Isovorin and neutropenia Patient Reports February 12, 2012

Isovorin Side Effects Report #5336902-1
Isovorin side effect was reported by a Health Professional from JAPAN on May 17, 2007. Female patient, weighting 121.3 lb, was diagnosed with diarrhoea, rectal cancer and was treated with Isovorin. After drug was administered, patient experienced the following side effects: duodenal ulcer perforation, leukopenia, neutropenia. Isovorin dosage: unknown. During the same period patient was treated with SOLDEM, FLUOROURACIL, OXALIPLATIN. Patient was hospitalized. Patient recovered.

Isovorin Side Effects Report #5117842-X
Isovorin side effect was reported by a Physician from JAPAN on May 19, 2006. Female patient was diagnosed with rectal cancer, blood pressure decreased, antibiotic prophylaxis, stomach discomfort, nausea  and was treated with Isovorin. After drug was administered, patient experienced the following side effects: cardiac arrest , leukopenia, neutropenia, pneumonia , septic shock, thrombocytopenia. Isovorin dosage: 100.8 MG/M2 ON DAYS 1 AND 2. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL, LIDOCAINE, EPINEPHRINE, IMIPENEM CILASTATIN, FAMOTIDINE, METOCLOPRAMIDE. Patient died on 03/17/2006.

Isovorin Side Effects Report #5788085-1
Isovorin side effect was reported by a Health Professional from JAPAN on June 17, 2008. Male patient, weighting 149.9 lb, was diagnosed with hypertension, rectal cancer and was treated with Isovorin. After drug was administered, patient experienced the following side effects: anaphylactic shock, myocardial ischaemia, neutropenia. Isovorin dosage: unknown. During the same period patient was treated with CALBLOCK, ELPLAT, FLUOROURACIL. Patient recovered.