Irinotecan and disseminated intravascular coagulation Patient Reports February 12, 2012

Irinotecan Side Effects Report #5290842-5
Irinotecan side effect was reported by a Health Professional from JAPAN on Mar 29, 2007. Female patient, weighting 172.0 lb, was diagnosed with sarcoma uterus, pancytopenia and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood pressure decreased, coagulation test abnormal, disseminated intravascular coagulation, dyspnoea, enterococcal infection, haemoglobin decreased, leukopenia, loss of consciousness, neutropenia. Irinotecan dosage: unknown. During the same period patient was treated with FRESH FROZEN PLASMA, SEROTONE, LASIX, OXYCONTIN. Patient died on 11/29/2006.

Irinotecan Side Effects Report #5148077-2
Irinotecan side effect was reported by a Physician from JAPAN on Oct 24, 2006. Female patient, 80 years of age, was diagnosed with rectal cancer recurrent and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: condition aggravated, disseminated intravascular coagulation, pancytopenia, pneumonia , respiratory disorder, staphylococcal infection . Irinotecan dosage: 140 MG (1 IN 1 WK), INTRAVENOUS. During the same period patient was treated with LEUCOVORIN CALCIUM. Patient died on 11/15/2005.

Irinotecan Side Effects Report #4656690-1
Irinotecan side effect was reported by a Consumer or non-health professional from on Apr 27, 2005. Male patient, 73 years of age, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, blood pressure decreased, condition aggravated, disseminated intravascular coagulation, escherichia infection, malaise, metastasis, neoplasm progression, pancytopenia. Irinotecan dosage: 100 MG, INTRAVENOUS. During the same period patient was treated with ZANTAC, FLUOROURACIL, CALCIUM LEVOFOLINATE. Patient was hospitalized and became disabled. Patient died on 02/26/2005.

Irinotecan Side Effects Report #4704326-3
Irinotecan side effect was reported by a Consumer or non-health professional from on Apr 27, 2005. Male patient, 73 years of age, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: alpha haemolytic streptococcal infection, anorexia, blood pressure decreased, condition aggravated, disseminated intravascular coagulation, escherichia infection, malaise, pancytopenia, sepsis . Irinotecan dosage: 100 MG INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, CALCIUM FOLINATE. Patient was hospitalized and became disabled. Patient died on 02/26/2005.


Irinotecan Side Effects Report #5926008-2
Irinotecan side effect was reported by a Health Professional from JAPAN on Oct 09, 2008. Male patient, 66 years of age, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: diarrhoea, disseminated intravascular coagulation, leukopenia, renal failure acute. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, BLOPRESS, SIMVASTATIN, PLETAL, SIGMART. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4767752-2
Irinotecan side effect was reported by a Physician from JAPAN on Aug 30, 2005. Male patient, 42 years of age, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: bone marrow depression, diarrhoea, disseminated intravascular coagulation, multi-organ failure, neutrophil count decreased, platelet count decreased, stomatitis, white blood cell count decreased. Irinotecan dosage: 80 MG (1 D), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, CALCIUM LEVOFOLINATE. Patient died on 08/29/2005.

Irinotecan Side Effects Report #4776561-X
Irinotecan side effect was reported by a Physician from JAPAN on Sept 02, 2005. Male patient, 42 years of age, weighting 105.8 lb, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, bone marrow depression, coagulopathy, condition aggravated, dehydration, diarrhoea, disseminated intravascular coagulation, haemorrhagic diathesis, malaise. Irinotecan dosage: 80 MG (1 D), INTRAVENOUS; 60 MG (1 D), INTRAVENOUS. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE, FLUOROURACIL, STRONG, CALCIUM LEVOFOLINATE, CALCIUM LEVOFOLINATE. Patient was hospitalized. Patient died on 08/29/2005.

Irinotecan Side Effects Report #5322815-8
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on Apr 25, 2007. Male patient was diagnosed with rectal cancer, hypertension, diabetes mellitus and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, diarrhoea, disseminated intravascular coagulation, dyspepsia, nausea , pyrexia, renal impairment, sepsis . Irinotecan dosage: DAILY DOSE:230MG. During the same period patient was treated with CALCIUM FOLINATE, FLUOROURACIL, NORVASC, ALMARL, AMARYL, OLMETEC, GLUCOBAY. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5333991-5
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on May 14, 2007. Male patient was diagnosed with rectal cancer, hypertension, diabetes mellitus and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, diarrhoea, disseminated intravascular coagulation, dyspepsia, nausea , pyrexia, renal impairment, sepsis . Irinotecan dosage: DAILY DOSE:230MG. During the same period patient was treated with CALCIUM FOLINATE, FLUOROURACIL, NORVASC, ALMARL, AMARYL, OLMETEC, GLUCOBAY. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5348424-2
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on May 25, 2007. Male patient was diagnosed with rectal cancer, hypertension, diabetes mellitus and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, blood bilirubin increased, diarrhoea, disseminated intravascular coagulation, nausea , pyrexia, renal impairment, sepsis . Irinotecan dosage: DAILY DOSE:150MG/M2. During the same period patient was treated with CALCIUM FOLINATE, FLUOROURACIL, NORVASC, ALMARL, AMARYL, OLMETEC, GLUCOBAY. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5013898-3
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on May 12, 2006. Female patient, 72 years of age, weighting 68.34 lb, was diagnosed with pancreatic carcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: bone marrow failure, disseminated intravascular coagulation, hepatic steatosis, malignant neoplasm progression, pancreatic carcinoma metastatic, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with PN TWIN, ELEMENMIC, INTRALIPID, DECADRON SRC. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4652226-X
Irinotecan side effect was reported by a Physician from on Apr 19, 2005. Female patient, 67 years of age, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaemia, anorexia, blood pressure decreased, diarrhoea, disseminated intravascular coagulation, jaundice , vomiting. Irinotecan dosage: 50 MG INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient died on 04/04/2005.

Irinotecan Side Effects Report #4664707-3
Irinotecan side effect was reported by a Physician from on May 02, 2005. Female patient, 67 years of age, weighting 81.57 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abnormal faeces, anaemia, anorexia, blood pressure decreased, bone marrow depression, depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, jaundice . Irinotecan dosage: 50 MG, INTRAVENOUS. During the same period patient was treated with CISPLATIN, DICLOFENAC, GLYCERYL TRINITRATE, HERBAL PREPARATION, MAGNESIUM OXIDE, LOPERAMIDE HYDROCHLORIDE, METOCLOPRAMIDE. Patient died on 04/04/2005.

Irinotecan Side Effects Report #4696146-3
Irinotecan side effect was reported by a Physician from on June 07, 2005. Female patient, 67 years of age, weighting 81.57 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abnormal faeces, anorexia, blood pressure decreased, bone marrow depression, depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, hyperbilirubinaemia, jaundice . Irinotecan dosage: 50 MG, INTRAVENOUS. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE SOLUTION, CISPLATIN, VOLTAREN, VASOLATOR, HANGE, MAGNESIUM HYDROXIDE, LOPEMIN, PRIMPERAN. Patient was hospitalized. Patient died on 04/04/2005.


Irinotecan Side Effects Report #4859961-9
Irinotecan side effect was reported by a Physician from JAPAN on Nov 30, 2005. Female patient, 51 years of age, weighting 97.00 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: bone marrow failure, disseminated intravascular coagulation, hepatic failure, intestinal perforation, pancytopenia, sepsis . Irinotecan dosage: 160 MG (160 MG, ) INTRAVENOUS. During the same period patient was treated with MITOMYCIN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4917756-1
Irinotecan side effect was reported by a Physician from JAPAN on Feb 02, 2006. Female patient, 51 years of age, weighting 97.00 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abdominal pain , bone marrow failure, diarrhoea, disseminated intravascular coagulation, enterococcal infection, hepatic function abnormal, intestinal perforation, liver disorder. Irinotecan dosage: 160 MG (160 MG) INTRAVENOUS. During the same period patient was treated with MITOMYCIN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5241869-0
Irinotecan side effect was reported by a Physician from JAPAN on Feb 08, 2007. Male patient, 72 years of age, was diagnosed with neoplasm of thymus and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaemia, disseminated intravascular coagulation, multi-organ failure, thrombocytopenia. Irinotecan dosage: unknown. During the same period patient was treated with KYTRIL, DECADRON, FESIN, PRIMPERAN. Patient was hospitalized. Patient died on 02/05/2007.

Irinotecan Side Effects Report #5256770-6
Irinotecan side effect was reported by a Physician from JAPAN on Feb 22, 2007. Male patient, 72 years of age, was diagnosed with neoplasm of thymus and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anaemia, disseminated intravascular coagulation, multi-organ failure, thrombocytopenia. Irinotecan dosage: unknown. During the same period patient was treated with KYTRIL, DECADRON, FESIN, PRIMPERAN, LACTEC. Patient was hospitalized. Patient died on 02/05/2007.

Irinotecan Side Effects Report #4591486-0
Irinotecan side effect was reported by a Physician from on Feb 08, 2005. Male patient, 70 years of age, weighting 103.6 lb, was diagnosed with gastric cancer, decreased appetite and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: anorexia, c-reactive protein increased, candida serology positive, disseminated intravascular coagulation, pulmonary fibrosis , pyrexia, respiratory failure, respiratory moniliasis. Irinotecan dosage: 50 MG/M2 (CYCLIC), INTRAVENOUS. During the same period patient was treated with PACLITAXEL, DEXAMETHASONE PHOSPHATE, PREDNISONE. Patient was hospitalized. Patient died on 11/19/2004.


Irinotecan Side Effects Report #5588617-2
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 02, 2008. Male patient, weighting 121.3 lb, was diagnosed with gastric cancer, polyuria, prophylaxis of nausea and vomiting and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, leukopenia, neutropenia, septic shock, thrombocytopenia. Irinotecan dosage: unknown. During the same period patient was treated with RANDA, LASIX, DECADRON, KYTRIL. Patient recovered.

Irinotecan Side Effects Report #5592380-9
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 09, 2008. Male patient, weighting 121.3 lb, was diagnosed with gastric cancer, polyuria, prophylaxis of nausea and vomiting and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, leukopenia, neutropenia, septic shock, thrombocytopenia. Irinotecan dosage: unknown. During the same period patient was treated with RANDA, LASIX, DECADRON, KYTRIL. Patient recovered.

Irinotecan Side Effects Report #4709036-4
Irinotecan side effect was reported by a Physician from JAPAN on June 22, 2005. Female patient, 46 years of age, weighting 79.37 lb, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: ascites, blood pressure systolic decreased, depressed level of consciousness, disseminated intravascular coagulation, haematochezia, intestinal ischaemia, metastases to liver, metastases to skin, oral intake reduced. Irinotecan dosage: 200 MG (CYCLICAL), INTRAVENOUS. During the same period patient was treated with ULCERMIN, LOXONIN, URSODIOL, LASIX, NOVAMIN, FENTANYL, FAMOTIDINE. Patient died on 01/26/2005.

Irinotecan Side Effects Report #5226646-9
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on Jan 25, 2007. Female patient, 58 years of age, was diagnosed with adenocarcinoma pancreas and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: diarrhoea, disseminated intravascular coagulation, neutropenia, pyrexia, shock. Irinotecan dosage: unknown. Patient died.

Irinotecan Side Effects Report #5346403-2
Irinotecan side effect was reported by a Consumer or non-health professional from SWITZERLAND on May 30, 2007. Male patient, weighting 172.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FOSICOMP, FORTECORTIN. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5353002-5
Irinotecan side effect was reported by a Consumer or non-health professional from SWITZERLAND on May 30, 2007. Male patient, weighting 172.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FOSICOMP, FORTECORTIN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5356118-2
Irinotecan side effect was reported by a Consumer or non-health professional from SWITZERLAND on June 05, 2007. Male patient, weighting 172.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FOSICOMP, FORTECORTIN, NEXIUM, HALDOL. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5478930-1
Irinotecan side effect was reported by a Consumer or non-health professional from SWITZERLAND on Oct 03, 2007. Male patient, weighting 172.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FOSICOMP, FORTECORTIN, NEXIUM, HALDOL. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5798983-0
Irinotecan side effect was reported by a Consumer or non-health professional from SWAZILAND on June 25, 2008. Male patient, weighting 172.0 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: disseminated intravascular coagulation, sepsis . Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, FOSICOMP, FORTECORTIN, NEXIUM, HALDOL. Patient was hospitalized. Patient recovered.