Irinotecan and depressed level of consciousness Patient Reports February 12, 2012

Irinotecan Side Effects Report #5044548-8
Irinotecan side effect was reported by a Physician from JAPAN on June 16, 2006. Male patient, 76 years of age, weighting 119.0 lb, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: contusion, depressed level of consciousness, head injury, interstitial lung disease, pulmonary oedema, road traffic accident, white blood cell count decreased. Irinotecan dosage: 220 MG (150 MG/M*2, IN 2 WEEKS), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, CALCIUM LEVOFOLINATE, GLYCYRRHIZA, MAGNESIUM OXIDE, BLOPRESS, AMLODIPINE. Patient recovered.

Irinotecan Side Effects Report #5045850-6
Irinotecan side effect was reported by a Physician from JAPAN on June 16, 2006. Male patient, 76 years of age, weighting 119.0 lb, was diagnosed with rectal cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: contusion, depressed level of consciousness, interstitial lung disease, road traffic accident. Irinotecan dosage: 220 MG (150 MG/M*2, IN 2 WEEKS), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, CALCIUM LEVOFOLINATE, GLYCYRRHIZA, MAGNESIUM OXIDE, BLOPRESS, AMLODIPINE. Patient recovered.

Irinotecan Side Effects Report #4664707-3
Irinotecan side effect was reported by a Physician from on May 02, 2005. Female patient, 67 years of age, weighting 81.57 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abnormal faeces, anaemia, anorexia, blood pressure decreased, bone marrow depression, depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, jaundice . Irinotecan dosage: 50 MG, INTRAVENOUS. During the same period patient was treated with CISPLATIN, DICLOFENAC, GLYCERYL TRINITRATE, HERBAL PREPARATION, MAGNESIUM OXIDE, LOPERAMIDE HYDROCHLORIDE, METOCLOPRAMIDE. Patient died on 04/04/2005.

Irinotecan Side Effects Report #4696146-3
Irinotecan side effect was reported by a Physician from on June 07, 2005. Female patient, 67 years of age, weighting 81.57 lb, was diagnosed with ovarian cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abnormal faeces, anorexia, blood pressure decreased, bone marrow depression, depressed level of consciousness, diarrhoea, disseminated intravascular coagulation, hyperbilirubinaemia, jaundice . Irinotecan dosage: 50 MG, INTRAVENOUS. During the same period patient was treated with IRINOTECAN HYDROCHLORIDE SOLUTION, CISPLATIN, VOLTAREN, VASOLATOR, HANGE, MAGNESIUM HYDROXIDE, LOPEMIN, PRIMPERAN. Patient was hospitalized. Patient died on 04/04/2005.


Irinotecan Side Effects Report #4866932-5
Irinotecan side effect was reported by a Physician from JAPAN on Dec 09, 2005. Female patient, 59 years of age, weighting 107.1 lb, was diagnosed with non-small cell lung cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: depressed level of consciousness, grand mal convulsion, inappropriate antidiuretic hormone secretion, vomiting. Irinotecan dosage: 60 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN, BICAROBONATE, URSODIOL, MAGNESIUM OXIDE, PRIMPERAN. Patient recovered.

Irinotecan Side Effects Report #4968730-0
Irinotecan side effect was reported by a Physician from JAPAN on Jan 12, 2006. Female patient, 59 years of age, weighting 107.1 lb, was diagnosed with non-small cell lung cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: ascites, depressed level of consciousness, grand mal convulsion, haemodilution, inappropriate antidiuretic hormone secretion, lung adenocarcinoma, malignant neoplasm progression, oral intake reduced, vomiting. Irinotecan dosage: 60 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN, BICARBONATE IN PLASTIC CONTAINER, URSO, MAGNESIUM OXIDE, PRIMPERAN. Patient recovered.

Irinotecan Side Effects Report #4844729-X
Irinotecan side effect was reported by a Physician from JAPAN on Nov 16, 2005. Female patient, 59 years of age, was diagnosed with lung adenocarcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: depressed level of consciousness, inappropriate antidiuretic hormone secretion, vomiting. Irinotecan dosage: 80 MG/M2. During the same period patient was treated with CISPLATIN. Patient recovered.

Irinotecan Side Effects Report #4854891-0
Irinotecan side effect was reported by a Physician from JAPAN on Nov 16, 2005. Female patient, 59 years of age, was diagnosed with lung adenocarcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: convulsion, depressed level of consciousness, inappropriate antidiuretic hormone secretion, vomiting. Irinotecan dosage: 60 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient recovered.

Irinotecan Side Effects Report #4860125-3
Irinotecan side effect was reported by a Physician from JAPAN on Dec 01, 2005. Female patient, 59 years of age, weighting 108.0 lb, was diagnosed with lung adenocarcinoma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: convulsion, decreased activity, depressed level of consciousness, hyponatraemia, inappropriate antidiuretic hormone secretion, vomiting. Irinotecan dosage: 60 MG/M2, INTRAVENOUS. During the same period patient was treated with CISPLATIN, BICARBONATE IN PLASTIC CONTAINER, URSODIOL, MAGNESIUM OXIDE, PRIMPERAN. Patient recovered.


Irinotecan Side Effects Report #5427033-0
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Aug 24, 2007. Male patient, weighting 185.2 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: brain herniation, brain oedema, depressed level of consciousness, diarrhoea, glioblastoma multiforme, nausea , neoplasm progression, somnolence. Irinotecan dosage: 325MG/M2 DAY 1,8,22,29 IV. During the same period patient was treated with TEMODAR, DEXAMETHASONE, ZANTAC, PHENOBARBITAL. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4801641-X
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 14, 2005. Female patient, weighting 147.5 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: depressed level of consciousness, glasgow coma scale abnormal, petechiae, somnolence, urinary tract infection . Irinotecan dosage: 570 MG. During the same period patient was treated with BEVACIZUMAB. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5017537-7
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on June 01, 2006. Female patient, weighting 125.9 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: brain herniation, depressed level of consciousness, fatigue, pyrexia, respiratory arrest, somnolence. Irinotecan dosage: 325MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, DILANTIN, PEPCID, DECADRON, FLORINEF. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5017894-1
Irinotecan side effect was reported by a Consumer or non-health professional from UNITED STATES on June 02, 2006. Female patient, weighting 125.9 lb, was diagnosed with glioblastoma multiforme and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: aphasia , brain herniation, computerised tomogram abnormal, condition aggravated, depressed level of consciousness, fatigue, pyrexia, respiratory arrest, somnolence. Irinotecan dosage: 325MG/M2 DAY 1, 8, 22, 29 IV. During the same period patient was treated with TEMODAR, DILANTIN, PEPCID, DECADRON, FLORINEF, MICARDIS, HUMALOG, LANTUS. Patient died on 05/31/2006.

Irinotecan Side Effects Report #5085937-5
Irinotecan side effect was reported by a Health Professional from JAPAN on Aug 04, 2006. Male patient, 67 years of age, weighting 131.8 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abasia, blood pressure systolic decreased, decreased appetite, dehydration, depressed level of consciousness, ectopic antidiuretic hormone secretion, inappropriate antidiuretic hormone secretion, swelling, tri-iodothyronine free decreased. Irinotecan dosage: 140 MG, INTRAVENOUS. During the same period patient was treated with TEGAFUR, AMLODIPINE, ENALAPRIL MALEATE, LANSOPRAZOLE, LASIX, ALDACTONE, AMARYL, PURSENNID. Patient was hospitalized. Patient recovered.


Irinotecan Side Effects Report #5044332-5
Irinotecan side effect was reported by a Consumer or non-health professional from JAPAN on June 16, 2006. Male patient, 67 years of age, weighting 131.8 lb, was diagnosed with gastric cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abasia, blood pressure decreased, depressed level of consciousness, inappropriate antidiuretic hormone secretion. Irinotecan dosage: 140 MG, INTRAVENOUS. During the same period patient was treated with TEGAFUR, AMLODIPINE, ENALAPRIL MALEATE, LANSOPRAZOLE, LASIX, ALDACTONE, AMARYL, PURSENNID. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #5290947-9
Irinotecan side effect was reported by a Consumer or non-health professional from FRANCE on Mar 30, 2007. Male patient, weighting 154.3 lb, was diagnosed with colorectal cancer metastatic and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: aphasia , colorectal cancer metastatic, condition aggravated, depressed level of consciousness, febrile bone marrow aplasia, febrile neutropenia, infection , platelet count decreased. Irinotecan dosage: unknown. During the same period patient was treated with FLUOROURACIL, CALCIUM FOLINATE, BEVACIZUMAB. Patient died on 01/01/2007.

Irinotecan Side Effects Report #4680074-3
Irinotecan side effect was reported by a Physician from on May 23, 2005. Male patient, 62 years of age, was diagnosed with colon cancer stage iv and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: coordination abnormal, depressed level of consciousness, diarrhoea, hypercalcaemia, hypernatraemia, kidney infection, renal failure. Irinotecan dosage: 144 MG (CYCLICAL), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, FRAXIPARIN, LORAZEPAM, ACETAMINOPHEN, LOSEC, CODEINE SUL. Patient was hospitalized. Patient died on 10/10/2004.

Irinotecan Side Effects Report #4989063-2
Irinotecan side effect was reported by a Health Professional from JAPAN on Apr 05, 2006. Male patient, 67 years of age, weighting 136.7 lb, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: acidosis, blood calcium increased, blood chloride decreased, blood potassium increased, convulsion, depressed level of consciousness, haemodialysis, heart rate decreased. Irinotecan dosage: 80 MG/M*2 (80 MG/M*2, ONE DAY), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM. Patient died on 03/29/2006.

Irinotecan Side Effects Report #5018268-X
Irinotecan side effect was reported by a Health Professional from JAPAN on May 15, 2006. Male patient, 67 years of age, weighting 136.7 lb, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: acidosis, blood calcium increased, convulsion, depressed level of consciousness, heart rate decreased, metabolic acidosis, multi-organ failure. Irinotecan dosage: 80 MG/M*2 (80 MG/M*2, ONE DAY), INTRAVENOUS. During the same period patient was treated with FLUOROURACIL, LEUCOVORIN CALCIUM, TANKARU. Patient died on 03/29/2006.


Irinotecan Side Effects Report #5152588-3
Irinotecan side effect was reported by a Consumer or non-health professional from FRANCE on Nov 09, 1993. Female patient, 62 years of age, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: abdominal pain , anaemia, cardiogenic shock, cerebral haemorrhage, colon cancer, convulsion, depressed level of consciousness, gastrointestinal haemorrhage. Irinotecan dosage: 560 MG (1 IN 3 WK), INTRAVENOUS. During the same period patient was treated with ENALAPRIL MALEATE, MORPHINE, OXAZEPAM, PREDNISOLONE, RANITIDINE. Patient was hospitalized. Patient died on 10/18/1993.

Irinotecan Side Effects Report #4709036-4
Irinotecan side effect was reported by a Physician from JAPAN on June 22, 2005. Female patient, 46 years of age, weighting 79.37 lb, was diagnosed with colon cancer and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: ascites, blood pressure systolic decreased, depressed level of consciousness, disseminated intravascular coagulation, haematochezia, intestinal ischaemia, metastases to liver, metastases to skin, oral intake reduced. Irinotecan dosage: 200 MG (CYCLICAL), INTRAVENOUS. During the same period patient was treated with ULCERMIN, LOXONIN, URSODIOL, LASIX, NOVAMIN, FENTANYL, FAMOTIDINE. Patient died on 01/26/2005.

Irinotecan Side Effects Report #5047162-3
Irinotecan side effect was reported by a Health Professional from JAPAN on June 22, 2006. Female patient, 43 years of age, was diagnosed with chloroma and was treated with Irinotecan. After drug was administered, patient experienced the following side effects: actinomycotic pulmonary infection, blood glucose increased, bronchial ulceration, cardiovascular disorder, cerebral haemorrhage, cholecystitis, depressed level of consciousness, diarrhoea. Irinotecan dosage: unknown. During the same period patient was treated with CISPLATIN, DESMOPRESSIN ACETATE, THEOPHYLLINE, HUSTAGIN, CODEINE PHOSPHATE, MAGNESIUM OXIDE, PRIMPERAN. Patient was hospitalized. Patient recovered.

Irinotecan Side Effects Report #4603087-6
Irinotecan side effect was reported by a Physician from on Feb 22, 2005. Male patient, 78 years of age, weighting 141.1 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, condition aggravated, depressed level of consciousness, interstitial lung disease, pneumonitis, respiratory failure. Irinotecan dosage: 60 MG (INTERMITTENT), INTRAVENOUS. During the same period patient was treated with CISPLATIN. Patient died on 01/16/2005.

Irinotecan Side Effects Report #4648778-6
Irinotecan side effect was reported by a Physician from on Apr 14, 2005. Male patient, 78 years of age, weighting 141.1 lb, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: blood lactate dehydrogenase increased, condition aggravated, depressed level of consciousness, interstitial lung disease, lung neoplasm malignant, pneumonitis, refusal of treatment by patient, respiratory failure. Irinotecan dosage: 60 MG (INTERMITTENT), INTRAVENOUS. During the same period patient was treated with CISPLATIN, HERBAL PREPARATION. Patient died on 01/16/2005.


Irinotecan Side Effects Report #5133778-2
Irinotecan side effect was reported by a Health Professional from JAPAN on May 19, 1999. Male patient, 69 years of age, was treated with Irinotecan. After drug was administered, patient experienced the following side effects: condition aggravated, contraindication to medical treatment, depressed level of consciousness, grand mal convulsion, hepatic failure, hypokalaemia, leukopenia, malignant neoplasm progression, metastases to liver. Irinotecan dosage: 100 MG/M*2, INTRAVENOUS. During the same period patient was treated with AMINO ACIDS, CEFOZOPRAN HYDROCHLORIDE, CLINDAMYCIN PHOSPHATE, HANGE, LENORGRASTIM, METOCLOPRAMIDE, PHENYTOIN, VALPROATE. Patient died on 04/04/1999.