Imatinib and malignant neoplasm progression Patient Reports February 11, 2012

Imatinib Side Effects Report #5393348-8
Imatinib side effect was reported by a Health Professional from NETHERLANDS on July 10, 2007. Male patient, 32 years of age, was diagnosed with medullary thyroid cancer and was treated with Imatinib. After drug was administered, patient experienced the following side effects: hypothyroidism, malignant neoplasm progression. Imatinib dosage: unknown. During the same period patient was treated with THYROID HORMONES. Patient recovered.

Imatinib Side Effects Report #5125989-7
Imatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 10, 2006. Female patient, 56 years of age, was diagnosed with glioblastoma multiforme and was treated with Imatinib. After drug was administered, patient experienced the following side effects: asthenia, confusional state, deep vein thrombosis , fall , head injury, intestinal perforation, malignant neoplasm progression, pulmonary embolism , thrombocytopenia. Imatinib dosage: 400 MG QD. During the same period patient was treated with HYDROXYUREA, DECADRON, KEPPRA, NEXIUM, CORGARD. Patient was hospitalized. Patient recovered.

Imatinib Side Effects Report #5126072-7
Imatinib side effect was reported by a Consumer or non-health professional from UNITED STATES on Oct 10, 2006. Female patient, 54 years of age, was diagnosed with glioblastoma multiforme and was treated with Imatinib. After drug was administered, patient experienced the following side effects: brain oedema, brain scan abnormal, confusional state, fatigue, headache , hemiparesis, malignant neoplasm progression, vision blurred. Imatinib dosage: 400 MG QD. During the same period patient was treated with HYDROXYUREA, KEPPRA, LIPITOR, METAMUCIL, ZOFRAN. Patient was hospitalized. Patient recovered.

Imatinib Side Effects Report #4646673-X
Imatinib side effect was reported by a Health Professional from on Apr 22, 2005. Female patient, weighting 113.5 lb, was diagnosed with glioblastoma multiforme and was treated with Imatinib. After drug was administered, patient experienced the following side effects: back pain , biopsy brain abnormal, brain oedema, encephalitis , gliosis, infection , malignant neoplasm progression, meningitis , meningoencephalitis bacterial. Imatinib dosage: 600MG PO QD. During the same period patient was treated with TEMOZOLOMIDE. Patient was hospitalized. Patient recovered.


Imatinib Side Effects Report #5056328-8
Imatinib side effect was reported by a Health Professional from NETHERLANDS on July 12, 2006. Female patient, 52 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with Imatinib. After drug was administered, patient experienced the following side effects: blood glucagon decreased, gastrointestinal stromal tumour, hypoglycaemia, insulin c-peptide decreased, insulin-like growth factor decreased, insulin-like growth factor increased, malignant neoplasm progression. Imatinib dosage: 400 MG, QD. Patient was hospitalized. Patient died.

Imatinib Side Effects Report #5140327-1
Imatinib side effect was reported by a Physician from UNITED KINGDOM on Oct 27, 2006. Female patient, 51 years of age, was diagnosed with gastrointestinal stromal tumour and was treated with Imatinib. After drug was administered, patient experienced the following side effects: abdominal neoplasm, cytoreductive surgery, malignant neoplasm progression, pulmonary embolism . Imatinib dosage: 400 MG, QD. During the same period patient was treated with SUNITINIB. Patient died.

Imatinib Side Effects Report #6124711-5
Imatinib side effect was reported by a Health Professional from UNITED STATES on Mar 10, 2009. Female patient was diagnosed with gastrointestinal stromal tumour and was treated with Imatinib. After drug was administered, patient experienced the following side effects: fatigue, gastrectomy, malignant neoplasm progression. Imatinib dosage: 300 MG DAILY. During the same period patient was treated with SUNITINIB MALATE. Patient was hospitalized. Patient recovered.

Imatinib Side Effects Report #4617202-1
Imatinib side effect was reported by a Health Professional from on Mar 16, 2005. Female patient, 76 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: dry skin, hirsutism, malignant neoplasm progression, nausea , pancytopenia, porphyria non-acute, serum ferritin increased, skin discolouration. Imatinib dosage: 600 MG/D. During the same period patient was treated with DEFEROXAMINE. Patient died.

Imatinib Side Effects Report #5960777-0
Imatinib side effect was reported by a Health Professional from JAPAN on Nov 07, 2008. Male patient, 59 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: malignant neoplasm progression. Imatinib dosage: 400 MG, UNK. During the same period patient was treated with IMATINIB MESYLATE. Patient recovered.


Imatinib Side Effects Report #5375885-5
Imatinib side effect was reported by a Health Professional from AUSTRALIA on June 27, 2007. Female patient, 56 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: acute myeloid leukaemia, bone marrow failure, chromosome analysis abnormal, chronic myeloid leukaemia, dysplasia, macrocytosis, malignant neoplasm progression, myelodysplastic syndrome, myeloid maturation arrest. Imatinib dosage: 400 MG/D. Patient died.

Imatinib Side Effects Report #4721986-1
Imatinib side effect was reported by a Consumer or non-health professional from AUSTRIA on July 12, 2005. Female patient, 54 years of age, was diagnosed with chronic myeloid leukaemia, stem cell transplant and was treated with Imatinib. After drug was administered, patient experienced the following side effects: malignant neoplasm progression, neutropenia, stem cell transplant. Imatinib dosage: 400 MG/D. During the same period patient was treated with CYCLOSPORINE, MYCOPHENOLATE MOFETIL, ATGAM, DEXAMETHASONE. Patient recovered.

Imatinib Side Effects Report #5604034-0
Imatinib side effect was reported by a Health Professional from JAPAN on Jan 14, 2008. Male patient, 35 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: blast crisis in myelogenous leukaemia, chromosome analysis abnormal, disseminated intravascular coagulation, fibrin d dimer increased, fibrin degradation products, haemorrhagic diathesis, hypovolaemic shock, malignant neoplasm progression, petechiae. Imatinib dosage: 600 MG/D. During the same period patient was treated with DANAPAROID. Patient was hospitalized. Patient recovered.

Imatinib Side Effects Report #5669602-9
Imatinib side effect was reported by a Health Professional from TURKEY on Mar 07, 2008. Male patient, 17 years of age, was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: asthenia, chloroma, cytogenetic analysis abnormal, fatigue, haemoglobin decreased, hepatosplenomegaly, malignant neoplasm progression, mass, oedema. Imatinib dosage: 400 MG/D. Patient died.

Imatinib Side Effects Report #5608989-X
Imatinib side effect was reported by a Health Professional from MALTA on Jan 25, 2008. Male patient was diagnosed with chronic myeloid leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: blast crisis in myelogenous leukaemia, bone marrow failure, gastrointestinal haemorrhage, lung infection, malignant neoplasm progression, myelodysplastic syndrome, pancytopenia, pulmonary haemorrhage, thrombocytopenia. Imatinib dosage: 600 MG/D. Patient died.


Imatinib Side Effects Report #4865944-5
Imatinib side effect was reported by a Consumer or non-health professional from JAPAN on Dec 21, 2005. Female patient, 72 years of age, was diagnosed with blast crisis in myelogenous leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: blood calcium increased, blood lactate dehydrogenase increased, bone pain, chromosome analysis abnormal, fatigue, malignant neoplasm progression, pancytopenia, parathyroid hormone-related protein increased, platelet count decreased. Imatinib dosage: 400 MG/D. Patient died on 05/31/2002.

Imatinib Side Effects Report #4813413-0
Imatinib side effect was reported by a Physician from GERMANY on Oct 21, 2005. Male patient, 29 years of age, was diagnosed with adenoid cystic carcinoma and was treated with Imatinib. After drug was administered, patient experienced the following side effects: bone pain, hyperhidrosis, malignant neoplasm progression, respiratory failure. Imatinib dosage: unknown. Patient died.

Imatinib Side Effects Report #5364683-4
Imatinib side effect was reported by a Health Professional from FRANCE on June 11, 2007. Female patient, 53 years of age, was diagnosed with acute megakaryocytic leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: cardiomegaly, convulsion, forced expiratory volume decreased, lung disorder, malignant neoplasm progression, sepsis , toxic shock syndrome. Imatinib dosage: 800 MG/D. During the same period patient was treated with IMATINIB MESYLATE, IDARUBICIN, CYTARABINE, DASATINIB. Patient was hospitalized. Patient recovered.

Imatinib Side Effects Report #5693247-8
Imatinib side effect was reported by a Health Professional from UNITED STATES on Mar 25, 2008. Female patient, 62 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: chromosome analysis abnormal, cytogenetic abnormality, fluid retention, malignant neoplasm progression, monocytosis, myelodysplastic syndrome, pancytopenia. Imatinib dosage: 600 MG/D. During the same period patient was treated with CYCLOPHOSPHAMIDE, VINCRISTINE, DOXORUBICIN, DEXAMETHASONE, PREDNISONE. Patient recovered.

Imatinib Side Effects Report #5823157-4
Imatinib side effect was reported by a Health Professional from UNITED STATES on July 17, 2008. Female patient, 62 years of age, was diagnosed with acute lymphocytic leukaemia and was treated with Imatinib. After drug was administered, patient experienced the following side effects: chromosome analysis abnormal, cytogenetic abnormality, fluid retention, malignant neoplasm progression, monocytosis, myelodysplastic syndrome, pancytopenia. Imatinib dosage: 600 MG/D. During the same period patient was treated with IMATINIB MESYLATE, IMATINIB MESYLATE, CYCLOPHOSPHAMIDE, VINCRISTINE, DOXORUBICIN, DEXAMETHASONE, PREDNISONE. Patient recovered.


Imatinib Side Effects Report #5320995-1
Imatinib side effect was reported by a Physician from UNITED STATES on May 04, 2007. Male patient, 66 years of age, was treated with Imatinib. After drug was administered, patient experienced the following side effects: hypokalaemia, malignant neoplasm progression, oedema. Imatinib dosage: 600 MG, QD. During the same period patient was treated with CAMPTOSAR, CARBOPLATIN, LASIX, POTASSIUM CHLORIDE. Patient was hospitalized. Patient died on 02/05/2004.