Leflunomide and hepatotoxicity Patient Reports February 11, 2012

Leflunomide Side Effects Report #5523292-4
Leflunomide side effect was reported by a Consumer or non-health professional from on Nov 15, 2007. Female patient, 74 years of age, was diagnosed with rheumatoid arthritis  and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity, rash . Leflunomide dosage: unknown. During the same period patient was treated with AMLODIPINE, ATENOLOL, AZATHIOPRINE, OMEPRAZOLE, PREDNISOLONE, RISEDRONATE, SIMVASTATIN. Patient recovered.

Leflunomide Side Effects Report #5624828-5
Leflunomide side effect was reported by a Consumer or non-health professional from on Feb 06, 2008. Male patient, 72 years of age, was diagnosed with rheumatoid arthritis , duodenal ulcer, asthma , pain  and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity, jaundice , liver function test abnormal. Leflunomide dosage: unknown. During the same period patient was treated with TRIMEPRAZINE, CELECOXIB, OMEPRAZOLE, SERETIDE, FOLIC ACID, PARACETAMOL. Patient was hospitalized. Patient recovered.

Leflunomide Side Effects Report #5205829-8
Leflunomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Jan 05, 2007. Female patient, 55 years of age, weighting 145.0 lb, was diagnosed with rheumatoid arthritis  and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: coagulopathy, haemorrhagic stroke, hepatic failure, hepatotoxicity, influenza like illness, liver disorder, lung disorder, no therapeutic response. Leflunomide dosage: 10 MG DAILY PO. During the same period patient was treated with HUMIRA. Patient died on 11/23/2005.

Leflunomide Side Effects Report #5652175-4
Leflunomide side effect was reported by a Consumer or non-health professional from FRANCE on Feb 18, 2008. Female patient, 34 years of age, was diagnosed with juvenile arthritis, therapeutic procedure and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatic fibrosis, hepatic lesion, hepatic necrosis, hepatitis fulminant, hepatomegaly, hepatotoxicity, vitamin k deficiency. Leflunomide dosage: 20 MG/DAY. During the same period patient was treated with CHOLESTYRAMINE, ACETAMINOPHEN W. Patient was hospitalized. Patient recovered.


Leflunomide Side Effects Report #5676746-4
Leflunomide side effect was reported by a Physician from FRANCE on Mar 03, 2008. Female patient, 34 years of age, was diagnosed with juvenile arthritis, therapeutic procedure and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: blood fibrinogen decreased, hepatic fibrosis, hepatic necrosis, hepatitis fulminant, hepatomegaly, hepatotoxicity, prothrombin level abnormal, serum ferritin increased, vitamin k deficiency. Leflunomide dosage: 20 MG/DAY. During the same period patient was treated with CHOLESTYRAMINE, ACETAMINOPHEN W, PREDNISONE, NICARDECREASEINE, CANDESARTAN CILEXETIL, CALCIUM CARBONATE, CHOLECALCIFEROL. Patient was hospitalized. Patient recovered.

Leflunomide Side Effects Report #5851320-5
Leflunomide side effect was reported by a Consumer or non-health professional from ITALY on Aug 14, 2008. Male patient, 40 years of age, was diagnosed with bk virus infection and was treated with Leflunomide. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, hepatic enzyme increased, hepatotoxicity, off label use. Leflunomide dosage: unknown. During the same period patient was treated with TACROLIMUS, MYCOPHENOLATE MOFETIL, CORTICOSTEROIDS. Patient recovered.

Leflunomide Side Effects Report #5494977-3
Leflunomide side effect was reported by a Consumer or non-health professional from on Oct 17, 2007. Male patient, 72 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity, jaundice . Leflunomide dosage: unknown. During the same period patient was treated with TRIMEPRAZINE, CELECOXIB, OMEPRAZOLE, SERETIDE. Patient was hospitalized. Patient recovered.

Leflunomide Side Effects Report #6082507-7
Leflunomide side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 05, 2009. Female patient, 59 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity, liver transplant . Leflunomide dosage: unknown. During the same period patient was treated with LOVASTATIN. Patient recovered.

Leflunomide Side Effects Report #5813296-6
Leflunomide side effect was reported by a Consumer or non-health professional from HUNGARY on July 14, 2008. Male patient, 48 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity. Leflunomide dosage: unknown. Patient recovered.


Leflunomide Side Effects Report #5816143-1
Leflunomide side effect was reported by a Consumer or non-health professional from HUNGARY on July 14, 2008. Male patient, 48 years of age, was treated with Leflunomide. After drug was administered, patient experienced the following side effects: hepatotoxicity. Leflunomide dosage: unknown. Patient recovered.