Isovorin and disseminated intravascular coagulation Patient Reports February 12, 2012

Isovorin Side Effects Report #5080440-0
Isovorin side effect was reported by a Health Professional from JAPAN on July 26, 2006. Male patient, 60 years of age, weighting 112.4 lb, was diagnosed with rectal cancer and was treated with Isovorin. After drug was administered, patient experienced the following side effects: bradycardia, cardiac arrest , depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, leukopenia, metabolic acidosis, neutropenia. Isovorin dosage: unknown. During the same period patient was treated with OXALIPLATIN, FLUOROURACIL. Patient died on 07/26/2006.

Isovorin Side Effects Report #5304826-1
Isovorin side effect was reported by a Health Professional from JAPAN on Apr 12, 2007. Female patient, weighting 70.55 lb, was diagnosed with rectal cancer and was treated with Isovorin. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, haemoglobin decreased, thrombocytopenia. Isovorin dosage: unknown. During the same period patient was treated with OXALIPLATIN, KYTRIL, DECADRON, FLUOROURACIL. Patient recovered.

Isovorin Side Effects Report #5649521-4
Isovorin side effect was reported by a Health Professional from JAPAN on Feb 22, 2008. Male patient, weighting 134.5 lb, was diagnosed with rectal cancer, prophylaxis of nausea and vomiting and was treated with Isovorin. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, leukopenia, necrotising fasciitis, thrombocytopenia. Isovorin dosage: 325MG/BODY = 203.1 MG/M2 IN INFUSION ON DAY 1. During the same period patient was treated with ELPLAT, SAWACILLIN, SINSERON, DECADRON, KYTRIL, FLUOROURACIL. Patient died on 11/26/2007.