Lapatinib and hyperbilirubinaemia 
Lapatinib and hyperbilirubinaemia Patient Reports February 10, 2012
Lapatinib Side Effects Report #5609160-8
Lapatinib side effect was reported by a Health Professional from UNITED STATES on Jan 30, 2008. Male patient, 80 years of age, weighting 123.0 lb, was diagnosed with pancreatic carcinoma and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain
, bile duct obstruction, chromaturia, dyspnoea, fatigue, hyperbilirubinaemia, jaundice , liver function test abnormal, malignant neoplasm progression. Lapatinib dosage: 1500MG DAILY PO. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5436003-8
Lapatinib side effect was reported by a Physician from UNITED STATES on Aug 29, 2007. Female patient, 62 years of age, weighting 111.3 lb, was diagnosed with pancreatic carcinoma and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain lower, arteriovenous malformation
, gastritis, gastrointestinal haemorrhage, haematemesis, haematochezia, hyperbilirubinaemia, hypokalaemia, jaundice . Lapatinib dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5942077-8
Lapatinib side effect was reported by a Physician from ITALY on Oct 31, 2008. Female patient, 58 years of age, weighting 127.9 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, haematotoxicity, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, lymphadenopathy. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5963371-0
Lapatinib side effect was reported by a Physician from ITALY on Nov 18, 2008. Female patient, 58 years of age, weighting 127.9 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, pyrexia, renal impairment. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5719608-6
Lapatinib side effect was reported by a Physician from ITALY on Apr 18, 2008. Female patient, 49 years of age, weighting 172.0 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: hyperbilirubinaemia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient died on 04/14/2008.
Lapatinib Side Effects Report #6133688-8
Lapatinib side effect was reported by a Physician from HUNGARY on Mar 16, 2009. Female patient, 68 years of age, weighting 143.3 lb, was diagnosed with breast cancer
, hypertension and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abnormal behaviour, blood magnesium decreased, headache , hepatic enzyme increased, hyperbilirubinaemia, hypoalbuminaemia, hypocalcaemia, hypokalaemia, somnolence. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with PIRACETAM, VINPOCETINE, FOSINOPRIL, ACETYLSALICYLIC ACID, COVEREX, CAVINTONTE, NOOTROPIL, MAGNESIUM SULPHATE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5813664-2
Lapatinib side effect was reported by a Physician from SOUTH AFRICA on July 14, 2008. Female patient, 63 years of age, weighting 158.7 lb, was diagnosed with breast cancer
, diaphragmatic hernia and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, hepatic pain, hyperbilirubinaemia. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with LANSOPRAZOLE, HERCEPTIN. Patient recovered.Lapatinib Side Effects Report #5870629-2
Lapatinib side effect was reported by a Physician from SOUTH AFRICA on Sept 02, 2008. Female patient, 47 years of age, weighting 218.3 lb, was diagnosed with breast cancer
, prophylaxis and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain upper, alanine aminotransferase increased, diarrhoea, faeces pale, hyperbilirubinaemia, perihepatic discomfort. Lapatinib dosage: 1000MG PER DAY. During the same period patient was treated with TRASTUZUMAB, PACLITAXEL, NEXIUM. Patient recovered.Lapatinib Side Effects Report #5886335-4
Lapatinib side effect was reported by a Physician from SOUTH AFRICA on Sept 12, 2008. Female patient, 47 years of age, weighting 218.3 lb, was diagnosed with breast cancer
, prophylaxis and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain upper, alanine aminotransferase increased, diarrhoea, faeces pale, hyperbilirubinaemia, perihepatic discomfort. Lapatinib dosage: 1000MG PER DAY. During the same period patient was treated with TRASTUZUMAB, PACLITAXEL, NEXIUM. Patient recovered.Lapatinib Side Effects Report #5922058-0
Lapatinib side effect was reported by a Physician from SOUTH AFRICA on Oct 10, 2008. Female patient, 47 years of age, weighting 218.3 lb, was diagnosed with breast cancer
, prophylaxis and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain upper, alanine aminotransferase increased, diarrhoea, faeces pale, hyperbilirubinaemia, perihepatic discomfort. Lapatinib dosage: 1000MG PER DAY. During the same period patient was treated with TRASTUZUMAB, PACLITAXEL, NEXIUM. Patient recovered.Lapatinib Side Effects Report #5395472-2
Lapatinib side effect was reported by a Physician from SPAIN on July 23, 2007. Female patient, 45 years of age, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea haemorrhagic, eating disorder , hepatotoxicity, hyperbilirubinaemia, mucosal inflammation, multi-organ failure, neutropenia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with XELODA. Patient died on 07/08/2007.Lapatinib Side Effects Report #5554278-1
Lapatinib side effect was reported by a Physician from SPAIN on Dec 12, 2007. Female patient, 45 years of age, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea haemorrhagic, eating disorder , hepatotoxicity, hyperbilirubinaemia, mucosal inflammation, multi-organ failure, neutropenia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with XELODA. Patient died on 07/08/2007.Lapatinib Side Effects Report #5554295-1
Lapatinib side effect was reported by a Physician from SPAIN on Dec 12, 2007. Female patient, 45 years of age, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea haemorrhagic, eating disorder , gastrointestinal toxicity, hepatotoxicity, hyperbilirubinaemia, ileus paralytic, mucosal inflammation, multi-organ failure, neutropenia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with XELODA. Patient was hospitalized. Patient died on 07/08/2007.Lapatinib Side Effects Report #5554276-8
Lapatinib side effect was reported by a Physician from ISRAEL on Dec 06, 2007. Female patient, 44 years of age, weighting 154.3 lb, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: dermatitis acneiform, fatigue, hepatotoxicity, hyperbilirubinaemia, jaundice , rash , transaminases increased. Lapatinib dosage: unknown. During the same period patient was treated with LORASTINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5612590-1
Lapatinib side effect was reported by a Physician from UNITED STATES on Jan 29, 2008. Male patient, 80 years of age, weighting 123.2 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain
, bile duct obstruction, chromaturia, dyspnoea, fatigue, hepatic enzyme increased, hepatic function abnormal, hyperbilirubinaemia, jaundice . Lapatinib dosage: 1500MG PER DAY. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5700943-2
Lapatinib side effect was reported by a Physician from GERMANY on Apr 08, 2008. Female patient, 69 years of age, weighting 136.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: haemangioma, hepatic cyst, hyperbilirubinaemia. Lapatinib dosage: unknown. During the same period patient was treated with CAPECITABINE. Patient recovered.
Lapatinib Side Effects Report #5338715-3
Lapatinib side effect was reported by a Physician from DENMARK on May 24, 2007. Female patient, 64 years of age, weighting 99.21 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: duodenal stenosis, hyperbilirubinaemia, jaundice
, nausea . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5448689-2
Lapatinib side effect was reported by a Physician from UNITED STATES on Sept 06, 2007. Female patient, 62 years of age, weighting 111.3 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain lower, gastritis, gastrointestinal haemorrhage, haematemesis, haematochezia, hyperbilirubinaemia, hypokalaemia, jaundice
, mesenteric vein thrombosis. Lapatinib dosage: unknown. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5978571-3
Lapatinib side effect was reported by a Physician from BRAZIL on Dec 01, 2008. Female patient, 61 years of age, weighting 111.1 lb, was diagnosed with gastritis prophylaxis and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: hyperbilirubinaemia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, OMEPRAZOLE. Patient recovered.
Lapatinib Side Effects Report #6006320-1
Lapatinib side effect was reported by a Physician from BRAZIL on Dec 15, 2008. Female patient, 61 years of age, weighting 111.1 lb, was diagnosed with gastritis prophylaxis and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: hyperbilirubinaemia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, OMEPRAZOLE. Patient recovered.
Lapatinib Side Effects Report #5934171-2
Lapatinib side effect was reported by a Physician from ITALY on Oct 24, 2008. Female patient, 58 years of age, weighting 127.9 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, pyrexia, renal impairment. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5946500-4
Lapatinib side effect was reported by a Physician from ITALY on Nov 05, 2008. Female patient, 58 years of age, weighting 127.9 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, pyrexia, renal impairment. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5950212-0
Lapatinib side effect was reported by a Physician from ITALY on Nov 10, 2008. Female patient, 58 years of age, weighting 127.9 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, pyrexia, renal impairment. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5972509-0
Lapatinib side effect was reported by a Physician from ITALY on Nov 28, 2008. Female patient, 58 years of age, weighting 127.9 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, diarrhoea, febrile neutropenia, hyperbilirubinaemia, hypercreatinaemia, laboratory test abnormal, leukopenia, pyrexia, renal impairment. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, VINORELBINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5380794-1
Lapatinib side effect was reported by a Physician from GERMANY on June 28, 2007. Female patient, 55 years of age, weighting 147.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct cancer, cholestasis, hyperbilirubinaemia, jaundice
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5580267-7
Lapatinib side effect was reported by a Physician from GERMANY on Dec 24, 2007. Female patient, 55 years of age, weighting 147.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct cancer, cholestasis, hyperbilirubinaemia, jaundice
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5915116-8
Lapatinib side effect was reported by a Physician from BELGIUM on Oct 07, 2008. Female patient, 53 years of age, weighting 132.3 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diarrhoea, hyperbilirubinaemia, hypokalaemia. Lapatinib dosage: 1250MGD PER DAY. During the same period patient was treated with CAPECITABINE, MEDROL. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5357376-0
Lapatinib side effect was reported by a Physician from ITALY on June 06, 2007. Female patient, 44 years of age, weighting 372.6 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: hyperbilirubinaemia, ill-defined disorder, thrombocytopenia. Lapatinib dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5384198-7
Lapatinib side effect was reported by a Physician from ITALY on July 04, 2007. Female patient, 44 years of age, weighting 372.6 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: hyperbilirubinaemia, ill-defined disorder, thrombocytopenia. Lapatinib dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5757056-3
Lapatinib side effect was reported by a Physician from BELGIUM on May 28, 2008. Female patient, 38 years of age, weighting 149.9 lb, was diagnosed with pain prophylaxis, urinary tract infection
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: haemolytic anaemia, haptoglobin decreased, hyperbilirubinaemia, ocular icterus. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with XELODA, IMODIUM, OMEPRAZOLE, CIPROFLOXACIN. Patient recovered.Lapatinib Side Effects Report #5787924-8
Lapatinib side effect was reported by a Physician from BELGIUM on June 17, 2008. Female patient, 38 years of age, weighting 149.9 lb, was diagnosed with pain prophylaxis, urinary tract infection
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: haemolytic anaemia, haptoglobin decreased, hyperbilirubinaemia, ocular icterus. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, IMODIUM, OMEPRAZOLE, CIPROFLOXACIN. Patient recovered.Lapatinib Side Effects Report #5798200-1
Lapatinib side effect was reported by a Physician from BELGIUM on June 25, 2008. Female patient, 38 years of age, weighting 149.9 lb, was diagnosed with pain prophylaxis, urinary tract infection
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: haemolytic anaemia, haptoglobin decreased, hyperbilirubinaemia, ocular icterus. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, IMODIUM, OMEPRAZOLE, CIPROFLOXACIN. Patient recovered.