Lapatinib and disease progression 
Lapatinib and disease progression Patient Reports February 10, 2012
Lapatinib Side Effects Report #5640007-X
Lapatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 26, 2008. Male patient, 80 years of age, weighting 126.0 lb, was diagnosed with pancreatic carcinoma and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal discomfort, blood alkaline phosphatase increased, blood bilirubin increased, constipation
, deep vein thrombosis , disease progression, dizziness , lung neoplasm. Lapatinib dosage: 1500MG DAILY ORAL. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5879349-1
Lapatinib side effect was reported by a Physician from CANADA on Sept 10, 2008. Female patient, 57 years of age, weighting 96.12 lb, was diagnosed with metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: asthenia, disease progression, headache
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with TOPOTECAN, CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5293486-4
Lapatinib side effect was reported by a Physician from FRANCE on Apr 03, 2007. Female patient, 45 years of age, weighting 125.7 lb, was diagnosed with metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, headache
. Lapatinib dosage: 750MG TWICE PER DAY. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5293487-6
Lapatinib side effect was reported by a Physician from UNITED STATES on Apr 03, 2007. Female patient, 42 years of age, weighting 139.6 lb, was diagnosed with metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: convulsion, disease progression. Lapatinib dosage: 750MG TWICE PER DAY. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5717955-5
Lapatinib side effect was reported by a Physician from IRELAND on Apr 18, 2008. Female patient, 35 years of age, weighting 143.3 lb, was diagnosed with cervix carcinoma, pain
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, colitis, diarrhoea, disease progression. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with PARACETAMOL. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #6071019-2
Lapatinib side effect was reported by a Physician from IRELAND on Feb 02, 2009. Female patient, 67 years of age, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, lower respiratory tract infection, pallor. Lapatinib dosage: 1250MG PER DAY. Patient died on 01/28/2009.
Lapatinib Side Effects Report #5877899-5
Lapatinib side effect was reported by a Physician from UNITED STATES on Sept 04, 2008. Female patient, 61 years of age, weighting 126.8 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anaemia, disease progression, faeces discoloured, gastric haemorrhage, gastritis, gastritis erosive, haemorrhagic anaemia, lower gastrointestinal haemorrhage. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with BEVACIZUMAB. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5523351-6
Lapatinib side effect was reported by a Physician from TAIWAN, PROVINCE OF CHINA on Nov 13, 2007. Female patient, 60 years of age, weighting 113.1 lb, was diagnosed with breast cancer metastatic, metastases to central nervous system, constipation
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood creatinine increased, blood glucose increased, blood pressure increased, blood sodium decreased, blood urea increased, diarrhoea, disease progression, febrile neutropenia, haematocrit decreased. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, PREDNISOLONE, SENNOSIDE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5862886-3
Lapatinib side effect was reported by a Physician from UNITED STATES on Aug 19, 2008. Female patient, 58 years of age, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, dyspnoea, effusion, oxygen saturation decreased. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5877937-X
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on Sept 03, 2008. Female patient, 58 years of age, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood alkaline phosphatase increased, brain oedema, brain scan abnormal, confusional state, disease progression, gamma-glutamyltransferase increased, herpes zoster, muscular weakness, urinary incontinence
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5917417-6
Lapatinib side effect was reported by a Physician from CHINA on Oct 09, 2008. Female patient, 54 years of age, weighting 158.7 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, ejection fraction decreased, ill-defined disorder. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, EPIRUBICIN. Patient recovered.
Lapatinib Side Effects Report #5293529-8
Lapatinib side effect was reported by a Physician from KOREA, REPUBLIC OF on Apr 02, 2007. Female patient, 46 years of age, weighting 90.39 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anorexia, disease progression, dyspnoea, hypotension, hypoxia, metastases to lung, rales. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, GEMCITABINE, PACLITAXEL, RADIATION, TRASTUZUMAB. Patient was hospitalized and became disabled. Patient died on 04/01/2007.
Lapatinib Side Effects Report #5310054-6
Lapatinib side effect was reported by a Physician from KOREA, REPUBLIC OF on Apr 19, 2007. Female patient, 46 years of age, weighting 90.39 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anorexia, disease progression, dyspnoea, hypotension, hypoxia, malignant neoplasm progression, metastases to adrenals, metastases to liver, metastases to lung. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, GEMCITABINE, PACLITAXEL, RADIATION, TRASTUZUMAB. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5651062-5
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on Feb 28, 2008. Female patient, 46 years of age, was diagnosed with breast cancer metastatic, pain
, insomnia and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: balance disorder, disease progression, fall . Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, DEXAMETHASONE, TEMAZEPAM. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5734876-2
Lapatinib side effect was reported by a Physician from FRANCE on May 02, 2008. Female patient, 44 years of age, weighting 121.3 lb, was diagnosed with breast cancer metastatic, epilepsy
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: altered state of consciousness, cholestasis, convulsion, disease progression, hepatocellular injury. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with XELODA, NEURONTIN. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5396673-X
Lapatinib side effect was reported by a Physician from ITALY on July 19, 2007. Female patient, 43 years of age, weighting 136.7 lb, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: alanine aminotransferase increased, aspartate aminotransferase increased, disease progression. Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with HEPARIN. Patient recovered.
Lapatinib Side Effects Report #5669757-6
Lapatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Mar 13, 2008. Female patient, 36 years of age, was diagnosed with breast cancer metastatic and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: breast cancer metastatic, disease progression, dyspnoea, neutropenia, treatment noncompliance. Lapatinib dosage: 1500MG ORAL, INTERMITTEN. During the same period patient was treated with VINORELBINE, OXYCONTIN, ATIVAN, COMPAZINE, NEUPOGEN. Patient recovered.
Lapatinib Side Effects Report #5395463-1
Lapatinib side effect was reported by a Physician from SPAIN on July 23, 2007. Female patient, 50 years of age, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: arthralgia, diarrhoea, disease progression, jaundice , metastases to lung, palmar-plantar erythrodysaesthesia syndrome. Lapatinib dosage: unknown. During the same period patient was treated with XELODA. Patient recovered.Lapatinib Side Effects Report #5554296-3
Lapatinib side effect was reported by a Physician from SPAIN on Dec 12, 2007. Female patient, 50 years of age, was diagnosed with breast cancer
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: blood bilirubin increased, diarrhoea, disease progression, gamma-glutamyltransferase increased, jaundice , palmar-plantar erythrodysaesthesia syndrome. Lapatinib dosage: unknown. During the same period patient was treated with XELODA. Patient recovered.Lapatinib Side Effects Report #5293492-X
Lapatinib side effect was reported by a Physician from UNITED STATES on Apr 03, 2007. Male patient, 77 years of age, weighting 126.8 lb, was diagnosed with adenocarcinoma and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain
, chills, decreased appetite, diarrhoea, disease progression, dyspnoea, fatigue, haemoglobin decreased, melaena. Lapatinib dosage: 1000MG PER DAY. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #6064599-4
Lapatinib side effect was reported by a Physician from IRELAND on Jan 29, 2009. Female patient, 67 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, lower respiratory tract infection. Lapatinib dosage: 1250MG PER DAY. Patient died on 01/28/2009.
Lapatinib Side Effects Report #6111368-2
Lapatinib side effect was reported by a Physician from IRELAND on Mar 06, 2009. Female patient, 67 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, lower respiratory tract infection. Lapatinib dosage: 1250MG PER DAY. Patient died on 01/28/2009.
Lapatinib Side Effects Report #6021360-4
Lapatinib side effect was reported by a Physician from IRELAND on Dec 23, 2008. Female patient, 66 years of age, weighting 170.9 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: breast discharge, disease progression, malaise, nausea
, neutropenia, skin lesion, white blood cell count decreased. Lapatinib dosage: unknown. During the same period patient was treated with EPIRUBICIN, EMCOR, DIAMICRON, RAMIPRIL. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5931544-9
Lapatinib side effect was reported by a Physician from FRANCE on Oct 17, 2008. Female patient, 65 years of age, weighting 143.3 lb, was diagnosed with anxiety
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: diplopia, disease progression. Lapatinib dosage: unknown. During the same period patient was treated with TAMOXIFEN CITRATE, RIVOTRIL, ANAFRANIL, GINKORT, ALDACTONE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5347942-0
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on May 31, 2007. Female patient, 63 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, dyspnoea, superior vena caval occlusion. Lapatinib dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5355619-0
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on June 08, 2007. Female patient, 63 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: disease progression, dyspnoea, superior vena caval occlusion. Lapatinib dosage: 1250MGM2 PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #5846647-7
Lapatinib side effect was reported by a Physician from UNITED KINGDOM on July 21, 2008. Female patient, 58 years of age, weighting 140.7 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: biliary sepsis, confusional state, disease progression, hypokalaemia, jaundice
, liver function test abnormal. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, ATENOLOL, BENDROFLUAZIDE, LAMOTRIGINE, LEVOTHYROXINE, BECLOMETHASONE DIPROPIONATE, ENOXAPARIN. Patient was hospitalized. Patient died on 06/15/2008.Lapatinib Side Effects Report #5793344-2
Lapatinib side effect was reported by a Physician from IRELAND on June 24, 2008. Female patient, 57 years of age, weighting 110.5 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anxiety
, cardiomyopathy , disease progression, dyspnoea, palpitations, productive cough. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5943193-7
Lapatinib side effect was reported by a Physician from BELGIUM on Oct 27, 2008. Female patient, 57 years of age, weighting 180.8 lb, was diagnosed with hypertension and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: cerebral ischaemia, cerebrovascular accident, disease progression, hemiplegia. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, ZESTRIL, DILTIAZEM. Patient was hospitalized. Patient recovered.
Lapatinib Side Effects Report #6042915-7
Lapatinib side effect was reported by a Physician from IRELAND on Jan 15, 2009. Female patient, 57 years of age, weighting 110.5 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anxiety
, cardiomyopathy , disease progression, dyspnoea, palpitations, productive cough. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #6124621-3
Lapatinib side effect was reported by a Physician from GERMANY on Mar 12, 2009. Female patient, 57 years of age, weighting 132.3 lb, was diagnosed with nausea
and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: asthenia, diarrhoea, disease progression, nausea , pain , pulmonary embolism , respiratory failure, weight decreased. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, METOCLOPRAMIDE, OMEPRAZOLE. Patient was hospitalized. Patient died on 03/02/2008.Lapatinib Side Effects Report #5401342-3
Lapatinib side effect was reported by a Physician from FRANCE on July 26, 2007. Female patient, 52 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anorexia, asthenia, disease progression, nausea
. Lapatinib dosage: 1500MG PER DAY. Patient was hospitalized. Patient died on 07/11/2007.Lapatinib Side Effects Report #5479629-8
Lapatinib side effect was reported by a Physician from FRANCE on Sept 28, 2007. Female patient, 52 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anorexia, asthenia, disease progression, nausea
. Lapatinib dosage: 1500MG PER DAY. Patient was hospitalized. Patient died on 07/11/2007.Lapatinib Side Effects Report #5349273-1
Lapatinib side effect was reported by a Physician from UNITED STATES on May 31, 2007. Female patient, 51 years of age, weighting 99.21 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: abdominal pain
, disease progression, nausea . Lapatinib dosage: 1500MG PER DAY. During the same period patient was treated with GEMCITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5342172-0
Lapatinib side effect was reported by a Physician from KOREA, REPUBLIC OF on May 24, 2007. Female patient, 46 years of age, weighting 90.39 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: anorexia, disease progression, dyspnoea, hypotension, hypoxia, metastases to lung, rales. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, GEMCITABINE, PACLITAXEL, RADIATION, TRASTUZUMAB. Patient was hospitalized. Patient died on 04/01/2007.
Lapatinib Side Effects Report #5811703-6
Lapatinib side effect was reported by a Physician from BRAZIL on July 08, 2008. Female patient, 46 years of age, weighting 149.9 lb, was diagnosed with hypertension, metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: confusional state, convulsion, disease progression, encephalitis
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, CAPOTEN, DEPAKENE, ZOMETA. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5830204-2
Lapatinib side effect was reported by a Physician from BRAZIL on July 25, 2008. Female patient, 46 years of age, weighting 149.9 lb, was diagnosed with hypertension, metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: confusional state, convulsion, disease progression, encephalitis
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, CAPOTEN, DEPAKENE, ZOMETA, RANITIDINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5852607-2
Lapatinib side effect was reported by a Physician from BRAZIL on Aug 14, 2008. Female patient, 46 years of age, weighting 149.9 lb, was diagnosed with hypertension, metastases to central nervous system and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: confusional state, disease progression, encephalitis
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, CAPOTEN, DEPAKENE, ZOMETA, RANITIDINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5907415-0
Lapatinib side effect was reported by a Physician from CANADA on Sept 26, 2008. Female patient, 41 years of age, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: dehydration, disease progression, nausea
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient recovered.Lapatinib Side Effects Report #5395439-4
Lapatinib side effect was reported by a Physician from UNITED STATES on July 18, 2007. Female patient, 39 years of age, weighting 130.1 lb, was treated with Lapatinib. After drug was administered, patient experienced the following side effects: bile duct obstruction, disease progression, jaundice
. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE. Patient was hospitalized. Patient died on 04/27/2007.Lapatinib Side Effects Report #5580273-2
Lapatinib side effect was reported by a Physician from ICELAND on Dec 24, 2007. Female patient, 39 years of age, was diagnosed with bone pain and was treated with Lapatinib. After drug was administered, patient experienced the following side effects: clostridial infection, dehydration, diarrhoea, disease progression, hypotension, pneumonia klebsiella, pyrexia, sepsis
, stent occlusion. Lapatinib dosage: 1250MG PER DAY. During the same period patient was treated with CAPECITABINE, CELEBRA. Patient was hospitalized. Patient recovered.