Lapatinib and jaundice Patient Reports February 10, 2012

Lapatinib Side Effects Report #5609160-8
Lapatinib side effect was reported by a Health Professional from UNITED STATES on Jan 30, 2008. Male patient, 80 years of age, weighting 123.0 lb, was diagnosed with pancreatic carcinoma and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , bile duct obstruction, chromaturia, dyspnoea, fatigue, hyperbilirubinaemia, jaundice , liver function test abnormal, malignant neoplasm progression. Lapatinib dosage: 1500MG DAILY PO. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5430975-3
Lapatinib side effect was reported by a Physician from DENMARK on Aug 22, 2007. Female patient, 58 years of age, weighting 210.5 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea, fatigue, hepatotoxicity, jaundice , nausea , weight decreased. Lapatinib dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5465747-7
Lapatinib side effect was reported by a Physician from DENMARK on Sept 17, 2007. Female patient, 58 years of age, weighting 210.5 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea, fatigue, hepatotoxicity, jaundice , nausea , pyrexia, weight decreased. Lapatinib dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5518244-4
Lapatinib side effect was reported by a Physician from DENMARK on Nov 06, 2007. Female patient, 58 years of age, weighting 210.5 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea, fatigue, hepatic failure, hepatotoxicity, jaundice , nausea , pyrexia, weight decreased. Lapatinib dosage: 1500MG PER DAY. Patient recovered.


Lapatinib Side Effects Report #5395463-1
Lapatinib side effect was reported by a Physician from SPAIN on July 23, 2007. Female patient, 50 years of age, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: arthralgia, diarrhoea, disease progression, jaundice , metastases to lung, palmar-plantar erythrodysaesthesia syndrome. Lapatinib dosage: unknown. During the same period patient was treated with XELODA. Patient recovered.

Lapatinib Side Effects Report #5554296-3
Lapatinib side effect was reported by a Physician from SPAIN on Dec 12, 2007. Female patient, 50 years of age, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, diarrhoea, disease progression, gamma-glutamyltransferase increased, jaundice , palmar-plantar erythrodysaesthesia syndrome. Lapatinib dosage: unknown. During the same period patient was treated with XELODA. Patient recovered.

Lapatinib Side Effects Report #6041617-0
Lapatinib side effect was reported by a Physician from INDIA on Jan 15, 2009. Female patient, 47 years of age, weighting 99.43 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, enzyme abnormality, hepatic enzyme increased, jaundice . Lapatinib dosage: 1000MGD PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #6055539-2
Lapatinib side effect was reported by a Physician from INDIA on Jan 21, 2009. Female patient, 47 years of age, weighting 99.43 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, hepatic enzyme increased, jaundice . Lapatinib dosage: 1000MGD PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5430961-3
Lapatinib side effect was reported by a Physician from LITHUANIA on Aug 23, 2007. Female patient, 45 years of age, weighting 176.4 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: jaundice . Lapatinib dosage: 1500MG PER DAY. Patient recovered.


Lapatinib Side Effects Report #5490708-1
Lapatinib side effect was reported by a Physician from LITHUANIA on Oct 10, 2007. Female patient, 45 years of age, weighting 176.4 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: jaundice . Lapatinib dosage: 1500MG PER DAY. Patient recovered.

Lapatinib Side Effects Report #5283204-8
Lapatinib side effect was reported by a Physician from ISRAEL on Mar 23, 2007. Female patient, 44 years of age, weighting 154.3 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, dermatitis acneiform, fatigue, hepatotoxicity, jaundice , rash , transaminases increased. Lapatinib dosage: unknown. During the same period patient was treated with LORASTINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5527810-1
Lapatinib side effect was reported by a Physician from ISRAEL on Nov 20, 2007. Female patient, 44 years of age, weighting 154.3 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, dermatitis acneiform, fatigue, hepatotoxicity, jaundice , rash , transaminases increased. Lapatinib dosage: unknown. During the same period patient was treated with LORASTINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5554276-8
Lapatinib side effect was reported by a Physician from ISRAEL on Dec 06, 2007. Female patient, 44 years of age, weighting 154.3 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: dermatitis acneiform, fatigue, hepatotoxicity, hyperbilirubinaemia, jaundice , rash , transaminases increased. Lapatinib dosage: unknown. During the same period patient was treated with LORASTINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5899979-0
Lapatinib side effect was reported by a Physician from PAKISTAN on Sept 23, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , diarrhoea, jaundice , liver function test abnormal, nausea , pyrexia, rash . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.


Lapatinib Side Effects Report #5917413-9
Lapatinib side effect was reported by a Physician from PAKISTAN on Oct 09, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , aspartate aminotransferase increased, blood bilirubin increased, blood phosphorus increased, diarrhoea, jaundice , liver function test abnormal, nausea , pyrexia. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5928077-2
Lapatinib side effect was reported by a Physician from PAKISTAN on Oct 20, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , aspartate aminotransferase increased, blood bilirubin increased, blood phosphorus increased, diarrhoea, jaundice , liver function test abnormal, liver injury, nausea . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5937456-9
Lapatinib side effect was reported by a Physician from PAKISTAN on Oct 24, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , aspartate aminotransferase increased, blood bilirubin increased, blood phosphorus increased, diarrhoea, jaundice , liver function test abnormal, liver injury, nausea . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5942076-6
Lapatinib side effect was reported by a Physician from PAKISTAN on Oct 31, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , aspartate aminotransferase increased, blood bilirubin increased, blood phosphorus increased, diarrhoea, jaundice , liver function test abnormal, liver injury, nausea . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.

Lapatinib Side Effects Report #5950211-9
Lapatinib side effect was reported by a Physician from PAKISTAN on Nov 06, 2008. Female patient, 43 years of age, weighting 141.1 lb, was diagnosed with breast cancer  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , aspartate aminotransferase increased, blood bilirubin increased, blood phosphorus increased, diarrhoea, jaundice , liver function test abnormal, liver injury, nausea . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with TRASTUZUMAB. Patient recovered.


Lapatinib Side Effects Report #5338715-3
Lapatinib side effect was reported by a Physician from DENMARK on May 24, 2007. Female patient, 64 years of age, weighting 99.21 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: duodenal stenosis, hyperbilirubinaemia, jaundice , nausea . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5448689-2
Lapatinib side effect was reported by a Physician from UNITED STATES on Sept 06, 2007. Female patient, 62 years of age, weighting 111.3 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain lower, gastritis, gastrointestinal haemorrhage, haematemesis, haematochezia, hyperbilirubinaemia, hypokalaemia, jaundice , mesenteric vein thrombosis. Lapatinib dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5569666-7
Lapatinib side effect was reported by a Physician from DENMARK on Dec 18, 2007. Female patient, 60 years of age, weighting 174.2 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: ascites, bone marrow failure, diarrhoea, diarrhoea haemorrhagic, haematemesis, jaundice , mouth haemorrhage, neutropenia, oedema peripheral. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 12/18/2007.

Lapatinib Side Effects Report #5587106-9
Lapatinib side effect was reported by a Physician from DENMARK on Jan 02, 2008. Female patient, 60 years of age, weighting 174.2 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: ascites, bone marrow failure, diarrhoea, diarrhoea haemorrhagic, haematemesis, jaundice , mouth haemorrhage, neutropenia, oedema peripheral. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 12/18/2007.

Lapatinib Side Effects Report #5846647-7
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on July 21, 2008. Female patient, 58 years of age, weighting 140.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: biliary sepsis, confusional state, disease progression, hypokalaemia, jaundice , liver function test abnormal. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, ATENOLOL, BENDROFLUAZIDE, LAMOTRIGINE, LEVOTHYROXINE, BECLOMETHASONE DIPROPIONATE, ENOXAPARIN. Patient was hospitalized. Patient died on 06/15/2008.


Lapatinib Side Effects Report #5483764-8
Lapatinib side effect was reported by a Physician from UNITED STATES on Oct 04, 2007. Female patient, 56 years of age, weighting 150.4 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, infection , jaundice , liver function test abnormal, ocular icterus. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5380794-1
Lapatinib side effect was reported by a Physician from GERMANY on June 28, 2007. Female patient, 55 years of age, weighting 147.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct cancer, cholestasis, hyperbilirubinaemia, jaundice . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5580267-7
Lapatinib side effect was reported by a Physician from GERMANY on Dec 24, 2007. Female patient, 55 years of age, weighting 147.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct cancer, cholestasis, hyperbilirubinaemia, jaundice . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5702713-8
Lapatinib side effect was reported by a Physician from UNITED STATES on Apr 10, 2008. Female patient, 51 years of age, weighting 186.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct obstruction, jaundice , pruritus. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5709603-5
Lapatinib side effect was reported by a Physician from UNITED STATES on Apr 10, 2008. Female patient, 51 years of age, weighting 186.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , bile duct obstruction, faeces pale, jaundice . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB, CLARITIN, EMOLLIENTS. Patient was hospitalized. Patient recovered.


Lapatinib Side Effects Report #5730575-1
Lapatinib side effect was reported by a Physician from UNITED STATES on Apr 25, 2008. Female patient, 51 years of age, weighting 186.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain , bile duct obstruction, faeces pale, jaundice . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB, CLARITIN, EMOLLIENTS. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5872071-7
Lapatinib side effect was reported by a Physician from UNITED STATES on Sept 03, 2008. Female patient, 51 years of age, weighting 186.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct obstruction, jaundice , pruritus. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient was hospitalized. Patient recovered.

Lapatinib Side Effects Report #5395439-4
Lapatinib side effect was reported by a Physician from UNITED STATES on July 18, 2007. Female patient, 39 years of age, weighting 130.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct obstruction, disease progression, jaundice . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 04/27/2007.

Lapatinib Side Effects Report #5725212-6
Lapatinib side effect was reported by a Physician from BELGIUM on Apr 24, 2008. Female patient, 38 years of age, weighting 149.9 lb, was diagnosed with pain prophylaxis, urinary tract infection  and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: haemolytic anaemia, jaundice . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, IMODIUM, OMEPRAZOLE, CIPROFLOXACIN. Patient recovered.

Lapatinib Side Effects Report #5499364-X
Lapatinib side effect was reported by a Physician from CANADA on Oct 19, 2007. Female patient, 36 years of age, weighting 97.00 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: epistaxis, hepatic enzyme increased, hepatic function abnormal, jaundice , thrombocytopenia, vomiting. Lapatinib dosage: unknown. During the same period patient was treated with FEMARA, ZOLADEX. Patient was hospitalized. Patient recovered.