLY; SC. During the same period patient was treated with ETANERCEPT, HYDROCORTISONE, CALCIUM CARBONATE, METOPROLOL, NAPROXEN, RABEPRAZOLE, ALENDRONATE. Patient was hospitalized. Patient recovered.


Methotrexate Side Effects Report #4898183-2
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 16, 2004. Male patient, 78 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: bronchiectasis, chronic obstructive pulmonary disease, condition aggravated, emphysema, interstitial lung disease, pulmonary hypertension , right ventricular failure. Methotrexate dosage: 15 MG WEEKLY SC. During the same period patient was treated with ENBREL, FLUDROCORTISONE, CALCIUM CARBONATE, METOPROLOL, VITAMIN, NAPROXEN, RABEPRAZOLE, ALENDRONATE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4514173-3
Methotrexate side effect was reported by a Consumer or non-health professional from on Nov 15, 2004. Female patient, 77 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: immunosuppression, infection , interstitial lung disease, multi-organ failure, respiratory failure, septic shock. Methotrexate dosage: 20 MG 1X PER 1 WK, ORAL. During the same period patient was treated with ENBREL. Patient was hospitalized. Patient died on 10/30/2004.

Methotrexate Side Effects Report #4765467-8
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on Sept 08, 2005. Female patient, 74 years of age, weighting 168.2 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cardiac failure, decreased appetite, interstitial lung disease, restrictive pulmonary disease, weight decreased. Methotrexate dosage: 10 MG IM Q WEEKS. During the same period patient was treated with REMICADE, FOLIC ACID, FERROUS SULPHATE, VIT D, SULAR. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4579125-6
Methotrexate side effect was reported by a Consumer or non-health professional from on Apr 20, 2004. Female patient, 73 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: dyspnoea, interstitial lung disease. Methotrexate dosage: 15 MG 1X PER 1 WK, ORAL. During the same period patient was treated with PREDNISONE, DIOVAN, IBUPROFEN, TYLENOL. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5420925-8
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 20, 2007. Male patient, 71 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, lymphoproliferative disorder. Methotrexate dosage: INCREASED TO 8 MG/WEEK.. Patient died.


Methotrexate Side Effects Report #5423490-4
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 21, 2007. Male patient, 71 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, lymphoproliferative disorder. Methotrexate dosage: INCREASED TO 8 MG/WEEK.. Patient died.

Methotrexate Side Effects Report #5442687-0
Methotrexate side effect was reported by a Consumer or non-health professional from on Aug 28, 2007. Male patient, 71 years of age, was diagnosed with rheumatoid arthritis , lymphoma , evidence based treatment and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: angiocentric lymphoma, axillary mass, diffuse alveolar damage, interstitial lung disease, lymphoproliferative disorder. Methotrexate dosage: unknown. During the same period patient was treated with CYCLOPHOSPHAMIDE, DOXORUBICIN, VINCRISTINE, METHYLPREDNISOLONE, PANIPENEM, FLUCONAZOLE, SULFAMETHOXAZOLE. Patient was hospitalized. Patient died on 08/05/2002.

Methotrexate Side Effects Report #5847437-1
Methotrexate side effect was reported by a Consumer or non-health professional from JAPAN on July 31, 2008. Male patient, 71 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: angiocentric lymphoma, blood immunoglobulin e increased, blood lactate dehydrogenase increased, diffuse alveolar damage, epstein-barr virus infection, haemoglobin decreased, hypoxia, interstitial lung disease, lymphocyte stimulation test positive. Methotrexate dosage: 6 MG/WEEK; 8 MG/WEEK. Patient died.

Methotrexate Side Effects Report #5509439-4
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 30, 2007. Male patient, 69 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: condition aggravated, dyspnoea, immunodeficiency, interstitial lung disease, nasopharyngitis, oxygen saturation decreased, viral infection . Methotrexate dosage: unknown. During the same period patient was treated with HUMIRA, SULFA. Patient died on 09/06/2007.

Methotrexate Side Effects Report #4806432-1
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on Oct 19, 2005. Male patient, 69 years of age, weighting 187.0 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: abdominal pain upper, asthenia, interstitial lung disease, metastatic neoplasm, oxygen saturation decreased, pulmonary function test abnormal. Methotrexate dosage: 8 TABLETS-20MG- EVERY WEEK PO (DURATION: ALMOST 3 YEARS). During the same period patient was treated with CITALOPRAM, DIGOXIN, DOCUSATE, ENOXAPARIN, FLUVASTATIN, FUROSEMIDE, NITROGLYCERIN, OMEPRAZOLE. Patient was hospitalized. Patient recovered.


Methotrexate Side Effects Report #5106906-2
Methotrexate side effect was reported by a Consumer or non-health professional from on Aug 30, 2006. Female patient, 64 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arthropathy, bullous lung disease, condition aggravated, interstitial lung disease, therapeutic response decreased. Methotrexate dosage: 22.5 MG/WEEK (22.5 MG). During the same period patient was treated with ENBREL. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4596682-4
Methotrexate side effect was reported by a Consumer or non-health professional from on June 09, 2004. Male patient, 64 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cardiac failure, interstitial lung disease, lymphocyte stimulation test positive, myocardial infarction, pneumocystis jiroveci pneumonia, pneumonia cytomegaloviral. Methotrexate dosage: 6 MG WEEKLY. During the same period patient was treated with FAMOTIDINE, FUROSEMIDE, BETAMETHASONE, TRIAZOLAM, NAPROXEN, ALENDRONATE, DICLOFENAC, PRAVASTATIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5069646-4
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on Aug 02, 2006. Male patient, 63 years of age, weighting 201.6 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #5099452-6
Methotrexate side effect was reported by a Health Professional from UNITED KINGDOM on Aug 28, 2006. Female patient, 61 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arrhythmia , interstitial lung disease, metabolic acidosis, renal failure. Methotrexate dosage: unknown. During the same period patient was treated with ENBREL. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #5122756-5
Methotrexate side effect was reported by a Health Professional from UNITED KINGDOM on Sept 25, 2006. Female patient, 61 years of age, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: arrhythmia , bacterial infection , interstitial lung disease, metabolic acidosis, pneumocystis jiroveci infection, renal failure, tuberculosis . Methotrexate dosage: 25 MG 2/WK. During the same period patient was treated with ENBREL. Patient died.


Methotrexate Side Effects Report #5755844-0
Methotrexate side effect was reported by a Health Professional from UNITED STATES on May 13, 2008. Female patient, 44 years of age, weighting 169.0 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, anaemia, catheter related complication, encephalopathy, gastrointestinal haemorrhage, interstitial lung disease, myopathy, pneumonia , respiratory failure. Methotrexate dosage: unknown. During the same period patient was treated with AMLODIPINE BESYLATE, IBUROFEN, ACETAMINOPHEN, ACETAMINOPHEN W. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5066022-5
Methotrexate side effect was reported by a Pharmacist from UNITED STATES on July 31, 2006. Female patient, 42 years of age, weighting 144.0 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cryptogenic organising pneumonia, interstitial lung disease, respiratory distress. Methotrexate dosage: 20MG WEEKLY PO. During the same period patient was treated with HUMALOG, LEVAQUIN, ZOCOR, GLUCOPHAGE, HYDROCHLOROTHIAZIDE, GLUCOTROL, PREDNISONE. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5412438-4
Methotrexate side effect was reported by a Health Professional from UNITED STATES on Aug 07, 2007. Female patient, weighting 217.6 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease. Methotrexate dosage: 1000 MG, DAYS 1+15. During the same period patient was treated with RITUXAN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #5758438-6
Methotrexate side effect was reported by a Health Professional from UNITED STATES on May 29, 2008. Female patient, weighting 217.6 lb, was diagnosed with rheumatoid arthritis  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease. Methotrexate dosage: 1000 MG, DAYS 1+15. During the same period patient was treated with RITUXAN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4987986-1
Methotrexate side effect was reported by a Consumer or non-health professional from on Apr 13, 2006. Male patient, 58 years of age, was diagnosed with psoriatic arthropathy and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: alveolitis, bronchiectasis, candidiasis, diffuse alveolar damage, haemoglobin decreased, interstitial lung disease, lung consolidation, nodal arrhythmia, oral candidiasis. Methotrexate dosage: 15 MG/WEEK. During the same period patient was treated with METHYLPREDNISOLONE, FOLIC ACID. Patient was hospitalized. Patient died.


Methotrexate Side Effects Report #4579645-4
Methotrexate side effect was reported by a Consumer or non-health professional from on Jan 25, 2005. Male patient, 49 years of age, was diagnosed with polyarthritis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: condition aggravated, dermatitis exfoliative, diarrhoea, hepatocellular damage, interstitial lung disease, nausea , pneumocystis jiroveci pneumonia, po2 decreased, polyarthritis. Methotrexate dosage: 4 MG WEEKLY. During the same period patient was treated with LEFLUNOMIDE, PREDNISOLONE. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #4805451-9
Methotrexate side effect was reported by a Physician from JAPAN on Oct 04, 2005. Male patient, 74 years of age, was diagnosed with pleural mesothelioma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease. Methotrexate dosage: 150 MG QD IV. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, DOXORUBICIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4846455-X
Methotrexate side effect was reported by a Physician from JAPAN on Nov 15, 2005. Male patient, 74 years of age, weighting 125.7 lb, was diagnosed with pleural mesothelioma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, lymphocyte stimulation test positive. Methotrexate dosage: 150 MG QD IV. During the same period patient was treated with CAMPTOSAR, DOXORUBICIN, LEUCOVORIN CALCIUM, PARIET, LOXONIN, MUCOSTA, DEPAS, BROCIN. Patient was hospitalized. Patient recovered.

Methotrexate Side Effects Report #4939219-X
Methotrexate side effect was reported by a Physician from JAPAN on Feb 23, 2006. Male patient, 54 years of age, was diagnosed with central nervous system lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, metastases to lung, pneumocystis jiroveci pneumonia. Methotrexate dosage: unknown. Patient recovered.

Methotrexate Side Effects Report #4633416-9
Methotrexate side effect was reported by a Consumer or non-health professional from on Mar 25, 2005. Male patient, 53 years of age, was diagnosed with b-cell lymphoma and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, pneumocystis jiroveci pneumonia. Methotrexate dosage: 15 MILLIGRAM INTRATHECAL. During the same period patient was treated with BLEOMYCIN, CYCLOPHOSPHAMIDE, VINDESINE SULPHATE, MABTHERA, DOXORUBICIN, PREDNISONE. Patient was hospitalized. Patient recovered.


Methotrexate Side Effects Report #5493755-9
Methotrexate side effect was reported by a Consumer or non-health professional from on Oct 16, 2007. Female patient, child 3 years of age, was diagnosed with b precursor type acute leukaemia, candidiasis, infection  and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: candidiasis, interstitial lung disease, neutropenia, oesophageal stenosis, oral candidiasis, pericarditis fungal. Methotrexate dosage: unknown. During the same period patient was treated with VINCRISTINE, DOXORUBICIN, PREDNISOLONE, MICONAZOLE, TAZOBACTAM, GENTAMICIN, FLUCONAZOLE. Patient recovered.

Methotrexate Side Effects Report #4831468-4
Methotrexate side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 14, 2005. Male patient, 61 years of age, weighting 246.9 lb, was diagnosed with arthritis , prophylaxis and was treated with Methotrexate. After drug was administered, patient experienced the following side effects: infection , interstitial lung disease, pneumonia , pulmonary fibrosis , respiratory failure, stomatitis. Methotrexate dosage: 2.5 MG, 4 TIMES/WEEK (2.5 MG), PO 3 TO 4 YEARS. During the same period patient was treated with FOLIC ACID, PREDNISONE, CELEBREX, CALCIUM, VITAMIN. Patient was hospitalized. Patient died on 09/06/2005.

Methotrexate Side Effects Report #4622928-X
Methotrexate side effect was reported by a Consumer or non-health professional from on Nov 25, 2004. Female patient, 85 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: fracture , interstitial lung disease, nasopharyngitis, pancytopenia, upper respiratory tract inflammation. Methotrexate dosage: 6 MG WEEKLY UNK. During the same period patient was treated with CALCITRIOL, ASPARATE CALCIUM, LEVOGLUTAMIDE, PREDNISOLONE. Patient died.

Methotrexate Side Effects Report #5862429-4
Methotrexate side effect was reported by a Consumer or non-health professional from JAPAN on Aug 14, 2008. Male patient, 71 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: angiocentric lymphoma, diffuse alveolar damage, interstitial lung disease, respiratory failure. Methotrexate dosage: 6 MG/WEEK, 8 MG/WEEK. Patient was hospitalized. Patient died.

Methotrexate Side Effects Report #4622956-4
Methotrexate side effect was reported by a Consumer or non-health professional from on Apr 01, 2004. Female patient, 64 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: hepatic failure, interstitial lung disease, mouth ulceration, renal failure, thrombocytopenic purpura. Methotrexate dosage: unknown. During the same period patient was treated with ETANERCEPT. Patient died.


Methotrexate Side Effects Report #4621499-1
Methotrexate side effect was reported by a Consumer or non-health professional from on Nov 25, 2003. Male patient, 61 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: anorexia, bone marrow depression, diarrhoea, interstitial lung disease, renal disorder. Methotrexate dosage: 0.857 MG. During the same period patient was treated with ALFACACIDOL, DICLOFENAC, MAGNESIUM OXIDE, MISOPROSTOL. Patient recovered.

Methotrexate Side Effects Report #4621527-3
Methotrexate side effect was reported by a Consumer or non-health professional from on Dec 02, 2003. Male patient, 18 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, pleurisy, pneumothorax, pulmonary fibrosis . Methotrexate dosage: unknown. Patient died.

Methotrexate Side Effects Report #4933529-8
Methotrexate side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2006. Male patient, 15 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: cytomegalovirus enterocolitis, diarrhoea, graft versus host disease, herpes zoster, interstitial lung disease, performance status decreased, sepsis , weight decreased. Methotrexate dosage: unknown. During the same period patient was treated with NEORAL. Patient recovered.

Methotrexate Side Effects Report #4944494-1
Methotrexate side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2006. Male patient, 15 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, cytomegalovirus enterocolitis, diarrhoea, graft versus host disease, herpes zoster, interstitial lung disease, performance status decreased, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with CYCLOSPORINE, IRRADIATION, CYCLOPHOSPHAMIDE, VEPESID. Patient recovered.

Methotrexate Side Effects Report #4957747-8
Methotrexate side effect was reported by a Consumer or non-health professional from JAPAN on Feb 22, 2006. Male patient, 15 years of age, was treated with Methotrexate. After drug was administered, patient experienced the following side effects: acute lymphocytic leukaemia recurrent, graft versus host disease, herpes zoster, interstitial lung disease, sepsis . Methotrexate dosage: unknown. During the same period patient was treated with SANDIMMUNE, IRRADIATION, CYCLOPHOSPHAMIDE, VEPESID. Patient recovered.


Methotrexate Side Effects Report #4622925-4
Methotrexate side effect was reported by a Consumer or non-health professional from on Mar 26, 2005. Female patient was treated with Methotrexate. After drug was administered, patient experienced the following side effects: interstitial lung disease, staphylococcal infection . Methotrexate dosage: 8 MG WEEKLY. Patient died.