Leflunomide and off label use Patient Reports February 11, 2012

Leflunomide Side Effects Report #5851320-5
Leflunomide side effect was reported by a Consumer or non-health professional from ITALY on Aug 14, 2008. Male patient, 40 years of age, was diagnosed with bk virus infection and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, hepatic enzyme increased, hepatotoxicity, off label use. Leflunomide dosage: unknown. During the same period patient was treated with TACROLIMUS, MYCOPHENOLATE MOFETIL, CORTICOSTEROIDS. Patient recovered.

Leflunomide Side Effects Report #5857992-3
Leflunomide side effect was reported by a Consumer or non-health professional from ITALY on Aug 19, 2008. Female patient, 36 years of age, was diagnosed with bk virus infection and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatitis c rna, off label use. Leflunomide dosage: unknown. During the same period patient was treated with THYMOGLOBULIN, CORTICOSTEROIDS, MYCOPHENOLATE MOFETIL, TACROLIMUS. Patient recovered.

Leflunomide Side Effects Report #5772026-7
Leflunomide side effect was reported by a Consumer or non-health professional from UNITED STATES on June 04, 2008. Female patient, 51 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood lactate dehydrogenase increased, ecchymosis, off label use, thrombocytopenia, thrombotic microangiopathy. Leflunomide dosage: unknown. During the same period patient was treated with TACROLIMUS, THYMOGLOBULIN, MYCOPHENOLATE MOFETIL. Patient recovered.

Leflunomide Side Effects Report #5794740-X
Leflunomide side effect was reported by a Consumer or non-health professional from UNITED STATES on June 17, 2008. Female patient, 51 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood lactate dehydrogenase increased, ecchymosis, haemolysis, off label use, overdose, thrombocytopenia, thrombotic microangiopathy. Leflunomide dosage: unknown. During the same period patient was treated with TACROLIMUS, THYMOGLOBULIN, MYCOPHENOLATE MOFETIL, CORTICOSTEROIDS, IVIGG, RITUXIMAB. Patient was hospitalized. Patient recovered.


Leflunomide Side Effects Report #5857991-1
Leflunomide side effect was reported by a Consumer or non-health professional from ITALY on Aug 19, 2008. Male patient, 40 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatic enzyme increased, off label use. Leflunomide dosage: unknown. During the same period patient was treated with TACROLIMUS, MYCOPHENOLATE MOFETIL, CORTICOSTEROIDS. Patient recovered.

Leflunomide Side Effects Report #5853787-5
Leflunomide side effect was reported by a Consumer or non-health professional from ITALY on Aug 14, 2008. Female patient, 36 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatitis c rna, off label use. Leflunomide dosage: unknown. During the same period patient was treated with THYMOGLOBULIN, CORTICOSTEROIDS, MYCOPHENOLATE MOFETIL, TACROLIMUS. Patient recovered.