Irinotecan and malignant neoplasm progression Patient Reports February 12, 2012

Irinotecan Side Effects Report #4745852-0
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Aug 15, 2005. Male patient, 45 years of age, weighting 154.3 lb, was diagnosed with small intestine carcinoma metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: adenocarcinoma, exophthalmos, eye swelling, fatigue, headache , hypercoagulation, malignant neoplasm progression, metastasis. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FLUOROURACIL, COMPAZINE, DECADRON, ZOFRAN, MIRACLE MOUTHWASH, DILAUDID. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4824629-1
Irinotecan side effect was reported by a Physician from GERMANY on July 27, 2005. Female patient, 81 years of age, weighting 127.9 lb, was diagnosed with rectosigmoid cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: body temperature increased, circulatory collapse, diarrhoea, malignant neoplasm progression, metastases to liver, rectosigmoid cancer, tachycardia paroxysmal. Irinotecan dosage: 80 MG/M2 (CYCLICAL, INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, CETUXIMAB, DEXAMETHASONE, ATROPINE SULPHATE, ZOFRAN, TAVEGIL, FOLIC ACID. Patient was hospitalized. Patient died on 12/14/2004.

Irinotecan Side Effects Report #5154626-0
Irinotecan side effect was reported by a Physician from GERMANY on Mar 28, 1998. Male patient, 67 years of age, was diagnosed with rectal cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: atrial fibrillation , leukopenia, malignant neoplasm progression, rectal cancer metastatic, sepsis , thrombocytopenia. Irinotecan dosage: 530 MG, INTRAVENOUS. During the same period patient was treated with ALLOPURINOL, DEXABENE, ZANTIC, ZOFRAN. Patient died on 03/25/1998.

Irinotecan Side Effects Report #4830322-1
Irinotecan side effect was reported by a Physician from JAPAN on Nov 02, 2005. Male patient, 62 years of age, was diagnosed with rectal cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: condition aggravated, interstitial lung disease, malignant neoplasm progression, metastases to lung, rectal cancer, tumour marker increased. Irinotecan dosage: 60-100 MG (EVERY TWO WEEKS), INTRAVENOUS. During the same period patient was treated with TEGAFUR. Patient recovered.


Irinotecan Side Effects Report #4642932-5
Irinotecan side effect was reported by a Physician from on Feb 17, 2005. Male patient, 62 years of age, weighting 160.9 lb, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: diarrhoea, haematuria, infusion related reaction, leukocytosis, malignant neoplasm progression, metastases to bladder, metastases to lung, polyneuropathy. Irinotecan dosage: 114 MG, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4912048-9
Irinotecan side effect was reported by a Physician from UNITED KINGDOM on Jan 09, 2006. Male patient, 49 years of age, weighting 181.4 lb, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: intestinal obstruction, malignant neoplasm progression, rectal cancer. Irinotecan dosage: (120 MG, WEEKLY), INTRAVENOUS. During the same period patient was treated with CAPECITABINE, ACETAMINOPHEN, IMODIUM, PYRIDOXINE. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5013898-3
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on May 12, 2006. Female patient, 72 years of age, weighting 68.34 lb, was diagnosed with pancreatic carcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: bone marrow failure, disseminated intravascular coagulation, hepatic steatosis, malignant neoplasm progression, pancreatic carcinoma metastatic, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with PN TWIN, ELEMENMIC, INTRALIPID, DECADRON SRC. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5013819-3
Irinotecan side effect was reported by a Physician from JAPAN on May 12, 2006. Female patient, 51 years of age, weighting 94.80 lb, was diagnosed with pancreatic carcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: diarrhoea, hepatic steatosis, leukopenia, malignant ascites, malignant neoplasm progression, multi-organ failure, pancreatic carcinoma. Irinotecan dosage: unknown. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE SOLUTION, IRINOTECAN HYDROCHLORIDE SOLUTION, NEUPOGEN, URSO, DECADRON SRC. Patient recovered.

Irinotecan Side Effects Report #5072971-4
Irinotecan side effect was reported by a Physician from JAPAN on July 20, 2006. Female patient, 82 years of age, weighting 72.75 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, interstitial lung disease, leukopenia, lung infection, lymphangiosis carcinomatosa, malaise, malignant ascites, malignant neoplasm progression, pyrexia. Irinotecan dosage: 25 MG (1 IN 1 WK), INTRAVENOUS. During the same period patient was treated with LANSOPRAZOLE, JUZENTAIHOTO, ALLOID, FLUCALIN. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5033367-4
Irinotecan side effect was reported by a Physician from JAPAN on June 07, 2006. Female patient, 82 years of age, weighting 72.75 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: interstitial lung disease, leukopenia, malignant neoplasm progression. Irinotecan dosage: unknown. During the same period patient was treated with LANSOPRAZOLE, JUZENTAIHOTO, ALLOID, FLUCALIN. Patient recovered.

Irinotecan Side Effects Report #4968730-0
Irinotecan side effect was reported by a Physician from JAPAN on Jan 12, 2006. Female patient, 59 years of age, weighting 107.1 lb, was diagnosed with non-small cell lung cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: ascites, depressed level of consciousness, grand mal convulsion, haemodilution, inappropriate antidiuretic hormone secretion, lung adenocarcinoma, malignant neoplasm progression, oral intake reduced, vomiting. Irinotecan dosage: 60 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN, BICARBONATE IN PLASTIC CONTAINER, URSO, MAGNESIUM OXIDE, PRIMPERAN. Patient recovered.

Irinotecan Side Effects Report #5107515-1
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Sept 13, 2006. Male patient, 69 years of age, weighting 141.0 lb, was diagnosed with neoplasm malignant and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: dysphasia, malignant neoplasm progression, performance status decreased, pneumonia aspiration. Irinotecan dosage: 50 MG/M2 D1,8,22,29 Q 6WKS IV. During the same period patient was treated with CISPLATIN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5042912-4
Irinotecan side effect was reported by a Physician from JAPAN on June 13, 2006. Male patient, weighting 138.5 lb, was diagnosed with neoplasm malignant and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: interstitial lung disease, lymphangiosis carcinomatosa, malignant neoplasm progression, pneumonia , pneumonia primary atypical. Irinotecan dosage: 100 MG/M*2 (100 MG/M*2), INTRAVENOUS. During the same period patient was treated with TEGAFUR, NORVASC. Patient recovered.

Irinotecan Side Effects Report #5051762-4
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 13, 2006. Female patient, weighting 116.4 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: condition aggravated, culture wound positive, erythema, malignant neoplasm progression, post procedural complication, serratia infection. Irinotecan dosage: 325MG/M2 DAY 1,8,22,29 IV. During the same period patient was treated with TEMODAR, DILANTIN, NEXIUM, DEXAMETHASONE, SENOKOT, ENDOCET. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5173437-3
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 08, 2006. Male patient, weighting 269.0 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: confusional state, convulsion, glioblastoma multiforme, malignant neoplasm progression, mental status changes. Irinotecan dosage: 325MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, DILANTIN, DEPAKOTE, DECADRON, PEPCID, CLORAZEPATE. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5427029-9
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 24, 2007. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: aphasia , confusional state, coordination abnormal, malignant neoplasm progression, neurological symptom, nuclear magnetic resonance imaging brain abnormal, speech disorder. Irinotecan dosage: 325MG/M2 DAY 1,8 IV. During the same period patient was treated with TEMODAR, NEXIUM, DILANTIN, DEXAMETHASONE, ATIVAN, AMBIEN CR. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5905518-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 01, 2008. Male patient, weighting 149.7 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: cardio-respiratory arrest, cognitive disorder, glioblastoma multiforme, headache , intracranial pressure increased, malignant neoplasm progression, muscular weakness. Irinotecan dosage: 325MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, IRINOTECAN HYDROCHLORIDE, IRINOTECAN HYDROCHLORIDE, TEMODAR, DILANTIN, DEXAMETHASONE, ATIVAN, FLONASE. Patient died on 11/11/2006.

Irinotecan Side Effects Report #5913409-1
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 08, 2008. Male patient, weighting 240.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: brain scan abnormal, cerebral ventricle dilatation, device malfunction, disease progression, headache , infection , malignant neoplasm progression, medical device complication, meningeal disorder. Irinotecan dosage: 125MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, DECADRON, LORTAB, CELEXA, ZOFRAN, PEPCID, IMODIUM. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4831333-2
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Nov 16, 2005. Female patient, weighting 204.6 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: gastritis, gastritis haemorrhagic, gastrointestinal haemorrhage, haematemesis, hiccups, malignant neoplasm progression, oesophagitis ulcerative. Irinotecan dosage: 265MG IV (DAY 1, 8,22 AND 29). During the same period patient was treated with BEVACIZUMAB, INSULIN, CITRUCEL, CELEXA, ZETIA, KEPPRA, LOVASTATIN. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #4836305-X
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Nov 21, 2005. Female patient, weighting 217.8 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaplastic astrocytoma, malignant neoplasm progression, neurological symptom. Irinotecan dosage: 280MG IV (DAY 1, 8, 22 AND 29). During the same period patient was treated with BEVACIZUMAB, DECADRON, PRILOSEC, KEPPRA, LAMICTAL. Patient was hospitalized. Patient died on 11/09/2005.

Irinotecan Side Effects Report #4635781-5
Irinotecan side effect was reported by a Health Professional from on Mar 31, 2005. Female patient, 63 years of age, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: asthenia, cardiac arrest , gastric cancer, malignant neoplasm progression, neuropathy peripheral, oedema peripheral, respiratory arrest. Irinotecan dosage: 110 MG, INTRAVENOUS. During the same period patient was treated with TEGAFUR, OMEPRAZOLE, FERROUS CITRATE, MAGNESIUM OXIDE. Patient died.

Irinotecan Side Effects Report #5108031-3
Irinotecan side effect was reported by a Physician from JAPAN on Sept 01, 2006. Female patient, 61 years of age, weighting 97.00 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: hyperkalaemia, ill-defined disorder, leukopenia, malignant neoplasm progression, metastases to peritoneum, neutropenia. Irinotecan dosage: 66.7 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient recovered.

Irinotecan Side Effects Report #5117839-X
Irinotecan side effect was reported by a Physician from JAPAN on Sept 14, 2006. Female patient, 61 years of age, weighting 97.00 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: hyperkalaemia, leukopenia, malignant neoplasm progression, neutropenia, peritoneal carcinoma. Irinotecan dosage: 66.7 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient recovered.

Irinotecan Side Effects Report #5053467-2
Irinotecan side effect was reported by a Physician from KOREA, REPUBLIC OF on June 29, 2006. Male patient, 52 years of age, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abdominal pain upper, anaemia, diarrhoea, febrile neutropenia, lymphadenopathy, malignant neoplasm progression, neuropathy peripheral, pneumonia streptococcal. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, MESNA, ETOPOSIDE, PACLITAXEL. Patient was hospitalized. Patient died on 08/01/2004.


Irinotecan Side Effects Report #5085927-2
Irinotecan side effect was reported by a Physician from KOREA, REPUBLIC OF on Aug 04, 2006. Male patient, 52 years of age, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaemia, ascites, diarrhoea, febrile neutropenia, gastric cancer, lymphadenopathy, malignant neoplasm progression, metastases to liver, neuropathy peripheral. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, MESNA, ETOPOSIDE, PACLITAXEL. Patient was hospitalized. Patient died on 08/01/2004.

Irinotecan Side Effects Report #4971587-5
Irinotecan side effect was reported by a Physician from JAPAN on Mar 24, 2006. Male patient, 75 years of age, weighting 132.3 lb, was diagnosed with gallbladder cancer  and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: emphysema, gallbladder cancer , interstitial lung disease, lymphangiosis carcinomatosa, malignant neoplasm progression, metastases to liver, platelet count increased. Irinotecan dosage: 100 MG (1 IN 1 WEEK); INTRAVENOUS. During the same period patient was treated with GEMZAR. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #6055996-1
Irinotecan side effect was reported by a Consumer or non-health professional from SPAIN on Jan 13, 2009. Male patient, 68 years of age, was diagnosed with colon cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: colon cancer metastatic, diffuse alveolar damage, disease progression, interstitial lung disease, left ventricular hypertrophy, malignant neoplasm progression, metastases to lung, myocardial ischaemia, neurotoxicity. Irinotecan dosage: unknown. During the same period patient was treated with OXALIPLATIN, FOLINIC ACID, FLUOROURACIL. Patient died.

Irinotecan Side Effects Report #5061728-6
Irinotecan side effect was reported by a Physician from JAPAN on July 04, 2006. Male patient, 82 years of age, was diagnosed with colon cancer, metastases to bone, metastases to liver, metastases to lung and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: candidiasis, catheter related infection, emphysema, interstitial lung disease, lymphangiosis carcinomatosa, malignant neoplasm progression, metastases to bone, metastasis, multi-organ failure. Irinotecan dosage: (100 MG, D1 AND D15, CYCLIC), INTRAVENOUS. During the same period patient was treated with MITOMYCIN, PIPERACILLIN. Patient died on 03/04/2003.

Irinotecan Side Effects Report #4893404-4
Irinotecan side effect was reported by a Physician from UNITED STATES on Jan 25, 2006. Female patient, weighting 15.21 lb, was diagnosed with central nervous system neoplasm and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abnormal behaviour, central nervous system neoplasm, computerised tomogram abnormal, convulsion, disease recurrence, fatigue, headache , malignant neoplasm progression, nodule. Irinotecan dosage: unknown. During the same period patient was treated with TEMOZOLOMIDE, VINCRISTINE, CEFIXIME CHEWABLE. Patient died on 01/16/2006.


Irinotecan Side Effects Report #4788844-8
Irinotecan side effect was reported by a Health Professional from JAPAN on Sept 21, 2005. Female patient, 43 years of age, was diagnosed with breast cancer recurrent and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: breast cancer , duodenal ulcer perforation, malignant neoplasm progression. Irinotecan dosage: 100 MG/M2 (1 IN 1 WK), INTRAVENOUS. Patient recovered.

Irinotecan Side Effects Report #4828107-5
Irinotecan side effect was reported by a Health Professional from JAPAN on Oct 12, 2005. Female patient, 43 years of age, was diagnosed with breast cancer recurrent, ill-defined disorder and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: breast cancer metastatic, duodenal ulcer perforation, malignant neoplasm progression. Irinotecan dosage: 100 MG/M2 (1 IN 1 WK), INTRAVENOUS. Patient recovered.

Irinotecan Side Effects Report #5133778-2
Irinotecan side effect was reported by a Health Professional from JAPAN on May 19, 1999. Male patient, 69 years of age, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: condition aggravated, contraindication to medical treatment, depressed level of consciousness, grand mal convulsion, hepatic failure, hypokalaemia, leukopenia, malignant neoplasm progression, metastases to liver. Irinotecan dosage: 100 MG/M*2, INTRAVENOUS. During the same period patient was treated with AMINO ACIDS, CEFOZOPRAN HYDROCHLORIDE, CLINDAMYCIN PHOSPHATE, HANGE, LENORGRASTIM, METOCLOPRAMIDE, PHENYTOIN, VALPROATE. Patient died on 04/04/1999.

Irinotecan Side Effects Report #4738644-X
Irinotecan side effect was reported by a Physician from GERMANY on July 27, 2005. Male patient, 63 years of age, weighting 132.3 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: convulsion, loss of consciousness, malignant neoplasm progression, metastases to central nervous system. Irinotecan dosage: 136 MG (136 MG, CYCLIC, 3 WEEKLY), INTRAVENOUS. During the same period patient was treated with CISPLATIN, VIOXX, TRAMADOL, BISOPROLOL FUMARATE, MORPHINE SULPHATE, ALLOPURINOL, THIOCTACID. Patient was hospitalized. Patient died on 08/26/2004.

Irinotecan Side Effects Report #4622364-6
Irinotecan side effect was reported by a Consumer or non-health professional from on Mar 25, 2005. Male patient, weighting 208.4 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: difficulty in walking, malignant neoplasm progression, oedema peripheral, pain in extremity. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, OXALIPLATIN, CETUXIMAB. Patient recovered.