Irinotecan and hypotension Patient Reports February 12, 2012

Irinotecan Side Effects Report #4862633-8
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Dec 19, 2005. Female patient, weighting 158.4 lb, was diagnosed with pancreatic carcinoma metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: dyspnoea, hypotension, orthopnoea, oxygen saturation abnormal, pleural effusion, renal failure acute, sepsis , therapeutic agent toxicity. Irinotecan dosage: 65MG/M2 Q 21 DAYS IV DRIP. During the same period patient was treated with DOCETAXEL. Patient was hospitalized. Patient died on 12/08/2005.

Irinotecan Side Effects Report #4846060-5
Irinotecan side effect was reported by a Physician from UNITED STATES on Nov 23, 2005. Female patient, child 8 years of age, was diagnosed with neoplasm and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: acute respiratory distress syndrome, haemoglobin decreased, hypotension, lung infiltration, pneumonitis, white blood cell count decreased. Irinotecan dosage: 22 MG (1 IN 1 D), INTRAVENOUS. During the same period patient was treated with CETUXIMAB, DEXAMETHASONE. Patient recovered.

Irinotecan Side Effects Report #5736596-7
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on May 02, 2008. Female patient, 69 years of age, weighting 224.9 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: atrial fibrillation , blood creatine phosphokinase increased, blood creatinine increased, cellulitis , dehydration, hyperglycaemia, hypotension, pleural effusion, somnolence. Irinotecan dosage: DAILY DOSE:125MG/M2-FREQ:OVER 90 MIN, DAYS 1 AND 15. During the same period patient was treated with BEVACIZUMAB, DEXAMETHASONE. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5146833-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 07, 2006. Male patient, weighting 161.6 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaemia, arrhythmia , cardiac disorder, central nervous system infection, ejection fraction decreased, hypoalbuminaemia, hypotension, immunosuppression, loss of consciousness. Irinotecan dosage: 125MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, DECADRON, ZANTAC, FLORINEF. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5403924-1
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on July 31, 2007. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: asthenia, atrial fibrillation , diarrhoea, hyperglycaemia, hypotension, neutropenia, renal failure acute, tachycardia, thrombocytopenia. Irinotecan dosage: 125MG/ M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, COUMADIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5409416-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 08, 2007. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: adrenal insufficiency, atrial fibrillation , clostridial infection, dehydration, diarrhoea, hyperglycaemia, hypotension, pancytopenia, renal failure acute. Irinotecan dosage: 125MG/M2, 60MG/M2 DAY 1, 8 IV. During the same period patient was treated with TEMODAR, COUMADIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5413061-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 08, 2007. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: adrenal insufficiency, arrhythmia supraventricular, atrial fibrillation , diarrhoea, hyperglycaemia, hypotension, pancytopenia, renal failure, renal failure acute. Irinotecan dosage: DAILY DOSE:125MG/M2-FREQ:FREQUENCY: ON DAY 1, 8, 22, 29. During the same period patient was treated with TEMODAR, WARFARIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient was hospitalized. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5441111-1
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 24, 2007. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: arrhythmia supraventricular, asthenia, diarrhoea, hyperglycaemia, hypotension, leukopenia, neutropenia, renal failure acute, sepsis . Irinotecan dosage: DAILY DOSE:125MG/M2-FREQ:ON DAY 1 OF 6-WEEK CYCLE. During the same period patient was treated with TEMODAR, WARFARIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient was hospitalized. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5449769-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 10, 2007. Male patient, weighting 153.4 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: band neutrophil count increased, colitis, constipation , febrile neutropenia, gastrointestinal disorder, haemoglobin decreased, hypotension, pulmonary embolism , sepsis . Irinotecan dosage: 125MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, VERAPAMIL, ASPIRIN, DEXAMETHASONE, DEPAKOTE, KLONOPIN. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5895164-7
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 23, 2008. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: asthenia, diarrhoea, hypotension, leukopenia, renal failure acute, sepsis , tachycardia. Irinotecan dosage: 125MG/M2, 80MG/M2 DAY 1, 8 IV. During the same period patient was treated with TEMODAR, COUMADIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5905520-6
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 01, 2008. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: asthenia, diarrhoea, hypotension, leukopenia, renal failure acute, sepsis , tachycardia. Irinotecan dosage: 125MG/M2, 80MG/M2 DAY 1, 8 IV. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, TEMODAR, COUMADIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5913280-8
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 08, 2008. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: arrhythmia supraventricular, asthenia, atrial fibrillation , diarrhoea, hyperglycaemia, hypotension, leukopenia, renal failure acute, sepsis . Irinotecan dosage: 125MG/M2, 80MG/M2 DAY 1, 8 IV. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, TEMODAR, COUMADIN, LOTREL, LASIX, TOPROL, DECADRON, LIPITOR. Patient died on 08/02/2007.

Irinotecan Side Effects Report #5947851-X
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 10, 2008. Male patient, weighting 218.3 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: asthenia, hypotension, renal failure acute, sepsis , tachycardia. Irinotecan dosage: 125MG/M2, 80MG/M2 DAY 1, 8 IV. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, TEMODAR. Patient died on 08/02/2007.

Irinotecan Side Effects Report #4910735-X
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Feb 09, 2006. Female patient, weighting 185.9 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: bacteraemia, body temperature increased, confusional state, cushingoid, dyspnoea, hypotension, hypoxia, lung infiltration, pulmonary embolism . Irinotecan dosage: 2406 MG. During the same period patient was treated with CAMPTOSAR, DEXAMETHASONE PHOSPHATE, DIFLUCAN, HEPARIN, KEPPRA, LEXAPRO, SYNTHROID, TYLENOL. Patient was hospitalized. Patient died on 02/06/2006.


Irinotecan Side Effects Report #5471426-2
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 17, 2007. Female patient, weighting 95.24 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abdominal pain , cardiac enzymes increased, dyspnoea, gastric perforation, haemoptysis, hypokalaemia, hypotension, intestinal infarction. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN, LORTAB, KYTRIL, OCEAN NASAL SPRAY. Patient was hospitalized. Patient died on 06/18/2007.

Irinotecan Side Effects Report #5505569-1
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 25, 2007. Female patient, weighting 95.24 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: cardiac enzymes increased, hypokalaemia, hypotension, leukopenia, metabolic acidosis. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, LORTAB, KYTRIL, OCEAN NASAL SPRAY. Patient was hospitalized. Patient died on 06/18/2007.

Irinotecan Side Effects Report #5917915-5
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 03, 2008. Female patient, weighting 95.24 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: cardiac enzymes increased, hypokalaemia, hypotension, leukopenia, metabolic acidosis. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, LORTAB, KYTRIL, OCEAN NASAL SPRAY. Patient was hospitalized. Patient died on 06/18/2007.

Irinotecan Side Effects Report #5985958-1
Irinotecan side effect was reported by a Consumer or non-health professional from ITALY on Dec 05, 2008. Male patient, 61 years of age, weighting 220.5 lb, was diagnosed with colorectal cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: arteriosclerosis, hypercholesterolaemia, hypotension, hypovolaemic shock, left ventricular hypertrophy, myocardial ischaemia, pericarditis, vomiting. Irinotecan dosage: 180 MG/M**2 Q2W IV. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN SOLUTION INFUSION, ASPIRIN, MODURETIC. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5241347-9
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Feb 15, 2007. Female patient, weighting 178.0 lb, was diagnosed with colorectal cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: clostridial infection, hypotension, hypovolaemia. Irinotecan dosage: 240 MG/M2 Q3W IV. During the same period patient was treated with XELODA, AVASTIN. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5512736-X
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Dec 01, 2005. Male patient was diagnosed with colorectal cancer  and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: clostridial infection, dehydration, hypotension, myocardial infarction, neutropenia, respiratory failure, septic shock. Irinotecan dosage: DAILY DOSE:216MG-FREQ:ON DAY 1 AND 8 EVERY 3 WEEKS. During the same period patient was treated with CELECOXIB, ADRUCIL, LEUCOVORIN CALCIUM. Patient was hospitalized. Patient died on 02/25/2003.

Irinotecan Side Effects Report #5231355-6
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Feb 05, 2007. Female patient, weighting 178.4 lb, was diagnosed with colon cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: clostridial infection, diarrhoea, hypotension, hypovolaemia, vomiting. Irinotecan dosage: 240MG/M2 Q3W IV. During the same period patient was treated with XELODA, AVASTIN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5154510-2
Irinotecan side effect was reported by a Physician from NETHERLANDS on July 07, 1995. Female patient, 37 years of age, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anal haemorrhage, haematemesis, haemoglobin decreased, hypotension, nausea , platelet count decreased, white blood cell count decreased. Irinotecan dosage: 520 MG, INTRAVENOUS. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4758746-1
Irinotecan side effect was reported by a Health Professional from UNITED STATES on Aug 31, 2005. Female patient, 52 years of age, weighting 223.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: hypotension, nausea , pyrexia. Irinotecan dosage: 100 MG , OVER 30-90 MIN IV DAY 1 + 8 X 4 CYCLES. During the same period patient was treated with CARBOPLATIN, ATIVAN, DECADRON, ZOFRAN, PHENERAGAN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5310481-7
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Apr 19, 2007. Female patient was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abdominal pain , chills, diarrhoea, hypotension, lethargy, lymphopenia, nausea , pyrexia, vaginal haemorrhage. Irinotecan dosage: DAILY DOSE:36MG. During the same period patient was treated with CETUXIMAB, ALOXI, COLACE, BACLOFEN, LYRICA, LUPRON. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5753771-6
Irinotecan side effect was reported by a Consumer or non-health professional from CANADA on May 27, 2008. Male patient, weighting 109.3 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood culture positive, blood sodium decreased, diarrhoea, hypotension, no therapeutic response, pyrexia, vomiting. Irinotecan dosage: 586 MG. During the same period patient was treated with VINCRISTINE SULPHATE. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5905241-X
Irinotecan side effect was reported by a Consumer or non-health professional from EGYPT on Sept 22, 2008. Male patient was diagnosed with diabetes mellitus, prophylaxis and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: coma, diarrhoea, gastrointestinal haemorrhage, haematemesis, haemoptysis, hiccups, hypotension, melaena, multi-organ failure. Irinotecan dosage: DAILY DOSE:100MG. During the same period patient was treated with CISPLATIN, INSULIN, ATROPINE, MANNITOL, ONDANSETRON, GRANISETRON, DEXTROSE, CHLORIDE. Patient died on 03/17/2004.

Irinotecan Side Effects Report #4767080-5
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Sept 09, 2005. Male patient, weighting 173.1 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood culture positive, body temperature increased, enterococcal infection, escherichia infection, hypotension, neutropenia, pseudomonas infection. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, ETOPOSIDE. Patient was hospitalized. Patient died on 09/03/2005.

Irinotecan Side Effects Report #4832439-4
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Nov 17, 2005. Male patient, weighting 173.1 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood culture positive, cholera, enterococcal infection, escherichia infection, hypotension, neutrophil count decreased, pseudomonas infection. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, ETOPOSIDE. Patient was hospitalized. Patient died on 09/03/2005.